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P21515 (ACPH_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acyl carrier protein phosphodiesterase

Short name=ACP phosphodiesterase
EC=3.1.4.14
Gene names
Name:acpH
Synonyms:yajB
Ordered Locus Names:b0404, JW0394
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length193 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP. Ref.5

Catalytic activity

Holo-[acyl-carrier-protein] + H2O = 4'-phosphopantetheine + apo-[acyl-carrier-protein]. Ref.5

Sequence similarities

Belongs to the AcpH family.

Sequence caution

The sequence AAA16113.1 differs from that shown. Reason: Frameshift at position 71.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 193193Acyl carrier protein phosphodiesterase HAMAP-Rule MF_01950
PRO_0000168605

Sequences

Sequence LengthMass (Da)Tools
P21515 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: 0DE6F0CE01D6C523

FASTA19322,961
        10         20         30         40         50         60 
MNFLAHLHLA HLAESSLSGN LLADFVRGNP EESFPPDVVA GIHMHRRIDV LTDNLPEVRE 

        70         80         90        100        110        120 
AREWFRSETR RVAPITLDVM WDHFLSRHWS QLSPDFPLQE FVCYAREQVM TILPDSPPRF 

       130        140        150        160        170        180 
INLNNYLWSE QWLVRYRDMD FIQNVLNGMA SRRPRLDALR DSWYDLDAHY DALETRFWQF 

       190 
YPRMMAQASR KAL 

« Hide

References

« Hide 'large scale' references
[1]"Structure and organization of Escherichia coli genes involved in biosynthesis of the deazaguanine derivative queuine, a nutrient factor for eukaryotes."
Reuter K., Slany R., Ullrich F., Kersten H.
J. Bacteriol. 173:2256-2264(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: K12.
[2]"Sequence of minutes 4-25 of Escherichia coli."
Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[3]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1462(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[4]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]"The enigmatic acyl carrier protein phosphodiesterase of Escherichia coli: genetic and enzymological characterization."
Thomas J., Cronan J.E.
J. Biol. Chem. 280:34675-34683(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, CATALYTIC ACTIVITY.
Strain: K12 / MG1655 / ATCC 47076.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M37702 Genomic DNA. Translation: AAA16113.1. Frameshift.
U82664 Genomic DNA. Translation: AAB40160.1.
U00096 Genomic DNA. Translation: AAC73507.1.
AP009048 Genomic DNA. Translation: BAE76184.1.
PIRD64769.
RefSeqNP_414938.1. NC_000913.3.
YP_488696.1. NC_007779.1.

3D structure databases

ProteinModelPortalP21515.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP21515. 2 interactions.
STRING511145.b0404.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC73507; AAC73507; b0404.
BAE76184; BAE76184; BAE76184.
GeneID12932723.
949132.
KEGGecj:Y75_p0392.
eco:b0404.
PATRIC32115957. VBIEscCol129921_0420.

Organism-specific databases

EchoBASEEB1087.
EcoGeneEG11095. acpH.

Phylogenomic databases

eggNOGCOG3124.
HOGENOMHOG000275880.
KOK08682.
OMAWLHRQID.
OrthoDBEOG6K6V7H.
PhylomeDBP21515.
ProtClustDBPRK10045.

Enzyme and pathway databases

BioCycEcoCyc:EG11095-MONOMER.
ECOL316407:JW0394-MONOMER.
MetaCyc:EG11095-MONOMER.
BRENDA3.1.4.14. 2026.

Gene expression databases

GenevestigatorP21515.

Family and domain databases

HAMAPMF_01950. AcpH.
InterProIPR007431. ACP_phosphodiesterase.
IPR023491. ACP_phosphodiesterase_gpbac.
[Graphical view]
PfamPF04336. DUF479. 1 hit.
[Graphical view]
PIRSFPIRSF011489. DUF479. 1 hit.
ProtoNetSearch...

Other

PROP21515.

Entry information

Entry nameACPH_ECOLI
AccessionPrimary (citable) accession number: P21515
Secondary accession number(s): P46123, P77369, Q2MC22
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene