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Protein

Early embryogenesis protein zyg-11

Gene

zyg-11

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as target recruitment subunit in the E3 ubiquitin ligase complex zyg-11-cul-2-elc-1. Required for metaphase to anaphase transition and M phase exit at meiosis II. Regulates polarity establishment.3 Publications

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior axis specification, embryo Source: WormBase
  • embryo development ending in birth or egg hatching Source: WormBase
  • meiotic nuclear division Source: WormBase
  • negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation Source: WormBase
  • positive regulation of metaphase/anaphase transition of meiotic cell cycle Source: WormBase
  • positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: WormBase
  • regulation of ubiquitin-protein transferase activity Source: GO_Central
  • sister chromosome movement towards spindle pole involved in meiotic sister chromatid segregation Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Meiosis, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Early embryogenesis protein zyg-11
Gene namesi
Name:zyg-11
ORF Names:C08B11.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiC08B11.1; CE01471; WBGene00006996; zyg-11.

Subcellular locationi

GO - Cellular componenti

  • Cul2-RING ubiquitin ligase complex Source: WormBase
Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi18 – 181L → S: Abolishes interaction with elc-1. 1 Publication
Mutagenesisi21 – 211L → S: Abolishes interaction with elc-1. 1 Publication
Mutagenesisi36 – 361P → S: No effect on interaction with elc-1. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 799799Early embryogenesis protein zyg-11PRO_0000066597Add
BLAST

Proteomic databases

PaxDbiP21541.
PRIDEiP21541.

Expressioni

Developmental stagei

Maternally expressed but its transcription is not limited to the female germline.

Interactioni

Subunit structurei

Interacts with elc-1. Part of an E3 ubiquitin ligase complex including zyg-11, cul-2 and elc-1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
cul-2Q173903EBI-314647,EBI-1811231
elc-1Q9BKS12EBI-314647,EBI-300574

Protein-protein interaction databases

BioGridi39616. 8 interactions.
DIPiDIP-25221N.
IntActiP21541. 4 interactions.
MINTiMINT-1047441.
STRINGi6239.C08B11.1.

Structurei

3D structure databases

ProteinModelPortaliP21541.
SMRiP21541. Positions 132-242, 278-322.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 131131Interaction with elc-1Add
BLAST

Sequence similaritiesi

Belongs to the zyg-11 family.Curated

Phylogenomic databases

eggNOGiKOG3665. Eukaryota.
ENOG410XPSX. LUCA.
GeneTreeiENSGT00530000063187.
HOGENOMiHOG000020023.
InParanoidiP21541.
KOiK10350.
OMAiTICNDYL.
OrthoDBiEOG72ZCD9.
PhylomeDBiP21541.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR032675. L_dom-like.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.

Sequencei

Sequence statusi: Complete.

P21541-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDHNAALTTC STSAIPRLAR LATERIAELI ENDALPEFDH KVIASCSNDI
60 70 80 90 100
FEVLRQKKKL NHQTLQTMCS TSRFQINKID LMGNKVELQD LELCSNQNLV
110 120 130 140 150
SFRLGDIDYF PNTNKIQVAD VLDTALNRTS RQQLRHLDLS GRHRITSNWP
160 170 180 190 200
TYVARKLPRL ESLAFANRST ANETLSQIGA SLLNLRFLDI SSTCVTDISC
210 220 230 240 250
ISSLRNLEVL IMYNLNILKG DVTETLSNLT KLRVLDISRK VNTDYLQETS
260 270 280 290 300
QDAHLDLALG IYNRSVEAIE SGTATPWAEL RAIDMSGLSI VQFGTDRALA
310 320 330 340 350
FVEKIIEAHP KLEQISLLAT PLDSSLIEIP NRNLQVINTV SRRSIIFALS
360 370 380 390 400
HYANLDRPAF ITHALHSVYY QLQSGYDKFS QEELKECLRL VCISMQQGLN
410 420 430 440 450
TLPVQIAGSA CLYHLCKMKR IKRLSVKEVN NCIERSLDAA EQYRSMTQLQ
460 470 480 490 500
KNVWLTICND YLLHLDEIDF YRTCKVALDT MLLNRDASVE RMTIAIVSIV
510 520 530 540 550
TPKMRPSEAK ILTTETKYVY HLVKIMNDYL EAYTREHRVG HERDNENALY
560 570 580 590 600
TLKFTLSALW NLTDECPATC KAFLDAGGVQ IAFRILKAFD YHGNVQTKVL
610 620 630 640 650
GILNNLAEVE ELHLGQLCKN EYISVLISCL DGSFNEVDSK GRYREVERSY
660 670 680 690 700
FAAGILANLL TNTDGWESEN QRDEACEKLL ELIEQYPTLP SAMVSYKSFI
710 720 730 740 750
PFSRIVRESN SNGAIMWCLW GVHHVLQHRE KNKAPTYEKG YIEMFMDSGL
760 770 780 790
SPIVEDMSHG HSKHIHNLDI RVVHLAREII DIVSCHSLSS SPVRLVRRV
Length:799
Mass (Da):90,780
Last modified:May 1, 1991 - v1
Checksum:iB216E54C8F6374BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16473 Genomic DNA. Translation: CAA34493.1.
Z46676 Genomic DNA. Translation: CAA86661.1.
PIRiS14908. BVKWZ1.
RefSeqiNP_495677.1. NM_063276.4.
UniGeneiCel.5766.

Genome annotation databases

EnsemblMetazoaiC08B11.1; C08B11.1; WBGene00006996.
GeneIDi174284.
KEGGicel:CELE_C08B11.1.
UCSCiC08B11.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16473 Genomic DNA. Translation: CAA34493.1.
Z46676 Genomic DNA. Translation: CAA86661.1.
PIRiS14908. BVKWZ1.
RefSeqiNP_495677.1. NM_063276.4.
UniGeneiCel.5766.

3D structure databases

ProteinModelPortaliP21541.
SMRiP21541. Positions 132-242, 278-322.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi39616. 8 interactions.
DIPiDIP-25221N.
IntActiP21541. 4 interactions.
MINTiMINT-1047441.
STRINGi6239.C08B11.1.

Proteomic databases

PaxDbiP21541.
PRIDEiP21541.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC08B11.1; C08B11.1; WBGene00006996.
GeneIDi174284.
KEGGicel:CELE_C08B11.1.
UCSCiC08B11.1. c. elegans.

Organism-specific databases

CTDi174284.
WormBaseiC08B11.1; CE01471; WBGene00006996; zyg-11.

Phylogenomic databases

eggNOGiKOG3665. Eukaryota.
ENOG410XPSX. LUCA.
GeneTreeiENSGT00530000063187.
HOGENOMiHOG000020023.
InParanoidiP21541.
KOiK10350.
OMAiTICNDYL.
OrthoDBiEOG72ZCD9.
PhylomeDBiP21541.

Miscellaneous databases

PROiP21541.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
3.80.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR032675. L_dom-like.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular analysis of zyg-11, a maternal-effect gene required for early embryogenesis of Caenorhabditis elegans."
    Carter P.W., Roos J.M., Kemphues K.J.
    Mol. Gen. Genet. 221:72-80(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  3. "CUL-2 and ZYG-11 promote meiotic anaphase II and the proper placement of the anterior-posterior axis in C. elegans."
    Liu J., Vasudevan S., Kipreos E.T.
    Development 131:3513-3525(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "Zyg-11 and cul-2 regulate progression through meiosis II and polarity establishment in C. elegans."
    Sonneville R., Goenczy P.
    Development 131:3527-3543(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved family of CUL-2 complex components."
    Vasudevan S., Starostina N.G., Kipreos E.T.
    EMBO Rep. 8:279-286(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ELC-1, IDENTIFICATION IN COMPLEX WITH CUL-2 AND ELC-1, MUTAGENESIS OF LEU-18; LEU-21 AND PRO-36.

Entry informationi

Entry nameiZYG11_CAEEL
AccessioniPrimary (citable) accession number: P21541
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: July 6, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.