UniProtKB - P21457 (RECO_BOVIN)
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Protein
Recoverin
Gene
RCVRN
Organism
Bos taurus (Bovine)
Status
Functioni
Seems to be implicated in the pathway from retinal rod guanylate cyclase to rhodopsin. May be involved in the inhibition of the phosphorylation of rhodopsin in a calcium-dependent manner. The calcium-bound recoverin prolongs the photoresponse.1 Publication
Miscellaneous
Binds two calcium ions; one with high affinity, the other with low affinity.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 74 – 85 | 1; low affinityAdd BLAST | 12 | |
Calcium bindingi | 110 – 121 | 2; high affinityAdd BLAST | 12 |
GO - Molecular functioni
- calcium ion binding Source: Ensembl
GO - Biological processi
- phototransduction Source: Ensembl
- regulation of calcium ion transport Source: Ensembl
- visual perception Source: UniProtKB-KW
Keywordsi
Biological process | Sensory transduction, Vision |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
Reactomei | R-BTA-2514859 Inactivation, recovery and regulation of the phototransduction cascade |
Names & Taxonomyi
Protein namesi | Recommended name: RecoverinAlternative name(s): p26 |
Gene namesi | Name:RCVRN Synonyms:RCV1 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:33838 RCVRN |
Subcellular locationi
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed | |||
ChainiPRO_0000073758 | 2 – 202 | RecoverinAdd BLAST | 201 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 2 | N-myristoyl glycine1 Publication | 1 |
Post-translational modificationi
The N-terminal glycine is linked to one of four different types of acyl groups. The most abundant is myristoleate (14:1), but 14:0, 14:2, and 12:0 acyl residues are also present. Myristoylation is necessary for recoverin to bind photoreceptor membranes when the calcium concentration is greater than one micromolar.1 Publication
Keywords - PTMi
Lipoprotein, MyristateProteomic databases
PaxDbi | P21457 |
PRIDEi | P21457 |
PTM databases
iPTMneti | P21457 |
Expressioni
Tissue specificityi
Retina and pineal gland.
Gene expression databases
Bgeei | ENSBTAG00000025088 |
Interactioni
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
GRK1 | P28327 | 2 | EBI-8592784,EBI-7865560 |
Protein-protein interaction databases
ELMi | P21457 |
IntActi | P21457 4 interactors. |
MINTi | P21457 |
STRINGi | 9913.ENSBTAP00000034949 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Helixi | 11 – 20 | Combined sources | 10 | |
Helixi | 25 – 38 | Combined sources | 14 | |
Beta strandi | 42 – 45 | Combined sources | 4 | |
Helixi | 46 – 56 | Combined sources | 11 | |
Beta strandi | 58 – 60 | Combined sources | 3 | |
Helixi | 63 – 73 | Combined sources | 11 | |
Beta strandi | 78 – 81 | Combined sources | 4 | |
Helixi | 83 – 94 | Combined sources | 12 | |
Helixi | 98 – 100 | Combined sources | 3 | |
Helixi | 102 – 109 | Combined sources | 8 | |
Beta strandi | 114 – 117 | Combined sources | 4 | |
Helixi | 119 – 130 | Combined sources | 12 | |
Helixi | 135 – 138 | Combined sources | 4 | |
Beta strandi | 139 – 141 | Combined sources | 3 | |
Helixi | 143 – 145 | Combined sources | 3 | |
Helixi | 148 – 158 | Combined sources | 11 | |
Beta strandi | 162 – 164 | Combined sources | 3 | |
Beta strandi | 166 – 168 | Combined sources | 3 | |
Helixi | 169 – 178 | Combined sources | 10 | |
Helixi | 180 – 186 | Combined sources | 7 | |
Helixi | 190 – 196 | Combined sources | 7 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1IKU | NMR | - | A | 2-202 | [»] | |
1JSA | NMR | - | A | 2-202 | [»] | |
1LA3 | NMR | - | A | 2-202 | [»] | |
1OMR | X-ray | 1.50 | A | 2-202 | [»] | |
1OMV | X-ray | 1.90 | A | 2-202 | [»] | |
1REC | X-ray | 1.90 | A | 2-202 | [»] | |
2HET | X-ray | 3.00 | A/B/C/D | 2-190 | [»] | |
2I94 | NMR | - | A | 1-202 | [»] | |
4M2O | X-ray | 1.50 | A | 2-197 | [»] | |
4M2P | X-ray | 1.45 | A | 2-202 | [»] | |
4M2Q | X-ray | 1.90 | A | 2-202 | [»] | |
4MLW | X-ray | 1.45 | A | 2-202 | [»] | |
4YI8 | X-ray | 1.20 | A | 2-202 | [»] | |
4YI9 | X-ray | 1.35 | A | 2-202 | [»] | |
ProteinModelPortali | P21457 | |||||
SMRi | P21457 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P21457 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 59 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 61 – 96 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 97 – 132 | EF-hand 3PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 147 – 182 | EF-hand 4PROSITE-ProRule annotationAdd BLAST | 36 |
Sequence similaritiesi
Belongs to the recoverin family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0044 Eukaryota COG5126 LUCA |
GeneTreei | ENSGT00760000118820 |
HOGENOMi | HOG000233019 |
HOVERGENi | HBG108179 |
InParanoidi | P21457 |
KOi | K13764 |
OMAi | KECPSGR |
OrthoDBi | EOG091G11T4 |
TreeFami | TF300009 |
Family and domain databases
CDDi | cd00051 EFh, 2 hits |
InterProi | View protein in InterPro IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom |
Pfami | View protein in Pfam PF13499 EF-hand_7, 1 hit PF13833 EF-hand_8, 1 hit |
SMARTi | View protein in SMART SM00054 EFh, 2 hits |
SUPFAMi | SSF47473 SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018 EF_HAND_1, 2 hits PS50222 EF_HAND_2, 4 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P21457-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGNSKSGALS KEILEELQLN TKFTEEELSS WYQSFLKECP SGRITRQEFQ
60 70 80 90 100
TIYSKFFPEA DPKAYAQHVF RSFDANSDGT LDFKEYVIAL HMTSAGKTNQ
110 120 130 140 150
KLEWAFSLYD VDGNGTISKN EVLEIVTAIF KMISPEDTKH LPEDENTPEK
160 170 180 190 200
RAEKIWGFFG KKDDDKLTEK EFIEGTLANK EILRLIQFEP QKVKEKLKEK
KL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 19 | L → Q AA sequence (PubMed:1672637).Curated | 1 | |
Sequence conflicti | 21 | T → N AA sequence (PubMed:1672637).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M95858 mRNA Translation: AAB59256.1 X63322 mRNA Translation: CAA44928.1 |
PIRi | A46129 |
RefSeqi | NP_776590.1, NM_174165.2 |
UniGenei | Bt.56904 |
Genome annotation databases
Ensembli | ENSBTAT00000035069; ENSBTAP00000034949; ENSBTAG00000025088 |
GeneIDi | 281447 |
KEGGi | bta:281447 |
Similar proteinsi
Entry informationi
Entry namei | RECO_BOVIN | |
Accessioni | P21457Primary (citable) accession number: P21457 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1991 |
Last sequence update: | January 23, 2007 | |
Last modified: | March 28, 2018 | |
This is version 156 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |