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P21526 (HN_PI4HA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hemagglutinin-neuraminidase

EC=3.2.1.18
Gene names
Name:HN
OrganismHuman parainfluenza 4a virus (strain Toshiba) (HPIV-4a)
Taxonomic identifier11225 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeRubulavirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length573 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion By similarity.

Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins By similarity.

Catalytic activity

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

Subcellular location

Virion membrane; Single-pass type II membrane protein Potential. Host cell membrane; Single-pass type II membrane protein Potential.

Sequence similarities

Belongs to the paramyxoviruses hemagglutinin-neuraminidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 573573Hemagglutinin-neuraminidase
PRO_0000142632

Regions

Topological domain1 – 2727Intravirion Potential
Transmembrane28 – 4821Helical; Potential
Topological domain49 – 573525Virion surface Potential

Amino acid modifications

Glycosylation2581N-linked (GlcNAc...); by host Potential
Glycosylation3301N-linked (GlcNAc...); by host Potential
Glycosylation3391N-linked (GlcNAc...); by host Potential
Glycosylation3471N-linked (GlcNAc...); by host Potential
Glycosylation4331N-linked (GlcNAc...); by host Potential
Glycosylation5021N-linked (GlcNAc...); by host Potential
Glycosylation5301N-linked (GlcNAc...); by host Potential

Sequences

Sequence LengthMass (Da)Tools
P21526 [UniParc].

Last modified May 1, 1991. Version 1.
Checksum: 3540F24F17931AC4

FASTA57365,544
        10         20         30         40         50         60 
MQDSHGNTQI LNQANSMVKR TWRLLFRIAT LILLVSIFVL SLIIVLQSTP GNLQNDINII 

        70         80         90        100        110        120 
RKELNELMEN FETTSKSLLS VSNQITYDVS VLTPIRQEAI ETNIISKIKD HCKDRVIKEG 

       130        140        150        160        170        180 
STCTLNRSPL HDVSFLNGFN KFYFTYKDNM QIKFKSLLDY PNFIPTATTP HGCIRIPSFS 

       190        200        210        220        230        240 
LGQTHWCYTH NINLLGCADP ASSNQYVSLG TLQVLKMGDP YFKVEHSHYL NDGRNRKSCS 

       250        260        270        280        290        300 
VVAVPDGCLR NCVTMTKNET ENFKDLNWQH NYLHTYHIMV PLKTRIINPP GSSRDWVHIA 

       310        320        330        340        350        360 
PGVGSGLLYA KLLIFPLYGG LTEKSVIHNN QSGKYFFPNS TKLQCRNSTM EKIKGAKDSY 

       370        380        390        400        410        420 
TITYFSGRLI QSAFLVCDLR QFLSEDCEIL IPSNDYMMVG AEGRLYNIEN NIFYYQRGSS 

       430        440        450        460        470        480 
WWPYPSLYRI RLNLSKKYPR ITEIKFTKIE IAPRPGNKDC PGNKACPKEC ITGVYQDILP 

       490        500        510        520        530        540 
LSYPNTAFPH LKQAYYTGFY LNNSLERRNP TFYTADNLDY HQQERLGKFN LTAGYSTTTC 

       550        560        570 
FKQTTTARLY CLYIIEVGDS VIGDFQITLF LAA 

« Hide

References

[1]"Molecular cloning and sequence analysis of human parainfluenza type 4A virus HN gene: its irregularities on structure and activities."
Bando H., Kondo K., Kawano M., Komada H., Tsurudome M., Nishio M., Ito Y.
Virology 175:307-312(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M34033 Genomic RNA. Translation: AAA46799.1.
PIRHNNZ4A. A34683.

3D structure databases

ProteinModelPortalP21526.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH83. Glycoside Hydrolase Family 83.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.120.10.10. 1 hit.
InterProIPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view]
PfamPF00423. HN. 1 hit.
[Graphical view]
PIRSFPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMSSF50939. SSF50939. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHN_PI4HA
AccessionPrimary (citable) accession number: P21526
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: April 16, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries