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Protein

fMet-Leu-Phe receptor

Gene

FPR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1712023, PubMed:10514456).4 Publications4 Publications

GO - Molecular functioni

  • complement receptor activity Source: GO_Central
  • N-formyl peptide receptor activity Source: MGI

GO - Biological processi

  • activation of MAPK activity Source: ProtInc
  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: ProtInc
  • cell chemotaxis Source: GO_Central
  • chemotaxis Source: ProtInc
  • complement receptor mediated signaling pathway Source: GO_Central
  • G-protein coupled receptor signaling pathway Source: ProtInc
  • inflammatory response Source: GO_Central
  • leukocyte migration Source: GO_Central
  • nitric oxide mediated signal transduction Source: ProtInc
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: MGI
  • positive regulation of cytosolic calcium ion concentration Source: GO_Central
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171051-MONOMER.
ReactomeiR-HSA-418594. G alpha (i) signalling events.
R-HSA-444473. Formyl peptide receptors bind formyl peptides and many other ligands.
R-HSA-6798695. Neutrophil degranulation.
SignaLinkiP21462.
SIGNORiP21462.

Names & Taxonomyi

Protein namesi
Recommended name:
fMet-Leu-Phe receptor
Short name:
fMLP receptor
Alternative name(s):
N-formyl peptide receptor
Short name:
FPR
N-formylpeptide chemoattractant receptor
Gene namesi
Name:FPR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:3826. FPR1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 50Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini51 – 61CytoplasmicSequence analysisAdd BLAST11
Transmembranei62 – 83Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini84 – 100ExtracellularSequence analysisAdd BLAST17
Transmembranei101 – 121Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini122 – 140CytoplasmicSequence analysisAdd BLAST19
Transmembranei141 – 162Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini163 – 205ExtracellularSequence analysisAdd BLAST43
Transmembranei206 – 226Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini227 – 242CytoplasmicSequence analysisAdd BLAST16
Transmembranei243 – 266Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini267 – 285ExtracellularSequence analysisAdd BLAST19
Transmembranei286 – 305Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini306 – 350CytoplasmicSequence analysisAdd BLAST45

GO - Cellular componenti

  • integral component of membrane Source: ProtInc
  • integral component of plasma membrane Source: GO_Central
  • intracellular Source: GOC
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2357.
OpenTargetsiENSG00000171051.
PharmGKBiPA28244.

Chemistry databases

ChEMBLiCHEMBL3359.
DrugBankiDB00716. Nedocromil.
GuidetoPHARMACOLOGYi222.

Polymorphism and mutation databases

BioMutaiFPR1.
DMDMi288558848.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694441 – 350fMet-Leu-Phe receptorAdd BLAST350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Glycosylationi10N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi98 ↔ 176PROSITE-ProRule annotation
Modified residuei328PhosphoserineSequence analysis1
Modified residuei329PhosphothreonineSequence analysis1
Modified residuei331PhosphothreonineSequence analysis1
Modified residuei332PhosphoserineSequence analysis1
Modified residuei334PhosphothreonineSequence analysis1
Modified residuei336PhosphothreonineSequence analysis1
Modified residuei338PhosphoserineSequence analysis1
Modified residuei339PhosphothreonineSequence analysis1

Post-translational modificationi

Phosphorylated; which is necessary for desensitization.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP21462.
PeptideAtlasiP21462.
PRIDEiP21462.

PTM databases

iPTMnetiP21462.
PhosphoSitePlusiP21462.

Expressioni

Tissue specificityi

Neutrophils.

Gene expression databases

BgeeiENSG00000171051.
CleanExiHS_FPR1.
ExpressionAtlasiP21462. baseline and differential.
GenevisibleiP21462. HS.

Organism-specific databases

HPAiHPA046550.
HPA061744.

Interactioni

Subunit structurei

Interacts with S.aureus chemotaxis inhibitory protein (CHIPS); the interaction blocks the receptor and may thus inhibit the immune response.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ADRBK1P250983EBI-2869495,EBI-3904795
MAPK13O152643EBI-2869495,EBI-2116951

Protein-protein interaction databases

BioGridi108640. 3 interactors.
IntActiP21462. 4 interactors.
STRINGi9606.ENSP00000302707.

Chemistry databases

BindingDBiP21462.

Structurei

3D structure databases

ProteinModelPortaliP21462.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II0H. Eukaryota.
ENOG410YB48. LUCA.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000234122.
HOVERGENiHBG107927.
InParanoidiP21462.
KOiK04172.
OMAiHKQGLIK.
OrthoDBiEOG091G09ZK.
PhylomeDBiP21462.
TreeFamiTF330976.

Family and domain databases

InterProiIPR027345. Formyl_pep_1_rcpt.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PTHR24225:SF15. PTHR24225:SF15. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21462-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METNSSLPTN ISGGTPAVSA GYLFLDIITY LVFAVTFVLG VLGNGLVIWV
60 70 80 90 100
AGFRMTHTVT TISYLNLAVA DFCFTSTLPF FMVRKAMGGH WPFGWFLCKF
110 120 130 140 150
VFTIVDINLF GSVFLIALIA LDRCVCVLHP VWTQNHRTVS LAKKVIIGPW
160 170 180 190 200
VMALLLTLPV IIRVTTVPGK TGTVACTFNF SPWTNDPKER INVAVAMLTV
210 220 230 240 250
RGIIRFIIGF SAPMSIVAVS YGLIATKIHK QGLIKSSRPL RVLSFVAAAF
260 270 280 290 300
FLCWSPYQVV ALIATVRIRE LLQGMYKEIG IAVDVTSALA FFNSCLNPML
310 320 330 340 350
YVFMGQDFRE RLIHALPASL ERALTEDSTQ TSDTATNSTL PSAEVELQAK
Length:350
Mass (Da):38,446
Last modified:February 9, 2010 - v3
Checksum:i06651DF820B1CBD1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti238R → P in AAA36362 (PubMed:2161213).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05591511I → T.1 PublicationCorresponds to variant rs5030878dbSNPEnsembl.1
Natural variantiVAR_003476101V → L.2 PublicationsCorresponds to variant rs2070745dbSNPEnsembl.1
Natural variantiVAR_055916190R → W.Corresponds to variant rs5030880dbSNPEnsembl.1
Natural variantiVAR_003477192N → K.2 PublicationsCorresponds to variant rs1042229dbSNPEnsembl.1
Natural variantiVAR_003478346E → A.3 PublicationsCorresponds to variant rs867228dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37128 mRNA. Translation: AAA36362.1.
M60626 mRNA. Translation: AAA35846.1.
M60627 mRNA. Translation: AAA35847.1.
L10820 Genomic DNA. Translation: AAA16863.1.
AY301273 Genomic DNA. Translation: AAP58403.1.
BT007429 mRNA. Translation: AAP36097.1.
AC018755 Genomic DNA. Translation: AAF87842.1.
BC005315 mRNA. Translation: AAH05315.1.
S49810 mRNA. Translation: AAD14906.1.
CCDSiCCDS12839.1.
PIRiJC2014. A42009.
RefSeqiNP_001180235.1. NM_001193306.1.
NP_002020.1. NM_002029.3.
UniGeneiHs.753.

Genome annotation databases

EnsembliENST00000304748; ENSP00000302707; ENSG00000171051.
ENST00000595042; ENSP00000471493; ENSG00000171051.
GeneIDi2357.
KEGGihsa:2357.
UCSCiuc002pxq.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37128 mRNA. Translation: AAA36362.1.
M60626 mRNA. Translation: AAA35846.1.
M60627 mRNA. Translation: AAA35847.1.
L10820 Genomic DNA. Translation: AAA16863.1.
AY301273 Genomic DNA. Translation: AAP58403.1.
BT007429 mRNA. Translation: AAP36097.1.
AC018755 Genomic DNA. Translation: AAF87842.1.
BC005315 mRNA. Translation: AAH05315.1.
S49810 mRNA. Translation: AAD14906.1.
CCDSiCCDS12839.1.
PIRiJC2014. A42009.
RefSeqiNP_001180235.1. NM_001193306.1.
NP_002020.1. NM_002029.3.
UniGeneiHs.753.

3D structure databases

ProteinModelPortaliP21462.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108640. 3 interactors.
IntActiP21462. 4 interactors.
STRINGi9606.ENSP00000302707.

Chemistry databases

BindingDBiP21462.
ChEMBLiCHEMBL3359.
DrugBankiDB00716. Nedocromil.
GuidetoPHARMACOLOGYi222.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP21462.
PhosphoSitePlusiP21462.

Polymorphism and mutation databases

BioMutaiFPR1.
DMDMi288558848.

Proteomic databases

PaxDbiP21462.
PeptideAtlasiP21462.
PRIDEiP21462.

Protocols and materials databases

DNASUi2357.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304748; ENSP00000302707; ENSG00000171051.
ENST00000595042; ENSP00000471493; ENSG00000171051.
GeneIDi2357.
KEGGihsa:2357.
UCSCiuc002pxq.4. human.

Organism-specific databases

CTDi2357.
DisGeNETi2357.
GeneCardsiFPR1.
H-InvDBHIX0015389.
HIX0174408.
HGNCiHGNC:3826. FPR1.
HPAiHPA046550.
HPA061744.
MIMi136537. gene.
neXtProtiNX_P21462.
OpenTargetsiENSG00000171051.
PharmGKBiPA28244.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II0H. Eukaryota.
ENOG410YB48. LUCA.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000234122.
HOVERGENiHBG107927.
InParanoidiP21462.
KOiK04172.
OMAiHKQGLIK.
OrthoDBiEOG091G09ZK.
PhylomeDBiP21462.
TreeFamiTF330976.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171051-MONOMER.
ReactomeiR-HSA-418594. G alpha (i) signalling events.
R-HSA-444473. Formyl peptide receptors bind formyl peptides and many other ligands.
R-HSA-6798695. Neutrophil degranulation.
SignaLinkiP21462.
SIGNORiP21462.

Miscellaneous databases

GeneWikiiFormyl_peptide_receptor_1.
GenomeRNAii2357.
PROiP21462.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171051.
CleanExiHS_FPR1.
ExpressionAtlasiP21462. baseline and differential.
GenevisibleiP21462. HS.

Family and domain databases

InterProiIPR027345. Formyl_pep_1_rcpt.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PTHR24225:SF15. PTHR24225:SF15. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFPR1_HUMAN
AccessioniPrimary (citable) accession number: P21462
Secondary accession number(s): Q14939
, Q7Z6A4, Q86U52, Q9NS48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: February 9, 2010
Last modified: November 30, 2016
This is version 171 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.