RCVRN

Functionⁱ

Seems to be implicated in the pathway from retinal rod guanylate cyclase to rhodopsin. May be involved in the inhibition of the phosphorylation of rhodopsin in a calcium-dependent manner. The calcium-bound recoverin prolongs the photoresponse.1 Publication

Miscellaneous

Binds two calcium ions; one with high affinity, the other with low affinity.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Calcium bindingⁱ	74 – 85	1; low affinityAdd BLAST		12
Calcium bindingⁱ	110 – 121	2; high affinityAdd BLAST		12

GO - Molecular functionⁱ

calcium ion binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

phototransduction Source: Ensembl
regulation of calcium ion transport Source: Ensembl
visual perception Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Sensory transduction, Vision
Ligand	Calcium, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-BTA-2514859 Inactivation, recovery and regulation of the phototransduction cascade

Reactomeⁱ

R-BTA-2514859 Inactivation, recovery and regulation of the phototransduction cascade

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Recoverin Alternative name(s): p26
Gene namesⁱ	Name:RCVRN Synonyms:RCV1
Organismⁱ	Bos taurus (Bovine)
Taxonomic identifierⁱ	9913 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos
Proteomesⁱ	UP000009136 Componentⁱ: Chromosome 19

Organism-specific databases

VGNCⁱ	VGNC:33838 RCVRN

VGNCⁱ

VGNC:33838 RCVRN

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed
ChainⁱPRO_0000073758	2 – 202	RecoverinAdd BLAST		201

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Lipidationⁱ	2	N-myristoyl glycine1 Publication		1

Post-translational modificationⁱ

The N-terminal glycine is linked to one of four different types of acyl groups. The most abundant is myristoleate (14:1), but 14:0, 14:2, and 12:0 acyl residues are also present. Myristoylation is necessary for recoverin to bind photoreceptor membranes when the calcium concentration is greater than one micromolar.1 Publication

Keywords - PTMⁱ

Lipoprotein, Myristate

Proteomic databases

PaxDbⁱ	P21457
PRIDEⁱ	P21457

PTM databases

iPTMnetⁱ	P21457

iPTMnetⁱ

P21457

Expressionⁱ

Tissue specificityⁱ

Retina and pineal gland.

Gene expression databases

Bgeeⁱ	ENSBTAG00000025088

Bgeeⁱ

ENSBTAG00000025088

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
GRK1	P28327	2	EBI-8592784,EBI-7865560

With

Entry

#Exp.

IntAct

Notes

GRK1

P28327

2

EBI-8592784,EBI-7865560

Protein-protein interaction databases

ELMⁱ	P21457
IntActⁱ	P21457 4 interactors.
Molecular INTeraction database More...MINTⁱ	P21457
STRINGⁱ	9913.ENSBTAP00000034949

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	11 – 20	Combined sources	10
Helixⁱ	25 – 38	Combined sources	14
Beta strandⁱ	42 – 45	Combined sources	4
Helixⁱ	46 – 56	Combined sources	11
Beta strandⁱ	58 – 60	Combined sources	3
Helixⁱ	63 – 73	Combined sources	11
Beta strandⁱ	78 – 81	Combined sources	4
Helixⁱ	83 – 94	Combined sources	12
Helixⁱ	98 – 100	Combined sources	3
Helixⁱ	102 – 109	Combined sources	8
Beta strandⁱ	114 – 117	Combined sources	4
Helixⁱ	119 – 130	Combined sources	12
Helixⁱ	135 – 138	Combined sources	4
Beta strandⁱ	139 – 141	Combined sources	3
Helixⁱ	143 – 145	Combined sources	3
Helixⁱ	148 – 158	Combined sources	11
Beta strandⁱ	162 – 164	Combined sources	3
Beta strandⁱ	166 – 168	Combined sources	3
Helixⁱ	169 – 178	Combined sources	10
Helixⁱ	180 – 186	Combined sources	7
Helixⁱ	190 – 196	Combined sources	7

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1IKU	NMR	-	A	2-202	[»]
	1JSA	NMR	-	A	2-202	[»]
	1LA3	NMR	-	A	2-202	[»]
	1OMR	X-ray	1.50	A	2-202	[»]
	1OMV	X-ray	1.90	A	2-202	[»]
	1REC	X-ray	1.90	A	2-202	[»]
	2HET	X-ray	3.00	A/B/C/D	2-190	[»]
	2I94	NMR	-	A	1-202	[»]
	4M2O	X-ray	1.50	A	2-197	[»]
	4M2P	X-ray	1.45	A	2-202	[»]
	4M2Q	X-ray	1.90	A	2-202	[»]
	4MLW	X-ray	1.45	A	2-202	[»]
	4YI8	X-ray	1.20	A	2-202	[»]
	4YI9	X-ray	1.35	A	2-202	[»]
ProteinModelPortalⁱ	P21457
SMRⁱ	P21457
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P21457

EvolutionaryTraceⁱ

P21457

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	24 – 59	EF-hand 1PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	61 – 96	EF-hand 2PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	97 – 132	EF-hand 3PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	147 – 182	EF-hand 4PROSITE-ProRule annotationAdd BLAST	36

Sequence similaritiesⁱ

Belongs to the recoverin family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG0044 Eukaryota COG5126 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118820
HOGENOMⁱ	HOG000233019
HOVERGENⁱ	HBG108179
InParanoidⁱ	P21457
KEGG Orthology (KO) More...KOⁱ	K13764
OMAⁱ	KECPSGR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G11T4
TreeFamⁱ	TF300009

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00051 EFh, 2 hits
InterProⁱ	View protein in InterPro IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13499 EF-hand_7, 1 hit PF13833 EF-hand_8, 1 hit
SMARTⁱ	View protein in SMART SM00054 EFh, 2 hits
SUPFAMⁱ	SSF47473 SSF47473, 1 hit
PROSITEⁱ	View protein in PROSITE PS00018 EF_HAND_1, 2 hits PS50222 EF_HAND_2, 4 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P21457-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGNSKSGALS KEILEELQLN TKFTEEELSS WYQSFLKECP SGRITRQEFQ 
        60         70         80         90        100
TIYSKFFPEA DPKAYAQHVF RSFDANSDGT LDFKEYVIAL HMTSAGKTNQ 
       110        120        130        140        150
KLEWAFSLYD VDGNGTISKN EVLEIVTAIF KMISPEDTKH LPEDENTPEK 
       160        170        180        190        200
RAEKIWGFFG KKDDDKLTEK EFIEGTLANK EILRLIQFEP QKVKEKLKEK 

KL

Length:202

Mass (Da):23,333

Last modified:January 23, 2007 - v3

Checksum:ⁱ75504DEBE8288BA8

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	19	L → Q AA sequence (PubMed:1672637).Curated		1
Sequence conflictⁱ	21	T → N AA sequence (PubMed:1672637).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M95858 mRNA Translation: AAB59256.1 X63322 mRNA Translation: CAA44928.1
PIRⁱ	A46129
NCBI Reference Sequences More...RefSeqⁱ	NP_776590.1, NM_174165.2
UniGeneⁱ	Bt.56904

Genome annotation databases

Ensemblⁱ	ENSBTAT00000035069; ENSBTAP00000034949; ENSBTAG00000025088
GeneIDⁱ	281447
KEGGⁱ	bta:281447

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P21457	P34057 Q2TB46 UPI0003C87D80 L5JWQ5 UPI0000112C18 UPI0000E57190 Q8MIH6 A0A2K6GWF9 A0A212DB66 M3Y8H3 +52	Mus musculus (Mouse) Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus) Pteropus alecto (Black flying fox) Bos taurus (Bovine) Canis lupus familiaris (Dog) (Canis familiaris) Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi coquereli) Cervus elaphus hippelaphus (European red deer) Mustela putorius furo (European domestic ferret) (Mustela furo) Ovis aries (Sheep) Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby) And more	202	UniRef90_P34057	Cluster: Recoverin	63

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P21457	P34057 Q2TB46 UPI0003C87D80 L5JWQ5 UPI0003AF541B UPI000BB6A555 UPI000A1BDD2E UPI0002C558C0 UPI00042C51E8 L8HV71 +252	Mus musculus (Mouse) Camelus ferus (Wild bactrian camel) (Camelus bactrianus ferus) Pteropus alecto (Black flying fox) Capra hircus (Goat) Delphinapterus leucas (Beluga whale) Odocoileus virginianus texanus Odobenus rosmarus divergens (Pacific walrus) Physeter catodon (Sperm whale) (Physeter macrocephalus) Bos mutus (wild yak) Manis javanica (Malayan pangolin) (Sunda pangolin) And more	202	UniRef50_P34057	Cluster: Recoverin	263

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M95858 mRNA Translation: AAB59256.1 X63322 mRNA Translation: CAA44928.1
PIRⁱ	A46129
NCBI Reference Sequences More...RefSeqⁱ	NP_776590.1, NM_174165.2
UniGeneⁱ	Bt.56904

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1IKU	NMR	-	A	2-202	[»]
	1JSA	NMR	-	A	2-202	[»]
	1LA3	NMR	-	A	2-202	[»]
	1OMR	X-ray	1.50	A	2-202	[»]
	1OMV	X-ray	1.90	A	2-202	[»]
	1REC	X-ray	1.90	A	2-202	[»]
	2HET	X-ray	3.00	A/B/C/D	2-190	[»]
	2I94	NMR	-	A	1-202	[»]
	4M2O	X-ray	1.50	A	2-197	[»]
	4M2P	X-ray	1.45	A	2-202	[»]
	4M2Q	X-ray	1.90	A	2-202	[»]
	4MLW	X-ray	1.45	A	2-202	[»]
	4YI8	X-ray	1.20	A	2-202	[»]
	4YI9	X-ray	1.35	A	2-202	[»]
ProteinModelPortalⁱ	P21457
SMRⁱ	P21457
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

ELMⁱ	P21457
IntActⁱ	P21457 4 interactors.
Molecular INTeraction database More...MINTⁱ	P21457
STRINGⁱ	9913.ENSBTAP00000034949

PTM databases

iPTMnetⁱ	P21457

iPTMnetⁱ

P21457

Proteomic databases

PaxDbⁱ	P21457
PRIDEⁱ	P21457

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSBTAT00000035069; ENSBTAP00000034949; ENSBTAG00000025088
GeneIDⁱ	281447
KEGGⁱ	bta:281447

Organism-specific databases

CTDⁱ	5957
VGNCⁱ	VGNC:33838 RCVRN

Phylogenomic databases

eggNOGⁱ	KOG0044 Eukaryota COG5126 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118820
HOGENOMⁱ	HOG000233019
HOVERGENⁱ	HBG108179
InParanoidⁱ	P21457
KEGG Orthology (KO) More...KOⁱ	K13764
OMAⁱ	KECPSGR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G11T4
TreeFamⁱ	TF300009

Enzyme and pathway databases

Reactomeⁱ	R-BTA-2514859 Inactivation, recovery and regulation of the phototransduction cascade

Reactomeⁱ

R-BTA-2514859 Inactivation, recovery and regulation of the phototransduction cascade

Miscellaneous databases

EvolutionaryTraceⁱ	P21457

EvolutionaryTraceⁱ

P21457

Gene expression databases

Bgeeⁱ	ENSBTAG00000025088

Bgeeⁱ

ENSBTAG00000025088

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00051 EFh, 2 hits
InterProⁱ	View protein in InterPro IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13499 EF-hand_7, 1 hit PF13833 EF-hand_8, 1 hit
SMARTⁱ	View protein in SMART SM00054 EFh, 2 hits
SUPFAMⁱ	SSF47473 SSF47473, 1 hit
PROSITEⁱ	View protein in PROSITE PS00018 EF_HAND_1, 2 hits PS50222 EF_HAND_2, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RECO_BOVIN
Accessionⁱ	P21457Primary (citable) accession number: P21457
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
	Last sequence update:	January 23, 2007
	Last modified:	March 28, 2018
	This is version 156 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P21457 (RECO_BOVIN)

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Recoverin

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ