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P21506

- ZNF10_HUMAN

UniProt

P21506 - ZNF10_HUMAN

Protein

Zinc finger protein 10

Gene

ZNF10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 150 (01 Oct 2014)
      Sequence version 3 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri206 – 23227C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri265 – 28723C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri293 – 31523C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri321 – 34323C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri349 – 37123C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri377 – 39923C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri405 – 42723C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri433 – 45523C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri461 – 48323C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri489 – 51123C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri517 – 53923C2H2-type 11; atypicalPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 10
    Alternative name(s):
    Zinc finger protein KOX1
    Gene namesi
    Name:ZNF10
    Synonyms:KOX1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:12879. ZNF10.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37468.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 573573Zinc finger protein 10PRO_0000047332Add
    BLAST

    Proteomic databases

    MaxQBiP21506.
    PRIDEiP21506.

    PTM databases

    PhosphoSiteiP21506.

    Expressioni

    Gene expression databases

    ArrayExpressiP21506.
    BgeeiP21506.
    CleanExiHS_ZNF10.
    GenevestigatoriP21506.

    Organism-specific databases

    HPAiHPA003204.

    Interactioni

    Subunit structurei

    Interacts (via the KRAB domain) with TRIM28 (via the RBCC domain).1 Publication

    Protein-protein interaction databases

    BioGridi113388. 8 interactions.
    IntActiP21506. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP21506.
    SMRiP21506. Positions 14-55, 219-572.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini14 – 8572KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri206 – 23227C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri265 – 28723C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri293 – 31523C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri321 – 34323C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri349 – 37123C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri377 – 39923C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri405 – 42723C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri433 – 45523C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri461 – 48323C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri489 – 51123C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri517 – 53923C2H2-type 11; atypicalPROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiP21506.
    KOiK09228.
    OMAiLREYFHK.
    PhylomeDBiP21506.
    TreeFamiTF337898.

    Family and domain databases

    Gene3Di3.30.160.60. 11 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 10 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 10 hits.
    PS50157. ZINC_FINGER_C2H2_2. 11 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P21506-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDAKSLTAWS RTLVTFKDVF VDFTREEWKL LDTAQQIVYR NVMLENYKNL    50
    VSLGYQLTKP DVILRLEKGE EPWLVEREIH QETHPDSETA FEIKSSVSSR 100
    SIFKDKQSCD IKMEGMARND LWYLSLEEVW KCRDQLDKYQ ENPERHLRQV 150
    AFTQKKVLTQ ERVSESGKYG GNCLLPAQLV LREYFHKRDS HTKSLKHDLV 200
    LNGHQDSCAS NSNECGQTFC QNIHLIQFAR THTGDKSYKC PDNDNSLTHG 250
    SSLGISKGIH REKPYECKEC GKFFSWRSNL TRHQLIHTGE KPYECKECGK 300
    SFSRSSHLIG HQKTHTGEEP YECKECGKSF SWFSHLVTHQ RTHTGDKLYT 350
    CNQCGKSFVH SSRLIRHQRT HTGEKPYECP ECGKSFRQST HLILHQRTHV 400
    RVRPYECNEC GKSYSQRSHL VVHHRIHTGL KPFECKDCGK CFSRSSHLYS 450
    HQRTHTGEKP YECHDCGKSF SQSSALIVHQ RIHTGEKPYE CCQCGKAFIR 500
    KNDLIKHQRI HVGEETYKCN QCGIIFSQNS PFIVHQIAHT GEQFLTCNQC 550
    GTALVNTSNL IGYQTNHIRE NAY 573
    Length:573
    Mass (Da):66,455
    Last modified:November 23, 2004 - v3
    Checksum:i5C850DBC8FF4A064
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti149 – 282134Missing(PubMed:2288909)CuratedAdd
    BLAST
    Sequence conflicti374 – 3741E → H in CAA36558. (PubMed:2288909)Curated
    Sequence conflicti514 – 5141E → A in CAA36558. (PubMed:2288909)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti227 – 2271Q → R.
    Corresponds to variant rs11147259 [ dbSNP | Ensembl ].
    VAR_052746

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52332 mRNA. Translation: CAA36558.1.
    AK314784 mRNA. Translation: BAG37318.1.
    CH471218 Genomic DNA. Translation: EAW54791.1.
    BC024182 mRNA. Translation: AAH24182.1.
    CCDSiCCDS9283.1.
    PIRiS10397.
    RefSeqiNP_056209.2. NM_015394.4.
    UniGeneiHs.573983.

    Genome annotation databases

    EnsembliENST00000248211; ENSP00000248211; ENSG00000256223.
    ENST00000426665; ENSP00000393814; ENSG00000256223.
    GeneIDi7556.
    KEGGihsa:7556.
    UCSCiuc001ulq.3. human.

    Polymorphism databases

    DMDMi55977778.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52332 mRNA. Translation: CAA36558.1 .
    AK314784 mRNA. Translation: BAG37318.1 .
    CH471218 Genomic DNA. Translation: EAW54791.1 .
    BC024182 mRNA. Translation: AAH24182.1 .
    CCDSi CCDS9283.1.
    PIRi S10397.
    RefSeqi NP_056209.2. NM_015394.4.
    UniGenei Hs.573983.

    3D structure databases

    ProteinModelPortali P21506.
    SMRi P21506. Positions 14-55, 219-572.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113388. 8 interactions.
    IntActi P21506. 3 interactions.

    PTM databases

    PhosphoSitei P21506.

    Polymorphism databases

    DMDMi 55977778.

    Proteomic databases

    MaxQBi P21506.
    PRIDEi P21506.

    Protocols and materials databases

    DNASUi 7556.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000248211 ; ENSP00000248211 ; ENSG00000256223 .
    ENST00000426665 ; ENSP00000393814 ; ENSG00000256223 .
    GeneIDi 7556.
    KEGGi hsa:7556.
    UCSCi uc001ulq.3. human.

    Organism-specific databases

    CTDi 7556.
    GeneCardsi GC12P133709.
    HGNCi HGNC:12879. ZNF10.
    HPAi HPA003204.
    MIMi 194538. gene.
    neXtProti NX_P21506.
    PharmGKBi PA37468.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi P21506.
    KOi K09228.
    OMAi LREYFHK.
    PhylomeDBi P21506.
    TreeFami TF337898.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    GeneWikii ZNF10.
    GenomeRNAii 7556.
    NextBioi 29563.
    PROi P21506.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P21506.
    Bgeei P21506.
    CleanExi HS_ZNF10.
    Genevestigatori P21506.

    Family and domain databases

    Gene3Di 3.30.160.60. 11 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 10 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 10 hits.
    PS50157. ZINC_FINGER_C2H2_2. 11 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Multiple genes encoding zinc finger domains are expressed in human T cells."
      Thiesen H.-J.
      New Biol. 2:363-374(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thalamus.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    5. "Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1."
      Wang W., Cai J., Wu Y., Hu L., Chen Z., Hu J., Chen Z., Li W., Guo M., Huang Z.
      Cell. Mol. Life Sci. 70:3947-3958(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ZNF268, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiZNF10_HUMAN
    AccessioniPrimary (citable) accession number: P21506
    Secondary accession number(s): B2RBS1, Q8TC91
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 150 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3