P21531 (RL3_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
60S ribosomal protein L3

Alternative name(s):
L4

Gene names

Name:

Rpl3

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	403 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	The L3 protein is a component of the large subunit of cytoplasmic ribosomes.
Subcellular location	Nucleus › nucleolus By similarity. Cytoplasm By similarity.
Sequence similarities	Belongs to the ribosomal protein L3P family.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Molecular function	Ribonucleoprotein Ribosomal protein
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	translation Inferred from electronic annotation. Source: InterPro
Cellular_component	nucleolus Inferred from sequence or structural similarity. Source: UniProtKB ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.3
	Chain	2 – 403	402	60S ribosomal protein L3		PRO_0000077231
Amino acid modifications
	Modified residue	13	1	Phosphoserine By similarity
	Modified residue	294	1	N6-acetyllysine By similarity
	Modified residue	304	1	Phosphoserine By similarity
	Modified residue	366	1	N6-acetyllysine By similarity
Experimental info
	Sequence conflict	19	1	R → T AA sequence Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P21531 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 4071E869B9184A49	FASTA	403	46,136
	10 20 30 40 50 60 MSHRKFSAPR HGSLGFLPRK RSSRHRGKVK SFPKDDPSKP VHLTAFLGYK AGMTHIVREV 70 80 90 100 110 120 DRPGSKVNKK EVVEAVTIVE TPPMVVVGIV GYVETPRGLR TFKTVFAEHI SDECKRRFYK 130 140 150 160 170 180 NWHKSKKKAF TKYCKKWQDD TGKKQLEKDF NSMKKYCQVI RIIAHTQMRL LPLRQKKAHL 190 200 210 220 230 240 MEIQVNGGTV AEKLDWARER LEQQVPVNQV FGQDEMIDVI GVTKGKGYKG VTSRWHTKKL 250 260 270 280 290 300 PRKTHRGLRK VACIGAWHPA RVAFSVARAG QKGYHHRTEI NKKIYKIGQG YLIKDGKLIK 310 320 330 340 350 360 NNASTDYDLS DKSINPLGGF VHYGEVTNDF IMLKGCVVGT KKRVLTLRKS LLVQTKRRAL 370 380 390 400 EKIDLKFIDT TSKFGHGRFQ TMEEKKAFMG PLKKDRIAKE EGA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The primary structure of rat ribosomal protein L3." Kuwano Y., Wool I.G. Biochem. Biophys. Res. Commun. 187:58-64(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Liver.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pituitary.
[3]	"Yeast ribosomal proteins: VII. Cytoplasmic ribosomal proteins from Schizosaccharomyces pombe." Otaka E., Higo K., Itoh T. Mol. Gen. Genet. 191:519-524(1983) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-20.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X62166 mRNA. Translation: CAA44095.1. BC058494 mRNA. Translation: AAH58494.1.
IPI	IPI00395285.
PIR	R5RT3L. JQ1536.
RefSeq	NP_942048.1. NM_198753.2.
UniGene	Rn.107726.
3D structure databases
ProteinModelPortal	P21531.
SMR	P21531. Positions 7-351.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000022949.
Proteomic databases
PaxDb	P21531.
PRIDE	P21531.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000067032; ENSRNOP00000060662; ENSRNOG00000016896.
GeneID	300079.
KEGG	rno:300079.
UCSC	RGD:735105. rat.
Organism-specific databases
CTD	6122.
RGD	735105. Rpl3.
Phylogenomic databases
eggNOG	COG0087.
GeneTree	ENSGT00390000017606.
HOGENOM	HOG000107319.
HOVERGEN	HBG001864.
InParanoid	P21531.
KO	K02925.
OrthoDB	EOG43XV3G.
Gene expression databases
Genevestigator	P21531.
GermOnline	ENSRNOG00000016896. Rattus norvegicus.
Family and domain databases
InterPro	IPR000597. Ribosomal_L3. IPR019926. Ribosomal_L3_CS. IPR009000. Transl_elong_init/rib_B-barrel. [Graphical view]
Pfam	PF00297. Ribosomal_L3. 1 hit. [Graphical view]
SUPFAM	SSF50447. Translat_factor. 1 hit.
PROSITE	PS00474. RIBOSOMAL_L3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	646297.

Entry information

Entry name

RL3_RAT

Accession

Primary (citable) accession number: P21531

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 97 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program