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Protein

Cytochrome c oxidase subunit 2

Gene

cox2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi182 – 1821Copper ACurated
Metal bindingi217 – 2171Copper ACurated
Metal bindingi221 – 2211Copper ACurated
Metal bindingi225 – 2251Copper ACurated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:cox2
ORF Names:SPMIT.11
Encoded oniMitochondrion
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485 Componenti: Mitochondrion

Organism-specific databases

PomBaseiSPMIT.11. cox2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3636Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Transmembranei37 – 5721HelicalSequence AnalysisAdd
BLAST
Topological domaini58 – 7518Mitochondrial matrixSequence AnalysisAdd
BLAST
Transmembranei76 – 10025HelicalSequence AnalysisAdd
BLAST
Topological domaini101 – 248148Mitochondrial intermembraneSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: PomBase
  • mitochondrial membrane Source: PomBase
  • mitochondrial respiratory chain complex IV Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 248248Cytochrome c oxidase subunit 2PRO_0000183686Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi4896.SPMIT.11.1.

Structurei

3D structure databases

ProteinModelPortaliP21534.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000264988.
InParanoidiP21534.
KOiK02261.
OrthoDBiEOG7WDNDC.
PhylomeDBiP21534.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21534-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFFNSILND APSSWALYFQ DGASPSYLGV THLNDYLMFY LTFIFIGVIY
60 70 80 90 100
AICKAVIEYN YNSHPIAAKY TTHGSIVEFI WTLIPALILI LVALPSFKLL
110 120 130 140 150
YLLDEVQKPS MTVKAIGRQW FWTYELNDFV TNENEPVSFD SYMVPEEDLE
160 170 180 190 200
EGSLRQLEVD NRLVLPIDTR IRLILTSGDV IHSWAVPSLG IKCDCIPGRL
210 220 230 240
NQVSLSIDRE GLFYGQCSEL CGVLHSSMPI VVQGVSLEDF LAWLEENS
Length:248
Mass (Da):28,121
Last modified:August 14, 2001 - v4
Checksum:i033A029DBB967871
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti123 – 1231T → S in CAA38293 (PubMed:9651494).Curated
Sequence conflicti198 – 1981G → S in CAA38293 (PubMed:9651494).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251293 Genomic DNA. Translation: CAB61572.1.
X54421 Genomic DNA. Translation: CAA38293.1.
RefSeqiNP_039508.1. NC_001326.1.

Genome annotation databases

EnsemblFungiiSPMIT.11.1; SPMIT.11.1:pep; SPMIT.11.
GeneIDi1669525.
KEGGispo:ScpofMp10.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251293 Genomic DNA. Translation: CAB61572.1.
X54421 Genomic DNA. Translation: CAA38293.1.
RefSeqiNP_039508.1. NC_001326.1.

3D structure databases

ProteinModelPortaliP21534.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4896.SPMIT.11.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPMIT.11.1; SPMIT.11.1:pep; SPMIT.11.
GeneIDi1669525.
KEGGispo:ScpofMp10.

Organism-specific databases

PomBaseiSPMIT.11. cox2.

Phylogenomic databases

HOGENOMiHOG000264988.
InParanoidiP21534.
KOiK02261.
OrthoDBiEOG7WDNDC.
PhylomeDBiP21534.

Miscellaneous databases

NextBioi20797081.
PROiP21534.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mosaic structure of the cox2 gene in the petite negative yeast Schizosaccharomyces pombe: a group II intron is inserted at the same location as the otherwise unrelated group II introns in the mitochondria of higher plants."
    Schaefer B., Kaulich K., Wolf K.
    Gene 214:101-112(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: EF2.
  2. "The mitochondrial genome of Schizosaccharomyces pombe."
    Lang B.F.
    (In) O'Brien S.J. (eds.); Genetic Maps (6th edition), pp.3118-3119, Cold Spring Harbor Laboratory Press, New York (1993)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AD7-50.

Entry informationi

Entry nameiCOX2_SCHPO
AccessioniPrimary (citable) accession number: P21534
Secondary accession number(s): Q9T653
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: August 14, 2001
Last modified: June 24, 2015
This is version 116 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.