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P21534

- COX2_SCHPO

UniProt

P21534 - COX2_SCHPO

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Protein
Cytochrome c oxidase subunit 2
Gene
cox2, SPMIT.11
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Copper A.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi182 – 1821Copper A Inferred
Metal bindingi217 – 2171Copper A Inferred
Metal bindingi221 – 2211Copper A Inferred
Metal bindingi225 – 2251Copper A Inferred

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: PomBase

GO - Biological processi

  1. aerobic respiration Source: PomBase
  2. hydrogen ion transmembrane transport Source: GOC
  3. mitochondrial electron transport, cytochrome c to oxygen Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:cox2
ORF Names:SPMIT.11
Encoded oniMitochondrion
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Mitochondrion

Organism-specific databases

PomBaseiSPMIT.11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3636Mitochondrial intermembrane Reviewed prediction
Add
BLAST
Transmembranei37 – 5721Helical; Reviewed prediction
Add
BLAST
Topological domaini58 – 7518Mitochondrial matrix Reviewed prediction
Add
BLAST
Transmembranei76 – 10025Helical; Reviewed prediction
Add
BLAST
Topological domaini101 – 248148Mitochondrial intermembrane Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial respiratory chain complex IV Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 248248Cytochrome c oxidase subunit 2
PRO_0000183686Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi4896.SPMIT.11-1.

Structurei

3D structure databases

ProteinModelPortaliP21534.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000264988.
KOiK02261.
OrthoDBiEOG7WDNDC.
PhylomeDBiP21534.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21534-1 [UniParc]FASTAAdd to Basket

« Hide

MLFFNSILND APSSWALYFQ DGASPSYLGV THLNDYLMFY LTFIFIGVIY    50
AICKAVIEYN YNSHPIAAKY TTHGSIVEFI WTLIPALILI LVALPSFKLL 100
YLLDEVQKPS MTVKAIGRQW FWTYELNDFV TNENEPVSFD SYMVPEEDLE 150
EGSLRQLEVD NRLVLPIDTR IRLILTSGDV IHSWAVPSLG IKCDCIPGRL 200
NQVSLSIDRE GLFYGQCSEL CGVLHSSMPI VVQGVSLEDF LAWLEENS 248
Length:248
Mass (Da):28,121
Last modified:August 14, 2001 - v4
Checksum:i033A029DBB967871
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti123 – 1231T → S in CAA38293. 1 Publication
Sequence conflicti198 – 1981G → S in CAA38293. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ251293 Genomic DNA. Translation: CAB61572.1.
X54421 Genomic DNA. Translation: CAA38293.1.
RefSeqiNP_039508.1. NC_001326.1.

Genome annotation databases

GeneIDi1669525.
KEGGispo:ScpofMp10.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ251293 Genomic DNA. Translation: CAB61572.1 .
X54421 Genomic DNA. Translation: CAA38293.1 .
RefSeqi NP_039508.1. NC_001326.1.

3D structure databases

ProteinModelPortali P21534.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4896.SPMIT.11-1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1669525.
KEGGi spo:ScpofMp10.

Organism-specific databases

PomBasei SPMIT.11.

Phylogenomic databases

HOGENOMi HOG000264988.
KOi K02261.
OrthoDBi EOG7WDNDC.
PhylomeDBi P21534.

Miscellaneous databases

NextBioi 20797081.
PROi P21534.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mosaic structure of the cox2 gene in the petite negative yeast Schizosaccharomyces pombe: a group II intron is inserted at the same location as the otherwise unrelated group II introns in the mitochondria of higher plants."
    Schaefer B., Kaulich K., Wolf K.
    Gene 214:101-112(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: EF2.
  2. "The mitochondrial genome of Schizosaccharomyces pombe."
    Lang B.F.
    (In) O'Brien S.J. (eds.); Genetic Maps (6th edition), pp.3118-3119, Cold Spring Harbor Laboratory Press, New York (1993)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AD7-50.

Entry informationi

Entry nameiCOX2_SCHPO
AccessioniPrimary (citable) accession number: P21534
Secondary accession number(s): Q9T653
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: August 14, 2001
Last modified: April 16, 2014
This is version 108 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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