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Protein

Platelet-activating factor receptor

Gene

PTAFR

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Chemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet-activating factor receptor
Short name:
PAF-R
Short name:
PAFr
Gene namesi
Name:PTAFR
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1616ExtracellularSequence analysisAdd
BLAST
Transmembranei17 – 3822Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini39 – 5416CytoplasmicSequence analysisAdd
BLAST
Transmembranei55 – 7420Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini75 – 9117ExtracellularSequence analysisAdd
BLAST
Transmembranei92 – 11322Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini114 – 13320CytoplasmicSequence analysisAdd
BLAST
Transmembranei134 – 15522Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini156 – 18429ExtracellularSequence analysisAdd
BLAST
Transmembranei185 – 20521Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini206 – 23328CytoplasmicSequence analysisAdd
BLAST
Transmembranei234 – 25421Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini255 – 27622ExtracellularSequence analysisAdd
BLAST
Transmembranei277 – 29620Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini297 – 34246CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL5136.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 342342Platelet-activating factor receptorPRO_0000070091Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence analysis
Disulfide bondi90 ↔ 173PROSITE-ProRule annotation
Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Interacts with ARRB1.By similarity

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000015534.

Chemistry

BindingDBiP21556.

Structurei

3D structure databases

ProteinModelPortaliP21556.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIY4. Eukaryota.
ENOG410YB0R. LUCA.
GeneTreeiENSGT00640000091213.
HOGENOMiHOG000013041.
HOVERGENiHBG101106.
InParanoidiP21556.
OMAiFLCNLAG.
OrthoDBiEOG7QVM3C.
TreeFamiTF350009.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002282. PAF_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01153. PAFRECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21556-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELNSSSRVD SEFRYTLFPI VYSIIFVLGI IANGYVLWVF ARLYPSKKLN
60 70 80 90 100
EIKIFMVNLT VADLLFLITL PLWIVYYSNQ GNWFLPKFLC NLAGCLFFIN
110 120 130 140 150
TYCSVAFLGV ITYNRFQAVK YPIKTAQATT RKRGIALSLV IWVAIVAAAS
160 170 180 190 200
YFLVMDSTNV VSNKAGSGNI TRCFEHYEKG SKPVLIIHIC IVLGFFIVFL
210 220 230 240 250
LILFCNLVII HTLLRQPVKQ QRNAEVRRRA LWMVCTVLAV FVICFVPHHM
260 270 280 290 300
VQLPWTLAEL GMWPSSNHQA INDAHQVTLC LLSTNCVLDP VIYCFLTKKF
310 320 330 340
RKHLSEKLNI MRSSQKCSRV TTDTGTEMAI PINHTPVNPI KN
Length:342
Mass (Da):38,984
Last modified:August 1, 1991 - v2
Checksum:iB6413B3A5C87B175
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56736 mRNA. Translation: CAA40060.1.
PIRiS13638.
RefSeqiXP_005004316.1. XM_005004259.2.
XP_013009648.1. XM_013154194.1.
XP_013009649.1. XM_013154195.1.

Genome annotation databases

EnsembliENSCPOT00000027623; ENSCPOP00000015534; ENSCPOG00000024245.
GeneIDi100720710.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56736 mRNA. Translation: CAA40060.1.
PIRiS13638.
RefSeqiXP_005004316.1. XM_005004259.2.
XP_013009648.1. XM_013154194.1.
XP_013009649.1. XM_013154195.1.

3D structure databases

ProteinModelPortaliP21556.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000015534.

Chemistry

BindingDBiP21556.
ChEMBLiCHEMBL5136.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCPOT00000027623; ENSCPOP00000015534; ENSCPOG00000024245.
GeneIDi100720710.

Organism-specific databases

CTDi5724.

Phylogenomic databases

eggNOGiENOG410IIY4. Eukaryota.
ENOG410YB0R. LUCA.
GeneTreeiENSGT00640000091213.
HOGENOMiHOG000013041.
HOVERGENiHBG101106.
InParanoidiP21556.
OMAiFLCNLAG.
OrthoDBiEOG7QVM3C.
TreeFamiTF350009.

Miscellaneous databases

PROiP21556.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002282. PAF_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01153. PAFRECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning by functional expression of platelet-activating factor receptor from guinea-pig lung."
    Honda Z., Nakamura M., Miki I., Minami M., Watanabe T., Seyama Y., Okado H., Toh H., Ito K., Miyamoto T., Shimizu T.
    Nature 349:342-346(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiPTAFR_CAVPO
AccessioniPrimary (citable) accession number: P21556
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: August 1, 1991
Last modified: June 8, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.