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Protein

Cytochrome c oxidase subunit 2

Gene

cox2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi182Copper ACurated1
Metal bindingi217Copper ACurated1
Metal bindingi221Copper ACurated1
Metal bindingi225Copper ACurated1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:cox2
ORF Names:SPMIT.11
Encoded oniMitochondrion
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Mitochondrion

Organism-specific databases

PomBaseiSPMIT.11 cox2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36Mitochondrial intermembraneSequence analysisAdd BLAST36
Transmembranei37 – 57HelicalSequence analysisAdd BLAST21
Topological domaini58 – 75Mitochondrial matrixSequence analysisAdd BLAST18
Transmembranei76 – 100HelicalSequence analysisAdd BLAST25
Topological domaini101 – 248Mitochondrial intermembraneSequence analysisAdd BLAST148

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001836861 – 248Cytochrome c oxidase subunit 2Add BLAST248

Proteomic databases

PaxDbiP21534
PRIDEiP21534

PTM databases

iPTMnetiP21534

Interactioni

Protein-protein interaction databases

STRINGi4896.SPMIT.11.1

Structurei

3D structure databases

ProteinModelPortaliP21534
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000264988
InParanoidiP21534
KOiK02261
OrthoDBiEOG092C40RV
PhylomeDBiP21534

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Complete.

P21534-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFFNSILND APSSWALYFQ DGASPSYLGV THLNDYLMFY LTFIFIGVIY
60 70 80 90 100
AICKAVIEYN YNSHPIAAKY TTHGSIVEFI WTLIPALILI LVALPSFKLL
110 120 130 140 150
YLLDEVQKPS MTVKAIGRQW FWTYELNDFV TNENEPVSFD SYMVPEEDLE
160 170 180 190 200
EGSLRQLEVD NRLVLPIDTR IRLILTSGDV IHSWAVPSLG IKCDCIPGRL
210 220 230 240
NQVSLSIDRE GLFYGQCSEL CGVLHSSMPI VVQGVSLEDF LAWLEENS
Length:248
Mass (Da):28,121
Last modified:August 14, 2001 - v4
Checksum:i033A029DBB967871
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti123T → S in CAA38293 (PubMed:9651494).Curated1
Sequence conflicti198G → S in CAA38293 (PubMed:9651494).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251293 Genomic DNA Translation: CAB61572.1
X54421 Genomic DNA Translation: CAA38293.1
RefSeqiNP_039508.1, NC_001326.1

Genome annotation databases

GeneIDi1669525
KEGGispo:ScpofMp10

Similar proteinsi

Entry informationi

Entry nameiCOX2_SCHPO
AccessioniPrimary (citable) accession number: P21534
Secondary accession number(s): Q9T653
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: August 14, 2001
Last modified: March 28, 2018
This is version 133 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health