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P21526

- HN_PI4HA

UniProt

P21526 - HN_PI4HA

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Protein

Hemagglutinin-neuraminidase

Gene

HN

Organism
Human parainfluenza 4a virus (strain Toshiba) (HPIV-4a)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity).By similarity
Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.By similarity

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

GO - Molecular functioni

  1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
  2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
  3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

GO - Biological processi

  1. viral entry into host cell Source: UniProtKB-KW
  2. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hemagglutinin, Hydrolase

Keywords - Biological processi

Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

Protein family/group databases

CAZyiGH83. Glycoside Hydrolase Family 83.

Names & Taxonomyi

Protein namesi
Recommended name:
Hemagglutinin-neuraminidase (EC:3.2.1.18)
Gene namesi
Name:HN
OrganismiHuman parainfluenza 4a virus (strain Toshiba) (HPIV-4a)
Taxonomic identifieri11225 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeRubulavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. viral envelope Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 573573Hemagglutinin-neuraminidasePRO_0000142632Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi258 – 2581N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi330 – 3301N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi339 – 3391N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi347 – 3471N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi433 – 4331N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi502 – 5021N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi530 – 5301N-linked (GlcNAc...); by hostSequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP21526.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727IntravirionSequence AnalysisAdd
BLAST
Topological domaini49 – 573525Virion surfaceSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei28 – 4821HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view]
PfamiPF00423. HN. 1 hit.
[Graphical view]
PIRSFiPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

P21526-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQDSHGNTQI LNQANSMVKR TWRLLFRIAT LILLVSIFVL SLIIVLQSTP
60 70 80 90 100
GNLQNDINII RKELNELMEN FETTSKSLLS VSNQITYDVS VLTPIRQEAI
110 120 130 140 150
ETNIISKIKD HCKDRVIKEG STCTLNRSPL HDVSFLNGFN KFYFTYKDNM
160 170 180 190 200
QIKFKSLLDY PNFIPTATTP HGCIRIPSFS LGQTHWCYTH NINLLGCADP
210 220 230 240 250
ASSNQYVSLG TLQVLKMGDP YFKVEHSHYL NDGRNRKSCS VVAVPDGCLR
260 270 280 290 300
NCVTMTKNET ENFKDLNWQH NYLHTYHIMV PLKTRIINPP GSSRDWVHIA
310 320 330 340 350
PGVGSGLLYA KLLIFPLYGG LTEKSVIHNN QSGKYFFPNS TKLQCRNSTM
360 370 380 390 400
EKIKGAKDSY TITYFSGRLI QSAFLVCDLR QFLSEDCEIL IPSNDYMMVG
410 420 430 440 450
AEGRLYNIEN NIFYYQRGSS WWPYPSLYRI RLNLSKKYPR ITEIKFTKIE
460 470 480 490 500
IAPRPGNKDC PGNKACPKEC ITGVYQDILP LSYPNTAFPH LKQAYYTGFY
510 520 530 540 550
LNNSLERRNP TFYTADNLDY HQQERLGKFN LTAGYSTTTC FKQTTTARLY
560 570
CLYIIEVGDS VIGDFQITLF LAA
Length:573
Mass (Da):65,544
Last modified:May 1, 1991 - v1
Checksum:i3540F24F17931AC4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M34033 Genomic RNA. Translation: AAA46799.1.
PIRiA34683. HNNZ4A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M34033 Genomic RNA. Translation: AAA46799.1 .
PIRi A34683. HNNZ4A.

3D structure databases

ProteinModelPortali P21526.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH83. Glycoside Hydrolase Family 83.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.120.10.10. 1 hit.
InterProi IPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view ]
Pfami PF00423. HN. 1 hit.
[Graphical view ]
PIRSFi PIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMi SSF50939. SSF50939. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and sequence analysis of human parainfluenza type 4A virus HN gene: its irregularities on structure and activities."
    Bando H., Kondo K., Kawano M., Komada H., Tsurudome M., Nishio M., Ito Y.
    Virology 175:307-312(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiHN_PI4HA
AccessioniPrimary (citable) accession number: P21526
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3