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Protein

Uncharacterized MFS-type transporter YcaD

Gene

ycaD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:YCAD-MONOMER.
ECOL316407:JW0881-MONOMER.

Protein family/group databases

TCDBi2.A.1.26.1. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized MFS-type transporter YcaD
Gene namesi
Name:ycaD
Ordered Locus Names:b0898, JW0881
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11242. ycaD.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Topological domaini35 – 44PeriplasmicSequence analysis10
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Topological domaini66 – 78CytoplasmicSequence analysisAdd BLAST13
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Topological domaini100 – 101PeriplasmicSequence analysis2
Transmembranei102 – 122HelicalSequence analysisAdd BLAST21
Topological domaini123 – 130CytoplasmicSequence analysis8
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Topological domaini152 – 156PeriplasmicSequence analysis5
Transmembranei157 – 177HelicalSequence analysisAdd BLAST21
Topological domaini178 – 203CytoplasmicSequence analysisAdd BLAST26
Transmembranei204 – 224HelicalSequence analysisAdd BLAST21
Topological domaini225 – 234PeriplasmicSequence analysis10
Transmembranei235 – 255HelicalSequence analysisAdd BLAST21
Topological domaini256 – 269CytoplasmicSequence analysisAdd BLAST14
Transmembranei270 – 290HelicalSequence analysisAdd BLAST21
Transmembranei291 – 311HelicalSequence analysisAdd BLAST21
Topological domaini312 – 324CytoplasmicSequence analysisAdd BLAST13
Transmembranei325 – 345HelicalSequence analysisAdd BLAST21
Topological domaini346 – 347PeriplasmicSequence analysis2
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Topological domaini369 – 382CytoplasmicSequence analysisAdd BLAST14

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000848891 – 382Uncharacterized MFS-type transporter YcaDAdd BLAST382

Proteomic databases

PaxDbiP21503.
PRIDEiP21503.

Interactioni

Protein-protein interaction databases

BioGridi4261691. 134 interactors.
STRINGi511145.b0898.

Structurei

3D structure databases

ProteinModelPortaliP21503.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108ISG. Bacteria.
ENOG410Y0GE. LUCA.
HOGENOMiHOG000280030.
InParanoidiP21503.
KOiK08219.
OMAiYWMALLI.
PhylomeDBiP21503.

Family and domain databases

CDDicd06174. MFS. 1 hit.
HAMAPiMF_01149. MFS_YcaD. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR023745. MFS_YcaD.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21503-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTYTQPVML LLSGLLLLTL AIAVLNTLVP LWLAQEHMST WQVGVVSSSY
60 70 80 90 100
FTGNLVGTLL TGYVIKRIGF NRSYYLASFI FAAGCAGLGL MIGFWSWLAW
110 120 130 140 150
RFVAGVGCAM IWVVVESALM CSGTSRNRGR LLAAYMMVYY VGTFLGQLLV
160 170 180 190 200
SKVSTELMSV LPWVTGLTLA GILPLLFTRV LNQQAENHDS TSITSMLKLR
210 220 230 240 250
QARLGVNGCI ISGIVLGSLY GLMPLYLNHK GVSNASIGFW MAVLVSAGIL
260 270 280 290 300
GQWPIGRLAD KFGRLLVLRV QVFVVILGSI AMLSQAAMAP ALFILGAAGF
310 320 330 340 350
TLYPVAMAWA CEKVEHHQLV AMNQALLLSY TVGSLLGPSF TAMLMQNFSD
360 370 380
NLLFIMIASV SFIYLLMLLR NAGHTPKPVA HV
Length:382
Mass (Da):41,432
Last modified:November 1, 1997 - v2
Checksum:i9C0F47A928B7C949
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73984.1.
AP009048 Genomic DNA. Translation: BAA35630.1.
J03412 Genomic DNA. Translation: AAA83847.1.
PIRiA64829.
RefSeqiNP_415418.1. NC_000913.3.
WP_000109259.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73984; AAC73984; b0898.
BAA35630; BAA35630; BAA35630.
GeneIDi945515.
KEGGiecj:JW0881.
eco:b0898.
PATRICi32117009. VBIEscCol129921_0929.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73984.1.
AP009048 Genomic DNA. Translation: BAA35630.1.
J03412 Genomic DNA. Translation: AAA83847.1.
PIRiA64829.
RefSeqiNP_415418.1. NC_000913.3.
WP_000109259.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP21503.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261691. 134 interactors.
STRINGi511145.b0898.

Protein family/group databases

TCDBi2.A.1.26.1. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiP21503.
PRIDEiP21503.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73984; AAC73984; b0898.
BAA35630; BAA35630; BAA35630.
GeneIDi945515.
KEGGiecj:JW0881.
eco:b0898.
PATRICi32117009. VBIEscCol129921_0929.

Organism-specific databases

EchoBASEiEB1224.
EcoGeneiEG11242. ycaD.

Phylogenomic databases

eggNOGiENOG4108ISG. Bacteria.
ENOG410Y0GE. LUCA.
HOGENOMiHOG000280030.
InParanoidiP21503.
KOiK08219.
OMAiYWMALLI.
PhylomeDBiP21503.

Enzyme and pathway databases

BioCyciEcoCyc:YCAD-MONOMER.
ECOL316407:JW0881-MONOMER.

Miscellaneous databases

PROiP21503.

Family and domain databases

CDDicd06174. MFS. 1 hit.
HAMAPiMF_01149. MFS_YcaD. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR023745. MFS_YcaD.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYCAD_ECOLI
AccessioniPrimary (citable) accession number: P21503
Secondary accession number(s): P75834
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.