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P21526

- HN_PI4HA

UniProt

P21526 - HN_PI4HA

Protein

Hemagglutinin-neuraminidase

Gene

HN

Organism
Human parainfluenza 4a virus (strain Toshiba) (HPIV-4a)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 May 1991)
      Previous versions | rss
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    Functioni

    Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion By similarity.By similarity
    Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.By similarity

    Catalytic activityi

    Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

    GO - Molecular functioni

    1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
    2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
    3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. viral entry into host cell Source: UniProtKB-KW
    2. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hemagglutinin, Hydrolase

    Keywords - Biological processi

    Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

    Protein family/group databases

    CAZyiGH83. Glycoside Hydrolase Family 83.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hemagglutinin-neuraminidase (EC:3.2.1.18)
    Gene namesi
    Name:HN
    OrganismiHuman parainfluenza 4a virus (strain Toshiba) (HPIV-4a)
    Taxonomic identifieri11225 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeRubulavirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]

    Subcellular locationi

    GO - Cellular componenti

    1. host cell plasma membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. viral envelope Source: UniProtKB-KW
    4. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 573573Hemagglutinin-neuraminidasePRO_0000142632Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi258 – 2581N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi330 – 3301N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi339 – 3391N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi347 – 3471N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi433 – 4331N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi502 – 5021N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi530 – 5301N-linked (GlcNAc...); by hostSequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliP21526.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2727IntravirionSequence AnalysisAdd
    BLAST
    Topological domaini49 – 573525Virion surfaceSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei28 – 4821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di2.120.10.10. 1 hit.
    InterProiIPR000665. Hemagglutn-neuramid.
    IPR016285. Hemagglutn-neuramid_paramyxo.
    IPR011040. Sialidases.
    [Graphical view]
    PfamiPF00423. HN. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
    SUPFAMiSSF50939. SSF50939. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P21526-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQDSHGNTQI LNQANSMVKR TWRLLFRIAT LILLVSIFVL SLIIVLQSTP    50
    GNLQNDINII RKELNELMEN FETTSKSLLS VSNQITYDVS VLTPIRQEAI 100
    ETNIISKIKD HCKDRVIKEG STCTLNRSPL HDVSFLNGFN KFYFTYKDNM 150
    QIKFKSLLDY PNFIPTATTP HGCIRIPSFS LGQTHWCYTH NINLLGCADP 200
    ASSNQYVSLG TLQVLKMGDP YFKVEHSHYL NDGRNRKSCS VVAVPDGCLR 250
    NCVTMTKNET ENFKDLNWQH NYLHTYHIMV PLKTRIINPP GSSRDWVHIA 300
    PGVGSGLLYA KLLIFPLYGG LTEKSVIHNN QSGKYFFPNS TKLQCRNSTM 350
    EKIKGAKDSY TITYFSGRLI QSAFLVCDLR QFLSEDCEIL IPSNDYMMVG 400
    AEGRLYNIEN NIFYYQRGSS WWPYPSLYRI RLNLSKKYPR ITEIKFTKIE 450
    IAPRPGNKDC PGNKACPKEC ITGVYQDILP LSYPNTAFPH LKQAYYTGFY 500
    LNNSLERRNP TFYTADNLDY HQQERLGKFN LTAGYSTTTC FKQTTTARLY 550
    CLYIIEVGDS VIGDFQITLF LAA 573
    Length:573
    Mass (Da):65,544
    Last modified:May 1, 1991 - v1
    Checksum:i3540F24F17931AC4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M34033 Genomic RNA. Translation: AAA46799.1.
    PIRiA34683. HNNZ4A.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M34033 Genomic RNA. Translation: AAA46799.1 .
    PIRi A34683. HNNZ4A.

    3D structure databases

    ProteinModelPortali P21526.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH83. Glycoside Hydrolase Family 83.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.120.10.10. 1 hit.
    InterProi IPR000665. Hemagglutn-neuramid.
    IPR016285. Hemagglutn-neuramid_paramyxo.
    IPR011040. Sialidases.
    [Graphical view ]
    Pfami PF00423. HN. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
    SUPFAMi SSF50939. SSF50939. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and sequence analysis of human parainfluenza type 4A virus HN gene: its irregularities on structure and activities."
      Bando H., Kondo K., Kawano M., Komada H., Tsurudome M., Nishio M., Ito Y.
      Virology 175:307-312(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiHN_PI4HA
    AccessioniPrimary (citable) accession number: P21526
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: May 1, 1991
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3