P21506 (ZNF10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 10

Alternative name(s):
Zinc finger protein KOX1

Gene names

Name:	ZNF10
Synonyms:	KOX1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	573 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 11 C2H2-type zinc fingers. Contains 1 KRAB domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 573	573	Zinc finger protein 10		PRO_0000047332
Regions
	Domain	14 – 85	72	KRAB
	Zinc finger	206 – 232	27	C2H2-type 1; atypical
	Zinc finger	265 – 287	23	C2H2-type 2
	Zinc finger	293 – 315	23	C2H2-type 3
	Zinc finger	321 – 343	23	C2H2-type 4
	Zinc finger	349 – 371	23	C2H2-type 5
	Zinc finger	377 – 399	23	C2H2-type 6
	Zinc finger	405 – 427	23	C2H2-type 7
	Zinc finger	433 – 455	23	C2H2-type 8
	Zinc finger	461 – 483	23	C2H2-type 9
	Zinc finger	489 – 511	23	C2H2-type 10
	Zinc finger	517 – 539	23	C2H2-type 11; atypical
Natural variations
	Natural variant	227	1	Q → R. Corresponds to variant rs11147259 [ dbSNP | Ensembl ].		VAR_052746
Experimental info
	Sequence conflict	149 – 282	134	Missing Ref.1
	Sequence conflict	374	1	E → H in CAA36558. Ref.1
	Sequence conflict	514	1	E → A in CAA36558. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P21506 [UniParc]. Last modified November 23, 2004. Version 3. Checksum: 5C850DBC8FF4A064	FASTA	573	66,455
	10 20 30 40 50 60 MDAKSLTAWS RTLVTFKDVF VDFTREEWKL LDTAQQIVYR NVMLENYKNL VSLGYQLTKP 70 80 90 100 110 120 DVILRLEKGE EPWLVEREIH QETHPDSETA FEIKSSVSSR SIFKDKQSCD IKMEGMARND 130 140 150 160 170 180 LWYLSLEEVW KCRDQLDKYQ ENPERHLRQV AFTQKKVLTQ ERVSESGKYG GNCLLPAQLV 190 200 210 220 230 240 LREYFHKRDS HTKSLKHDLV LNGHQDSCAS NSNECGQTFC QNIHLIQFAR THTGDKSYKC 250 260 270 280 290 300 PDNDNSLTHG SSLGISKGIH REKPYECKEC GKFFSWRSNL TRHQLIHTGE KPYECKECGK 310 320 330 340 350 360 SFSRSSHLIG HQKTHTGEEP YECKECGKSF SWFSHLVTHQ RTHTGDKLYT CNQCGKSFVH 370 380 390 400 410 420 SSRLIRHQRT HTGEKPYECP ECGKSFRQST HLILHQRTHV RVRPYECNEC GKSYSQRSHL 430 440 450 460 470 480 VVHHRIHTGL KPFECKDCGK CFSRSSHLYS HQRTHTGEKP YECHDCGKSF SQSSALIVHQ 490 500 510 520 530 540 RIHTGEKPYE CCQCGKAFIR KNDLIKHQRI HVGEETYKCN QCGIIFSQNS PFIVHQIAHT 550 560 570 GEQFLTCNQC GTALVNTSNL IGYQTNHIRE NAY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Multiple genes encoding zinc finger domains are expressed in human T cells." Thiesen H.-J. New Biol. 2:363-374(1990) [PubMed: 2288909] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thalamus.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X52332 mRNA. Translation: CAA36558.1. AK314784 mRNA. Translation: BAG37318.1. CH471218 Genomic DNA. Translation: EAW54791.1. BC024182 mRNA. Translation: AAH24182.1.
IPI	IPI00009267.
PIR	S10397.
RefSeq	NP_056209.2. NM_015394.4.
UniGene	Hs.507355.
3D structure databases
ProteinModelPortal	P21506.
SMR	P21506. Positions 8-62, 129-567.
ModBase	Search...
Protein-protein interaction databases
IntAct	P21506. 3 interactions.
STRING	P21506.
Polymorphism databases
DMDM	55977778.
Proteomic databases
PRIDE	P21506.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000248211; ENSP00000248211; ENSG00000090612. ENST00000426665; ENSP00000393814; ENSG00000090612.
GeneID	7556.
KEGG	hsa:7556.
UCSC	uc001ulq.1. human.
Organism-specific databases
CTD	7556.
GeneCards	GC12P133709.
HGNC	HGNC:12879. ZNF10.
HPA	HPA003204.
MIM	194538. gene.
neXtProt	NX_P21506.
PharmGKB	PA37468.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG16729.
HOVERGEN	HBG018163.
InParanoid	P21506.
OMA	VVHHRTH.
OrthoDB	EOG4P8FHK.
PhylomeDB	P21506.
Enzyme and pathway databases
Reactome	REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	P21506.
Bgee	P21506.
CleanEx	HS_ZNF10.
Genevestigator	P21506.
GermOnline	ENSG00000090612. Homo sapiens.
Family and domain databases
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 11 hits.
KO	K09228.
Pfam	PF01352. KRAB. 1 hit. PF00096. zf-C2H2. 10 hits. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 10 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 10 hits. PS50157. ZINC_FINGER_C2H2_2. 11 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	29563.
SOURCE	Search...

Entry information

Entry name

ZNF10_HUMAN

Accession

Primary (citable) accession number: P21506
Secondary accession number(s): B2RBS1, Q8TC91

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
Last sequence update:	November 23, 2004
Last modified:	January 25, 2012
This is version 124 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.