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P21529

- CBP3_HORVU

UniProt

P21529 - CBP3_HORVU

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Protein
Serine carboxypeptidase 3
Gene
CBP3, CXP;3
Organism
Hordeum vulgare (Barley)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Release of a C-terminal amino acid with broad specificity.

Enzyme regulationi

Inhibited by mercuric ions.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei223 – 2231 By similarity
Active sitei411 – 4111 By similarity
Binding sitei414 – 4141Substrate
Active sitei468 – 4681 By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Protein family/group databases

    MEROPSiS10.009.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine carboxypeptidase 3 (EC:3.4.16.5)
    Alternative name(s):
    CP-MIII
    Serine carboxypeptidase III
    Gene namesi
    Name:CBP3
    Synonyms:CXP;3
    OrganismiHordeum vulgare (Barley)
    Taxonomic identifieri4513 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaeTriticeaeHordeum

    Organism-specific databases

    GrameneiP21529.

    Subcellular locationi

    Secreted
    Note: Secreted into the endosperm.

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919 Reviewed prediction
    Add
    BLAST
    Propeptidei20 – 8061
    PRO_0000004324Add
    BLAST
    Chaini81 – 491411Serine carboxypeptidase 3
    PRO_0000004325Add
    BLAST
    Propeptidei492 – 50817
    PRO_0000004326Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei81 – 811Blocked amino end (Leu)
    Disulfide bondi133 ↔ 373 By similarity
    Glycosylationi151 – 1511N-linked (GlcNAc...)
    Disulfide bondi301 ↔ 316 By similarity
    Disulfide bondi339 ↔ 344 By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Expressioni

    Developmental stagei

    Expressed mainly in the aleurone and, to a lesser extent in the embryo, throughout the 5-days germination period exclusively, with a maximal level at 3 days. Also found in the roots and shoots of the growing seedling.

    Gene expression databases

    GenevestigatoriP21529.

    Interactioni

    Subunit structurei

    Monomer.

    Structurei

    3D structure databases

    ProteinModelPortaliP21529.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
    PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P21529-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVTTPRLVSL LLLLALCAAA AGALRLPPDA SFPGAQAERL IRALNLLPKD    50
    SSSSSGRHGA RVGEGNEDVA PGQLLERRVT LPGLPEGVAD LGHHAGYYRL 100
    PNTHDARMFY FFFESRGKKE DPVVIWLTGG PGCSSELAVF YENGPFTIAN 150
    NMSLVWNKFG WDKISNIIFV DQPTGTGFSY SSDDRDTRHD ETGVSNDLYD 200
    FLQVFFKKHP EFIKNDFFIT GESYAGHYIP AFASRVHQGN KKNEGTHINL 250
    KGFAIGNGLT DPAIQYKAYT DYALEMNLIQ KADYERINKF IPPCEFAIKL 300
    CGTNGKASCM AAYMVCNTIF NSIMKLVGTK NYYDVRKECE GKLCYDFSNL 350
    EKFFGDKAVR QAIGVGDIEF VSCSTSVYQA MLTDWMRNLE VGIPALLEDG 400
    INVLIYAGEY DLICNWLGNS RWVHSMEWSG QKDFAKTAES SFLVDDAQAG 450
    VLKSHGALSF LKVHNAGHMV PMDQPKAALE MLRRFTQGKL KEAVPEEESS 500
    TTSFYAAM 508
    Length:508
    Mass (Da):56,362
    Last modified:July 15, 1998 - v2
    Checksum:i70C6751D78D40AB6
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti265 – 2651Q → V Polymorphism.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y09604 mRNA. Translation: CAA70817.1.
    PIRiA35275.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y09604 mRNA. Translation: CAA70817.1 .
    PIRi A35275.

    3D structure databases

    ProteinModelPortali P21529.
    ModBasei Search...

    Protein family/group databases

    MEROPSi S10.009.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    Gramenei P21529.

    Gene expression databases

    Genevestigatori P21529.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
    PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Rocher A., Lok F., Cameron-Mills V., von Wettstein D.
      Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Himalaya.
      Tissue: Aleurone.
    2. "Primary structure of carboxypeptidase III from malted barley."
      Soerensen S.B., Svendsen I., Breddam K.
      Carlsberg Res. Commun. 54:193-202(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 81-491.
      Strain: cv. Gula.

    Entry informationi

    Entry nameiCBP3_HORVU
    AccessioniPrimary (citable) accession number: P21529
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: July 15, 1998
    Last modified: June 11, 2014
    This is version 86 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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