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P21534

- COX2_SCHPO

UniProt

P21534 - COX2_SCHPO

Protein

Cytochrome c oxidase subunit 2

Gene

cox2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 4 (14 Aug 2001)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Copper A.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi182 – 1821Copper ACurated
    Metal bindingi217 – 2171Copper ACurated
    Metal bindingi221 – 2211Copper ACurated
    Metal bindingi225 – 2251Copper ACurated

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: PomBase

    GO - Biological processi

    1. aerobic respiration Source: PomBase
    2. hydrogen ion transmembrane transport Source: GOC
    3. mitochondrial electron transport, cytochrome c to oxygen Source: PomBase

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide II
    Gene namesi
    Name:cox2
    ORF Names:SPMIT.11
    Encoded oniMitochondrion
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Mitochondrion

    Organism-specific databases

    PomBaseiSPMIT.11.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial respiratory chain complex IV Source: PomBase

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 248248Cytochrome c oxidase subunit 2PRO_0000183686Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi4896.SPMIT.11-1.

    Structurei

    3D structure databases

    ProteinModelPortaliP21534.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3636Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini58 – 7518Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini101 – 248148Mitochondrial intermembraneSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei37 – 5721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei76 – 10025HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000264988.
    KOiK02261.
    OrthoDBiEOG7WDNDC.
    PhylomeDBiP21534.

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProiIPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PfamiPF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsiTIGR02866. CoxB. 1 hit.
    PROSITEiPS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P21534-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLFFNSILND APSSWALYFQ DGASPSYLGV THLNDYLMFY LTFIFIGVIY    50
    AICKAVIEYN YNSHPIAAKY TTHGSIVEFI WTLIPALILI LVALPSFKLL 100
    YLLDEVQKPS MTVKAIGRQW FWTYELNDFV TNENEPVSFD SYMVPEEDLE 150
    EGSLRQLEVD NRLVLPIDTR IRLILTSGDV IHSWAVPSLG IKCDCIPGRL 200
    NQVSLSIDRE GLFYGQCSEL CGVLHSSMPI VVQGVSLEDF LAWLEENS 248
    Length:248
    Mass (Da):28,121
    Last modified:August 14, 2001 - v4
    Checksum:i033A029DBB967871
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti123 – 1231T → S in CAA38293. (PubMed:9651494)Curated
    Sequence conflicti198 – 1981G → S in CAA38293. (PubMed:9651494)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ251293 Genomic DNA. Translation: CAB61572.1.
    X54421 Genomic DNA. Translation: CAA38293.1.
    RefSeqiNP_039508.1. NC_001326.1.

    Genome annotation databases

    GeneIDi1669525.
    KEGGispo:ScpofMp10.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ251293 Genomic DNA. Translation: CAB61572.1 .
    X54421 Genomic DNA. Translation: CAA38293.1 .
    RefSeqi NP_039508.1. NC_001326.1.

    3D structure databases

    ProteinModelPortali P21534.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4896.SPMIT.11-1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1669525.
    KEGGi spo:ScpofMp10.

    Organism-specific databases

    PomBasei SPMIT.11.

    Phylogenomic databases

    HOGENOMi HOG000264988.
    KOi K02261.
    OrthoDBi EOG7WDNDC.
    PhylomeDBi P21534.

    Miscellaneous databases

    NextBioi 20797081.
    PROi P21534.

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProi IPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    Pfami PF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsi TIGR02866. CoxB. 1 hit.
    PROSITEi PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mosaic structure of the cox2 gene in the petite negative yeast Schizosaccharomyces pombe: a group II intron is inserted at the same location as the otherwise unrelated group II introns in the mitochondria of higher plants."
      Schaefer B., Kaulich K., Wolf K.
      Gene 214:101-112(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: EF2.
    2. "The mitochondrial genome of Schizosaccharomyces pombe."
      Lang B.F.
      (In) O'Brien S.J. (eds.); Genetic Maps (6th edition), pp.3118-3119, Cold Spring Harbor Laboratory Press, New York (1993)
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AD7-50.

    Entry informationi

    Entry nameiCOX2_SCHPO
    AccessioniPrimary (citable) accession number: P21534
    Secondary accession number(s): Q9T653
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: August 14, 2001
    Last modified: October 1, 2014
    This is version 109 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3