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P21452

- NK2R_HUMAN

UniProt

P21452 - NK2R_HUMAN

Protein

Substance-K receptor

Gene

TACR2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 3 (05 May 2009)
      Previous versions | rss
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    Functioni

    This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. substance K receptor activity Source: Ensembl
    3. tachykinin receptor activity Source: ProtInc

    GO - Biological processi

    1. excretion Source: ProtInc
    2. intestine smooth muscle contraction Source: Ensembl
    3. muscle contraction Source: ProtInc
    4. negative regulation of luteinizing hormone secretion Source: Ensembl
    5. operant conditioning Source: Ensembl
    6. positive regulation of acetylcholine secretion, neurotransmission Source: Ensembl
    7. positive regulation of uterine smooth muscle contraction Source: Ensembl
    8. positive regulation of vascular permeability Source: Ensembl
    9. prolactin secretion Source: Ensembl
    10. tachykinin receptor signaling pathway Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_16963. Tachykinin receptors bind tachykinins.
    REACT_18283. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Substance-K receptor
    Short name:
    SKR
    Alternative name(s):
    NK-2 receptor
    Short name:
    NK-2R
    Neurokinin A receptor
    Tachykinin receptor 2
    Gene namesi
    Name:TACR2
    Synonyms:NK2R, NKNAR, TAC2R
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:11527. TACR2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36303.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 398398Substance-K receptorPRO_0000069893Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi11 – 111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi19 – 191N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi106 ↔ 181PROSITE-ProRule annotation
    Lipidationi324 – 3241S-palmitoyl cysteineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiP21452.
    PRIDEiP21452.

    PTM databases

    PhosphoSiteiP21452.

    Expressioni

    Gene expression databases

    ArrayExpressiP21452.
    BgeeiP21452.
    CleanExiHS_TACR2.
    GenevestigatoriP21452.

    Organism-specific databases

    HPAiHPA012084.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TAC1P203662EBI-6655413,EBI-6655449

    Protein-protein interaction databases

    BioGridi112728. 2 interactions.
    IntActiP21452. 1 interaction.
    STRINGi9606.ENSP00000362403.

    Structurei

    3D structure databases

    ProteinModelPortaliP21452.
    SMRiP21452. Positions 9-347.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3232ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini57 – 6913CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini91 – 10717ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini130 – 14920CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini171 – 19626ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini219 – 25133CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini273 – 29018ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini311 – 39888CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei33 – 5624Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei70 – 9021Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei108 – 12922Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei150 – 17021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei197 – 21822Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei252 – 27221Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei291 – 31020Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG331485.
    HOGENOMiHOG000013018.
    HOVERGENiHBG103412.
    InParanoidiP21452.
    KOiK04223.
    OMAiLCMAAFN.
    PhylomeDBiP21452.
    TreeFamiTF315303.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001681. Neurokn_rcpt.
    IPR000913. NK2_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01025. NEUROKININ2R.
    PR00244. NEUROKININR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P21452-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGTCDIVTEA NISSGPESNT TGITAFSMPS WQLALWATAY LALVLVAVTG    50
    NAIVIWIILA HRRMRTVTNY FIVNLALADL CMAAFNAAFN FVYASHNIWY 100
    FGRAFCYFQN LFPITAMFVS IYSMTAIAAD RYMAIVHPFQ PRLSAPSTKA 150
    VIAGIWLVAL ALASPQCFYS TVTMDQGATK CVVAWPEDSG GKTLLLYHLV 200
    VIALIYFLPL AVMFVAYSVI GLTLWRRAVP GHQAHGANLR HLQAMKKFVK 250
    TMVLVVLTFA ICWLPYHLYF ILGSFQEDIY CHKFIQQVYL ALFWLAMSST 300
    MYNPIIYCCL NHRFRSGFRL AFRCCPWVTP TKEDKLELTP TTSLSTRVNR 350
    CHTKETLFMA GDTAPSEATS GEAGRPQDGS GLWFGYGLLA PTKTHVEI 398
    Length:398
    Mass (Da):44,442
    Last modified:May 5, 2009 - v3
    Checksum:i20AD618EF74263A7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti38 – 381T → P in AAC31760. (PubMed:2173708)Curated
    Sequence conflicti38 – 381T → P in AAA60347. (PubMed:2173708)Curated
    Sequence conflicti40 – 401Y → V(PubMed:1659297)Curated
    Sequence conflicti264 – 2641L → P in AAH96842. (PubMed:15489334)Curated
    Sequence conflicti293 – 2931F → FF(PubMed:1848773)Curated
    Sequence conflicti340 – 3401P → R in AAH96842. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti23 – 231I → T.2 Publications
    Corresponds to variant rs5030920 [ dbSNP | Ensembl ].
    VAR_016159
    Natural varianti47 – 471A → T.
    Corresponds to variant rs57500981 [ dbSNP | Ensembl ].
    VAR_061221
    Natural varianti245 – 2451M → K.7 Publications
    Corresponds to variant rs55953810 [ dbSNP | Ensembl ].
    VAR_061222
    Natural varianti363 – 3631T → A.
    Corresponds to variant rs57900755 [ dbSNP | Ensembl ].
    VAR_061223
    Natural varianti375 – 3751R → H.1 Publication
    Corresponds to variant rs2229170 [ dbSNP | Ensembl ].
    VAR_014680
    Natural varianti395 – 3951H → R.
    Corresponds to variant rs58692969 [ dbSNP | Ensembl ].
    VAR_061224

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M57414 mRNA. Translation: AAC31760.1.
    M60284
    , M57415, M60281, M60282, M60283 Genomic DNA. Translation: AAA60347.1.
    M75105
    , M75101, M75102, M75103, M75104 Genomic DNA. Translation: AAB05897.1.
    AB065731 Genomic DNA. Translation: BAC05952.1.
    AK291996 mRNA. Translation: BAF84685.1.
    AY322545 mRNA. Translation: AAP84358.1.
    CH471083 Genomic DNA. Translation: EAW54324.1.
    BC096842 mRNA. Translation: AAH96842.1.
    CCDSiCCDS7293.1.
    PIRiJQ1059.
    RefSeqiNP_001048.2. NM_001057.2.
    UniGeneiHs.88372.

    Genome annotation databases

    EnsembliENST00000373306; ENSP00000362403; ENSG00000075073.
    GeneIDi6865.
    KEGGihsa:6865.
    UCSCiuc001jpn.2. human.

    Polymorphism databases

    DMDMi229462950.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M57414 mRNA. Translation: AAC31760.1 .
    M60284
    , M57415 , M60281 , M60282 , M60283 Genomic DNA. Translation: AAA60347.1 .
    M75105
    , M75101 , M75102 , M75103 , M75104 Genomic DNA. Translation: AAB05897.1 .
    AB065731 Genomic DNA. Translation: BAC05952.1 .
    AK291996 mRNA. Translation: BAF84685.1 .
    AY322545 mRNA. Translation: AAP84358.1 .
    CH471083 Genomic DNA. Translation: EAW54324.1 .
    BC096842 mRNA. Translation: AAH96842.1 .
    CCDSi CCDS7293.1.
    PIRi JQ1059.
    RefSeqi NP_001048.2. NM_001057.2.
    UniGenei Hs.88372.

    3D structure databases

    ProteinModelPortali P21452.
    SMRi P21452. Positions 9-347.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112728. 2 interactions.
    IntActi P21452. 1 interaction.
    STRINGi 9606.ENSP00000362403.

    Chemistry

    BindingDBi P21452.
    ChEMBLi CHEMBL2327.
    DrugBanki DB00575. Clonidine.
    DB00104. Octreotide.
    GuidetoPHARMACOLOGYi 361.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P21452.

    Polymorphism databases

    DMDMi 229462950.

    Proteomic databases

    PaxDbi P21452.
    PRIDEi P21452.

    Protocols and materials databases

    DNASUi 6865.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000373306 ; ENSP00000362403 ; ENSG00000075073 .
    GeneIDi 6865.
    KEGGi hsa:6865.
    UCSCi uc001jpn.2. human.

    Organism-specific databases

    CTDi 6865.
    GeneCardsi GC10M071163.
    H-InvDB HIX0008887.
    HGNCi HGNC:11527. TACR2.
    HPAi HPA012084.
    MIMi 162321. gene.
    neXtProti NX_P21452.
    PharmGKBi PA36303.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG331485.
    HOGENOMi HOG000013018.
    HOVERGENi HBG103412.
    InParanoidi P21452.
    KOi K04223.
    OMAi LCMAAFN.
    PhylomeDBi P21452.
    TreeFami TF315303.

    Enzyme and pathway databases

    Reactomei REACT_16963. Tachykinin receptors bind tachykinins.
    REACT_18283. G alpha (q) signalling events.

    Miscellaneous databases

    GeneWikii Tachykinin_receptor_2.
    GenomeRNAii 6865.
    NextBioi 26793.
    PROi P21452.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P21452.
    Bgeei P21452.
    CleanExi HS_TACR2.
    Genevestigatori P21452.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001681. Neurokn_rcpt.
    IPR000913. NK2_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01025. NEUROKININ2R.
    PR00244. NEUROKININR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human neurokinin A (substance K) receptor. Molecular cloning of the gene, chromosome localization, and isolation of cDNA from tracheal and gastric tissues."
      Gerard N.P., Eddy R.L. Jr., Shows T.B., Gerard C.
      J. Biol. Chem. 265:20455-20462(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT LYS-245.
      Tissue: Stomach and Trachea.
    2. Erratum
      Gerard N.P., Eddy R.L. Jr., Shows T.B., Gerard C.
      J. Biol. Chem. 266:1354-1354(1991) [PubMed] [Europe PMC] [Abstract]
    3. "Molecular cloning of the human neurokinin-2 receptor cDNA by polymerase chain reaction and isolation of the gene."
      Gerard N.P., Gerard C.
      Ann. N. Y. Acad. Sci. 632:389-390(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Cloning, expression of the human substance K receptor, and analysis of its role in mitogenesis."
      Cyr C., South V., Saltzman A., Felder S., Ricca G.A., Jaye M., Huebner K., Kagan J., Croce C.M., Schlessinger J.
      Ann. N. Y. Acad. Sci. 632:426-427(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, VARIANTS THR-23 AND LYS-245.
      Tissue: Jejunum.
    5. "Isolation and characterisation of the human lung NK-2 receptor gene using rapid amplification of cDNA ends."
      Graham A., Hopkins B., Powell S.J., Danks P., Briggs I.
      Biochem. Biophys. Res. Commun. 177:8-16(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-23 AND LYS-245.
      Tissue: Lung.
    6. "Cloning and expression of the human substance K receptor and analysis of its role in mitogenesis."
      Kris R.M., South V., Saltzman A., Felder S., Ricca G.A., Jaye M., Huebner K., Kagan J., Croce C.M., Schlessinger J.
      Cell Growth Differ. 2:15-22(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-375.
    7. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-245.
      Tissue: Small intestine.
    9. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A., Aronstam R.S., Sharma S.V.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-245.
      Tissue: Stomach.
    10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LYS-245.
    11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-245.

    Entry informationi

    Entry nameiNK2R_HUMAN
    AccessioniPrimary (citable) accession number: P21452
    Secondary accession number(s): A8K7I1
    , Q4QRI5, Q8NGQ8, Q9UDE6, Q9UDE7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 138 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3