Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Gamma-aminobutyric acid receptor subunit gamma-2

Gene

GABRG2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity).By similarity

Miscellaneous

This subunit carries the benzodiazepine binding site.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChloride channel, Ion channel
Biological processIon transport, Transport
LigandChloride

Enzyme and pathway databases

ReactomeiR-GGA-977441 GABA A receptor activation

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit gamma-2
Alternative name(s):
GABA(A) receptor subunit gamma-2
Gene namesi
Name:GABRG2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini39 – 272ExtracellularCuratedAdd BLAST234
Transmembranei273 – 295HelicalCuratedAdd BLAST23
Transmembranei299 – 321HelicalCuratedAdd BLAST23
Transmembranei333 – 355HelicalCuratedAdd BLAST23
Topological domaini356 – 450CytoplasmicCuratedAdd BLAST95
Transmembranei451 – 474HelicalCuratedAdd BLAST24

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 38Sequence analysisAdd BLAST38
ChainiPRO_000000048039 – 474Gamma-aminobutyric acid receptor subunit gamma-2Add BLAST436

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi51N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi128N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi189 ↔ 203By similarity
Glycosylationi246N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi266N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP21548
PRIDEiP21548

PTM databases

iPTMnetiP21548

Expressioni

Gene expression databases

BgeeiENSGALG00000001706

Interactioni

Subunit structurei

Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000034151

Structurei

3D structure databases

ProteinModelPortaliP21548
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni376 – 383Insertion, similar to human gamma-2 sequence which is proposed to be caused by alternative splicing8

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3642 Eukaryota
ENOG410XNQG LUCA
GeneTreeiENSGT00760000119010
HOGENOMiHOG000231337
HOVERGENiHBG051707
InParanoidiP21548
KOiK05186
OrthoDBiEOG091G0805
PhylomeDBiP21548

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006028 GABAA/Glycine_rcpt
IPR005439 GABBAg2_rcpt
IPR005437 GABBAg_rcpt
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00253 GABAARECEPTR
PR01620 GABAARGAMMA
PR01622 GABAARGAMMA2
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21548-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPSNPTRLG STALLNPAFS LKMMVWALVF LSLIQCSTQK GDDDYEDYTS
60 70 80 90 100
NKTWVLTPKV HESDVTLILN GLLEGYDNKL RPDIGVKPTV IHTDMYVNSI
110 120 130 140 150
GPVNAINMEY TIDIFFAQTW YDRRLKFNST IKVLRLNSNM VGKIWIPDTF
160 170 180 190 200
FRNSKKADAH WITTPNRMLR IWNDGRVLYT LRLTIDAECQ LQLHNFPMDA
210 220 230 240 250
HSCPLEFSSY GYPREEIIYQ WKRSSVEVGD TRSWRLYQFS FTGLRNTTEV
260 270 280 290 300
VKTTSGDYVV MSVYFNLSRR MGYFTIQTYI PCTLIVVLSW VSFWINKDAV
310 320 330 340 350
PARTSLGITT VLTMTTLSTI ARKSLPKVSY VTAMDLFVSV CFIFVFSALV
360 370 380 390 400
EYGTLHYFVS NRKPSKDKDK KKKNPLLRMF SFKAPTIDIR PRSATIQMNN
410 420 430 440 450
ATHLQERDEE YGYECLDGKD CASFFCCFED CRTGAWRHGR IHIRIAKMDS
460 470
YARIFFPTAF CLFNLVYWVS YLYL
Length:474
Mass (Da):54,970
Last modified:May 1, 1991 - v1
Checksum:i79A172CCEA59C9CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54944 mRNA Translation: CAA38704.1
PIRiS13086
RefSeqiNP_990676.1, NM_205345.2
UniGeneiGga.50106

Genome annotation databases

EnsembliENSGALT00000065912; ENSGALP00000053851; ENSGALG00000038042
GeneIDi396289
KEGGigga:396289

Similar proteinsi

Entry informationi

Entry nameiGBRG2_CHICK
AccessioniPrimary (citable) accession number: P21548
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: May 23, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health