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P21554

- CNR1_HUMAN

UniProt

P21554 - CNR1_HUMAN

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Protein

Cannabinoid receptor 1

Gene
CNR1, CNR
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca2+ channel current. Isoform 2 and isoform 3 have altered ligand binding.1 Publication

GO - Molecular functioni

  1. cannabinoid receptor activity Source: UniProtKB
  2. drug binding Source: Ensembl

GO - Biological processi

  1. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: UniProtKB
  2. aging Source: Ensembl
  3. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
  4. maternal process involved in female pregnancy Source: Ensembl
  5. memory Source: Ensembl
  6. negative regulation of action potential Source: Ensembl
  7. negative regulation of blood pressure Source: Ensembl
  8. negative regulation of dopamine secretion Source: Ensembl
  9. negative regulation of fatty acid beta-oxidation Source: Ensembl
  10. negative regulation of mast cell activation Source: Ensembl
  11. negative regulation of nitric-oxide synthase activity Source: Ensembl
  12. positive regulation of acute inflammatory response to antigenic stimulus Source: Ensembl
  13. positive regulation of apoptotic process Source: Ensembl
  14. positive regulation of blood pressure Source: Ensembl
  15. positive regulation of fever generation Source: Ensembl
  16. positive regulation of neuron projection development Source: Ensembl
  17. regulation of feeding behavior Source: Ensembl
  18. regulation of insulin secretion Source: Ensembl
  19. regulation of penile erection Source: Ensembl
  20. regulation of synaptic transmission, GABAergic Source: Ensembl
  21. regulation of synaptic transmission, glutamatergic Source: Ensembl
  22. response to cocaine Source: Ensembl
  23. response to ethanol Source: Ensembl
  24. response to lipopolysaccharide Source: Ensembl
  25. response to morphine Source: Ensembl
  26. response to nicotine Source: Ensembl
  27. response to nutrient Source: Ensembl
  28. sensory perception of pain Source: Ensembl
  29. spermatogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14828. Class A/1 (Rhodopsin-like receptors).
REACT_19231. G alpha (i) signalling events.

Protein family/group databases

TCDBi9.A.14.2.2. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Cannabinoid receptor 1
Short name:
CB-R
Short name:
CB1
Alternative name(s):
CANN6
Gene namesi
Name:CNR1
Synonyms:CNR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:2159. CNR1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 116116Extracellular Reviewed predictionAdd
BLAST
Transmembranei117 – 14226Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini143 – 15412Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei155 – 17521Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini176 – 18712Extracellular Reviewed predictionAdd
BLAST
Transmembranei188 – 21225Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini213 – 23220Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei233 – 25523Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini256 – 27318Extracellular Reviewed predictionAdd
BLAST
Transmembranei274 – 29926Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini300 – 34445Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei345 – 36521Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini366 – 37712Extracellular Reviewed predictionAdd
BLAST
Transmembranei378 – 39922Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini400 – 47273Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26681.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 472472Cannabinoid receptor 1PRO_0000069314Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi77 – 771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi83 – 831N-linked (GlcNAc...) Reviewed prediction
Glycosylationi112 – 1121N-linked (GlcNAc...) Reviewed prediction
Lipidationi415 – 4151S-palmitoyl cysteine1 Publication

Post-translational modificationi

Palmitoylation at Cys-415 is important for recruitment at both plasma membrane and lipid rafts.1 Publication

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP21554.
PRIDEiP21554.

PTM databases

PhosphoSiteiP21554.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

ArrayExpressiP21554.
BgeeiP21554.
CleanExiHS_CNR1.
GenevestigatoriP21554.

Organism-specific databases

HPAiCAB005603.

Interactioni

Subunit structurei

Interacts (via C-terminus) with CNRIP1.1 Publication

Protein-protein interaction databases

BioGridi107668. 4 interactions.
IntActiP21554. 1 interaction.

Structurei

Secondary structure

1
472
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni340 – 3445
Helixi378 – 39114
Turni394 – 4018
Helixi403 – 4108
Helixi411 – 4144

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LVQNMR-A338-346[»]
1LVRNMR-A338-346[»]
2B0YNMR-A400-414[»]
2KOENMR-A377-414[»]
ProteinModelPortaliP21554.
SMRiP21554. Positions 115-416.

Miscellaneous databases

EvolutionaryTraceiP21554.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148018.
HOVERGENiHBG051045.
InParanoidiP21554.
KOiK04277.
OMAiVAFCVMW.
OrthoDBiEOG7CK36K.
PhylomeDBiP21554.
TreeFamiTF330052.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000810. Canbinoid_rcpt_1.
IPR002230. Cnbnoid_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR22750:SF10. PTHR22750:SF10. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PIRSFiPIRSF037995. Cnoid_rcpt_1. 1 hit.
PRINTSiPR00522. CANABINOID1R.
PR00362. CANNABINOIDR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P21554-1) [UniParc]FASTAAdd to Basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKSILDGLAD TTFRTITTDL LYVGSNDIQY EDIKGDMASK LGYFPQKFPL    50
TSFRGSPFQE KMTAGDNPQL VPADQVNITE FYNKSLSSFK ENEENIQCGE 100
NFMDIECFMV LNPSQQLAIA VLSLTLGTFT VLENLLVLCV ILHSRSLRCR 150
PSYHFIGSLA VADLLGSVIF VYSFIDFHVF HRKDSRNVFL FKLGGVTASF 200
TASVGSLFLT AIDRYISIHR PLAYKRIVTR PKAVVAFCLM WTIAIVIAVL 250
PLLGWNCEKL QSVCSDIFPH IDETYLMFWI GVTSVLLLFI VYAYMYILWK 300
AHSHAVRMIQ RGTQKSIIIH TSEDGKVQVT RPDQARMDIR LAKTLVLILV 350
VLIICWGPLL AIMVYDVFGK MNKLIKTVFA FCSMLCLLNS TVNPIIYALR 400
SKDLRHAFRS MFPSCEGTAQ PLDNSMGDSD CLHKHANNAA SVHRAAESCI 450
KSTVKIAKVT MSVSTDTSAE AL 472
Length:472
Mass (Da):52,858
Last modified:May 1, 1991 - v1
Checksum:i1D2E49061D12ABF2
GO
Isoform 2 (identifier: P21554-2) [UniParc]FASTAAdd to Basket

Also known as: CB1a, Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-89: MKSILDGLAD...EFYNKSLSSF → MALQIPPSAPSPLTSCTWAQMTFSTKTS

Note: Dubious isoform. A putative downstream initiation AUG is used to produce isoform 2 (PubMed:1718258). The use of the first AUG (same as isoform 1) gives a truncated protein of 36 AA.

Show »
Length:411
Mass (Da):45,874
Checksum:iE3C31ACAB4066BC1
GO
Isoform 3 (identifier: P21554-3) [UniParc]FASTAAdd to Basket

Also known as: CB1b

The sequence of this isoform differs from the canonical sequence as follows:
     22-54: Missing.

Show »
Length:439
Mass (Da):49,060
Checksum:iC80C6B8D640412C1
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8989MKSIL…SLSSF → MALQIPPSAPSPLTSCTWAQ MTFSTKTS in isoform 2. VSP_001868Add
BLAST
Alternative sequencei22 – 5433Missing in isoform 3. VSP_016529Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti94 – 941E → G in AAH95513. 1 Publication
Sequence conflicti103 – 1031M → I in AAH95513. 1 Publication
Sequence conflicti149 – 1491C → R in AAH95513. 1 Publication
Sequence conflicti200 – 2001F → L in AAD34320. 1 Publication
Sequence conflicti216 – 2161I → V in AAD34320. 1 Publication
Sequence conflicti246 – 2461V → A in AAD34320. 1 Publication
Sequence conflicti298 – 2981L → P in AAH95513. 1 Publication
Sequence conflicti332 – 3321P → S in AAI00972. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X54937 mRNA. Translation: CAA38699.1.
X81120 mRNA. Translation: CAA57018.1.
X81121 mRNA. Translation: CAA57019.1.
AY766182 mRNA. Translation: AAV35030.1.
AF107262 mRNA. Translation: AAD34320.1.
U73304 Genomic DNA. Translation: AAB18200.1.
DQ067455 mRNA. Translation: AAY68486.1.
AY225225 Genomic DNA. Translation: AAO67710.1.
AL136096 Genomic DNA. Translation: CAB96726.1.
AL136096 Genomic DNA. Translation: CAI19916.1.
AK313908 mRNA. Translation: BAG36631.1.
CH471051 Genomic DNA. Translation: EAW48574.1.
CH471051 Genomic DNA. Translation: EAW48575.1.
CH471051 Genomic DNA. Translation: EAW48576.1.
BC074811 mRNA. Translation: AAH74811.1.
BC074812 mRNA. Translation: AAH74812.1.
BC095513 mRNA. Translation: AAH95513.1.
BC100968 mRNA. Translation: AAI00969.1.
BC100969 mRNA. Translation: AAI00970.1.
BC100970 mRNA. Translation: AAI00971.1.
BC100971 mRNA. Translation: AAI00972.1.
CCDSiCCDS5015.1. [P21554-1]
CCDS5016.2. [P21554-3]
PIRiS17595.
RefSeqiNP_001153698.1. NM_001160226.1. [P21554-1]
NP_001153730.1. NM_001160258.1. [P21554-1]
NP_001153731.1. NM_001160259.1. [P21554-1]
NP_057167.2. NM_016083.4. [P21554-1]
NP_149421.2. NM_033181.3. [P21554-3]
XP_005248707.1. XM_005248650.2. [P21554-1]
XP_006715393.1. XM_006715330.1. [P21554-1]
UniGeneiHs.75110.

Genome annotation databases

EnsembliENST00000369499; ENSP00000358511; ENSG00000118432. [P21554-1]
ENST00000369501; ENSP00000358513; ENSG00000118432. [P21554-1]
ENST00000428600; ENSP00000412192; ENSG00000118432. [P21554-1]
ENST00000468898; ENSP00000420188; ENSG00000118432. [P21554-3]
ENST00000535130; ENSP00000442689; ENSG00000118432. [P21554-1]
ENST00000537554; ENSP00000441046; ENSG00000118432. [P21554-1]
ENST00000549716; ENSP00000449549; ENSG00000118432. [P21554-2]
ENST00000549890; ENSP00000446819; ENSG00000118432. [P21554-1]
GeneIDi1268.
KEGGihsa:1268.
UCSCiuc003pmq.4. human. [P21554-1]
uc010kca.3. human. [P21554-3]

Polymorphism databases

DMDMi115562.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X54937 mRNA. Translation: CAA38699.1 .
X81120 mRNA. Translation: CAA57018.1 .
X81121 mRNA. Translation: CAA57019.1 .
AY766182 mRNA. Translation: AAV35030.1 .
AF107262 mRNA. Translation: AAD34320.1 .
U73304 Genomic DNA. Translation: AAB18200.1 .
DQ067455 mRNA. Translation: AAY68486.1 .
AY225225 Genomic DNA. Translation: AAO67710.1 .
AL136096 Genomic DNA. Translation: CAB96726.1 .
AL136096 Genomic DNA. Translation: CAI19916.1 .
AK313908 mRNA. Translation: BAG36631.1 .
CH471051 Genomic DNA. Translation: EAW48574.1 .
CH471051 Genomic DNA. Translation: EAW48575.1 .
CH471051 Genomic DNA. Translation: EAW48576.1 .
BC074811 mRNA. Translation: AAH74811.1 .
BC074812 mRNA. Translation: AAH74812.1 .
BC095513 mRNA. Translation: AAH95513.1 .
BC100968 mRNA. Translation: AAI00969.1 .
BC100969 mRNA. Translation: AAI00970.1 .
BC100970 mRNA. Translation: AAI00971.1 .
BC100971 mRNA. Translation: AAI00972.1 .
CCDSi CCDS5015.1. [P21554-1 ]
CCDS5016.2. [P21554-3 ]
PIRi S17595.
RefSeqi NP_001153698.1. NM_001160226.1. [P21554-1 ]
NP_001153730.1. NM_001160258.1. [P21554-1 ]
NP_001153731.1. NM_001160259.1. [P21554-1 ]
NP_057167.2. NM_016083.4. [P21554-1 ]
NP_149421.2. NM_033181.3. [P21554-3 ]
XP_005248707.1. XM_005248650.2. [P21554-1 ]
XP_006715393.1. XM_006715330.1. [P21554-1 ]
UniGenei Hs.75110.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1LVQ NMR - A 338-346 [» ]
1LVR NMR - A 338-346 [» ]
2B0Y NMR - A 400-414 [» ]
2KOE NMR - A 377-414 [» ]
ProteinModelPortali P21554.
SMRi P21554. Positions 115-416.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107668. 4 interactions.
IntActi P21554. 1 interaction.

Chemistry

BindingDBi P21554.
ChEMBLi CHEMBL2096981.
DrugBanki DB00470. Marinol.
DB00486. Nabilone.
DB06155. Rimonabant.
GuidetoPHARMACOLOGYi 56.

Protein family/group databases

TCDBi 9.A.14.2.2. the g-protein-coupled receptor (gpcr) family.
GPCRDBi Search...

PTM databases

PhosphoSitei P21554.

Polymorphism databases

DMDMi 115562.

Proteomic databases

PaxDbi P21554.
PRIDEi P21554.

Protocols and materials databases

DNASUi 1268.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000369499 ; ENSP00000358511 ; ENSG00000118432 . [P21554-1 ]
ENST00000369501 ; ENSP00000358513 ; ENSG00000118432 . [P21554-1 ]
ENST00000428600 ; ENSP00000412192 ; ENSG00000118432 . [P21554-1 ]
ENST00000468898 ; ENSP00000420188 ; ENSG00000118432 . [P21554-3 ]
ENST00000535130 ; ENSP00000442689 ; ENSG00000118432 . [P21554-1 ]
ENST00000537554 ; ENSP00000441046 ; ENSG00000118432 . [P21554-1 ]
ENST00000549716 ; ENSP00000449549 ; ENSG00000118432 . [P21554-2 ]
ENST00000549890 ; ENSP00000446819 ; ENSG00000118432 . [P21554-1 ]
GeneIDi 1268.
KEGGi hsa:1268.
UCSCi uc003pmq.4. human. [P21554-1 ]
uc010kca.3. human. [P21554-3 ]

Organism-specific databases

CTDi 1268.
GeneCardsi GC06M088850.
H-InvDB HIX0165039.
HGNCi HGNC:2159. CNR1.
HPAi CAB005603.
MIMi 114610. gene.
neXtProti NX_P21554.
PharmGKBi PA26681.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG148018.
HOVERGENi HBG051045.
InParanoidi P21554.
KOi K04277.
OMAi VAFCVMW.
OrthoDBi EOG7CK36K.
PhylomeDBi P21554.
TreeFami TF330052.

Enzyme and pathway databases

Reactomei REACT_14828. Class A/1 (Rhodopsin-like receptors).
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

EvolutionaryTracei P21554.
GeneWikii Cannabinoid_receptor_type_1.
GenomeRNAii 1268.
NextBioi 5133.
PROi P21554.
SOURCEi Search...

Gene expression databases

ArrayExpressi P21554.
Bgeei P21554.
CleanExi HS_CNR1.
Genevestigatori P21554.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000810. Canbinoid_rcpt_1.
IPR002230. Cnbnoid_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR22750:SF10. PTHR22750:SF10. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF037995. Cnoid_rcpt_1. 1 hit.
PRINTSi PR00522. CANABINOID1R.
PR00362. CANNABINOIDR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of a human cannabinoid receptor cDNA."
    Gerard C., Mollereau C., Vassart G., Parmentier M.
    Nucleic Acids Res. 18:7142-7142(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain stem.
  2. "Molecular cloning of a human cannabinoid receptor which is also expressed in testis."
    Gerard C., Mollereau C., Vassart G., Parmentier M.
    Biochem. J. 279:129-134(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain stem.
  3. "An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing."
    Shire D., Carillon C., Kaghad M., Calandra B., Rinaldi-Carmona M., Le Fur G., Caput D., Ferrara P.
    J. Biol. Chem. 270:3726-3731(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Lung.
  4. "Identification and characterisation of a novel splice variant of the human CB1 receptor."
    Ryberg E., Vu H.K., Larsson N., Groblewski T., Hjorth S., Elebring T., Sjoegren S., Greasley P.J.
    FEBS Lett. 579:259-264(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION, TISSUE SPECIFICITY.
  5. Kathmann M., Schlicker E.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Hippocampus.
  6. Bonner T.I.
    Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  7. Kumar S., Gupta S., Sharma G.
    Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain tumor.
  8. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  9. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Hippocampus.
  10. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  12. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  13. "CB1 cannabinoid receptor activity is modulated by the cannabinoid receptor interacting protein CRIP 1a."
    Niehaus J.L., Liu Y., Wallis K.T., Egertova M., Bhartur S.G., Mukhopadhyay S., Shi S., He H., Selley D.E., Howlett A.C., Elphick M.R., Lewis D.L.
    Mol. Pharmacol. 72:1557-1566(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CNRIP1.
    Tissue: Brain.
  14. "Effects of palmitoylation of Cys(415) in helix 8 of the CB(1) cannabinoid receptor on membrane localization and signalling."
    Oddi S., Dainese E., Sandiford S., Fezza F., Lanuti M., Chiurchiu V., Totaro A., Catanzaro G., Barcaroli D., De Laurenzi V., Centonze D., Mukhopadhyay S., Selent J., Howlett A.C., Maccarrone M.
    Br. J. Pharmacol. 165:2635-2651(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PALMITOYLATION AT CYS-415.
  15. "Cannabinoid receptor-G protein interactions: G(alphai1)-bound structures of IC3 and a mutant with altered G protein specificity."
    Ulfers A.L., McMurry J.L., Miller A., Wang L., Kendall D.A., Mierke D.F.
    Protein Sci. 11:2526-2531(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 338-346.

Entry informationi

Entry nameiCNR1_HUMAN
AccessioniPrimary (citable) accession number: P21554
Secondary accession number(s): B2R9T4
, E1P512, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: September 3, 2014
This is version 153 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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