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P21462

- FPR1_HUMAN

UniProt

P21462 - FPR1_HUMAN

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Protein
fMet-Leu-Phe receptor
Gene
FPR1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

High affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  1. N-formyl peptide receptor activity Source: MGI
  2. protein binding Source: IntAct
  3. receptor activity Source: ProtInc

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: ProtInc
  2. activation of MAPK activity Source: ProtInc
  3. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: ProtInc
  4. cellular component movement Source: ProtInc
  5. chemotaxis Source: ProtInc
  6. nitric oxide mediated signal transduction Source: ProtInc
  7. phospholipase C-activating G-protein coupled receptor signaling pathway Source: MGI
  8. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiREACT_19231. G alpha (i) signalling events.
REACT_21264. Formyl peptide receptors bind formyl peptides and many other ligands.
SignaLinkiP21462.

Names & Taxonomyi

Protein namesi
Recommended name:
fMet-Leu-Phe receptor
Short name:
fMLP receptor
Alternative name(s):
N-formyl peptide receptor
Short name:
FPR
N-formylpeptide chemoattractant receptor
Gene namesi
Name:FPR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:3826. FPR1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727Extracellular Reviewed prediction
Add
BLAST
Transmembranei28 – 5023Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini51 – 6111Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei62 – 8322Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini84 – 10017Extracellular Reviewed prediction
Add
BLAST
Transmembranei101 – 12121Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini122 – 14019Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei141 – 16222Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini163 – 20543Extracellular Reviewed prediction
Add
BLAST
Transmembranei206 – 22621Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini227 – 24216Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei243 – 26624Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini267 – 28519Extracellular Reviewed prediction
Add
BLAST
Transmembranei286 – 30520Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini306 – 35045Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endosome Source: ProtInc
  2. integral component of membrane Source: ProtInc
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28244.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 350350fMet-Leu-Phe receptor
PRO_0000069444Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...) Reviewed prediction
Glycosylationi10 – 101N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi98 ↔ 176 Reviewed prediction
Modified residuei328 – 3281Phosphoserine Reviewed prediction
Modified residuei329 – 3291Phosphothreonine Reviewed prediction
Modified residuei331 – 3311Phosphothreonine Reviewed prediction
Modified residuei332 – 3321Phosphoserine Reviewed prediction
Modified residuei334 – 3341Phosphothreonine Reviewed prediction
Modified residuei336 – 3361Phosphothreonine Reviewed prediction
Modified residuei338 – 3381Phosphoserine Reviewed prediction
Modified residuei339 – 3391Phosphothreonine Reviewed prediction

Post-translational modificationi

Phosphorylated; which is necessary for desensitization.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP21462.
PRIDEiP21462.

PTM databases

PhosphoSiteiP21462.

Expressioni

Tissue specificityi

Neutrophils.

Gene expression databases

ArrayExpressiP21462.
BgeeiP21462.
CleanExiHS_FPR1.
GenevestigatoriP21462.

Organism-specific databases

HPAiHPA046550.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ADRBK1P250983EBI-2869495,EBI-3904795
MAPK13O152643EBI-2869495,EBI-2116951

Protein-protein interaction databases

BioGridi108640. 1 interaction.
IntActiP21462. 4 interactions.
STRINGi9606.ENSP00000302707.

Structurei

3D structure databases

ProteinModelPortaliP21462.
SMRiP21462. Positions 14-342.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150376.
HOGENOMiHOG000234122.
HOVERGENiHBG107927.
InParanoidiP21462.
KOiK04172.
OMAiVIIGPWV.
OrthoDBiEOG77DJ6B.
PhylomeDBiP21462.
TreeFamiTF330976.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR027345. Formyl_pep_1_rcpt.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PTHR24225:SF15. PTHR24225:SF15. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21462-1 [UniParc]FASTAAdd to Basket

« Hide

METNSSLPTN ISGGTPAVSA GYLFLDIITY LVFAVTFVLG VLGNGLVIWV    50
AGFRMTHTVT TISYLNLAVA DFCFTSTLPF FMVRKAMGGH WPFGWFLCKF 100
VFTIVDINLF GSVFLIALIA LDRCVCVLHP VWTQNHRTVS LAKKVIIGPW 150
VMALLLTLPV IIRVTTVPGK TGTVACTFNF SPWTNDPKER INVAVAMLTV 200
RGIIRFIIGF SAPMSIVAVS YGLIATKIHK QGLIKSSRPL RVLSFVAAAF 250
FLCWSPYQVV ALIATVRIRE LLQGMYKEIG IAVDVTSALA FFNSCLNPML 300
YVFMGQDFRE RLIHALPASL ERALTEDSTQ TSDTATNSTL PSAEVELQAK 350
Length:350
Mass (Da):38,446
Last modified:February 9, 2010 - v3
Checksum:i06651DF820B1CBD1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti11 – 111I → T.1 Publication
Corresponds to variant rs5030878 [ dbSNP | Ensembl ].
VAR_055915
Natural varianti101 – 1011V → L.2 Publications
Corresponds to variant rs2070745 [ dbSNP | Ensembl ].
VAR_003476
Natural varianti190 – 1901R → W.
Corresponds to variant rs5030880 [ dbSNP | Ensembl ].
VAR_055916
Natural varianti192 – 1921N → K.2 Publications
Corresponds to variant rs1042229 [ dbSNP | Ensembl ].
VAR_003477
Natural varianti346 – 3461E → A.3 Publications
Corresponds to variant rs867228 [ dbSNP | Ensembl ].
VAR_003478

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti238 – 2381R → P in AAA36362. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M37128 mRNA. Translation: AAA36362.1.
M60626 mRNA. Translation: AAA35846.1.
M60627 mRNA. Translation: AAA35847.1.
L10820 Genomic DNA. Translation: AAA16863.1.
AY301273 Genomic DNA. Translation: AAP58403.1.
BT007429 mRNA. Translation: AAP36097.1.
AC018755 Genomic DNA. Translation: AAF87842.1.
BC005315 mRNA. Translation: AAH05315.1.
S49810 mRNA. Translation: AAD14906.1.
CCDSiCCDS12839.1.
PIRiJC2014. A42009.
RefSeqiNP_001180235.1. NM_001193306.1.
NP_002020.1. NM_002029.3.
UniGeneiHs.753.

Genome annotation databases

EnsembliENST00000304748; ENSP00000302707; ENSG00000171051.
ENST00000595042; ENSP00000471493; ENSG00000171051.
GeneIDi2357.
KEGGihsa:2357.
UCSCiuc002pxq.3. human.

Polymorphism databases

DMDMi288558848.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M37128 mRNA. Translation: AAA36362.1 .
M60626 mRNA. Translation: AAA35846.1 .
M60627 mRNA. Translation: AAA35847.1 .
L10820 Genomic DNA. Translation: AAA16863.1 .
AY301273 Genomic DNA. Translation: AAP58403.1 .
BT007429 mRNA. Translation: AAP36097.1 .
AC018755 Genomic DNA. Translation: AAF87842.1 .
BC005315 mRNA. Translation: AAH05315.1 .
S49810 mRNA. Translation: AAD14906.1 .
CCDSi CCDS12839.1.
PIRi JC2014. A42009.
RefSeqi NP_001180235.1. NM_001193306.1.
NP_002020.1. NM_002029.3.
UniGenei Hs.753.

3D structure databases

ProteinModelPortali P21462.
SMRi P21462. Positions 14-342.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108640. 1 interaction.
IntActi P21462. 4 interactions.
STRINGi 9606.ENSP00000302707.

Chemistry

BindingDBi P21462.
ChEMBLi CHEMBL3038479.
DrugBanki DB00716. Nedocromil.
GuidetoPHARMACOLOGYi 222.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P21462.

Polymorphism databases

DMDMi 288558848.

Proteomic databases

PaxDbi P21462.
PRIDEi P21462.

Protocols and materials databases

DNASUi 2357.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000304748 ; ENSP00000302707 ; ENSG00000171051 .
ENST00000595042 ; ENSP00000471493 ; ENSG00000171051 .
GeneIDi 2357.
KEGGi hsa:2357.
UCSCi uc002pxq.3. human.

Organism-specific databases

CTDi 2357.
GeneCardsi GC19M052249.
H-InvDB HIX0015389.
HIX0174408.
HGNCi HGNC:3826. FPR1.
HPAi HPA046550.
MIMi 136537. gene.
neXtProti NX_P21462.
PharmGKBi PA28244.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG150376.
HOGENOMi HOG000234122.
HOVERGENi HBG107927.
InParanoidi P21462.
KOi K04172.
OMAi VIIGPWV.
OrthoDBi EOG77DJ6B.
PhylomeDBi P21462.
TreeFami TF330976.

Enzyme and pathway databases

Reactomei REACT_19231. G alpha (i) signalling events.
REACT_21264. Formyl peptide receptors bind formyl peptides and many other ligands.
SignaLinki P21462.

Miscellaneous databases

GeneWikii Formyl_peptide_receptor_1.
GenomeRNAii 2357.
NextBioi 9561.
PROi P21462.
SOURCEi Search...

Gene expression databases

ArrayExpressi P21462.
Bgeei P21462.
CleanExi HS_FPR1.
Genevestigatori P21462.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR027345. Formyl_pep_1_rcpt.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24225. PTHR24225. 1 hit.
PTHR24225:SF15. PTHR24225:SF15. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Synthesis and use of a novel N-formyl peptide derivative to isolate a human N-formyl peptide receptor cDNA."
    Boulay F., Tardif M., Brouchon L., Vignais P.
    Biochem. Biophys. Res. Commun. 168:1103-1109(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS LEU-101 AND ALA-346.
  2. "The human N-formylpeptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptors."
    Boulay F., Tardif M., Brouchon L., Vignais P.
    Biochemistry 29:11123-11133(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS LEU-101 AND ALA-346.
  3. "Functional expression of the human formyl peptide receptor in Xenopus oocytes requires a complementary human factor."
    Murphy P.M., McDermott D.
    J. Biol. Chem. 266:12560-12567(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19."
    Bao L., Gerard N.P., Eddy R.L. Jr., Shows T.B., Gerard C.
    Genomics 13:437-440(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LYS-192.
  5. Perez H.D.
    Submitted (MAR-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-346.
  6. "Sequence and organization of the human N-formyl peptide receptor-encoding gene."
    Murphy P.M., Tiffany H.L., McDermott D., Ahuja S.K.
    Gene 133:285-290(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  7. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS THR-11 AND LYS-192.
  8. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  9. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  11. "Cloning of the gene coding for a human receptor for formyl peptides. Characterization of a promoter region and evidence for polymorphic expression."
    Perez H.D., Holmes R., Kelly E., McClary J., Chou Q., Andrews W.H.
    Biochemistry 31:11595-11599(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-5.
    Tissue: Bone marrow.
  12. "Differential phosphorylation paradigms dictate desensitization and internalization of the N-formyl peptide receptor."
    Maestes D.C., Potter R.M., Prossnitz E.R.
    J. Biol. Chem. 274:29791-29795(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-328; THR-329; THR-331; SER-332; THR-334; THR-336; SER-338 AND THR-339.

Entry informationi

Entry nameiFPR1_HUMAN
AccessioniPrimary (citable) accession number: P21462
Secondary accession number(s): Q14939
, Q7Z6A4, Q86U52, Q9NS48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: February 9, 2010
Last modified: September 3, 2014
This is version 151 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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