Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acyl carrier protein phosphodiesterase

Gene

acpH

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP.UniRule annotation1 Publication

Catalytic activityi

Holo-[acyl-carrier-protein] + H2O = 4'-phosphopantetheine + apo-[acyl-carrier-protein].UniRule annotation1 Publication

GO - Molecular functioni

  1. [acyl-carrier-protein] phosphodiesterase activity Source: EcoCyc

GO - Biological processi

  1. fatty acid biosynthetic process Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciEcoCyc:EG11095-MONOMER.
ECOL316407:JW0394-MONOMER.
MetaCyc:EG11095-MONOMER.
BRENDAi3.1.4.14. 2026.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl carrier protein phosphodiesteraseUniRule annotation (EC:3.1.4.14UniRule annotation)
Short name:
ACP phosphodiesteraseUniRule annotation
Gene namesi
Name:acpHUniRule annotation
Synonyms:yajB
Ordered Locus Names:b0404, JW0394
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318 Componenti: Chromosome UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11095. acpH.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 193193Acyl carrier protein phosphodiesterasePRO_0000168605Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriP21515.

Interactioni

Protein-protein interaction databases

IntActiP21515. 2 interactions.
STRINGi511145.b0404.

Structurei

3D structure databases

ProteinModelPortaliP21515.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AcpH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3124.
HOGENOMiHOG000275880.
InParanoidiP21515.
KOiK08682.
OMAiHFLAKNW.
OrthoDBiEOG6K6V7H.
PhylomeDBiP21515.

Family and domain databases

HAMAPiMF_01950. AcpH.
InterProiIPR007431. ACP_phosphodiesterase.
IPR023491. ACP_phosphodiesterase_gpbac.
[Graphical view]
PfamiPF04336. DUF479. 1 hit.
[Graphical view]
PIRSFiPIRSF011489. DUF479. 1 hit.

Sequencei

Sequence statusi: Complete.

P21515-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFLAHLHLA HLAESSLSGN LLADFVRGNP EESFPPDVVA GIHMHRRIDV
60 70 80 90 100
LTDNLPEVRE AREWFRSETR RVAPITLDVM WDHFLSRHWS QLSPDFPLQE
110 120 130 140 150
FVCYAREQVM TILPDSPPRF INLNNYLWSE QWLVRYRDMD FIQNVLNGMA
160 170 180 190
SRRPRLDALR DSWYDLDAHY DALETRFWQF YPRMMAQASR KAL
Length:193
Mass (Da):22,961
Last modified:November 1, 1997 - v2
Checksum:i0DE6F0CE01D6C523
GO

Sequence cautioni

The sequence AAA16113.1 differs from that shown. Reason: Frameshift at position 71. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37702 Genomic DNA. Translation: AAA16113.1. Frameshift.
U82664 Genomic DNA. Translation: AAB40160.1.
U00096 Genomic DNA. Translation: AAC73507.1.
AP009048 Genomic DNA. Translation: BAE76184.1.
PIRiD64769.
RefSeqiNP_414938.1. NC_000913.3.
YP_488696.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC73507; AAC73507; b0404.
BAE76184; BAE76184; BAE76184.
GeneIDi12932723.
949132.
KEGGiecj:Y75_p0392.
eco:b0404.
PATRICi32115957. VBIEscCol129921_0420.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37702 Genomic DNA. Translation: AAA16113.1. Frameshift.
U82664 Genomic DNA. Translation: AAB40160.1.
U00096 Genomic DNA. Translation: AAC73507.1.
AP009048 Genomic DNA. Translation: BAE76184.1.
PIRiD64769.
RefSeqiNP_414938.1. NC_000913.3.
YP_488696.1. NC_007779.1.

3D structure databases

ProteinModelPortaliP21515.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP21515. 2 interactions.
STRINGi511145.b0404.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73507; AAC73507; b0404.
BAE76184; BAE76184; BAE76184.
GeneIDi12932723.
949132.
KEGGiecj:Y75_p0392.
eco:b0404.
PATRICi32115957. VBIEscCol129921_0420.

Organism-specific databases

EchoBASEiEB1087.
EcoGeneiEG11095. acpH.

Phylogenomic databases

eggNOGiCOG3124.
HOGENOMiHOG000275880.
InParanoidiP21515.
KOiK08682.
OMAiHFLAKNW.
OrthoDBiEOG6K6V7H.
PhylomeDBiP21515.

Enzyme and pathway databases

BioCyciEcoCyc:EG11095-MONOMER.
ECOL316407:JW0394-MONOMER.
MetaCyc:EG11095-MONOMER.
BRENDAi3.1.4.14. 2026.

Miscellaneous databases

PROiP21515.

Gene expression databases

GenevestigatoriP21515.

Family and domain databases

HAMAPiMF_01950. AcpH.
InterProiIPR007431. ACP_phosphodiesterase.
IPR023491. ACP_phosphodiesterase_gpbac.
[Graphical view]
PfamiPF04336. DUF479. 1 hit.
[Graphical view]
PIRSFiPIRSF011489. DUF479. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and organization of Escherichia coli genes involved in biosynthesis of the deazaguanine derivative queuine, a nutrient factor for eukaryotes."
    Reuter K., Slany R., Ullrich F., Kersten H.
    J. Bacteriol. 173:2256-2264(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. "Sequence of minutes 4-25 of Escherichia coli."
    Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
    Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "The enigmatic acyl carrier protein phosphodiesterase of Escherichia coli: genetic and enzymological characterization."
    Thomas J., Cronan J.E.
    J. Biol. Chem. 280:34675-34683(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY.
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiACPH_ECOLI
AccessioniPrimary (citable) accession number: P21515
Secondary accession number(s): P46123, P77369, Q2MC22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: November 1, 1997
Last modified: January 7, 2015
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.