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Protein

60S ribosomal protein L6

Gene

Rpl6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the large ribosomal subunit.By similarity

GO - Molecular functioni

  • 5.8S rRNA binding Source: RGD
  • mRNA binding Source: RGD
  • structural constituent of ribosome Source: GO_Central
  • tRNA binding Source: RGD

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-RNO-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L6
Alternative name(s):
Neoplasm-related protein C140
Gene namesi
Name:Rpl6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi619826 Rpl6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001710122 – 29860S ribosomal protein L6Add BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki5Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei104N6-succinyllysineBy similarity1
Modified residuei137PhosphoserineBy similarity1
Modified residuei217N6-succinyllysineBy similarity1
Modified residuei249N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP21533
PRIDEiP21533

PTM databases

iPTMnetiP21533
PhosphoSitePlusiP21533
SwissPalmiP21533

Expressioni

Gene expression databases

BgeeiENSRNOG00000025936
GenevisibleiP21533 RN

Interactioni

Subunit structurei

Component of the large ribosomal subunit (By similarity). May bind IPO9 with low affinity (By similarity).By similarity

Protein-protein interaction databases

BioGridi250640, 2 interactors
IntActiP21533, 1 interactor
STRINGi10116.ENSRNOP00000051135

Structurei

3D structure databases

ProteinModelPortaliP21533
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1694 Eukaryota
COG2163 LUCA
GeneTreeiENSGT00390000003682
HOGENOMiHOG000207317
HOVERGENiHBG002565
InParanoidiP21533
KOiK02934
OMAiLTKNDRA
OrthoDBiEOG091G0L13
PhylomeDBiP21533

Family and domain databases

Gene3Di2.30.30.30, 1 hit
InterProiView protein in InterPro
IPR000915 60S_ribosomal_L6E
IPR014722 Rib_L2_dom2
IPR005568 Ribosomal_L6_N
IPR008991 Translation_prot_SH3-like_sf
PANTHERiPTHR10715 PTHR10715, 1 hit
PfamiView protein in Pfam
PF01159 Ribosomal_L6e, 1 hit
PF03868 Ribosomal_L6e_N, 1 hit
SUPFAMiSSF50104 SSF50104, 1 hit
PROSITEiView protein in PROSITE
PS01170 RIBOSOMAL_L6E, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21533-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGEKAEKPD KKEQKPAAKK AGGDATAPRA LPAGAVKKSS SKAKKLRKSK
60 70 80 90 100
PHCSRNPVLV RGIGRYSRSA MYSRKALYKR KYSAAKTKVE KKKKKEKVLA
110 120 130 140 150
TVTKTVGGDK NGGTRVVKLR KMPRYYPTED VPRKLLSHGK KPFSQHVRRL
160 170 180 190 200
RSSITPGTVL IILTGRHRGK RVVFLKQLGS GLLLVTGPLA LNRVPLRRTH
210 220 230 240 250
QKFVIATSTK VDISKVKIPK HLTDAYFKKK PLRKPRHQEG EIFDTEKEKY
260 270 280 290
EITEQRKADQ KAVDSQILPK IKAVPQLQGY LRSQFSLTNG MYPHKLVF
Length:298
Mass (Da):33,562
Last modified:January 23, 2007 - v5
Checksum:iC92724D0F998503C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31 – 35LPAGA → GAWC in CAA60588 (PubMed:8828793).Curated5
Sequence conflicti184L → P in AAB30818 (PubMed:8185817).Curated1
Sequence conflicti191 – 220LNRVP…VKIPK → STEFLCVGHTRSLSSPPLQK LISARLKFQ in AAB30818 (PubMed:8185817).CuratedAdd BLAST30
Sequence conflicti264 – 279DSQIL…PQLQG → TRRFCQRSKLSPSSRA in AAB30818 (PubMed:8185817).CuratedAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87107 mRNA Translation: CAA60588.1
BC078761 mRNA Translation: AAH78761.1
BC097295 mRNA Translation: AAH97295.1
S71021 mRNA Translation: AAB30818.2
PIRiS11416
T50782
RefSeqiNP_446423.2, NM_053971.3
XP_006249440.1, XM_006249378.3
UniGeneiRn.217183
Rn.234072
Rn.2660

Genome annotation databases

EnsembliENSRNOT00000034951; ENSRNOP00000038065; ENSRNOG00000025936
GeneIDi117042
KEGGirno:117042
UCSCiRGD:619826 rat

Similar proteinsi

Entry informationi

Entry nameiRL6_RAT
AccessioniPrimary (citable) accession number: P21533
Secondary accession number(s): Q4QRA9, Q64624, Q68G26
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 140 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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