Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

60S ribosomal protein L6

Gene

Rpl6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • 5.8S rRNA binding Source: RGD
  • mRNA binding Source: RGD
  • structural constituent of ribosome Source: GO_Central
  • tRNA binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L6
Alternative name(s):
Neoplasm-related protein C140
Gene namesi
Name:Rpl6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi619826. Rpl6.

Subcellular locationi

GO - Cellular componenti

  • A band Source: RGD
  • cytosolic large ribosomal subunit Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001710122 – 29860S ribosomal protein L6Add BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei137PhosphoserineBy similarity1
Modified residuei249N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP21533.
PRIDEiP21533.

PTM databases

iPTMnetiP21533.
PhosphoSitePlusiP21533.
SwissPalmiP21533.

Expressioni

Gene expression databases

ExpressionAtlasiP21533. differential.
GenevisibleiP21533. RN.

Interactioni

Subunit structurei

May bind IPO9 with low affinity.By similarity

Protein-protein interaction databases

BioGridi250640. 2 interactors.
IntActiP21533. 1 interactor.
MINTiMINT-4566588.
STRINGi10116.ENSRNOP00000051135.

Structurei

3D structure databases

ProteinModelPortaliP21533.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L6e family.Curated

Phylogenomic databases

eggNOGiKOG1694. Eukaryota.
COG2163. LUCA.
GeneTreeiENSGT00390000003682.
HOGENOMiHOG000207317.
HOVERGENiHBG002565.
InParanoidiP21533.
KOiK02934.
OMAiKYHASRN.
OrthoDBiEOG091G0L13.
PhylomeDBiP21533.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
InterProiIPR000915. 60S_ribosomal_L6E.
IPR014722. Rib_L2_dom2.
IPR005568. Ribosomal_L6_N.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR10715. PTHR10715. 1 hit.
PfamiPF01159. Ribosomal_L6e. 1 hit.
PF03868. Ribosomal_L6e_N. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
PROSITEiPS01170. RIBOSOMAL_L6E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21533-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGEKAEKPD KKEQKPAAKK AGGDATAPRA LPAGAVKKSS SKAKKLRKSK
60 70 80 90 100
PHCSRNPVLV RGIGRYSRSA MYSRKALYKR KYSAAKTKVE KKKKKEKVLA
110 120 130 140 150
TVTKTVGGDK NGGTRVVKLR KMPRYYPTED VPRKLLSHGK KPFSQHVRRL
160 170 180 190 200
RSSITPGTVL IILTGRHRGK RVVFLKQLGS GLLLVTGPLA LNRVPLRRTH
210 220 230 240 250
QKFVIATSTK VDISKVKIPK HLTDAYFKKK PLRKPRHQEG EIFDTEKEKY
260 270 280 290
EITEQRKADQ KAVDSQILPK IKAVPQLQGY LRSQFSLTNG MYPHKLVF
Length:298
Mass (Da):33,562
Last modified:January 23, 2007 - v5
Checksum:iC92724D0F998503C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31 – 35LPAGA → GAWC in CAA60588 (PubMed:8828793).Curated5
Sequence conflicti184L → P in AAB30818 (PubMed:8185817).Curated1
Sequence conflicti191 – 220LNRVP…VKIPK → STEFLCVGHTRSLSSPPLQK LISARLKFQ in AAB30818 (PubMed:8185817).CuratedAdd BLAST30
Sequence conflicti264 – 279DSQIL…PQLQG → TRRFCQRSKLSPSSRA in AAB30818 (PubMed:8185817).CuratedAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87107 mRNA. Translation: CAA60588.1.
BC078761 mRNA. Translation: AAH78761.1.
BC097295 mRNA. Translation: AAH97295.1.
S71021 mRNA. Translation: AAB30818.2.
PIRiS11416.
T50782.
RefSeqiNP_446423.2. NM_053971.3.
XP_006249440.1. XM_006249378.3.
UniGeneiRn.217183.
Rn.234072.
Rn.2660.

Genome annotation databases

EnsembliENSRNOT00000034951; ENSRNOP00000038065; ENSRNOG00000025936.
GeneIDi117042.
KEGGirno:117042.
UCSCiRGD:619826. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87107 mRNA. Translation: CAA60588.1.
BC078761 mRNA. Translation: AAH78761.1.
BC097295 mRNA. Translation: AAH97295.1.
S71021 mRNA. Translation: AAB30818.2.
PIRiS11416.
T50782.
RefSeqiNP_446423.2. NM_053971.3.
XP_006249440.1. XM_006249378.3.
UniGeneiRn.217183.
Rn.234072.
Rn.2660.

3D structure databases

ProteinModelPortaliP21533.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250640. 2 interactors.
IntActiP21533. 1 interactor.
MINTiMINT-4566588.
STRINGi10116.ENSRNOP00000051135.

PTM databases

iPTMnetiP21533.
PhosphoSitePlusiP21533.
SwissPalmiP21533.

Proteomic databases

PaxDbiP21533.
PRIDEiP21533.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000034951; ENSRNOP00000038065; ENSRNOG00000025936.
GeneIDi117042.
KEGGirno:117042.
UCSCiRGD:619826. rat.

Organism-specific databases

CTDi6128.
RGDi619826. Rpl6.

Phylogenomic databases

eggNOGiKOG1694. Eukaryota.
COG2163. LUCA.
GeneTreeiENSGT00390000003682.
HOGENOMiHOG000207317.
HOVERGENiHBG002565.
InParanoidiP21533.
KOiK02934.
OMAiKYHASRN.
OrthoDBiEOG091G0L13.
PhylomeDBiP21533.

Miscellaneous databases

PROiP21533.

Gene expression databases

ExpressionAtlasiP21533. differential.
GenevisibleiP21533. RN.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
InterProiIPR000915. 60S_ribosomal_L6E.
IPR014722. Rib_L2_dom2.
IPR005568. Ribosomal_L6_N.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR10715. PTHR10715. 1 hit.
PfamiPF01159. Ribosomal_L6e. 1 hit.
PF03868. Ribosomal_L6e_N. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
PROSITEiPS01170. RIBOSOMAL_L6E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL6_RAT
AccessioniPrimary (citable) accession number: P21533
Secondary accession number(s): Q4QRA9, Q64624, Q68G26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 127 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.