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P21515

- ACPH_ECOLI

UniProt

P21515 - ACPH_ECOLI

Protein

Acyl carrier protein phosphodiesterase

Gene

acpH

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP.1 PublicationUniRule annotation

    Catalytic activityi

    Holo-[acyl-carrier-protein] + H2O = 4'-phosphopantetheine + apo-[acyl-carrier-protein].1 PublicationUniRule annotation

    GO - Molecular functioni

    1. [acyl-carrier-protein] phosphodiesterase activity Source: EcoCyc

    GO - Biological processi

    1. fatty acid biosynthetic process Source: EcoCyc

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciEcoCyc:EG11095-MONOMER.
    ECOL316407:JW0394-MONOMER.
    MetaCyc:EG11095-MONOMER.
    BRENDAi3.1.4.14. 2026.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acyl carrier protein phosphodiesteraseUniRule annotation (EC:3.1.4.14UniRule annotation)
    Short name:
    ACP phosphodiesteraseUniRule annotation
    Gene namesi
    Name:acpHUniRule annotation
    Synonyms:yajB
    Ordered Locus Names:b0404, JW0394
    OrganismiEscherichia coli (strain K12)
    Taxonomic identifieri83333 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

    Organism-specific databases

    EcoGeneiEG11095. acpH.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 193193Acyl carrier protein phosphodiesterasePRO_0000168605Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriP21515.

    Interactioni

    Protein-protein interaction databases

    IntActiP21515. 2 interactions.
    STRINGi511145.b0404.

    Structurei

    3D structure databases

    ProteinModelPortaliP21515.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AcpH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3124.
    HOGENOMiHOG000275880.
    KOiK08682.
    OMAiWLHRQID.
    OrthoDBiEOG6K6V7H.
    PhylomeDBiP21515.

    Family and domain databases

    HAMAPiMF_01950. AcpH.
    InterProiIPR007431. ACP_phosphodiesterase.
    IPR023491. ACP_phosphodiesterase_gpbac.
    [Graphical view]
    PfamiPF04336. DUF479. 1 hit.
    [Graphical view]
    PIRSFiPIRSF011489. DUF479. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P21515-1 [UniParc]FASTAAdd to Basket

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    MNFLAHLHLA HLAESSLSGN LLADFVRGNP EESFPPDVVA GIHMHRRIDV    50
    LTDNLPEVRE AREWFRSETR RVAPITLDVM WDHFLSRHWS QLSPDFPLQE 100
    FVCYAREQVM TILPDSPPRF INLNNYLWSE QWLVRYRDMD FIQNVLNGMA 150
    SRRPRLDALR DSWYDLDAHY DALETRFWQF YPRMMAQASR KAL 193
    Length:193
    Mass (Da):22,961
    Last modified:November 1, 1997 - v2
    Checksum:i0DE6F0CE01D6C523
    GO

    Sequence cautioni

    The sequence AAA16113.1 differs from that shown. Reason: Frameshift at position 71.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M37702 Genomic DNA. Translation: AAA16113.1. Frameshift.
    U82664 Genomic DNA. Translation: AAB40160.1.
    U00096 Genomic DNA. Translation: AAC73507.1.
    AP009048 Genomic DNA. Translation: BAE76184.1.
    PIRiD64769.
    RefSeqiNP_414938.1. NC_000913.3.
    YP_488696.1. NC_007779.1.

    Genome annotation databases

    EnsemblBacteriaiAAC73507; AAC73507; b0404.
    BAE76184; BAE76184; BAE76184.
    GeneIDi12932723.
    949132.
    KEGGiecj:Y75_p0392.
    eco:b0404.
    PATRICi32115957. VBIEscCol129921_0420.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M37702 Genomic DNA. Translation: AAA16113.1 . Frameshift.
    U82664 Genomic DNA. Translation: AAB40160.1 .
    U00096 Genomic DNA. Translation: AAC73507.1 .
    AP009048 Genomic DNA. Translation: BAE76184.1 .
    PIRi D64769.
    RefSeqi NP_414938.1. NC_000913.3.
    YP_488696.1. NC_007779.1.

    3D structure databases

    ProteinModelPortali P21515.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P21515. 2 interactions.
    STRINGi 511145.b0404.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC73507 ; AAC73507 ; b0404 .
    BAE76184 ; BAE76184 ; BAE76184 .
    GeneIDi 12932723.
    949132.
    KEGGi ecj:Y75_p0392.
    eco:b0404.
    PATRICi 32115957. VBIEscCol129921_0420.

    Organism-specific databases

    EchoBASEi EB1087.
    EcoGenei EG11095. acpH.

    Phylogenomic databases

    eggNOGi COG3124.
    HOGENOMi HOG000275880.
    KOi K08682.
    OMAi WLHRQID.
    OrthoDBi EOG6K6V7H.
    PhylomeDBi P21515.

    Enzyme and pathway databases

    BioCyci EcoCyc:EG11095-MONOMER.
    ECOL316407:JW0394-MONOMER.
    MetaCyc:EG11095-MONOMER.
    BRENDAi 3.1.4.14. 2026.

    Miscellaneous databases

    PROi P21515.

    Gene expression databases

    Genevestigatori P21515.

    Family and domain databases

    HAMAPi MF_01950. AcpH.
    InterProi IPR007431. ACP_phosphodiesterase.
    IPR023491. ACP_phosphodiesterase_gpbac.
    [Graphical view ]
    Pfami PF04336. DUF479. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF011489. DUF479. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Structure and organization of Escherichia coli genes involved in biosynthesis of the deazaguanine derivative queuine, a nutrient factor for eukaryotes."
      Reuter K., Slany R., Ullrich F., Kersten H.
      J. Bacteriol. 173:2256-2264(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: K12.
    2. "Sequence of minutes 4-25 of Escherichia coli."
      Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
      Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MG1655 / ATCC 47076.
    4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
      Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
      Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
    5. "The enigmatic acyl carrier protein phosphodiesterase of Escherichia coli: genetic and enzymological characterization."
      Thomas J., Cronan J.E.
      J. Biol. Chem. 280:34675-34683(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CATALYTIC ACTIVITY.
      Strain: K12 / MG1655 / ATCC 47076.

    Entry informationi

    Entry nameiACPH_ECOLI
    AccessioniPrimary (citable) accession number: P21515
    Secondary accession number(s): P46123, P77369, Q2MC22
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Escherichia coli
      Escherichia coli (strain K12): entries and cross-references to EcoGene
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3