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Protein

Acyl carrier protein phosphodiesterase

Gene

acpH

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP.UniRule annotation1 Publication

Catalytic activityi

Holo-[acyl-carrier-protein] + H2O = 4'-phosphopantetheine + apo-[acyl-carrier-protein].UniRule annotation1 Publication

GO - Molecular functioni

  • [acyl-carrier-protein] phosphodiesterase activity Source: EcoCyc

GO - Biological processi

  • fatty acid biosynthetic process Source: EcoCyc

Keywordsi

Molecular functionHydrolase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciEcoCyc:EG11095-MONOMER
MetaCyc:EG11095-MONOMER
BRENDAi3.1.4.14 2026

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl carrier protein phosphodiesteraseUniRule annotation (EC:3.1.4.14UniRule annotation)
Short name:
ACP phosphodiesteraseUniRule annotation
Gene namesi
Name:acpHUniRule annotation
Synonyms:yajB
Ordered Locus Names:b0404, JW0394
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11095 acpH

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001686051 – 193Acyl carrier protein phosphodiesteraseAdd BLAST193

Proteomic databases

PaxDbiP21515
PRIDEiP21515

Interactioni

Protein-protein interaction databases

BioGridi4261717, 13 interactors
IntActiP21515, 2 interactors
STRINGi316385.ECDH10B_0360

Structurei

3D structure databases

ProteinModelPortaliP21515
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AcpH family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZYK Bacteria
COG3124 LUCA
HOGENOMiHOG000275880
InParanoidiP21515
KOiK08682
OMAiMNFLAHI
PhylomeDBiP21515

Family and domain databases

HAMAPiMF_01950 AcpH, 1 hit
InterProiView protein in InterPro
IPR007431 ACP_PD
IPR023491 ACP_phosphodiesterase_gpbac
PANTHERiPTHR38764 PTHR38764, 1 hit
PfamiView protein in Pfam
PF04336 ACP_PD, 1 hit
PIRSFiPIRSF011489 DUF479, 1 hit

Sequencei

Sequence statusi: Complete.

P21515-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFLAHLHLA HLAESSLSGN LLADFVRGNP EESFPPDVVA GIHMHRRIDV
60 70 80 90 100
LTDNLPEVRE AREWFRSETR RVAPITLDVM WDHFLSRHWS QLSPDFPLQE
110 120 130 140 150
FVCYAREQVM TILPDSPPRF INLNNYLWSE QWLVRYRDMD FIQNVLNGMA
160 170 180 190
SRRPRLDALR DSWYDLDAHY DALETRFWQF YPRMMAQASR KAL
Length:193
Mass (Da):22,961
Last modified:November 1, 1997 - v2
Checksum:i0DE6F0CE01D6C523
GO

Sequence cautioni

The sequence AAA16113 differs from that shown. Reason: Frameshift at position 71.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37702 Genomic DNA Translation: AAA16113.1 Frameshift.
U82664 Genomic DNA Translation: AAB40160.1
U00096 Genomic DNA Translation: AAC73507.1
AP009048 Genomic DNA Translation: BAE76184.1
PIRiD64769
RefSeqiNP_414938.1, NC_000913.3
WP_001009885.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73507; AAC73507; b0404
BAE76184; BAE76184; BAE76184
GeneIDi949132
KEGGiecj:JW0394
eco:b0404
PATRICifig|511145.12.peg.420

Similar proteinsi

Entry informationi

Entry nameiACPH_ECOLI
AccessioniPrimary (citable) accession number: P21515
Secondary accession number(s): P46123, P77369, Q2MC22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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