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Protein

fMet-Leu-Phe receptor

Gene

FPR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1712023, PubMed:10514456).4 Publications4 Publications

GO - Molecular functioni

GO - Biological processi

  • activation of MAPK activity Source: ProtInc
  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: ProtInc
  • cell chemotaxis Source: GO_Central
  • chemotaxis Source: ProtInc
  • complement receptor mediated signaling pathway Source: GO_Central
  • cytokine-mediated signaling pathway Source: Reactome
  • G-protein coupled receptor signaling pathway Source: Reactome
  • inflammatory response Source: GO_Central
  • leukocyte migration Source: GO_Central
  • neutrophil degranulation Source: Reactome
  • nitric oxide mediated signal transduction Source: ProtInc
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: MGI
  • positive regulation of cytosolic calcium ion concentration Source: GO_Central
  • signal transduction Source: ProtInc

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processChemotaxis

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-444473 Formyl peptide receptors bind formyl peptides and many other ligands
R-HSA-6783783 Interleukin-10 signaling
R-HSA-6798695 Neutrophil degranulation
SignaLinkiP21462
SIGNORiP21462

Names & Taxonomyi

Protein namesi
Recommended name:
fMet-Leu-Phe receptor
Short name:
fMLP receptor
Alternative name(s):
N-formyl peptide receptor
Short name:
FPR
N-formylpeptide chemoattractant receptor
Gene namesi
Name:FPR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000171051.8
HGNCiHGNC:3826 FPR1
MIMi136537 gene
neXtProtiNX_P21462

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 50Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini51 – 61CytoplasmicSequence analysisAdd BLAST11
Transmembranei62 – 83Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini84 – 100ExtracellularSequence analysisAdd BLAST17
Transmembranei101 – 121Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini122 – 140CytoplasmicSequence analysisAdd BLAST19
Transmembranei141 – 162Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini163 – 205ExtracellularSequence analysisAdd BLAST43
Transmembranei206 – 226Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini227 – 242CytoplasmicSequence analysisAdd BLAST16
Transmembranei243 – 266Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini267 – 285ExtracellularSequence analysisAdd BLAST19
Transmembranei286 – 305Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini306 – 350CytoplasmicSequence analysisAdd BLAST45

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2357
MalaCardsiFPR1
OpenTargetsiENSG00000171051
PharmGKBiPA28244

Chemistry databases

ChEMBLiCHEMBL3359
DrugBankiDB00716 Nedocromil
GuidetoPHARMACOLOGYi222

Polymorphism and mutation databases

BioMutaiFPR1
DMDMi288558848

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694441 – 350fMet-Leu-Phe receptorAdd BLAST350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi98 ↔ 176PROSITE-ProRule annotation
Modified residuei328PhosphoserineSequence analysis1
Modified residuei329PhosphothreonineSequence analysis1
Modified residuei331PhosphothreonineSequence analysis1
Modified residuei332PhosphoserineSequence analysis1
Modified residuei334PhosphothreonineSequence analysis1
Modified residuei336PhosphothreonineSequence analysis1
Modified residuei338PhosphoserineSequence analysis1
Modified residuei339PhosphothreonineSequence analysis1

Post-translational modificationi

Phosphorylated; which is necessary for desensitization.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP21462
PeptideAtlasiP21462
PRIDEiP21462

PTM databases

iPTMnetiP21462
PhosphoSitePlusiP21462

Expressioni

Tissue specificityi

Neutrophils.

Gene expression databases

BgeeiENSG00000171051
CleanExiHS_FPR1
ExpressionAtlasiP21462 baseline and differential
GenevisibleiP21462 HS

Organism-specific databases

HPAiHPA046550
HPA061744

Interactioni

Subunit structurei

Interacts with S.aureus chemotaxis inhibitory protein (CHIPS); the interaction blocks the receptor and may thus inhibit the immune response.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108640, 3 interactors
IntActiP21462, 4 interactors
STRINGi9606.ENSP00000302707

Chemistry databases

BindingDBiP21462

Structurei

3D structure databases

ProteinModelPortaliP21462
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II0H Eukaryota
ENOG410YB48 LUCA
GeneTreeiENSGT00760000118990
HOGENOMiHOG000234122
HOVERGENiHBG107927
InParanoidiP21462
KOiK04172
OMAiGHWPFGW
OrthoDBiEOG091G09ZK
PhylomeDBiP21462
TreeFamiTF330976

Family and domain databases

InterProiView protein in InterPro
IPR027345 Formyl_pep_1_rcpt
IPR000826 Formyl_rcpt-rel
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24225 PTHR24225, 1 hit
PTHR24225:SF15 PTHR24225:SF15, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P21462-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METNSSLPTN ISGGTPAVSA GYLFLDIITY LVFAVTFVLG VLGNGLVIWV
60 70 80 90 100
AGFRMTHTVT TISYLNLAVA DFCFTSTLPF FMVRKAMGGH WPFGWFLCKF
110 120 130 140 150
VFTIVDINLF GSVFLIALIA LDRCVCVLHP VWTQNHRTVS LAKKVIIGPW
160 170 180 190 200
VMALLLTLPV IIRVTTVPGK TGTVACTFNF SPWTNDPKER INVAVAMLTV
210 220 230 240 250
RGIIRFIIGF SAPMSIVAVS YGLIATKIHK QGLIKSSRPL RVLSFVAAAF
260 270 280 290 300
FLCWSPYQVV ALIATVRIRE LLQGMYKEIG IAVDVTSALA FFNSCLNPML
310 320 330 340 350
YVFMGQDFRE RLIHALPASL ERALTEDSTQ TSDTATNSTL PSAEVELQAK
Length:350
Mass (Da):38,446
Last modified:February 9, 2010 - v3
Checksum:i06651DF820B1CBD1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti238R → P in AAA36362 (PubMed:2161213).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05591511I → T1 PublicationCorresponds to variant dbSNP:rs5030878EnsemblClinVar.1
Natural variantiVAR_003476101V → L2 PublicationsCorresponds to variant dbSNP:rs2070745EnsemblClinVar.1
Natural variantiVAR_055916190R → W. Corresponds to variant dbSNP:rs5030880Ensembl.1
Natural variantiVAR_003477192N → K2 PublicationsCorresponds to variant dbSNP:rs1042229EnsemblClinVar.1
Natural variantiVAR_003478346E → A3 PublicationsCorresponds to variant dbSNP:rs867228EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37128 mRNA Translation: AAA36362.1
M60626 mRNA Translation: AAA35846.1
M60627 mRNA Translation: AAA35847.1
L10820 Genomic DNA Translation: AAA16863.1
AY301273 Genomic DNA Translation: AAP58403.1
BT007429 mRNA Translation: AAP36097.1
AC018755 Genomic DNA Translation: AAF87842.1
BC005315 mRNA Translation: AAH05315.1
S49810 mRNA Translation: AAD14906.1
CCDSiCCDS12839.1
PIRiJC2014 A42009
RefSeqiNP_001180235.1, NM_001193306.1
NP_002020.1, NM_002029.3
UniGeneiHs.753

Genome annotation databases

EnsembliENST00000304748; ENSP00000302707; ENSG00000171051
ENST00000595042; ENSP00000471493; ENSG00000171051
GeneIDi2357
KEGGihsa:2357
UCSCiuc002pxq.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFPR1_HUMAN
AccessioniPrimary (citable) accession number: P21462
Secondary accession number(s): Q14939
, Q7Z6A4, Q86U52, Q9NS48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: February 9, 2010
Last modified: May 23, 2018
This is version 182 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

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