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P21554

- CNR1_HUMAN

UniProt

P21554 - CNR1_HUMAN

Protein

Cannabinoid receptor 1

Gene

CNR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 154 (01 Oct 2014)
      Sequence version 1 (01 May 1991)
      Previous versions | rss
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    Functioni

    Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca2+ channel current. Isoform 2 and isoform 3 have altered ligand binding.1 Publication

    GO - Molecular functioni

    1. cannabinoid receptor activity Source: UniProtKB
    2. drug binding Source: Ensembl

    GO - Biological processi

    1. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: UniProtKB
    2. aging Source: Ensembl
    3. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
    4. maternal process involved in female pregnancy Source: Ensembl
    5. memory Source: Ensembl
    6. negative regulation of action potential Source: Ensembl
    7. negative regulation of blood pressure Source: Ensembl
    8. negative regulation of dopamine secretion Source: Ensembl
    9. negative regulation of fatty acid beta-oxidation Source: Ensembl
    10. negative regulation of mast cell activation Source: Ensembl
    11. negative regulation of nitric-oxide synthase activity Source: Ensembl
    12. positive regulation of acute inflammatory response to antigenic stimulus Source: Ensembl
    13. positive regulation of apoptotic process Source: Ensembl
    14. positive regulation of blood pressure Source: Ensembl
    15. positive regulation of fever generation Source: Ensembl
    16. positive regulation of neuron projection development Source: Ensembl
    17. regulation of feeding behavior Source: Ensembl
    18. regulation of insulin secretion Source: Ensembl
    19. regulation of penile erection Source: Ensembl
    20. regulation of synaptic transmission, GABAergic Source: Ensembl
    21. regulation of synaptic transmission, glutamatergic Source: Ensembl
    22. response to cocaine Source: Ensembl
    23. response to ethanol Source: Ensembl
    24. response to lipopolysaccharide Source: Ensembl
    25. response to morphine Source: Ensembl
    26. response to nicotine Source: Ensembl
    27. response to nutrient Source: Ensembl
    28. sensory perception of pain Source: Ensembl
    29. spermatogenesis Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_14828. Class A/1 (Rhodopsin-like receptors).
    REACT_19231. G alpha (i) signalling events.

    Protein family/group databases

    TCDBi9.A.14.2.2. the g-protein-coupled receptor (gpcr) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cannabinoid receptor 1
    Short name:
    CB-R
    Short name:
    CB1
    Alternative name(s):
    CANN6
    Gene namesi
    Name:CNR1
    Synonyms:CNR
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:2159. CNR1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26681.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 472472Cannabinoid receptor 1PRO_0000069314Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi77 – 771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi83 – 831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence Analysis
    Lipidationi415 – 4151S-palmitoyl cysteine1 Publication

    Post-translational modificationi

    Palmitoylation at Cys-415 is important for recruitment at both plasma membrane and lipid rafts.1 Publication

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiP21554.
    PRIDEiP21554.

    PTM databases

    PhosphoSiteiP21554.

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Gene expression databases

    ArrayExpressiP21554.
    BgeeiP21554.
    CleanExiHS_CNR1.
    GenevestigatoriP21554.

    Organism-specific databases

    HPAiCAB005603.

    Interactioni

    Subunit structurei

    Interacts (via C-terminus) with CNRIP1.1 Publication

    Protein-protein interaction databases

    BioGridi107668. 4 interactions.
    IntActiP21554. 1 interaction.

    Structurei

    Secondary structure

    1
    472
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni340 – 3445
    Helixi378 – 39114
    Turni394 – 4018
    Helixi403 – 4108
    Helixi411 – 4144

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1LVQNMR-A338-346[»]
    1LVRNMR-A338-346[»]
    2B0YNMR-A400-414[»]
    2KOENMR-A377-414[»]
    ProteinModelPortaliP21554.
    SMRiP21554. Positions 115-416.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP21554.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 116116ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini143 – 15412CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini176 – 18712ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini213 – 23220CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini256 – 27318ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini300 – 34445CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini366 – 37712ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini400 – 47273CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei117 – 14226Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei155 – 17521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei188 – 21225Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei233 – 25523Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei274 – 29926Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei345 – 36521Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei378 – 39922Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG148018.
    HOVERGENiHBG051045.
    InParanoidiP21554.
    KOiK04277.
    OMAiVAFCVMW.
    OrthoDBiEOG7CK36K.
    PhylomeDBiP21554.
    TreeFamiTF330052.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000810. Canbinoid_rcpt_1.
    IPR002230. Cnbnoid_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR22750:SF10. PTHR22750:SF10. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037995. Cnoid_rcpt_1. 1 hit.
    PRINTSiPR00522. CANABINOID1R.
    PR00362. CANNABINOIDR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P21554-1) [UniParc]FASTAAdd to Basket

    Also known as: Long

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKSILDGLAD TTFRTITTDL LYVGSNDIQY EDIKGDMASK LGYFPQKFPL    50
    TSFRGSPFQE KMTAGDNPQL VPADQVNITE FYNKSLSSFK ENEENIQCGE 100
    NFMDIECFMV LNPSQQLAIA VLSLTLGTFT VLENLLVLCV ILHSRSLRCR 150
    PSYHFIGSLA VADLLGSVIF VYSFIDFHVF HRKDSRNVFL FKLGGVTASF 200
    TASVGSLFLT AIDRYISIHR PLAYKRIVTR PKAVVAFCLM WTIAIVIAVL 250
    PLLGWNCEKL QSVCSDIFPH IDETYLMFWI GVTSVLLLFI VYAYMYILWK 300
    AHSHAVRMIQ RGTQKSIIIH TSEDGKVQVT RPDQARMDIR LAKTLVLILV 350
    VLIICWGPLL AIMVYDVFGK MNKLIKTVFA FCSMLCLLNS TVNPIIYALR 400
    SKDLRHAFRS MFPSCEGTAQ PLDNSMGDSD CLHKHANNAA SVHRAAESCI 450
    KSTVKIAKVT MSVSTDTSAE AL 472
    Length:472
    Mass (Da):52,858
    Last modified:May 1, 1991 - v1
    Checksum:i1D2E49061D12ABF2
    GO
    Isoform 2 (identifier: P21554-2) [UniParc]FASTAAdd to Basket

    Also known as: CB1a, Short

    The sequence of this isoform differs from the canonical sequence as follows:
         1-89: MKSILDGLAD...EFYNKSLSSF → MALQIPPSAPSPLTSCTWAQMTFSTKTS

    Note: Dubious isoform. A putative downstream initiation AUG is used to produce isoform 2 (PubMed:1718258). The use of the first AUG (same as isoform 1) gives a truncated protein of 36 AA.1 Publication

    Show »
    Length:411
    Mass (Da):45,874
    Checksum:iE3C31ACAB4066BC1
    GO
    Isoform 3 (identifier: P21554-3) [UniParc]FASTAAdd to Basket

    Also known as: CB1b

    The sequence of this isoform differs from the canonical sequence as follows:
         22-54: Missing.

    Show »
    Length:439
    Mass (Da):49,060
    Checksum:iC80C6B8D640412C1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti94 – 941E → G in AAH95513. (PubMed:15489334)Curated
    Sequence conflicti103 – 1031M → I in AAH95513. (PubMed:15489334)Curated
    Sequence conflicti149 – 1491C → R in AAH95513. (PubMed:15489334)Curated
    Sequence conflicti200 – 2001F → L in AAD34320. 1 PublicationCurated
    Sequence conflicti216 – 2161I → V in AAD34320. 1 PublicationCurated
    Sequence conflicti246 – 2461V → A in AAD34320. 1 PublicationCurated
    Sequence conflicti298 – 2981L → P in AAH95513. (PubMed:15489334)Curated
    Sequence conflicti332 – 3321P → S in AAI00972. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8989MKSIL…SLSSF → MALQIPPSAPSPLTSCTWAQ MTFSTKTS in isoform 2. 1 PublicationVSP_001868Add
    BLAST
    Alternative sequencei22 – 5433Missing in isoform 3. 1 PublicationVSP_016529Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X54937 mRNA. Translation: CAA38699.1.
    X81120 mRNA. Translation: CAA57018.1.
    X81121 mRNA. Translation: CAA57019.1.
    AY766182 mRNA. Translation: AAV35030.1.
    AF107262 mRNA. Translation: AAD34320.1.
    U73304 Genomic DNA. Translation: AAB18200.1.
    DQ067455 mRNA. Translation: AAY68486.1.
    AY225225 Genomic DNA. Translation: AAO67710.1.
    AL136096 Genomic DNA. Translation: CAB96726.1.
    AL136096 Genomic DNA. Translation: CAI19916.1.
    AK313908 mRNA. Translation: BAG36631.1.
    CH471051 Genomic DNA. Translation: EAW48574.1.
    CH471051 Genomic DNA. Translation: EAW48575.1.
    CH471051 Genomic DNA. Translation: EAW48576.1.
    BC074811 mRNA. Translation: AAH74811.1.
    BC074812 mRNA. Translation: AAH74812.1.
    BC095513 mRNA. Translation: AAH95513.1.
    BC100968 mRNA. Translation: AAI00969.1.
    BC100969 mRNA. Translation: AAI00970.1.
    BC100970 mRNA. Translation: AAI00971.1.
    BC100971 mRNA. Translation: AAI00972.1.
    CCDSiCCDS5015.1. [P21554-1]
    CCDS5016.2. [P21554-3]
    PIRiS17595.
    RefSeqiNP_001153698.1. NM_001160226.1. [P21554-1]
    NP_001153730.1. NM_001160258.1. [P21554-1]
    NP_001153731.1. NM_001160259.1. [P21554-1]
    NP_057167.2. NM_016083.4. [P21554-1]
    NP_149421.2. NM_033181.3. [P21554-3]
    XP_005248707.1. XM_005248650.2. [P21554-1]
    XP_006715393.1. XM_006715330.1. [P21554-1]
    UniGeneiHs.75110.

    Genome annotation databases

    EnsembliENST00000369499; ENSP00000358511; ENSG00000118432. [P21554-1]
    ENST00000369501; ENSP00000358513; ENSG00000118432. [P21554-1]
    ENST00000428600; ENSP00000412192; ENSG00000118432. [P21554-1]
    ENST00000468898; ENSP00000420188; ENSG00000118432. [P21554-3]
    ENST00000549890; ENSP00000446819; ENSG00000118432. [P21554-1]
    GeneIDi1268.
    KEGGihsa:1268.
    UCSCiuc003pmq.4. human. [P21554-1]
    uc010kca.3. human. [P21554-3]

    Polymorphism databases

    DMDMi115562.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X54937 mRNA. Translation: CAA38699.1 .
    X81120 mRNA. Translation: CAA57018.1 .
    X81121 mRNA. Translation: CAA57019.1 .
    AY766182 mRNA. Translation: AAV35030.1 .
    AF107262 mRNA. Translation: AAD34320.1 .
    U73304 Genomic DNA. Translation: AAB18200.1 .
    DQ067455 mRNA. Translation: AAY68486.1 .
    AY225225 Genomic DNA. Translation: AAO67710.1 .
    AL136096 Genomic DNA. Translation: CAB96726.1 .
    AL136096 Genomic DNA. Translation: CAI19916.1 .
    AK313908 mRNA. Translation: BAG36631.1 .
    CH471051 Genomic DNA. Translation: EAW48574.1 .
    CH471051 Genomic DNA. Translation: EAW48575.1 .
    CH471051 Genomic DNA. Translation: EAW48576.1 .
    BC074811 mRNA. Translation: AAH74811.1 .
    BC074812 mRNA. Translation: AAH74812.1 .
    BC095513 mRNA. Translation: AAH95513.1 .
    BC100968 mRNA. Translation: AAI00969.1 .
    BC100969 mRNA. Translation: AAI00970.1 .
    BC100970 mRNA. Translation: AAI00971.1 .
    BC100971 mRNA. Translation: AAI00972.1 .
    CCDSi CCDS5015.1. [P21554-1 ]
    CCDS5016.2. [P21554-3 ]
    PIRi S17595.
    RefSeqi NP_001153698.1. NM_001160226.1. [P21554-1 ]
    NP_001153730.1. NM_001160258.1. [P21554-1 ]
    NP_001153731.1. NM_001160259.1. [P21554-1 ]
    NP_057167.2. NM_016083.4. [P21554-1 ]
    NP_149421.2. NM_033181.3. [P21554-3 ]
    XP_005248707.1. XM_005248650.2. [P21554-1 ]
    XP_006715393.1. XM_006715330.1. [P21554-1 ]
    UniGenei Hs.75110.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1LVQ NMR - A 338-346 [» ]
    1LVR NMR - A 338-346 [» ]
    2B0Y NMR - A 400-414 [» ]
    2KOE NMR - A 377-414 [» ]
    ProteinModelPortali P21554.
    SMRi P21554. Positions 115-416.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107668. 4 interactions.
    IntActi P21554. 1 interaction.

    Chemistry

    BindingDBi P21554.
    ChEMBLi CHEMBL2096981.
    DrugBanki DB00470. Marinol.
    DB00486. Nabilone.
    DB06155. Rimonabant.
    GuidetoPHARMACOLOGYi 56.

    Protein family/group databases

    TCDBi 9.A.14.2.2. the g-protein-coupled receptor (gpcr) family.
    GPCRDBi Search...

    PTM databases

    PhosphoSitei P21554.

    Polymorphism databases

    DMDMi 115562.

    Proteomic databases

    PaxDbi P21554.
    PRIDEi P21554.

    Protocols and materials databases

    DNASUi 1268.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000369499 ; ENSP00000358511 ; ENSG00000118432 . [P21554-1 ]
    ENST00000369501 ; ENSP00000358513 ; ENSG00000118432 . [P21554-1 ]
    ENST00000428600 ; ENSP00000412192 ; ENSG00000118432 . [P21554-1 ]
    ENST00000468898 ; ENSP00000420188 ; ENSG00000118432 . [P21554-3 ]
    ENST00000549890 ; ENSP00000446819 ; ENSG00000118432 . [P21554-1 ]
    GeneIDi 1268.
    KEGGi hsa:1268.
    UCSCi uc003pmq.4. human. [P21554-1 ]
    uc010kca.3. human. [P21554-3 ]

    Organism-specific databases

    CTDi 1268.
    GeneCardsi GC06M088850.
    H-InvDB HIX0165039.
    HGNCi HGNC:2159. CNR1.
    HPAi CAB005603.
    MIMi 114610. gene.
    neXtProti NX_P21554.
    PharmGKBi PA26681.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG148018.
    HOVERGENi HBG051045.
    InParanoidi P21554.
    KOi K04277.
    OMAi VAFCVMW.
    OrthoDBi EOG7CK36K.
    PhylomeDBi P21554.
    TreeFami TF330052.

    Enzyme and pathway databases

    Reactomei REACT_14828. Class A/1 (Rhodopsin-like receptors).
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    EvolutionaryTracei P21554.
    GeneWikii Cannabinoid_receptor_type_1.
    GenomeRNAii 1268.
    NextBioi 5133.
    PROi P21554.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P21554.
    Bgeei P21554.
    CleanExi HS_CNR1.
    Genevestigatori P21554.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000810. Canbinoid_rcpt_1.
    IPR002230. Cnbnoid_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR22750:SF10. PTHR22750:SF10. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037995. Cnoid_rcpt_1. 1 hit.
    PRINTSi PR00522. CANABINOID1R.
    PR00362. CANNABINOIDR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of a human cannabinoid receptor cDNA."
      Gerard C., Mollereau C., Vassart G., Parmentier M.
      Nucleic Acids Res. 18:7142-7142(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain stem.
    2. "Molecular cloning of a human cannabinoid receptor which is also expressed in testis."
      Gerard C., Mollereau C., Vassart G., Parmentier M.
      Biochem. J. 279:129-134(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain stem.
    3. "An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing."
      Shire D., Carillon C., Kaghad M., Calandra B., Rinaldi-Carmona M., Le Fur G., Caput D., Ferrara P.
      J. Biol. Chem. 270:3726-3731(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Tissue: Lung.
    4. "Identification and characterisation of a novel splice variant of the human CB1 receptor."
      Ryberg E., Vu H.K., Larsson N., Groblewski T., Hjorth S., Elebring T., Sjoegren S., Greasley P.J.
      FEBS Lett. 579:259-264(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION, TISSUE SPECIFICITY.
    5. Kathmann M., Schlicker E.
      Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Hippocampus.
    6. Bonner T.I.
      Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    7. Kumar S., Gupta S., Sharma G.
      Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain tumor.
    8. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A., Aronstam R.S., Sharma S.V.
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    9. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Hippocampus.
    10. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    12. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.
    13. "CB1 cannabinoid receptor activity is modulated by the cannabinoid receptor interacting protein CRIP 1a."
      Niehaus J.L., Liu Y., Wallis K.T., Egertova M., Bhartur S.G., Mukhopadhyay S., Shi S., He H., Selley D.E., Howlett A.C., Elphick M.R., Lewis D.L.
      Mol. Pharmacol. 72:1557-1566(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CNRIP1.
      Tissue: Brain.
    14. "Effects of palmitoylation of Cys(415) in helix 8 of the CB(1) cannabinoid receptor on membrane localization and signalling."
      Oddi S., Dainese E., Sandiford S., Fezza F., Lanuti M., Chiurchiu V., Totaro A., Catanzaro G., Barcaroli D., De Laurenzi V., Centonze D., Mukhopadhyay S., Selent J., Howlett A.C., Maccarrone M.
      Br. J. Pharmacol. 165:2635-2651(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: PALMITOYLATION AT CYS-415.
    15. "Cannabinoid receptor-G protein interactions: G(alphai1)-bound structures of IC3 and a mutant with altered G protein specificity."
      Ulfers A.L., McMurry J.L., Miller A., Wang L., Kendall D.A., Mierke D.F.
      Protein Sci. 11:2526-2531(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 338-346.

    Entry informationi

    Entry nameiCNR1_HUMAN
    AccessioniPrimary (citable) accession number: P21554
    Secondary accession number(s): B2R9T4
    , E1P512, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: May 1, 1991
    Last modified: October 1, 2014
    This is version 154 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3