RCVRN

Functionⁱ

Seems to be implicated in the pathway from retinal rod guanylate cyclase to rhodopsin. May be involved in the inhibition of the phosphorylation of rhodopsin in a calcium-dependent manner. The calcium-bound recoverin prolongs the photoresponse.1 Publication

Miscellaneous

Binds two calcium ions; one with high affinity, the other with low affinity.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Calcium bindingⁱ	74 – 85	1; low affinityAdd BLAST		12
Calcium bindingⁱ	110 – 121	2; high affinityAdd BLAST		12

GO - Molecular functionⁱ

calcium ion binding Source: Ensembl

Complete GO annotation...

GO - Biological processⁱ

phototransduction Source: Ensembl
regulation of calcium ion transport Source: Ensembl
regulation of rhodopsin mediated signaling pathway Source: Reactome
visual perception Source: UniProtKB-KW

Complete GO annotation...

Keywordsⁱ

Biological process	Sensory transduction, Vision
Ligand	Calcium, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-BTA-2514859. Inactivation, recovery and regulation of the phototransduction cascade.

Reactomeⁱ

R-BTA-2514859. Inactivation, recovery and regulation of the phototransduction cascade.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Recoverin Alternative name(s): p26
Gene namesⁱ	Name:RCVRN Synonyms:RCV1
Organismⁱ	Bos taurus (Bovine)
Taxonomic identifierⁱ	9913 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos
Proteomesⁱ	UP000009136 Componentⁱ: Chromosome 19

Subcellular locationⁱ

GO - Cellular componentⁱ

cytosol Source: Reactome

Complete GO annotation...

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed
ChainⁱPRO_0000073758	2 – 202	RecoverinAdd BLAST		201

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Lipidationⁱ	2	N-myristoyl glycine1 Publication		1

Post-translational modificationⁱ

The N-terminal glycine is linked to one of four different types of acyl groups. The most abundant is myristoleate (14:1), but 14:0, 14:2, and 12:0 acyl residues are also present. Myristoylation is necessary for recoverin to bind photoreceptor membranes when the calcium concentration is greater than one micromolar.1 Publication

Keywords - PTMⁱ

Lipoprotein, Myristate

Proteomic databases

PaxDbⁱ	P21457.
PRIDEⁱ	P21457.

Expressionⁱ

Tissue specificityⁱ

Retina and pineal gland.

Gene expression databases

Bgeeⁱ	ENSBTAG00000025088.

Bgeeⁱ

ENSBTAG00000025088.

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
GRK1	P28327	2	EBI-8592784,EBI-7865560

With

Entry

#Exp.

IntAct

Notes

GRK1

P28327

2

EBI-8592784,EBI-7865560

Protein-protein interaction databases

ELMⁱ	P21457.
IntActⁱ	P21457. 4 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-1507490.
STRINGⁱ	9913.ENSBTAP00000034949.

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	11 – 20	Combined sources	10
Helixⁱ	25 – 38	Combined sources	14
Beta strandⁱ	42 – 45	Combined sources	4
Helixⁱ	46 – 56	Combined sources	11
Beta strandⁱ	58 – 60	Combined sources	3
Helixⁱ	63 – 73	Combined sources	11
Beta strandⁱ	78 – 81	Combined sources	4
Helixⁱ	83 – 94	Combined sources	12
Helixⁱ	98 – 100	Combined sources	3
Helixⁱ	102 – 109	Combined sources	8
Beta strandⁱ	114 – 117	Combined sources	4
Helixⁱ	119 – 130	Combined sources	12
Helixⁱ	135 – 138	Combined sources	4
Beta strandⁱ	139 – 141	Combined sources	3
Helixⁱ	143 – 145	Combined sources	3
Helixⁱ	148 – 158	Combined sources	11
Beta strandⁱ	162 – 164	Combined sources	3
Beta strandⁱ	166 – 168	Combined sources	3
Helixⁱ	169 – 178	Combined sources	10
Helixⁱ	180 – 186	Combined sources	7
Helixⁱ	190 – 196	Combined sources	7

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1IKU	NMR	-	A	2-202	[»]
	1JSA	NMR	-	A	2-202	[»]
	1LA3	NMR	-	A	2-202	[»]
	1OMR	X-ray	1.50	A	2-202	[»]
	1OMV	X-ray	1.90	A	2-202	[»]
	1REC	X-ray	1.90	A	2-202	[»]
	2HET	X-ray	3.00	A/B/C/D	2-190	[»]
	2I94	NMR	-	A	1-202	[»]
	4M2O	X-ray	1.50	A	2-197	[»]
	4M2P	X-ray	1.45	A	2-202	[»]
	4M2Q	X-ray	1.90	A	2-202	[»]
	4MLW	X-ray	1.45	A	2-202	[»]
	4YI8	X-ray	1.20	A	2-202	[»]
	4YI9	X-ray	1.35	A	2-202	[»]
ProteinModelPortalⁱ	P21457.
SMRⁱ	P21457.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P21457.

EvolutionaryTraceⁱ

P21457.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	24 – 59	EF-hand 1PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	61 – 96	EF-hand 2PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	97 – 132	EF-hand 3PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	147 – 182	EF-hand 4PROSITE-ProRule annotationAdd BLAST	36

Sequence similaritiesⁱ

Belongs to the recoverin family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG0044. Eukaryota. COG5126. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118820.
HOGENOMⁱ	HOG000233019.
HOVERGENⁱ	HBG108179.
InParanoidⁱ	P21457.
KEGG Orthology (KO) More...KOⁱ	K13764.
OMAⁱ	KECPSGR.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G11T4.
TreeFamⁱ	TF300009.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00051. EFh. 2 hits.
InterProⁱ	View protein in InterPro IPR011992. EF-hand-dom_pair. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13499. EF-hand_7. 1 hit. PF13833. EF-hand_8. 1 hit.
SMARTⁱ	View protein in SMART SM00054. EFh. 2 hits.
SUPFAMⁱ	SSF47473. SSF47473. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00018. EF_HAND_1. 2 hits. PS50222. EF_HAND_2. 4 hits.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P21457-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGNSKSGALS KEILEELQLN TKFTEEELSS WYQSFLKECP SGRITRQEFQ 
        60         70         80         90        100
TIYSKFFPEA DPKAYAQHVF RSFDANSDGT LDFKEYVIAL HMTSAGKTNQ 
       110        120        130        140        150
KLEWAFSLYD VDGNGTISKN EVLEIVTAIF KMISPEDTKH LPEDENTPEK 
       160        170        180        190        200
RAEKIWGFFG KKDDDKLTEK EFIEGTLANK EILRLIQFEP QKVKEKLKEK 

KL

Length:202

Mass (Da):23,333

Last modified:January 23, 2007 - v3

Checksum:ⁱ75504DEBE8288BA8

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	19	L → Q AA sequence (PubMed:1672637).Curated		1
Sequence conflictⁱ	21	T → N AA sequence (PubMed:1672637).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M95858 mRNA. Translation: AAB59256.1. X63322 mRNA. Translation: CAA44928.1.
PIRⁱ	A46129.
NCBI Reference Sequences More...RefSeqⁱ	NP_776590.1. NM_174165.2.
UniGeneⁱ	Bt.56904.

Genome annotation databases

Ensemblⁱ	ENSBTAT00000035069; ENSBTAP00000034949; ENSBTAG00000025088.
GeneIDⁱ	281447.
KEGGⁱ	bta:281447.

Similar proteinsⁱ

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
P21457	P34057 Q2TB46 UPI0003C87D80 L5JWQ5 I3L706 Q8MIH6 UPI0002BCFA5A UPI0003336D2F UPI0003C82074 UPI00072E869C +50	Mus musculus (Mouse) Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus) Pteropus alecto (Black flying fox) Sus scrofa (Pig) Canis lupus familiaris (Dog) (Canis familiaris) Orcinus orca (Killer whale) Octodon degus (Degu) (Sciurus degus) Vicugna pacos (Alpaca) (Lama pacos) Acinonyx jubatus (Cheetah) Mus caroli (Ryukyu mouse) (Ricefield mouse) And more	202	UniRef90_P34057	Cluster: Recoverin	61

Entry	Cluster members	Organisms	Length	Cluster ID	Cluster name	Size
P21457	P34057 Q2TB46 UPI0003C87D80 I3L706 L5JWQ5 UPI0003AF541B UPI000A1BDD2E UPI0002C558C0 UPI00042C51E8 L8HV71 +244	Mus musculus (Mouse) Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus) Sus scrofa (Pig) Pteropus alecto (Black flying fox) Capra hircus (Goat) Odocoileus virginianus texanus Odobenus rosmarus divergens (Pacific walrus) Physeter catodon (Sperm whale) (Physeter macrocephalus) Bos mutus (wild yak) Manis javanica (Malayan pangolin) (Sunda pangolin) And more	202	UniRef50_P34057	Cluster: Recoverin	255

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M95858 mRNA. Translation: AAB59256.1. X63322 mRNA. Translation: CAA44928.1.
PIRⁱ	A46129.
NCBI Reference Sequences More...RefSeqⁱ	NP_776590.1. NM_174165.2.
UniGeneⁱ	Bt.56904.

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1IKU	NMR	-	A	2-202	[»]
	1JSA	NMR	-	A	2-202	[»]
	1LA3	NMR	-	A	2-202	[»]
	1OMR	X-ray	1.50	A	2-202	[»]
	1OMV	X-ray	1.90	A	2-202	[»]
	1REC	X-ray	1.90	A	2-202	[»]
	2HET	X-ray	3.00	A/B/C/D	2-190	[»]
	2I94	NMR	-	A	1-202	[»]
	4M2O	X-ray	1.50	A	2-197	[»]
	4M2P	X-ray	1.45	A	2-202	[»]
	4M2Q	X-ray	1.90	A	2-202	[»]
	4MLW	X-ray	1.45	A	2-202	[»]
	4YI8	X-ray	1.20	A	2-202	[»]
	4YI9	X-ray	1.35	A	2-202	[»]
ProteinModelPortalⁱ	P21457.
SMRⁱ	P21457.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

ELMⁱ	P21457.
IntActⁱ	P21457. 4 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-1507490.
STRINGⁱ	9913.ENSBTAP00000034949.

Proteomic databases

PaxDbⁱ	P21457.
PRIDEⁱ	P21457.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSBTAT00000035069; ENSBTAP00000034949; ENSBTAG00000025088.
GeneIDⁱ	281447.
KEGGⁱ	bta:281447.

Organism-specific databases

CTDⁱ	5957.

CTDⁱ

5957.

Phylogenomic databases

eggNOGⁱ	KOG0044. Eukaryota. COG5126. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118820.
HOGENOMⁱ	HOG000233019.
HOVERGENⁱ	HBG108179.
InParanoidⁱ	P21457.
KEGG Orthology (KO) More...KOⁱ	K13764.
OMAⁱ	KECPSGR.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G11T4.
TreeFamⁱ	TF300009.

Enzyme and pathway databases

Reactomeⁱ	R-BTA-2514859. Inactivation, recovery and regulation of the phototransduction cascade.

Reactomeⁱ

R-BTA-2514859. Inactivation, recovery and regulation of the phototransduction cascade.

Miscellaneous databases

EvolutionaryTraceⁱ	P21457.

EvolutionaryTraceⁱ

P21457.

Gene expression databases

Bgeeⁱ	ENSBTAG00000025088.

Bgeeⁱ

ENSBTAG00000025088.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00051. EFh. 2 hits.
InterProⁱ	View protein in InterPro IPR011992. EF-hand-dom_pair. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13499. EF-hand_7. 1 hit. PF13833. EF-hand_8. 1 hit.
SMARTⁱ	View protein in SMART SM00054. EFh. 2 hits.
SUPFAMⁱ	SSF47473. SSF47473. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00018. EF_HAND_1. 2 hits. PS50222. EF_HAND_2. 4 hits.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RECO_BOVIN
Accessionⁱ	P21457Primary (citable) accession number: P21457
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
	Last sequence update:	January 23, 2007
	Last modified:	August 30, 2017
	This is version 152 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P21457 (RECO_BOVIN)

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Recoverin

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ