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Protein

Gamma-aminobutyric acid receptor subunit gamma-2

Gene

GABRG2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Enzyme and pathway databases

ReactomeiR-GGA-975298. Ligand-gated ion channel transport.
R-GGA-977441. GABA A receptor activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit gamma-2
Alternative name(s):
GABA(A) receptor subunit gamma-2
Gene namesi
Name:GABRG2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini39 – 272234ExtracellularCuratedAdd
BLAST
Transmembranei273 – 29523HelicalCuratedAdd
BLAST
Transmembranei299 – 32123HelicalCuratedAdd
BLAST
Transmembranei333 – 35523HelicalCuratedAdd
BLAST
Topological domaini356 – 45095CytoplasmicCuratedAdd
BLAST
Transmembranei451 – 47424HelicalCuratedAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3838Sequence analysisAdd
BLAST
Chaini39 – 474436Gamma-aminobutyric acid receptor subunit gamma-2PRO_0000000480Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi51 – 511N-linked (GlcNAc...)Sequence analysis
Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence analysis
Disulfide bondi189 ↔ 203By similarity
Glycosylationi246 – 2461N-linked (GlcNAc...)Sequence analysis
Glycosylationi266 – 2661N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP21548.

PTM databases

iPTMnetiP21548.

Expressioni

Gene expression databases

BgeeiENSGALG00000001706.
ExpressionAtlasiP21548. baseline.

Interactioni

Subunit structurei

Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000034151.

Structurei

3D structure databases

ProteinModelPortaliP21548.
SMRiP21548. Positions 300-357.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni376 – 3838Insertion, similar to human gamma-2 sequence which is proposed to be caused by alternative splicing

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3642. Eukaryota.
ENOG410XNQG. LUCA.
HOGENOMiHOG000231337.
HOVERGENiHBG051707.
InParanoidiP21548.
KOiK05186.
OrthoDBiEOG091G0805.
PhylomeDBiP21548.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR005439. GABBAg2_rcpt.
IPR005437. GABBAg_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR01620. GABAARGAMMA.
PR01622. GABAARGAMMA2.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21548-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPSNPTRLG STALLNPAFS LKMMVWALVF LSLIQCSTQK GDDDYEDYTS
60 70 80 90 100
NKTWVLTPKV HESDVTLILN GLLEGYDNKL RPDIGVKPTV IHTDMYVNSI
110 120 130 140 150
GPVNAINMEY TIDIFFAQTW YDRRLKFNST IKVLRLNSNM VGKIWIPDTF
160 170 180 190 200
FRNSKKADAH WITTPNRMLR IWNDGRVLYT LRLTIDAECQ LQLHNFPMDA
210 220 230 240 250
HSCPLEFSSY GYPREEIIYQ WKRSSVEVGD TRSWRLYQFS FTGLRNTTEV
260 270 280 290 300
VKTTSGDYVV MSVYFNLSRR MGYFTIQTYI PCTLIVVLSW VSFWINKDAV
310 320 330 340 350
PARTSLGITT VLTMTTLSTI ARKSLPKVSY VTAMDLFVSV CFIFVFSALV
360 370 380 390 400
EYGTLHYFVS NRKPSKDKDK KKKNPLLRMF SFKAPTIDIR PRSATIQMNN
410 420 430 440 450
ATHLQERDEE YGYECLDGKD CASFFCCFED CRTGAWRHGR IHIRIAKMDS
460 470
YARIFFPTAF CLFNLVYWVS YLYL
Length:474
Mass (Da):54,970
Last modified:May 1, 1991 - v1
Checksum:i79A172CCEA59C9CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54944 mRNA. Translation: CAA38704.1.
PIRiS13086.
RefSeqiNP_990676.1. NM_205345.2.
UniGeneiGga.50106.

Genome annotation databases

GeneIDi396289.
KEGGigga:396289.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54944 mRNA. Translation: CAA38704.1.
PIRiS13086.
RefSeqiNP_990676.1. NM_205345.2.
UniGeneiGga.50106.

3D structure databases

ProteinModelPortaliP21548.
SMRiP21548. Positions 300-357.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000034151.

PTM databases

iPTMnetiP21548.

Proteomic databases

PaxDbiP21548.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396289.
KEGGigga:396289.

Organism-specific databases

CTDi2566.

Phylogenomic databases

eggNOGiKOG3642. Eukaryota.
ENOG410XNQG. LUCA.
HOGENOMiHOG000231337.
HOVERGENiHBG051707.
InParanoidiP21548.
KOiK05186.
OrthoDBiEOG091G0805.
PhylomeDBiP21548.

Enzyme and pathway databases

ReactomeiR-GGA-975298. Ligand-gated ion channel transport.
R-GGA-977441. GABA A receptor activation.

Miscellaneous databases

PROiP21548.

Gene expression databases

BgeeiENSGALG00000001706.
ExpressionAtlasiP21548. baseline.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR005439. GABBAg2_rcpt.
IPR005437. GABBAg_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR01620. GABAARGAMMA.
PR01622. GABAARGAMMA2.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGBRG2_CHICK
AccessioniPrimary (citable) accession number: P21548
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: September 7, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This subunit carries the benzodiazepine binding site.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.