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Protein

Protein scabrous

Gene

sca

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in regulation of neurogenesis. May encode a lateral inhibitor of R8 differentiation. In conjunction with Gp150, promotes Notch activation in response to Delta by regulating acquisition of insensitivity to Delta in a subset of cells.2 Publications

GO - Molecular functioni

  • signal transducer activity Source: FlyBase

GO - Biological processi

  • chaeta morphogenesis Source: FlyBase
  • compound eye development Source: FlyBase
  • female meiosis chromosome segregation Source: FlyBase
  • imaginal disc-derived wing margin morphogenesis Source: FlyBase
  • lateral inhibition Source: FlyBase
  • nervous system development Source: FlyBase
  • Notch signaling pathway Source: UniProtKB-KW
  • ommatidial rotation Source: FlyBase
  • R8 cell fate commitment Source: FlyBase
  • regulation of R8 cell spacing in compound eye Source: FlyBase
  • response to alcohol Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Notch signaling pathway

Enzyme and pathway databases

SignaLinkiP21520.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein scabrous
Gene namesi
Name:sca
ORF Names:CG17579
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0003326. sca.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: FlyBase
  • late endosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 51Sequence analysisAdd BLAST51
ChainiPRO_000000910852 – 799Protein scabrousAdd BLAST748

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi372N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi542 ↔ 568PROSITE-ProRule annotation
Glycosylationi587N-linked (GlcNAc...)Sequence analysis1
Glycosylationi618N-linked (GlcNAc...)Sequence analysis1
Glycosylationi660N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi687 ↔ 700PROSITE-ProRule annotation
Glycosylationi744N-linked (GlcNAc...)Sequence analysis1
Glycosylationi787N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Possesses five pairs of dibasic residues that may be the target of proteolytic processing.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP21520.
PRIDEiP21520.

Expressioni

Gene expression databases

BgeeiFBgn0003326.
GenevisibleiP21520. DM.

Interactioni

Protein-protein interaction databases

BioGridi62183. 8 interactors.
IntActiP21520. 2 interactors.
MINTiMINT-188855.
STRINGi7227.FBpp0086969.

Structurei

3D structure databases

ProteinModelPortaliP21520.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini533 – 737Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST205

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi200 – 343Gln-richAdd BLAST144

Sequence similaritiesi

Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00830000128240.
InParanoidiP21520.
OMAiIAPAGQH.
OrthoDBiEOG091G03M1.
PhylomeDBiP21520.

Family and domain databases

CDDicd00087. FReD. 1 hit.
Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21520-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDWQTFPDL QKKKVSRDHL NCPATMAGSN VLWPILLAVV LLQISVAFVS
60 70 80 90 100
GAASGGVVLS DVNNMLRDAK VVTSEKPVVH SKQETEAPES SVELLRFVDD
110 120 130 140 150
DEDSEDISSI ERQDGRTMES KKMADQVRLL TKQLNALMLR RREDYEMLEH
160 170 180 190 200
NLRKSLRLTT NANSVDADMR SELNQLREEL AALRSSQSGN KERLTVEWLQ
210 220 230 240 250
QTISEIRKQL VDLQRTASNV AQDVQQRSST FEDLATIRSD YQQLKLDLAA
260 270 280 290 300
QRERQQQTEV YVQELREEML QQEQDFQHAL VKLQQRTRKD GSSASVEEES
310 320 330 340 350
GSQEANQEQT GLETTADHKR RHCRFQSEQI HQLQLAQRNL RRQVNGLRFH
360 370 380 390 400
HIDERVRSIE VEQHRIANAN FNLSSQIASL DKLHTSMLEL LEDVEGLQTK
410 420 430 440 450
MDKSIPELRH EISKLEFANA QITSEQSLIR EEGTNAARSL QAMAVSVSVL
460 470 480 490 500
QEEREGMRKL SANVDQLRTN VDRLQSLVND EMKNKLTHLN KPHKRPHHQN
510 520 530 540 550
VQAQMPQDDS PIDSVLAETL VSELENVETQ YEAIINKLPH DCSEVHTQTD
560 570 580 590 600
GLHLIAPAGQ RHPLMTHCTA DGWTTVQRRF DGSADFNRSW ADYAQGFGAP
610 620 630 640 650
GGEFWIGNEQ LHHLTLDNCS RLQVQMQDIY DNVWVAEYKR FYISSRADGY
660 670 680 690 700
RLHIAEYSGN ASDALNYQQG MQFSAIDDDR DISQTHCAAN YEGGWWFSHC
710 720 730 740 750
QHANLNGRYN LGLTWFDAAR NEWIAVKSSR MLVKRLPAVE CQANASASGA
760 770 780 790
FVSVSGSAAD AAPSSGATTT TTTATAAPAT VTTPKTNNSV VQFVAAGQA
Length:799
Mass (Da):90,119
Last modified:October 24, 2003 - v3
Checksum:i87E1B4D60D4F5C29
GO

Sequence cautioni

The sequence AAA28880 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti301G → C in AAA28880 (PubMed:2175046).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60065 Genomic DNA. Translation: AAA28880.1. Different initiation.
AE013599 Genomic DNA. Translation: AAF58455.2.
AY129456 mRNA. Translation: AAM76198.1.
PIRiA39832.
RefSeqiNP_476710.2. NM_057362.3.
NP_725230.2. NM_165951.2.
UniGeneiDm.4735.

Genome annotation databases

EnsemblMetazoaiFBtr0087855; FBpp0086968; FBgn0003326.
FBtr0087856; FBpp0086969; FBgn0003326.
GeneIDi36411.
KEGGidme:Dmel_CG17579.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60065 Genomic DNA. Translation: AAA28880.1. Different initiation.
AE013599 Genomic DNA. Translation: AAF58455.2.
AY129456 mRNA. Translation: AAM76198.1.
PIRiA39832.
RefSeqiNP_476710.2. NM_057362.3.
NP_725230.2. NM_165951.2.
UniGeneiDm.4735.

3D structure databases

ProteinModelPortaliP21520.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi62183. 8 interactors.
IntActiP21520. 2 interactors.
MINTiMINT-188855.
STRINGi7227.FBpp0086969.

Proteomic databases

PaxDbiP21520.
PRIDEiP21520.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0087855; FBpp0086968; FBgn0003326.
FBtr0087856; FBpp0086969; FBgn0003326.
GeneIDi36411.
KEGGidme:Dmel_CG17579.

Organism-specific databases

CTDi36411.
FlyBaseiFBgn0003326. sca.

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00830000128240.
InParanoidiP21520.
OMAiIAPAGQH.
OrthoDBiEOG091G03M1.
PhylomeDBiP21520.

Enzyme and pathway databases

SignaLinkiP21520.

Miscellaneous databases

GenomeRNAii36411.
PROiP21520.

Gene expression databases

BgeeiFBgn0003326.
GenevisibleiP21520. DM.

Family and domain databases

CDDicd00087. FReD. 1 hit.
Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCA_DROME
AccessioniPrimary (citable) accession number: P21520
Secondary accession number(s): Q0E998, Q8MQI8, Q9V6G9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: October 24, 2003
Last modified: November 30, 2016
This is version 141 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.