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Protein

Neuropeptide Y receptor type 1

Gene

Npy1r

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for neuropeptide Y and peptide YY.1 Publication

GO - Molecular functioni

GO - Biological processi

  • aging Source: RGD
  • cell surface receptor signaling pathway Source: GO_Central
  • feeding behavior Source: GO_Central
  • negative regulation of cytosolic calcium ion concentration Source: RGD
  • negative regulation of hormone secretion Source: RGD
  • neuropeptide signaling pathway Source: GO_Central
  • peristalsis Source: RGD
  • positive regulation of vasoconstriction Source: RGD
  • response to estradiol Source: RGD
  • sensory perception of pain Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide Y receptor type 1
Short name:
NPY1-R
Alternative name(s):
FC5
Gene namesi
Name:Npy1r
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3198. Npy1r.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333ExtracellularSequence analysisAdd
BLAST
Transmembranei34 – 5421Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini55 – 7521CytoplasmicSequence analysisAdd
BLAST
Transmembranei76 – 9621Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini97 – 11519ExtracellularSequence analysisAdd
BLAST
Transmembranei116 – 13621Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini137 – 15317CytoplasmicSequence analysisAdd
BLAST
Transmembranei154 – 17421Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini175 – 21036ExtracellularSequence analysisAdd
BLAST
Transmembranei211 – 23121Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini232 – 25928CytoplasmicSequence analysisAdd
BLAST
Transmembranei260 – 28021Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini281 – 29818ExtracellularSequence analysisAdd
BLAST
Transmembranei299 – 31921Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini320 – 38263CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • axon Source: RGD
  • cytosol Source: RGD
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: RGD
  • synaptic vesicle Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2587.
GuidetoPHARMACOLOGYi305.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382Neuropeptide Y receptor type 1PRO_0000069923Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...)Sequence analysis
Glycosylationi11 – 111N-linked (GlcNAc...)Sequence analysis
Glycosylationi17 – 171N-linked (GlcNAc...)Sequence analysis
Disulfide bondi112 ↔ 197PROSITE-ProRule annotation
Lipidationi337 – 3371S-palmitoyl cysteineSequence analysis
Modified residuei367 – 3671PhosphoserineCombined sources
Modified residuei375 – 3751PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP21555.

PTM databases

iPTMnetiP21555.
PhosphoSiteiP21555.
SwissPalmiP21555.

Expressioni

Tissue specificityi

Brain.

Interactioni

Protein-protein interaction databases

IntActiP21555. 1 interaction.
STRINGi10116.ENSRNOP00000018952.

Chemistry

BindingDBiP21555.

Structurei

3D structure databases

ProteinModelPortaliP21555.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000050229.
HOVERGENiHBG105676.
InParanoidiP21555.
PhylomeDBiP21555.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000351. NPY1_rcpt.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01013. NRPEPTIDEY1R.
PR01012. NRPEPTIDEYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21555-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSTLFSRVE NYSVHYNVSE NSPFLAFEND DCHLPLAVIF TLALAYGAVI
60 70 80 90 100
ILGVSGNLAL IIIILKQKEM RNVTNILIVN LSFSDLLVAV MCLPFTFVYT
110 120 130 140 150
LMDHWVFGET MCKLNPFVQC VSITVSIFSL VLIAVERHQL IINPRGWRPN
160 170 180 190 200
NRHAYIGITV IWVLAVASSL PFVIYQILTD EPFQNVSLAA FKDKYVCFDK
210 220 230 240 250
FPSDSHRLSY TTLLLVLQYF GPLCFIFICY FKIYIRLKRR NNMMDKIRDS
260 270 280 290 300
KYRSSETKRI NVMLLSIVVA FAVCWLPLTI FNTVFDWNHQ IIATCNHNLL
310 320 330 340 350
FLLCHLTAMI STCVNPIFYG FLNKNFQRDL QFFFNFCDFR SRDDDYETIA
360 370 380
MSTMHTDVSK TSLKQASPVA FKKISMNDNE KI
Length:382
Mass (Da):44,117
Last modified:May 1, 1992 - v3
Checksum:i1D6AA038065C07C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11504 mRNA. Translation: CAA77579.1.
PIRiS12863.
UniGeneiRn.11642.

Genome annotation databases

UCSCiRGD:3198. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11504 mRNA. Translation: CAA77579.1.
PIRiS12863.
UniGeneiRn.11642.

3D structure databases

ProteinModelPortaliP21555.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP21555. 1 interaction.
STRINGi10116.ENSRNOP00000018952.

Chemistry

BindingDBiP21555.
ChEMBLiCHEMBL2587.
GuidetoPHARMACOLOGYi305.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP21555.
PhosphoSiteiP21555.
SwissPalmiP21555.

Proteomic databases

PaxDbiP21555.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:3198. rat.

Organism-specific databases

RGDi3198. Npy1r.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000050229.
HOVERGENiHBG105676.
InParanoidiP21555.
PhylomeDBiP21555.

Miscellaneous databases

PROiP21555.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000351. NPY1_rcpt.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01013. NRPEPTIDEY1R.
PR01012. NRPEPTIDEYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a novel G protein-coupled receptor that may belong to the neuropeptide receptor family."
    Eva C., Keinaenen K., Monyer H., Seeburg P.H., Sprengel R.
    FEBS Lett. 271:81-84(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. Krause J.E., Eva C., Seeburg P.H., Sprengel R.
    Submitted (NOV-1991) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION, FUNCTION.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-367, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNPY1R_RAT
AccessioniPrimary (citable) accession number: P21555
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1992
Last modified: July 6, 2016
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.