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Reviewed, UniProtKB/Swiss-Prot P21506 (ZNF10_HUMAN)

Last modified July 7, 2009. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Zinc finger protein 10
Alternative name(s):
    Zinc finger protein KOX1
Gene names
Name: ZNF10
Synonyms: KOX1
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length573 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 11 C2H2-type zinc fingers.

Contains 1 KRAB domain.

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Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processregulation of transcription, DNA-dependent

Inferred from electronic annotation. Source: UniProtKB-KW

transcription

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein binding

Inferred from physical interaction. Source: IntAct

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

TRIM28Q132632EBI-1105324,EBI-78139

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 573573Zinc finger protein 10
PRO_0000047332

Regions

Domain14 – 8572KRAB
Zinc finger206 – 23227C2H2-type 1; atypical
Zinc finger265 – 28723C2H2-type 2
Zinc finger293 – 31523C2H2-type 3
Zinc finger321 – 34323C2H2-type 4
Zinc finger349 – 37123C2H2-type 5
Zinc finger377 – 39923C2H2-type 6
Zinc finger405 – 42723C2H2-type 7
Zinc finger433 – 45523C2H2-type 8
Zinc finger461 – 48323C2H2-type 9
Zinc finger489 – 51123C2H2-type 10
Zinc finger517 – 53923C2H2-type 11; atypical

Natural variations

Natural variant2271Q → R: dbSNP rs11147259.
VAR_052746

Experimental info

Sequence conflict149 – 282134Missing Ref.1
Sequence conflict3741E → H in CAA36558. Ref.1
Sequence conflict5141E → A in CAA36558. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
P21506-1 [UniParc].

Last modified November 23, 2004. Version 3.
Checksum: 5C850DBC8FF4A064

FASTA57366,455
        10         20         30         40         50         60 
MDAKSLTAWS RTLVTFKDVF VDFTREEWKL LDTAQQIVYR NVMLENYKNL VSLGYQLTKP 

        70         80         90        100        110        120 
DVILRLEKGE EPWLVEREIH QETHPDSETA FEIKSSVSSR SIFKDKQSCD IKMEGMARND 

       130        140        150        160        170        180 
LWYLSLEEVW KCRDQLDKYQ ENPERHLRQV AFTQKKVLTQ ERVSESGKYG GNCLLPAQLV 

       190        200        210        220        230        240 
LREYFHKRDS HTKSLKHDLV LNGHQDSCAS NSNECGQTFC QNIHLIQFAR THTGDKSYKC 

       250        260        270        280        290        300 
PDNDNSLTHG SSLGISKGIH REKPYECKEC GKFFSWRSNL TRHQLIHTGE KPYECKECGK 

       310        320        330        340        350        360 
SFSRSSHLIG HQKTHTGEEP YECKECGKSF SWFSHLVTHQ RTHTGDKLYT CNQCGKSFVH 

       370        380        390        400        410        420 
SSRLIRHQRT HTGEKPYECP ECGKSFRQST HLILHQRTHV RVRPYECNEC GKSYSQRSHL 

       430        440        450        460        470        480 
VVHHRIHTGL KPFECKDCGK CFSRSSHLYS HQRTHTGEKP YECHDCGKSF SQSSALIVHQ 

       490        500        510        520        530        540 
RIHTGEKPYE CCQCGKAFIR KNDLIKHQRI HVGEETYKCN QCGIIFSQNS PFIVHQIAHT 

       550        560        570 
GEQFLTCNQC GTALVNTSNL IGYQTNHIRE NAY

« Hide

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References

« Hide 'large scale' references
[1]"Multiple genes encoding zinc finger domains are expressed in human T cells."
Thiesen H.-J.
New Biol. 2:363-374(1990) [PubMed: 2288909] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.

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Cross-references

Sequence databases

X52332 mRNA. Translation: CAA36558.1.
BC024182 mRNA. Translation: AAH24182.1.
IPIIPI00009267.
PIRS10397.
RefSeqNP_056209.2.
UniGeneHs.507355

3D structure databases

HSSPHSSP built from PDB template 1SP2 based on UniProtKB P08047.
ModBaseSearch...

Protein-protein interaction databases

IntActP21506. 3 interactions.

PTM databases

PhosphoSiteP21506.

Proteomic databases

PRIDEP21506.

Genome annotation databases

EnsemblENSG00000090612. Homo sapiens. [Contig view]
GeneID7556.
KEGGhsa:7556.
UCSCuc001ulq.1. human.

Organism-specific databases

GeneCardsGC12P132317.
HGNCHGNC:12879. ZNF10.
HPAHPA003204.
MIM194538. gene.
PharmGKBPA37468.
GenAtlasSearch...

Phylogenomic databases

HOGENOMP21506.
HOVERGENP21506.
OMAP21506. VVHHRTH.

Gene expression databases

ArrayExpressP21506.
BgeeP21506.
CleanExHS_ZNF10.
GermOnlineENSG00000090612. Homo sapiens.

Family and domain databases

InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
Gene3DG3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 10 hits.
PfamPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 10 hits.
[Graphical view]
ProDomPD000003. Znf_C2H2. 9 hits.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio29563.
SOURCESearch...

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Entry information

Entry nameZNF10_HUMAN
AccessionPrimary (citable) accession number: P21506
Secondary accession number(s): Q8TC91
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: November 23, 2004
Last modified: July 7, 2009
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents