Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P21552

- WNT2_MOUSE

UniProt

P21552 - WNT2_MOUSE

Protein

Protein Wnt-2

Gene

Wnt2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

    GO - Molecular functioni

    1. frizzled binding Source: RefGenome

    GO - Biological processi

    1. atrial cardiac muscle tissue morphogenesis Source: MGI
    2. canonical Wnt signaling pathway Source: MGI
    3. cardiac epithelial to mesenchymal transition Source: MGI
    4. cellular response to transforming growth factor beta stimulus Source: Ensembl
    5. labyrinthine layer blood vessel development Source: MGI
    6. lung development Source: Ensembl
    7. lung induction Source: MGI
    8. mammary gland epithelium development Source: Ensembl
    9. neuron differentiation Source: RefGenome
    10. positive regulation of canonical Wnt signaling pathway Source: Ensembl
    11. positive regulation of cardiac muscle cell proliferation Source: MGI
    12. positive regulation of endothelial cell proliferation Source: Ensembl
    13. positive regulation of epithelial cell proliferation involved in lung morphogenesis Source: MGI
    14. positive regulation of fibroblast proliferation Source: Ensembl
    15. positive regulation of mesenchymal cell proliferation Source: MGI
    16. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
    17. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    18. Wnt signaling pathway Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_213918. WNT ligand biogenesis and trafficking.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Wnt-2
    Alternative name(s):
    INT-1-related protein
    Short name:
    IRP
    Gene namesi
    Name:Wnt2
    Synonyms:Irp, Wnt-2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:98954. Wnt2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. extracellular space Source: RefGenome
    3. plasma membrane Source: Ensembl
    4. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 360335Protein Wnt-2PRO_0000041411Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi76 ↔ 87By similarity
    Disulfide bondi127 ↔ 135By similarity
    Disulfide bondi137 ↔ 157By similarity
    Disulfide bondi206 ↔ 220By similarity
    Disulfide bondi208 ↔ 215By similarity
    Lipidationi212 – 2121O-palmitoyl serine; by PORCNBy similarity
    Disulfide bondi294 ↔ 309By similarity
    Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi324 ↔ 339By similarity
    Disulfide bondi326 ↔ 336By similarity
    Disulfide bondi331 ↔ 332By similarity

    Post-translational modificationi

    Palmitoylation at Ser-212 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiP21552.
    PRIDEiP21552.

    PTM databases

    PhosphoSiteiP21552.

    Expressioni

    Tissue specificityi

    In embryos in the developing allantois, pericardium heart, and ventral-lateral mesoderm; in adults in lung, brain, heart and placenta.

    Gene expression databases

    ArrayExpressiP21552.
    BgeeiP21552.
    CleanExiMM_WNT2.
    GenevestigatoriP21552.

    Interactioni

    Protein-protein interaction databases

    BioGridi204572. 1 interaction.
    STRINGi10090.ENSMUSP00000010941.

    Structurei

    3D structure databases

    ProteinModelPortaliP21552.
    SMRiP21552. Positions 64-348.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Wnt family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG284879.
    GeneTreeiENSGT00740000115400.
    HOGENOMiHOG000039529.
    HOVERGENiHBG001595.
    InParanoidiQ9CZW3.
    KOiK00182.
    OMAiWKKYNGA.
    OrthoDBiEOG7C8GJ8.
    TreeFamiTF105310.

    Family and domain databases

    InterProiIPR005817. Wnt.
    IPR009140. Wnt2.
    IPR018161. Wnt_CS.
    [Graphical view]
    PANTHERiPTHR12027. PTHR12027. 1 hit.
    PfamiPF00110. wnt. 1 hit.
    [Graphical view]
    PRINTSiPR01842. WNT2PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTiSM00097. WNT1. 1 hit.
    [Graphical view]
    PROSITEiPS00246. WNT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P21552-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNVPLGGIWL WLPLLLTWLT PEVSSSWWYM RATGGSSRVM CDNVPGLVSR    50
    QRQLCHRHPD VMRAIGLGVA EWTAECQHQF RQHRWNCNTL DRDHSLFGRV 100
    LLRSSRESAF VYAISSAGVV FAITRACSQG ELKSCSCDPK KKGSAKDSKG 150
    TFDWGGCSDN IDYGIKFARA FVDAKERKGK DARALMNLHN NRAGRKAVKR 200
    FLKQECKCHG VSGSCTLRTC WLAMADFRKT GDYLWRKYNG AIQVVMNQDG 250
    TGFTVANKRF KKPTKNDLVY FENSPDYCIR DREAGSLGTA GRVCNLTSRG 300
    MDSCEVMCCG RGYDTSHVTR MTKCECKFHW CCAVRCQDCL EALDVHTCKA 350
    PKSADWATPT 360
    Length:360
    Mass (Da):40,482
    Last modified:July 27, 2011 - v2
    Checksum:i5E37644D3815EEAD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti232 – 2321D → E no nucleotide entry (PubMed:2693041)Curated
    Sequence conflicti232 – 2321D → E no nucleotide entry (PubMed:2279700)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK012093 mRNA. Translation: BAB28025.1.
    CH466533 Genomic DNA. Translation: EDL13868.1.
    BC026373 mRNA. Translation: AAH26373.1.
    CCDSiCCDS19928.1.
    PIRiB36470.
    RefSeqiNP_076142.3. NM_023653.5.
    UniGeneiMm.33653.

    Genome annotation databases

    EnsembliENSMUST00000010941; ENSMUSP00000010941; ENSMUSG00000010797.
    GeneIDi22413.
    KEGGimmu:22413.
    UCSCiuc009bag.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK012093 mRNA. Translation: BAB28025.1 .
    CH466533 Genomic DNA. Translation: EDL13868.1 .
    BC026373 mRNA. Translation: AAH26373.1 .
    CCDSi CCDS19928.1.
    PIRi B36470.
    RefSeqi NP_076142.3. NM_023653.5.
    UniGenei Mm.33653.

    3D structure databases

    ProteinModelPortali P21552.
    SMRi P21552. Positions 64-348.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204572. 1 interaction.
    STRINGi 10090.ENSMUSP00000010941.

    Chemistry

    BindingDBi P21552.

    PTM databases

    PhosphoSitei P21552.

    Proteomic databases

    PaxDbi P21552.
    PRIDEi P21552.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000010941 ; ENSMUSP00000010941 ; ENSMUSG00000010797 .
    GeneIDi 22413.
    KEGGi mmu:22413.
    UCSCi uc009bag.2. mouse.

    Organism-specific databases

    CTDi 7472.
    MGIi MGI:98954. Wnt2.

    Phylogenomic databases

    eggNOGi NOG284879.
    GeneTreei ENSGT00740000115400.
    HOGENOMi HOG000039529.
    HOVERGENi HBG001595.
    InParanoidi Q9CZW3.
    KOi K00182.
    OMAi WKKYNGA.
    OrthoDBi EOG7C8GJ8.
    TreeFami TF105310.

    Enzyme and pathway databases

    Reactomei REACT_213918. WNT ligand biogenesis and trafficking.

    Miscellaneous databases

    NextBioi 302821.
    PROi P21552.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P21552.
    Bgeei P21552.
    CleanExi MM_WNT2.
    Genevestigatori P21552.

    Family and domain databases

    InterProi IPR005817. Wnt.
    IPR009140. Wnt2.
    IPR018161. Wnt_CS.
    [Graphical view ]
    PANTHERi PTHR12027. PTHR12027. 1 hit.
    Pfami PF00110. wnt. 1 hit.
    [Graphical view ]
    PRINTSi PR01842. WNT2PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTi SM00097. WNT1. 1 hit.
    [Graphical view ]
    PROSITEi PS00246. WNT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence, chromosomal localization and developmental expression of the mouse int-1-related gene."
      McMahon J.A., McMahon A.P.
      Development 107:643-650(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development."
      Gavin B.J., McMahon J.A., McMahon A.P.
      Genes Dev. 4:2319-2332(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Liver.

    Entry informationi

    Entry nameiWNT2_MOUSE
    AccessioniPrimary (citable) accession number: P21552
    Secondary accession number(s): Q9CZW3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3