ID   ZNF10_HUMAN             Reviewed;         573 AA.
AC   P21506; B2RBS1; Q8TC91;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 3.
DT   27-MAR-2024, entry version 216.
DE   RecName: Full=Zinc finger protein 10;
DE   AltName: Full=Zinc finger protein KOX1;
GN   Name=ZNF10; Synonyms=KOX1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2288909;
RA   Thiesen H.-J.;
RT   "Multiple genes encoding zinc finger domains are expressed in human T
RT   cells.";
RL   New Biol. 2:363-374(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Thalamus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   INTERACTION WITH ZNF268, AND SUBCELLULAR LOCATION.
RX   PubMed=23665872; DOI=10.1007/s00018-013-1359-4;
RA   Wang W., Cai J., Wu Y., Hu L., Chen Z., Hu J., Chen Z., Li W., Guo M.,
RA   Huang Z.;
RT   "Novel activity of KRAB domain that functions to reinforce nuclear
RT   localization of KRAB-containing zinc finger proteins by interacting with
RT   KAP1.";
RL   Cell. Mol. Life Sci. 70:3947-3958(2013).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBUNIT: Interacts (via the KRAB domain) with TRIM28 (via the RBCC
CC       domain). {ECO:0000269|PubMed:23665872}.
CC   -!- INTERACTION:
CC       P21506; Q9BWT7: CARD10; NbExp=3; IntAct=EBI-1105324, EBI-3866279;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23665872}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; X52332; CAA36558.1; -; mRNA.
DR   EMBL; AK314784; BAG37318.1; -; mRNA.
DR   EMBL; CH471218; EAW54791.1; -; Genomic_DNA.
DR   EMBL; BC024182; AAH24182.1; -; mRNA.
DR   CCDS; CCDS9283.1; -.
DR   PIR; S10397; S10397.
DR   RefSeq; NP_056209.2; NM_015394.4.
DR   AlphaFoldDB; P21506; -.
DR   SMR; P21506; -.
DR   BioGRID; 113388; 15.
DR   IntAct; P21506; 6.
DR   STRING; 9606.ENSP00000248211; -.
DR   GlyGen; P21506; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; P21506; -.
DR   PhosphoSitePlus; P21506; -.
DR   BioMuta; ZNF10; -.
DR   DMDM; 55977778; -.
DR   jPOST; P21506; -.
DR   MassIVE; P21506; -.
DR   MaxQB; P21506; -.
DR   PaxDb; 9606-ENSP00000248211; -.
DR   PeptideAtlas; P21506; -.
DR   ProteomicsDB; 53873; -.
DR   Antibodypedia; 53315; 177 antibodies from 20 providers.
DR   DNASU; 7556; -.
DR   Ensembl; ENST00000248211.11; ENSP00000248211.6; ENSG00000256223.6.
DR   Ensembl; ENST00000426665.6; ENSP00000393814.2; ENSG00000256223.6.
DR   GeneID; 7556; -.
DR   KEGG; hsa:7556; -.
DR   MANE-Select; ENST00000248211.11; ENSP00000248211.6; NM_015394.5; NP_056209.2.
DR   UCSC; uc001ulq.4; human.
DR   AGR; HGNC:12879; -.
DR   CTD; 7556; -.
DR   DisGeNET; 7556; -.
DR   GeneCards; ZNF10; -.
DR   HGNC; HGNC:12879; ZNF10.
DR   HPA; ENSG00000256223; Low tissue specificity.
DR   MIM; 194538; gene.
DR   neXtProt; NX_P21506; -.
DR   OpenTargets; ENSG00000256223; -.
DR   PharmGKB; PA37468; -.
DR   VEuPathDB; HostDB:ENSG00000256223; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000162949; -.
DR   HOGENOM; CLU_002678_44_5_1; -.
DR   InParanoid; P21506; -.
DR   OMA; HTGEQFF; -.
DR   OrthoDB; 3120634at2759; -.
DR   PhylomeDB; P21506; -.
DR   TreeFam; TF337898; -.
DR   PathwayCommons; P21506; -.
DR   Reactome; R-HSA-212436; Generic Transcription Pathway.
DR   SignaLink; P21506; -.
DR   BioGRID-ORCS; 7556; 8 hits in 1160 CRISPR screens.
DR   ChiTaRS; ZNF10; human.
DR   GeneWiki; ZNF10; -.
DR   GenomeRNAi; 7556; -.
DR   Pharos; P21506; Tbio.
DR   PRO; PR:P21506; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; P21506; Protein.
DR   Bgee; ENSG00000256223; Expressed in adenohypophysis and 157 other cell types or tissues.
DR   ExpressionAtlas; P21506; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0032991; C:protein-containing complex; IDA:UniProtKB.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   Gene3D; 6.10.140.140; -; 1.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 11.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036051; KRAB_dom_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR24390; ZINC FINGER PROTEIN; 1.
DR   PANTHER; PTHR24390:SF227; ZINC FINGER PROTEIN 662; 1.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 8.
DR   Pfam; PF13465; zf-H2C2_2; 1.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 10.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 7.
DR   SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
DR   Genevisible; P21506; HS.
PE   1: Evidence at protein level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..573
FT                   /note="Zinc finger protein 10"
FT                   /id="PRO_0000047332"
FT   DOMAIN          14..85
FT                   /note="KRAB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT   ZN_FING         206..232
FT                   /note="C2H2-type 1; atypical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         265..287
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         293..315
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         321..343
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         349..371
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         377..399
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         405..427
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         433..455
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         461..483
FT                   /note="C2H2-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         489..511
FT                   /note="C2H2-type 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         517..539
FT                   /note="C2H2-type 11; atypical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   VARIANT         227
FT                   /note="Q -> R (in dbSNP:rs11147259)"
FT                   /id="VAR_052746"
FT   CONFLICT        149..282
FT                   /note="Missing (in Ref. 1)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        374
FT                   /note="E -> H (in Ref. 1; CAA36558)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        514
FT                   /note="E -> A (in Ref. 1; CAA36558)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   573 AA;  66455 MW;  5C850DBC8FF4A064 CRC64;
     MDAKSLTAWS RTLVTFKDVF VDFTREEWKL LDTAQQIVYR NVMLENYKNL VSLGYQLTKP
     DVILRLEKGE EPWLVEREIH QETHPDSETA FEIKSSVSSR SIFKDKQSCD IKMEGMARND
     LWYLSLEEVW KCRDQLDKYQ ENPERHLRQV AFTQKKVLTQ ERVSESGKYG GNCLLPAQLV
     LREYFHKRDS HTKSLKHDLV LNGHQDSCAS NSNECGQTFC QNIHLIQFAR THTGDKSYKC
     PDNDNSLTHG SSLGISKGIH REKPYECKEC GKFFSWRSNL TRHQLIHTGE KPYECKECGK
     SFSRSSHLIG HQKTHTGEEP YECKECGKSF SWFSHLVTHQ RTHTGDKLYT CNQCGKSFVH
     SSRLIRHQRT HTGEKPYECP ECGKSFRQST HLILHQRTHV RVRPYECNEC GKSYSQRSHL
     VVHHRIHTGL KPFECKDCGK CFSRSSHLYS HQRTHTGEKP YECHDCGKSF SQSSALIVHQ
     RIHTGEKPYE CCQCGKAFIR KNDLIKHQRI HVGEETYKCN QCGIIFSQNS PFIVHQIAHT
     GEQFLTCNQC GTALVNTSNL IGYQTNHIRE NAY
//