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Protein

60S ribosomal protein L3

Gene

Rpl3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

The L3 protein is a component of the large subunit of cytoplasmic ribosomes.

GO - Molecular functioni

  • 5S rRNA binding Source: RGD
  • poly(A) RNA binding Source: Ensembl
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-RNO-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-RNO-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-RNO-6791226. Major pathway of rRNA processing in the nucleolus.
R-RNO-72689. Formation of a pool of free 40S subunits.
R-RNO-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-RNO-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-RNO-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L3
Alternative name(s):
L4
Gene namesi
Name:Rpl3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi735105. Rpl3.

Subcellular locationi

GO - Cellular componenti

  • cytosolic large ribosomal subunit Source: RGD
  • extracellular exosome Source: Ensembl
  • focal adhesion Source: Ensembl
  • nucleolus Source: UniProtKB
  • nucleoplasm Source: Ensembl
  • ribosome Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 40340260S ribosomal protein L3PRO_0000077231Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei13 – 131PhosphoserineBy similarity
Modified residuei136 – 1361N6-acetyllysineBy similarity
Modified residuei286 – 2861N6-acetyllysineBy similarity
Modified residuei294 – 2941N6-acetyllysine; alternateBy similarity
Cross-linki294 – 294Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Modified residuei304 – 3041PhosphoserineBy similarity
Modified residuei366 – 3661N6-acetyllysineBy similarity
Modified residuei373 – 3731N6-acetyllysineBy similarity
Cross-linki399 – 399Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP21531.
PRIDEiP21531.

PTM databases

iPTMnetiP21531.
PhosphoSiteiP21531.
SwissPalmiP21531.

Expressioni

Gene expression databases

BgeeiENSRNOG00000016896.
GenevisibleiP21531. RN.

Interactioni

Subunit structurei

Interacts with METTL18.By similarity

Protein-protein interaction databases

BioGridi256443. 2 interactions.
MINTiMINT-4575603.
STRINGi10116.ENSRNOP00000060662.

Structurei

3D structure databases

ProteinModelPortaliP21531.
SMRiP21531. Positions 7-351.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L3P family.Curated

Phylogenomic databases

eggNOGiKOG0746. Eukaryota.
COG0087. LUCA.
GeneTreeiENSGT00390000017606.
HOGENOMiHOG000107319.
HOVERGENiHBG001864.
InParanoidiP21531.
KOiK02925.
OMAiTNDFIMV.
PhylomeDBiP21531.
TreeFamiTF300555.

Family and domain databases

InterProiIPR000597. Ribosomal_L3.
IPR019926. Ribosomal_L3_CS.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF00297. Ribosomal_L3. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
PROSITEiPS00474. RIBOSOMAL_L3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21531-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHRKFSAPR HGSLGFLPRK RSSRHRGKVK SFPKDDPSKP VHLTAFLGYK
60 70 80 90 100
AGMTHIVREV DRPGSKVNKK EVVEAVTIVE TPPMVVVGIV GYVETPRGLR
110 120 130 140 150
TFKTVFAEHI SDECKRRFYK NWHKSKKKAF TKYCKKWQDD TGKKQLEKDF
160 170 180 190 200
NSMKKYCQVI RIIAHTQMRL LPLRQKKAHL MEIQVNGGTV AEKLDWARER
210 220 230 240 250
LEQQVPVNQV FGQDEMIDVI GVTKGKGYKG VTSRWHTKKL PRKTHRGLRK
260 270 280 290 300
VACIGAWHPA RVAFSVARAG QKGYHHRTEI NKKIYKIGQG YLIKDGKLIK
310 320 330 340 350
NNASTDYDLS DKSINPLGGF VHYGEVTNDF IMLKGCVVGT KKRVLTLRKS
360 370 380 390 400
LLVQTKRRAL EKIDLKFIDT TSKFGHGRFQ TMEEKKAFMG PLKKDRIAKE

EGA
Length:403
Mass (Da):46,136
Last modified:January 23, 2007 - v3
Checksum:i4071E869B9184A49
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191R → T AA sequence (PubMed:6355773).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62166 mRNA. Translation: CAA44095.1.
BC058494 mRNA. Translation: AAH58494.1.
PIRiJQ1536. R5RT3L.
RefSeqiNP_942048.1. NM_198753.2.
UniGeneiRn.107726.

Genome annotation databases

EnsembliENSRNOT00000067032; ENSRNOP00000060662; ENSRNOG00000016896.
ENSRNOT00000089407; ENSRNOP00000069877; ENSRNOG00000016896.
GeneIDi300079.
KEGGirno:300079.
UCSCiRGD:735105. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62166 mRNA. Translation: CAA44095.1.
BC058494 mRNA. Translation: AAH58494.1.
PIRiJQ1536. R5RT3L.
RefSeqiNP_942048.1. NM_198753.2.
UniGeneiRn.107726.

3D structure databases

ProteinModelPortaliP21531.
SMRiP21531. Positions 7-351.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi256443. 2 interactions.
MINTiMINT-4575603.
STRINGi10116.ENSRNOP00000060662.

PTM databases

iPTMnetiP21531.
PhosphoSiteiP21531.
SwissPalmiP21531.

Proteomic databases

PaxDbiP21531.
PRIDEiP21531.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000067032; ENSRNOP00000060662; ENSRNOG00000016896.
ENSRNOT00000089407; ENSRNOP00000069877; ENSRNOG00000016896.
GeneIDi300079.
KEGGirno:300079.
UCSCiRGD:735105. rat.

Organism-specific databases

CTDi6122.
RGDi735105. Rpl3.

Phylogenomic databases

eggNOGiKOG0746. Eukaryota.
COG0087. LUCA.
GeneTreeiENSGT00390000017606.
HOGENOMiHOG000107319.
HOVERGENiHBG001864.
InParanoidiP21531.
KOiK02925.
OMAiTNDFIMV.
PhylomeDBiP21531.
TreeFamiTF300555.

Enzyme and pathway databases

ReactomeiR-RNO-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-RNO-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-RNO-6791226. Major pathway of rRNA processing in the nucleolus.
R-RNO-72689. Formation of a pool of free 40S subunits.
R-RNO-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-RNO-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-RNO-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

PROiP21531.

Gene expression databases

BgeeiENSRNOG00000016896.
GenevisibleiP21531. RN.

Family and domain databases

InterProiIPR000597. Ribosomal_L3.
IPR019926. Ribosomal_L3_CS.
IPR009000. Transl_B-barrel.
[Graphical view]
PfamiPF00297. Ribosomal_L3. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
PROSITEiPS00474. RIBOSOMAL_L3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL3_RAT
AccessioniPrimary (citable) accession number: P21531
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.