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P21534 (COX2_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:cox2
ORF Names:SPMIT.11
Encoded onMitochondrion
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length248 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 248248Cytochrome c oxidase subunit 2
PRO_0000183686

Regions

Topological domain1 – 3636Mitochondrial intermembrane Potential
Transmembrane37 – 5721Helical; Potential
Topological domain58 – 7518Mitochondrial matrix Potential
Transmembrane76 – 10025Helical; Potential
Topological domain101 – 248148Mitochondrial intermembrane Potential

Sites

Metal binding1821Copper A Probable
Metal binding2171Copper A Probable
Metal binding2211Copper A Probable
Metal binding2251Copper A Probable

Experimental info

Sequence conflict1231T → S in CAA38293. Ref.1
Sequence conflict1981G → S in CAA38293. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P21534 [UniParc].

Last modified August 14, 2001. Version 4.
Checksum: 033A029DBB967871

FASTA24828,121
        10         20         30         40         50         60 
MLFFNSILND APSSWALYFQ DGASPSYLGV THLNDYLMFY LTFIFIGVIY AICKAVIEYN 

        70         80         90        100        110        120 
YNSHPIAAKY TTHGSIVEFI WTLIPALILI LVALPSFKLL YLLDEVQKPS MTVKAIGRQW 

       130        140        150        160        170        180 
FWTYELNDFV TNENEPVSFD SYMVPEEDLE EGSLRQLEVD NRLVLPIDTR IRLILTSGDV 

       190        200        210        220        230        240 
IHSWAVPSLG IKCDCIPGRL NQVSLSIDRE GLFYGQCSEL CGVLHSSMPI VVQGVSLEDF 


LAWLEENS 

« Hide

References

« Hide 'large scale' references
[1]"Mosaic structure of the cox2 gene in the petite negative yeast Schizosaccharomyces pombe: a group II intron is inserted at the same location as the otherwise unrelated group II introns in the mitochondria of higher plants."
Schaefer B., Kaulich K., Wolf K.
Gene 214:101-112(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: EF2.
[2]"The mitochondrial genome of Schizosaccharomyces pombe."
Lang B.F.
(In) O'Brien S.J. (eds.); Genetic Maps (6th edition), pp.3118-3119, Cold Spring Harbor Laboratory Press, New York (1993)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AD7-50.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ251293 Genomic DNA. Translation: CAB61572.1.
X54421 Genomic DNA. Translation: CAA38293.1.
RefSeqNP_039508.1. NC_001326.1.

3D structure databases

ProteinModelPortalP21534.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4896.SPMIT.11-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1669525.
KEGGspo:ScpofMp10.

Organism-specific databases

PomBaseSPMIT.11.

Phylogenomic databases

HOGENOMHOG000264988.
KOK02261.
OrthoDBEOG7WDNDC.
PhylomeDBP21534.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20797081.
PROP21534.

Entry information

Entry nameCOX2_SCHPO
AccessionPrimary (citable) accession number: P21534
Secondary accession number(s): Q9T653
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: August 14, 2001
Last modified: April 16, 2014
This is version 108 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names