ID WNT2_MOUSE Reviewed; 360 AA. AC P21552; Q9CZW3; DT 01-MAY-1991, integrated into UniProtKB/Swiss-Prot. DT 27-JUL-2011, sequence version 2. DT 27-MAR-2024, entry version 176. DE RecName: Full=Protein Wnt-2; DE AltName: Full=INT-1-related protein {ECO:0000303|PubMed:2693041}; DE Short=IRP; DE Flags: Precursor; GN Name=Wnt2; Synonyms=Irp, Wnt-2; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=2693041; DOI=10.1242/dev.107.3.643; RA McMahon J.A., McMahon A.P.; RT "Nucleotide sequence, chromosomal localization and developmental expression RT of the mouse int-1-related gene."; RL Development 107:643-650(1989). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=2279700; DOI=10.1101/gad.4.12b.2319; RA Gavin B.J., McMahon J.A., McMahon A.P.; RT "Expression of multiple novel Wnt-1/int-1-related genes during fetal and RT adult mouse development."; RL Genes Dev. 4:2319-2332(1990). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6J; TISSUE=Embryo; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=FVB/N; TISSUE=Liver; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [6] RP FUNCTION, DISRUPTION PHENOTYPE, AND DEVELOPMENTAL STAGE. RX PubMed=19686689; DOI=10.1016/j.devcel.2009.06.005; RA Goss A.M., Tian Y., Tsukiyama T., Cohen E.D., Zhou D., Lu M.M., RA Yamaguchi T.P., Morrisey E.E.; RT "Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify RT lung progenitors in the foregut."; RL Dev. Cell 17:290-298(2009). RN [7] RP DEVELOPMENTAL STAGE, AND FUNCTION. RX PubMed=20018874; DOI=10.1074/jbc.m109.079822; RA Sousa K.M., Villaescusa J.C., Cajanek L., Ondr J.K., Castelo-Branco G., RA Hofstra W., Bryja V., Palmberg C., Bergman T., Wainwright B., Lang R.A., RA Arenas E.; RT "Wnt2 regulates progenitor proliferation in the developing ventral RT midbrain."; RL J. Biol. Chem. 285:7246-7253(2010). RN [8] RP FUNCTION, AND DISRUPTION PHENOTYPE. RX PubMed=21704027; DOI=10.1016/j.ydbio.2011.06.011; RA Goss A.M., Tian Y., Cheng L., Yang J., Zhou D., Cohen E.D., Morrisey E.E.; RT "Wnt2 signaling is necessary and sufficient to activate the airway smooth RT muscle program in the lung by regulating myocardin/Mrtf-B and Fgf10 RT expression."; RL Dev. Biol. 356:541-552(2011). CC -!- FUNCTION: Ligand for members of the frizzled family of seven CC transmembrane receptors. Functions in the canonical Wnt/beta-catenin CC signaling pathway (PubMed:19686689). Functions as a upstream regulator CC of FGF10 expression (PubMed:19686689). Plays an important role in CC embryonic lung development (PubMed:19686689). May contribute to CC embryonic brain development by regulating the proliferation of CC dopaminergic precursors and neurons (PubMed:20018874). CC {ECO:0000269|PubMed:19686689, ECO:0000305, CC ECO:0000305|PubMed:20018874}. CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular CC matrix {ECO:0000250|UniProtKB:P09544}. Secreted CC {ECO:0000250|UniProtKB:P09544}. CC -!- TISSUE SPECIFICITY: In embryos in the developing allantois, pericardium CC heart, and ventral-lateral mesoderm; in adults in lung, brain, heart CC and placenta. CC -!- DEVELOPMENTAL STAGE: Detected in ventral mesencephalon from 10.5 to CC 15.5 dpc; expression levels decrease moderately, but steadily during CC this period (PubMed:20018874). Detected in the lateral plate mesoderm CC surrounding the ventral aspect of the anterior foregut from 9.0 to 10.5 CC dpc (PubMed:19686689). Detected in the developing mesenchyme with CC higher levels surrounding the distal regions of the branching airways CC from 12.5 to 18.5 dpc (PubMed:19686689). {ECO:0000269|PubMed:19686689, CC ECO:0000269|PubMed:20018874}. CC -!- PTM: Palmitoleoylation is required for efficient binding to frizzled CC receptors. Depalmitoleoylation leads to Wnt signaling pathway CC inhibition. {ECO:0000250|UniProtKB:P09544}. CC -!- DISRUPTION PHENOTYPE: Nearly complete perinatal lethality within CC minutes after birth, due to lung hypoplasia (PubMed:19686689). About 4% CC survive for more than 30 days (PubMed:19686689). Combined disruption of CC Wnt2 and Wnt2b leads to lung agenesis and loss of trachea development CC (PubMed:19686689). In contrast, development of liver, stomach, CC intestine, pancreas and kidneys appears grossly normal CC (PubMed:19686689). {ECO:0000269|PubMed:19686689}. CC -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK012093; BAB28025.1; -; mRNA. DR EMBL; CH466533; EDL13868.1; -; Genomic_DNA. DR EMBL; BC026373; AAH26373.1; -; mRNA. DR CCDS; CCDS19928.1; -. DR PIR; B36470; B36470. DR RefSeq; NP_076142.3; NM_023653.5. DR AlphaFoldDB; P21552; -. DR SMR; P21552; -. DR BioGRID; 204572; 2. DR STRING; 10090.ENSMUSP00000010941; -. DR BindingDB; P21552; -. DR GlyCosmos; P21552; 1 site, No reported glycans. DR GlyGen; P21552; 1 site. DR iPTMnet; P21552; -. DR PhosphoSitePlus; P21552; -. DR MaxQB; P21552; -. DR PaxDb; 10090-ENSMUSP00000010941; -. DR ProteomicsDB; 299995; -. DR Antibodypedia; 4474; 322 antibodies from 34 providers. DR DNASU; 22413; -. DR Ensembl; ENSMUST00000010941.6; ENSMUSP00000010941.3; ENSMUSG00000010797.7. DR GeneID; 22413; -. DR KEGG; mmu:22413; -. DR UCSC; uc009bag.2; mouse. DR AGR; MGI:98954; -. DR CTD; 7472; -. DR MGI; MGI:98954; Wnt2. DR VEuPathDB; HostDB:ENSMUSG00000010797; -. DR eggNOG; KOG3913; Eukaryota. DR GeneTree; ENSGT00940000159231; -. DR HOGENOM; CLU_033039_1_4_1; -. DR InParanoid; P21552; -. DR OMA; ITRMTKC; -. DR OrthoDB; 2874082at2759; -. DR PhylomeDB; P21552; -. DR TreeFam; TF105310; -. DR Reactome; R-MMU-3238698; WNT ligand biogenesis and trafficking. DR BioGRID-ORCS; 22413; 4 hits in 77 CRISPR screens. DR PRO; PR:P21552; -. DR Proteomes; UP000000589; Chromosome 6. DR RNAct; P21552; Protein. DR Bgee; ENSMUSG00000010797; Expressed in prostatic urethra and 114 other cell types or tissues. DR GO; GO:0062023; C:collagen-containing extracellular matrix; ISO:MGI. DR GO; GO:0005737; C:cytoplasm; ISO:MGI. DR GO; GO:0005576; C:extracellular region; ISO:MGI. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0005125; F:cytokine activity; ISO:MGI. DR GO; GO:0005109; F:frizzled binding; ISO:MGI. DR GO; GO:0048018; F:receptor ligand activity; ISO:MGI. DR GO; GO:0055009; P:atrial cardiac muscle tissue morphogenesis; IMP:MGI. DR GO; GO:0060070; P:canonical Wnt signaling pathway; IDA:MGI. DR GO; GO:0060317; P:cardiac epithelial to mesenchymal transition; IMP:MGI. DR GO; GO:0060038; P:cardiac muscle cell proliferation; IMP:MGI. DR GO; GO:0045165; P:cell fate commitment; IBA:GO_Central. DR GO; GO:0033278; P:cell proliferation in midbrain; IMP:CACAO. DR GO; GO:0007267; P:cell-cell signaling; ISO:MGI. DR GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEA:Ensembl. DR GO; GO:0050673; P:epithelial cell proliferation; IMP:MGI. DR GO; GO:0060502; P:epithelial cell proliferation involved in lung morphogenesis; IMP:MGI. DR GO; GO:0060716; P:labyrinthine layer blood vessel development; IMP:MGI. DR GO; GO:0060492; P:lung induction; IGI:MGI. DR GO; GO:0061180; P:mammary gland epithelium development; IEA:Ensembl. DR GO; GO:0010463; P:mesenchymal cell proliferation; IMP:MGI. DR GO; GO:1904948; P:midbrain dopaminergic neuron differentiation; ISO:MGI. DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central. DR GO; GO:0060045; P:positive regulation of cardiac muscle cell proliferation; IMP:MGI. DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:MGI. DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; ISO:MGI. DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IMP:MGI. DR GO; GO:0060501; P:positive regulation of epithelial cell proliferation involved in lung morphogenesis; IMP:MGI. DR GO; GO:0048146; P:positive regulation of fibroblast proliferation; ISO:MGI. DR GO; GO:0002053; P:positive regulation of mesenchymal cell proliferation; IMP:MGI. DR GO; GO:0050769; P:positive regulation of neurogenesis; IDA:CACAO. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI. DR GO; GO:0016055; P:Wnt signaling pathway; IGI:MGI. DR CDD; cd19345; Wnt_Wnt2; 1. DR Gene3D; 3.30.2460.20; -; 1. DR InterPro; IPR005817; Wnt. DR InterPro; IPR009140; Wnt2. DR InterPro; IPR043158; Wnt_C. DR InterPro; IPR018161; Wnt_CS. DR PANTHER; PTHR12027:SF86; PROTEIN WNT-2; 1. DR PANTHER; PTHR12027; WNT RELATED; 1. DR Pfam; PF00110; wnt; 1. DR PRINTS; PR01842; WNT2PROTEIN. DR PRINTS; PR01349; WNTPROTEIN. DR SMART; SM00097; WNT1; 1. DR PROSITE; PS00246; WNT1; 1. DR Genevisible; P21552; MM. PE 2: Evidence at transcript level; KW Developmental protein; Disulfide bond; Extracellular matrix; Glycoprotein; KW Lipoprotein; Reference proteome; Secreted; Signal; Wnt signaling pathway. FT SIGNAL 1..25 FT /evidence="ECO:0000255" FT CHAIN 26..360 FT /note="Protein Wnt-2" FT /id="PRO_0000041411" FT LIPID 212 FT /note="O-palmitoleoyl serine; by PORCN" FT /evidence="ECO:0000250|UniProtKB:P56704" FT CARBOHYD 295 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 76..87 FT /evidence="ECO:0000250|UniProtKB:P28026" FT DISULFID 127..135 FT /evidence="ECO:0000250|UniProtKB:P28026" FT DISULFID 137..157 FT /evidence="ECO:0000250|UniProtKB:P28026" FT DISULFID 206..220 FT /evidence="ECO:0000250|UniProtKB:P28026" FT DISULFID 208..215 FT /evidence="ECO:0000250|UniProtKB:P28026" FT DISULFID 278..309 FT /evidence="ECO:0000250|UniProtKB:P28026" FT DISULFID 294..304 FT /evidence="ECO:0000250|UniProtKB:P28026" FT DISULFID 308..348 FT /evidence="ECO:0000250|UniProtKB:P28026" FT DISULFID 324..339 FT /evidence="ECO:0000250|UniProtKB:P28026" FT DISULFID 326..336 FT /evidence="ECO:0000250|UniProtKB:P28026" FT DISULFID 331..332 FT /evidence="ECO:0000250|UniProtKB:P28026" FT CONFLICT 232 FT /note="D -> E (in Ref. 1; no nucleotide entry and 2; no FT nucleotide entry)" FT /evidence="ECO:0000305" SQ SEQUENCE 360 AA; 40482 MW; 5E37644D3815EEAD CRC64; MNVPLGGIWL WLPLLLTWLT PEVSSSWWYM RATGGSSRVM CDNVPGLVSR QRQLCHRHPD VMRAIGLGVA EWTAECQHQF RQHRWNCNTL DRDHSLFGRV LLRSSRESAF VYAISSAGVV FAITRACSQG ELKSCSCDPK KKGSAKDSKG TFDWGGCSDN IDYGIKFARA FVDAKERKGK DARALMNLHN NRAGRKAVKR FLKQECKCHG VSGSCTLRTC WLAMADFRKT GDYLWRKYNG AIQVVMNQDG TGFTVANKRF KKPTKNDLVY FENSPDYCIR DREAGSLGTA GRVCNLTSRG MDSCEVMCCG RGYDTSHVTR MTKCECKFHW CCAVRCQDCL EALDVHTCKA PKSADWATPT //