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Protein

Uncharacterized MFS-type transporter YcaD

Gene

ycaD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:YCAD-MONOMER.
ECOL316407:JW0881-MONOMER.

Protein family/group databases

TCDBi2.A.1.26.1. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized MFS-type transporter YcaD
Gene namesi
Name:ycaD
Ordered Locus Names:b0898, JW0881
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11242. ycaD.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1313CytoplasmicSequence analysisAdd
BLAST
Transmembranei14 – 3421HelicalSequence analysisAdd
BLAST
Topological domaini35 – 4410PeriplasmicSequence analysis
Transmembranei45 – 6521HelicalSequence analysisAdd
BLAST
Topological domaini66 – 7813CytoplasmicSequence analysisAdd
BLAST
Transmembranei79 – 9921HelicalSequence analysisAdd
BLAST
Topological domaini100 – 1012PeriplasmicSequence analysis
Transmembranei102 – 12221HelicalSequence analysisAdd
BLAST
Topological domaini123 – 1308CytoplasmicSequence analysis
Transmembranei131 – 15121HelicalSequence analysisAdd
BLAST
Topological domaini152 – 1565PeriplasmicSequence analysis
Transmembranei157 – 17721HelicalSequence analysisAdd
BLAST
Topological domaini178 – 20326CytoplasmicSequence analysisAdd
BLAST
Transmembranei204 – 22421HelicalSequence analysisAdd
BLAST
Topological domaini225 – 23410PeriplasmicSequence analysis
Transmembranei235 – 25521HelicalSequence analysisAdd
BLAST
Topological domaini256 – 26914CytoplasmicSequence analysisAdd
BLAST
Transmembranei270 – 29021HelicalSequence analysisAdd
BLAST
Transmembranei291 – 31121HelicalSequence analysisAdd
BLAST
Topological domaini312 – 32413CytoplasmicSequence analysisAdd
BLAST
Transmembranei325 – 34521HelicalSequence analysisAdd
BLAST
Topological domaini346 – 3472PeriplasmicSequence analysis
Transmembranei348 – 36821HelicalSequence analysisAdd
BLAST
Topological domaini369 – 38214CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382Uncharacterized MFS-type transporter YcaDPRO_0000084889Add
BLAST

Proteomic databases

PaxDbiP21503.

Interactioni

Protein-protein interaction databases

BioGridi4261691. 134 interactions.
STRINGi511145.b0898.

Structurei

3D structure databases

ProteinModelPortaliP21503.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108ISG. Bacteria.
ENOG410Y0GE. LUCA.
HOGENOMiHOG000280030.
InParanoidiP21503.
KOiK08219.
OMAiYWMALLI.
OrthoDBiEOG6X3W2W.
PhylomeDBiP21503.

Family and domain databases

HAMAPiMF_01149. MFS_YcaD.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR023745. MFS_YcaD.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21503-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTYTQPVML LLSGLLLLTL AIAVLNTLVP LWLAQEHMST WQVGVVSSSY
60 70 80 90 100
FTGNLVGTLL TGYVIKRIGF NRSYYLASFI FAAGCAGLGL MIGFWSWLAW
110 120 130 140 150
RFVAGVGCAM IWVVVESALM CSGTSRNRGR LLAAYMMVYY VGTFLGQLLV
160 170 180 190 200
SKVSTELMSV LPWVTGLTLA GILPLLFTRV LNQQAENHDS TSITSMLKLR
210 220 230 240 250
QARLGVNGCI ISGIVLGSLY GLMPLYLNHK GVSNASIGFW MAVLVSAGIL
260 270 280 290 300
GQWPIGRLAD KFGRLLVLRV QVFVVILGSI AMLSQAAMAP ALFILGAAGF
310 320 330 340 350
TLYPVAMAWA CEKVEHHQLV AMNQALLLSY TVGSLLGPSF TAMLMQNFSD
360 370 380
NLLFIMIASV SFIYLLMLLR NAGHTPKPVA HV
Length:382
Mass (Da):41,432
Last modified:November 1, 1997 - v2
Checksum:i9C0F47A928B7C949
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73984.1.
AP009048 Genomic DNA. Translation: BAA35630.1.
J03412 Genomic DNA. Translation: AAA83847.1.
PIRiA64829.
RefSeqiNP_415418.1. NC_000913.3.
WP_000109259.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73984; AAC73984; b0898.
BAA35630; BAA35630; BAA35630.
GeneIDi945515.
KEGGiecj:JW0881.
eco:b0898.
PATRICi32117009. VBIEscCol129921_0929.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73984.1.
AP009048 Genomic DNA. Translation: BAA35630.1.
J03412 Genomic DNA. Translation: AAA83847.1.
PIRiA64829.
RefSeqiNP_415418.1. NC_000913.3.
WP_000109259.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP21503.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261691. 134 interactions.
STRINGi511145.b0898.

Protein family/group databases

TCDBi2.A.1.26.1. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiP21503.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73984; AAC73984; b0898.
BAA35630; BAA35630; BAA35630.
GeneIDi945515.
KEGGiecj:JW0881.
eco:b0898.
PATRICi32117009. VBIEscCol129921_0929.

Organism-specific databases

EchoBASEiEB1224.
EcoGeneiEG11242. ycaD.

Phylogenomic databases

eggNOGiENOG4108ISG. Bacteria.
ENOG410Y0GE. LUCA.
HOGENOMiHOG000280030.
InParanoidiP21503.
KOiK08219.
OMAiYWMALLI.
OrthoDBiEOG6X3W2W.
PhylomeDBiP21503.

Enzyme and pathway databases

BioCyciEcoCyc:YCAD-MONOMER.
ECOL316407:JW0881-MONOMER.

Miscellaneous databases

PROiP21503.

Family and domain databases

HAMAPiMF_01149. MFS_YcaD.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR023745. MFS_YcaD.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Nucleotide sequence of the dmsABC operon encoding the anaerobic dimethylsulphoxide reductase of Escherichia coli."
    Bilous P.T., Cole S.T., Anderson W.F., Weiner J.H.
    Mol. Microbiol. 2:785-795(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-264.
    Strain: K12 / C600 / ATCC 23724 / DSM 3925 / LMG 3041 / NCIB 10222.
  5. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiYCAD_ECOLI
AccessioniPrimary (citable) accession number: P21503
Secondary accession number(s): P75834
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: November 1, 1997
Last modified: January 20, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.