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Protein

Platelet-activating factor receptor

Gene

PTAFR

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Chemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet-activating factor receptor
Short name:
PAF-R
Short name:
PAFr
Gene namesi
Name:PTAFR
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16ExtracellularSequence analysisAdd BLAST16
Transmembranei17 – 38Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini39 – 54CytoplasmicSequence analysisAdd BLAST16
Transmembranei55 – 74Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini75 – 91ExtracellularSequence analysisAdd BLAST17
Transmembranei92 – 113Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini114 – 133CytoplasmicSequence analysisAdd BLAST20
Transmembranei134 – 155Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini156 – 184ExtracellularSequence analysisAdd BLAST29
Transmembranei185 – 205Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini206 – 233CytoplasmicSequence analysisAdd BLAST28
Transmembranei234 – 254Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini255 – 276ExtracellularSequence analysisAdd BLAST22
Transmembranei277 – 296Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini297 – 342CytoplasmicSequence analysisAdd BLAST46

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5136.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700911 – 342Platelet-activating factor receptorAdd BLAST342

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi90 ↔ 173PROSITE-ProRule annotation
Glycosylationi169N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Interacts with ARRB1.By similarity

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000015534.

Chemistry databases

BindingDBiP21556.

Structurei

3D structure databases

ProteinModelPortaliP21556.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIY4. Eukaryota.
ENOG410YB0R. LUCA.
GeneTreeiENSGT00640000091213.
HOGENOMiHOG000013041.
HOVERGENiHBG101106.
InParanoidiP21556.
OMAiFLCNLAG.
OrthoDBiEOG091G0A7Q.
TreeFamiTF350009.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002282. PAF_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01153. PAFRECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21556-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELNSSSRVD SEFRYTLFPI VYSIIFVLGI IANGYVLWVF ARLYPSKKLN
60 70 80 90 100
EIKIFMVNLT VADLLFLITL PLWIVYYSNQ GNWFLPKFLC NLAGCLFFIN
110 120 130 140 150
TYCSVAFLGV ITYNRFQAVK YPIKTAQATT RKRGIALSLV IWVAIVAAAS
160 170 180 190 200
YFLVMDSTNV VSNKAGSGNI TRCFEHYEKG SKPVLIIHIC IVLGFFIVFL
210 220 230 240 250
LILFCNLVII HTLLRQPVKQ QRNAEVRRRA LWMVCTVLAV FVICFVPHHM
260 270 280 290 300
VQLPWTLAEL GMWPSSNHQA INDAHQVTLC LLSTNCVLDP VIYCFLTKKF
310 320 330 340
RKHLSEKLNI MRSSQKCSRV TTDTGTEMAI PINHTPVNPI KN
Length:342
Mass (Da):38,984
Last modified:August 1, 1991 - v2
Checksum:iB6413B3A5C87B175
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56736 mRNA. Translation: CAA40060.1.
PIRiS13638.
RefSeqiXP_005004316.1. XM_005004259.2.
XP_013009648.1. XM_013154194.1.
XP_013009649.1. XM_013154195.1.

Genome annotation databases

EnsembliENSCPOT00000027623; ENSCPOP00000015534; ENSCPOG00000024245.
GeneIDi100720710.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56736 mRNA. Translation: CAA40060.1.
PIRiS13638.
RefSeqiXP_005004316.1. XM_005004259.2.
XP_013009648.1. XM_013154194.1.
XP_013009649.1. XM_013154195.1.

3D structure databases

ProteinModelPortaliP21556.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000015534.

Chemistry databases

BindingDBiP21556.
ChEMBLiCHEMBL5136.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCPOT00000027623; ENSCPOP00000015534; ENSCPOG00000024245.
GeneIDi100720710.

Organism-specific databases

CTDi5724.

Phylogenomic databases

eggNOGiENOG410IIY4. Eukaryota.
ENOG410YB0R. LUCA.
GeneTreeiENSGT00640000091213.
HOGENOMiHOG000013041.
HOVERGENiHBG101106.
InParanoidiP21556.
OMAiFLCNLAG.
OrthoDBiEOG091G0A7Q.
TreeFamiTF350009.

Miscellaneous databases

PROiP21556.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002282. PAF_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01153. PAFRECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTAFR_CAVPO
AccessioniPrimary (citable) accession number: P21556
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: August 1, 1991
Last modified: November 30, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.