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P21520 (SCA_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein scabrous
Gene names
Name:sca
ORF Names:CG17579
OrganismDrosophila melanogaster (Fruit fly)
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length799 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in regulation of neurogenesis. May encode a lateral inhibitor of R8 differentiation. In conjunction with Gp150, promotes Notch activation in response to Delta by regulating acquisition of insensitivity to Delta in a subset of cells. Ref.1 Ref.5

Subcellular location

Late endosome. Note: Colocalizes in late endosomes with Gp150. Ref.1 Ref.5

Post-translational modification

Possesses five pairs of dibasic residues that may be the target of proteolytic processing.

Sequence similarities

Contains 1 fibrinogen C-terminal domain.

Sequence caution

The sequence AAA28880.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 5151 Potential
Chain52 – 799748Protein scabrous
PRO_0000009108

Regions

Domain533 – 737205Fibrinogen C-terminal
Compositional bias200 – 343144Gln-rich

Amino acid modifications

Glycosylation3721N-linked (GlcNAc...) Potential
Glycosylation5871N-linked (GlcNAc...) Potential
Glycosylation6181N-linked (GlcNAc...) Potential
Glycosylation6601N-linked (GlcNAc...) Potential
Glycosylation7441N-linked (GlcNAc...) Potential
Glycosylation7871N-linked (GlcNAc...) Potential
Disulfide bond542 ↔ 568 By similarity
Disulfide bond687 ↔ 700 By similarity

Experimental info

Sequence conflict3011G → C in AAA28880. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P21520 [UniParc].

Last modified October 24, 2003. Version 3.
Checksum: 87E1B4D60D4F5C29

FASTA79990,119
        10         20         30         40         50         60 
MRDWQTFPDL QKKKVSRDHL NCPATMAGSN VLWPILLAVV LLQISVAFVS GAASGGVVLS 

        70         80         90        100        110        120 
DVNNMLRDAK VVTSEKPVVH SKQETEAPES SVELLRFVDD DEDSEDISSI ERQDGRTMES 

       130        140        150        160        170        180 
KKMADQVRLL TKQLNALMLR RREDYEMLEH NLRKSLRLTT NANSVDADMR SELNQLREEL 

       190        200        210        220        230        240 
AALRSSQSGN KERLTVEWLQ QTISEIRKQL VDLQRTASNV AQDVQQRSST FEDLATIRSD 

       250        260        270        280        290        300 
YQQLKLDLAA QRERQQQTEV YVQELREEML QQEQDFQHAL VKLQQRTRKD GSSASVEEES 

       310        320        330        340        350        360 
GSQEANQEQT GLETTADHKR RHCRFQSEQI HQLQLAQRNL RRQVNGLRFH HIDERVRSIE 

       370        380        390        400        410        420 
VEQHRIANAN FNLSSQIASL DKLHTSMLEL LEDVEGLQTK MDKSIPELRH EISKLEFANA 

       430        440        450        460        470        480 
QITSEQSLIR EEGTNAARSL QAMAVSVSVL QEEREGMRKL SANVDQLRTN VDRLQSLVND 

       490        500        510        520        530        540 
EMKNKLTHLN KPHKRPHHQN VQAQMPQDDS PIDSVLAETL VSELENVETQ YEAIINKLPH 

       550        560        570        580        590        600 
DCSEVHTQTD GLHLIAPAGQ RHPLMTHCTA DGWTTVQRRF DGSADFNRSW ADYAQGFGAP 

       610        620        630        640        650        660 
GGEFWIGNEQ LHHLTLDNCS RLQVQMQDIY DNVWVAEYKR FYISSRADGY RLHIAEYSGN 

       670        680        690        700        710        720 
ASDALNYQQG MQFSAIDDDR DISQTHCAAN YEGGWWFSHC QHANLNGRYN LGLTWFDAAR 

       730        740        750        760        770        780 
NEWIAVKSSR MLVKRLPAVE CQANASASGA FVSVSGSAAD AAPSSGATTT TTTATAAPAT 

       790 
VTTPKTNNSV VQFVAAGQA

« Hide

References

« Hide 'large scale' references
[1]"Spacing differentiation in the developing Drosophila eye: a fibrinogen-related lateral inhibitor encoded by scabrous."
Baker N.E., Mlodzik M., Rubin G.M.
Science 250:1370-1377(1990) [PubMed: 2175046] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[4]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Embryo.
[5]"Scabrous and Gp150 are endosomal proteins that regulate Notch activity."
Li Y., Fetchko M., Lai Z.C., Baker N.E.
Development 130:2819-2827(2003) [PubMed: 12756167] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M60065 Genomic DNA. Translation: AAA28880.1. Different initiation.
AE013599 Genomic DNA. Translation: AAF58455.2.
AY129456 mRNA. Translation: AAM76198.1.
PIRA39832.
RefSeqNP_476710.2. NM_057362.2.
NP_725230.2. NM_165951.1.
UniGeneDm.4735.

3D structure databases

ProteinModelPortalP21520.
SMRP21520. Positions 536-736.
ModBaseSearch...

Protein-protein interaction databases

IntActP21520. 1 interaction.
MINTMINT-188855.
STRINGP21520.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0087855; FBpp0086968; FBgn0003326.
FBtr0087856; FBpp0086969; FBgn0003326.
GeneID36411.
KEGGdme:Dmel_CG17579.

Organism-specific databases

CTD36411.
FlyBaseFBgn0003326. sca.

Phylogenomic databases

eggNOGinNOG04261.
GeneTreeEMGT00070000025672.
InParanoidP21520.
OMACAANYEG.
OrthoDBEOG4TX97B.
PhylomeDBP21520.

Gene expression databases

BgeeP21520.
GermOnlineCG17579. Drosophila melanogaster.

Family and domain databases

InterProIPR002181. Fibrinogen_a/b/g_C.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR020837. Fibrinogen_CS.
[Graphical view]
Gene3DG3DSA:3.90.215.10. Fibrinogen_a/b/g_C_1. 1 hit.
G3DSA:4.10.530.10. Fibrinogen_a/b/g_C_2. 1 hit.
PfamPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMSSF56496. Fibrinogen_a/b/g_C. 1 hit.
PROSITEPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio798423.

Entry information

Entry nameSCA_DROME
AccessionPrimary (citable) accession number: P21520
Secondary accession number(s): Q0E998, Q8MQI8, Q9V6G9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: October 24, 2003
Last modified: January 25, 2012
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents