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P21506

- ZNF10_HUMAN

UniProt

P21506 - ZNF10_HUMAN

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Protein

Zinc finger protein 10

Gene

ZNF10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri206 – 23227C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri265 – 28723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri293 – 31523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri321 – 34323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri349 – 37123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri377 – 39923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri405 – 42723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri433 – 45523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri461 – 48323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri489 – 51123C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri517 – 53923C2H2-type 11; atypicalPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 10
Alternative name(s):
Zinc finger protein KOX1
Gene namesi
Name:ZNF10
Synonyms:KOX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:12879. ZNF10.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37468.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 573573Zinc finger protein 10PRO_0000047332Add
BLAST

Proteomic databases

MaxQBiP21506.
PRIDEiP21506.

PTM databases

PhosphoSiteiP21506.

Expressioni

Gene expression databases

BgeeiP21506.
CleanExiHS_ZNF10.
ExpressionAtlasiP21506. baseline and differential.
GenevestigatoriP21506.

Organism-specific databases

HPAiHPA003204.

Interactioni

Subunit structurei

Interacts (via the KRAB domain) with TRIM28 (via the RBCC domain).1 Publication

Protein-protein interaction databases

BioGridi113388. 8 interactions.
IntActiP21506. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliP21506.
SMRiP21506. Positions 14-55, 219-572.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 8572KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri206 – 23227C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri265 – 28723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri293 – 31523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri321 – 34323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri349 – 37123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri377 – 39923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri405 – 42723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri433 – 45523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri461 – 48323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri489 – 51123C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri517 – 53923C2H2-type 11; atypicalPROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00760000119265.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP21506.
KOiK09228.
OMAiLREYFHK.
PhylomeDBiP21506.
TreeFamiTF337898.

Family and domain databases

Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21506-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDAKSLTAWS RTLVTFKDVF VDFTREEWKL LDTAQQIVYR NVMLENYKNL
60 70 80 90 100
VSLGYQLTKP DVILRLEKGE EPWLVEREIH QETHPDSETA FEIKSSVSSR
110 120 130 140 150
SIFKDKQSCD IKMEGMARND LWYLSLEEVW KCRDQLDKYQ ENPERHLRQV
160 170 180 190 200
AFTQKKVLTQ ERVSESGKYG GNCLLPAQLV LREYFHKRDS HTKSLKHDLV
210 220 230 240 250
LNGHQDSCAS NSNECGQTFC QNIHLIQFAR THTGDKSYKC PDNDNSLTHG
260 270 280 290 300
SSLGISKGIH REKPYECKEC GKFFSWRSNL TRHQLIHTGE KPYECKECGK
310 320 330 340 350
SFSRSSHLIG HQKTHTGEEP YECKECGKSF SWFSHLVTHQ RTHTGDKLYT
360 370 380 390 400
CNQCGKSFVH SSRLIRHQRT HTGEKPYECP ECGKSFRQST HLILHQRTHV
410 420 430 440 450
RVRPYECNEC GKSYSQRSHL VVHHRIHTGL KPFECKDCGK CFSRSSHLYS
460 470 480 490 500
HQRTHTGEKP YECHDCGKSF SQSSALIVHQ RIHTGEKPYE CCQCGKAFIR
510 520 530 540 550
KNDLIKHQRI HVGEETYKCN QCGIIFSQNS PFIVHQIAHT GEQFLTCNQC
560 570
GTALVNTSNL IGYQTNHIRE NAY
Length:573
Mass (Da):66,455
Last modified:November 23, 2004 - v3
Checksum:i5C850DBC8FF4A064
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti149 – 282134Missing(PubMed:2288909)CuratedAdd
BLAST
Sequence conflicti374 – 3741E → H in CAA36558. (PubMed:2288909)Curated
Sequence conflicti514 – 5141E → A in CAA36558. (PubMed:2288909)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti227 – 2271Q → R.
Corresponds to variant rs11147259 [ dbSNP | Ensembl ].
VAR_052746

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52332 mRNA. Translation: CAA36558.1.
AK314784 mRNA. Translation: BAG37318.1.
CH471218 Genomic DNA. Translation: EAW54791.1.
BC024182 mRNA. Translation: AAH24182.1.
CCDSiCCDS9283.1.
PIRiS10397.
RefSeqiNP_056209.2. NM_015394.4.
UniGeneiHs.573983.

Genome annotation databases

EnsembliENST00000248211; ENSP00000248211; ENSG00000256223.
ENST00000426665; ENSP00000393814; ENSG00000256223.
GeneIDi7556.
KEGGihsa:7556.
UCSCiuc001ulq.3. human.

Polymorphism databases

DMDMi55977778.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52332 mRNA. Translation: CAA36558.1 .
AK314784 mRNA. Translation: BAG37318.1 .
CH471218 Genomic DNA. Translation: EAW54791.1 .
BC024182 mRNA. Translation: AAH24182.1 .
CCDSi CCDS9283.1.
PIRi S10397.
RefSeqi NP_056209.2. NM_015394.4.
UniGenei Hs.573983.

3D structure databases

ProteinModelPortali P21506.
SMRi P21506. Positions 14-55, 219-572.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113388. 8 interactions.
IntActi P21506. 3 interactions.

PTM databases

PhosphoSitei P21506.

Polymorphism databases

DMDMi 55977778.

Proteomic databases

MaxQBi P21506.
PRIDEi P21506.

Protocols and materials databases

DNASUi 7556.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000248211 ; ENSP00000248211 ; ENSG00000256223 .
ENST00000426665 ; ENSP00000393814 ; ENSG00000256223 .
GeneIDi 7556.
KEGGi hsa:7556.
UCSCi uc001ulq.3. human.

Organism-specific databases

CTDi 7556.
GeneCardsi GC12P133709.
HGNCi HGNC:12879. ZNF10.
HPAi HPA003204.
MIMi 194538. gene.
neXtProti NX_P21506.
PharmGKBi PA37468.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00760000119265.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi P21506.
KOi K09228.
OMAi LREYFHK.
PhylomeDBi P21506.
TreeFami TF337898.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GeneWikii ZNF10.
GenomeRNAii 7556.
NextBioi 29563.
PROi P21506.
SOURCEi Search...

Gene expression databases

Bgeei P21506.
CleanExi HS_ZNF10.
ExpressionAtlasi P21506. baseline and differential.
Genevestigatori P21506.

Family and domain databases

Gene3Di 3.30.160.60. 11 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Multiple genes encoding zinc finger domains are expressed in human T cells."
    Thiesen H.-J.
    New Biol. 2:363-374(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thalamus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  5. "Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1."
    Wang W., Cai J., Wu Y., Hu L., Chen Z., Hu J., Chen Z., Li W., Guo M., Huang Z.
    Cell. Mol. Life Sci. 70:3947-3958(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ZNF268, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiZNF10_HUMAN
AccessioniPrimary (citable) accession number: P21506
Secondary accession number(s): B2RBS1, Q8TC91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: November 23, 2004
Last modified: October 29, 2014
This is version 151 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3