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Protein

Cystatin-C

Gene

Cst3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei31 – 311Reactive site

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Thiol protease inhibitor

Protein family/group databases

MEROPSiI25.004.

Names & Taxonomyi

Protein namesi
Recommended name:
Cystatin-C
Alternative name(s):
Cystatin-3
Gene namesi
Name:Cst3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:102519. Cst3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Add
BLAST
Chaini21 – 140120Cystatin-CPRO_0000006642Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi93 ↔ 103By similarity
Disulfide bondi117 ↔ 137By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiP21460.
MaxQBiP21460.
PaxDbiP21460.
PeptideAtlasiP21460.
PRIDEiP21460.

PTM databases

iPTMnetiP21460.
PhosphoSiteiP21460.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027447.
CleanExiMM_CST3.
ExpressionAtlasiP21460. baseline and differential.
GenevisibleiP21460. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiP21460. 3 interactions.
MINTiMINT-4092770.
STRINGi10090.ENSMUSP00000028938.

Structurei

3D structure databases

ProteinModelPortaliP21460.
SMRiP21460. Positions 31-140.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi75 – 795Secondary area of contact

Sequence similaritiesi

Belongs to the cystatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZZH. Eukaryota.
ENOG4112CFJ. LUCA.
GeneTreeiENSGT00840000129787.
HOGENOMiHOG000231754.
HOVERGENiHBG009556.
InParanoidiP21460.
KOiK13899.
OMAiYTVPWLG.
OrthoDBiEOG091G0TP1.
PhylomeDBiP21460.

Family and domain databases

InterProiIPR027214. Cystatin.
IPR000010. Cystatin_dom.
IPR018073. Prot_inh_cystat_CS.
[Graphical view]
PANTHERiPTHR11413. PTHR11413. 1 hit.
PfamiPF00031. Cystatin. 1 hit.
[Graphical view]
SMARTiSM00043. CY. 1 hit.
[Graphical view]
PROSITEiPS00287. CYSTATIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21460-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPLRSLLF LLAVLAVAWA ATPKQGPRML GAPEEADANE EGVRRALDFA
60 70 80 90 100
VSEYNKGSND AYHSRAIQVV RARKQLVAGV NYFLDVEMGR TTCTKSQTNL
110 120 130 140
TDCPFHDQPH LMRKALCSFQ IYSVPWKGTH SLTKFSCKNA
Length:140
Mass (Da):15,531
Last modified:February 1, 1996 - v2
Checksum:i3A563406DD58D0F5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161A → G in AAA63298 (PubMed:2241983).Curated
Sequence conflicti84 – 841L → F in AAA63298 (PubMed:2241983).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59470 mRNA. Translation: AAA63298.1.
U10098 Unassigned DNA. Translation: AAB41056.1.
AF483486 mRNA. Translation: AAL90760.1.
AF483487 mRNA. Translation: AAL90761.1.
AK002438 mRNA. Translation: BAB22101.1.
AK013676 mRNA. Translation: BAB28949.1.
AK014368 mRNA. Translation: BAB29303.1.
AK131728 mRNA. Translation: BAE20785.1.
AK146333 mRNA. Translation: BAE27088.1.
AK151160 mRNA. Translation: BAE30165.1.
AK161856 mRNA. Translation: BAE36608.1.
AK166430 mRNA. Translation: BAE38771.1.
BC002072 mRNA. Translation: AAH02072.1.
CCDSiCCDS16852.1.
PIRiA36163.
RefSeqiNP_034106.2. NM_009976.4.
UniGeneiMm.4263.

Genome annotation databases

EnsembliENSMUST00000028938; ENSMUSP00000028938; ENSMUSG00000027447.
GeneIDi13010.
KEGGimmu:13010.
UCSCiuc008mtt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59470 mRNA. Translation: AAA63298.1.
U10098 Unassigned DNA. Translation: AAB41056.1.
AF483486 mRNA. Translation: AAL90760.1.
AF483487 mRNA. Translation: AAL90761.1.
AK002438 mRNA. Translation: BAB22101.1.
AK013676 mRNA. Translation: BAB28949.1.
AK014368 mRNA. Translation: BAB29303.1.
AK131728 mRNA. Translation: BAE20785.1.
AK146333 mRNA. Translation: BAE27088.1.
AK151160 mRNA. Translation: BAE30165.1.
AK161856 mRNA. Translation: BAE36608.1.
AK166430 mRNA. Translation: BAE38771.1.
BC002072 mRNA. Translation: AAH02072.1.
CCDSiCCDS16852.1.
PIRiA36163.
RefSeqiNP_034106.2. NM_009976.4.
UniGeneiMm.4263.

3D structure databases

ProteinModelPortaliP21460.
SMRiP21460. Positions 31-140.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP21460. 3 interactions.
MINTiMINT-4092770.
STRINGi10090.ENSMUSP00000028938.

Protein family/group databases

MEROPSiI25.004.

PTM databases

iPTMnetiP21460.
PhosphoSiteiP21460.

Proteomic databases

EPDiP21460.
MaxQBiP21460.
PaxDbiP21460.
PeptideAtlasiP21460.
PRIDEiP21460.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028938; ENSMUSP00000028938; ENSMUSG00000027447.
GeneIDi13010.
KEGGimmu:13010.
UCSCiuc008mtt.1. mouse.

Organism-specific databases

CTDi1471.
MGIiMGI:102519. Cst3.

Phylogenomic databases

eggNOGiENOG410IZZH. Eukaryota.
ENOG4112CFJ. LUCA.
GeneTreeiENSGT00840000129787.
HOGENOMiHOG000231754.
HOVERGENiHBG009556.
InParanoidiP21460.
KOiK13899.
OMAiYTVPWLG.
OrthoDBiEOG091G0TP1.
PhylomeDBiP21460.

Miscellaneous databases

PROiP21460.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027447.
CleanExiMM_CST3.
ExpressionAtlasiP21460. baseline and differential.
GenevisibleiP21460. MM.

Family and domain databases

InterProiIPR027214. Cystatin.
IPR000010. Cystatin_dom.
IPR018073. Prot_inh_cystat_CS.
[Graphical view]
PANTHERiPTHR11413. PTHR11413. 1 hit.
PfamiPF00031. Cystatin. 1 hit.
[Graphical view]
SMARTiSM00043. CY. 1 hit.
[Graphical view]
PROSITEiPS00287. CYSTATIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYTC_MOUSE
AccessioniPrimary (citable) accession number: P21460
Secondary accession number(s): Q544Y0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: February 1, 1996
Last modified: September 7, 2016
This is version 150 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.