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Protein

Substance-K receptor

Gene

TACR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P.1 Publication

GO - Molecular functioni

  1. substance K receptor activity Source: Ensembl
  2. tachykinin receptor activity Source: ProtInc

GO - Biological processi

  1. excretion Source: ProtInc
  2. intestine smooth muscle contraction Source: Ensembl
  3. muscle contraction Source: ProtInc
  4. negative regulation of luteinizing hormone secretion Source: Ensembl
  5. operant conditioning Source: Ensembl
  6. positive regulation of acetylcholine secretion, neurotransmission Source: Ensembl
  7. positive regulation of uterine smooth muscle contraction Source: Ensembl
  8. positive regulation of vascular permeability Source: Ensembl
  9. prolactin secretion Source: Ensembl
  10. response to electrical stimulus Source: Ensembl
  11. tachykinin receptor signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_16963. Tachykinin receptors bind tachykinins.
REACT_18283. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Substance-K receptor
Short name:
SKR
Alternative name(s):
NK-2 receptor
Short name:
NK-2R
Neurokinin A receptor
Tachykinin receptor 2
Gene namesi
Name:TACR2
Synonyms:NK2R, NKNAR, TAC2R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:11527. TACR2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232ExtracellularSequence AnalysisAdd
BLAST
Transmembranei33 – 5624Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini57 – 6913CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei70 – 9021Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini91 – 10717ExtracellularSequence AnalysisAdd
BLAST
Transmembranei108 – 12922Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini130 – 14920CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei150 – 17021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini171 – 19626ExtracellularSequence AnalysisAdd
BLAST
Transmembranei197 – 21822Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini219 – 25133CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei252 – 27221Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini273 – 29018ExtracellularSequence AnalysisAdd
BLAST
Transmembranei291 – 31020Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini311 – 39888CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36303.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 398398Substance-K receptorPRO_0000069893Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi11 – 111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi19 – 191N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi106 ↔ 181PROSITE-ProRule annotation
Lipidationi324 – 3241S-palmitoyl cysteineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP21452.
PRIDEiP21452.

PTM databases

PhosphoSiteiP21452.

Expressioni

Gene expression databases

BgeeiP21452.
CleanExiHS_TACR2.
ExpressionAtlasiP21452. baseline.
GenevestigatoriP21452.

Organism-specific databases

HPAiHPA012084.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TAC1P203662EBI-6655413,EBI-6655449

Protein-protein interaction databases

BioGridi112728. 2 interactions.
IntActiP21452. 1 interaction.
STRINGi9606.ENSP00000362403.

Structurei

3D structure databases

ProteinModelPortaliP21452.
SMRiP21452. Positions 9-347.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG331485.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000013018.
HOVERGENiHBG103412.
InParanoidiP21452.
KOiK04223.
OMAiLCMAAFN.
PhylomeDBiP21452.
TreeFamiTF315303.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001681. Neurokn_rcpt.
IPR000913. NK2_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01025. NEUROKININ2R.
PR00244. NEUROKININR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21452-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTCDIVTEA NISSGPESNT TGITAFSMPS WQLALWATAY LALVLVAVTG
60 70 80 90 100
NAIVIWIILA HRRMRTVTNY FIVNLALADL CMAAFNAAFN FVYASHNIWY
110 120 130 140 150
FGRAFCYFQN LFPITAMFVS IYSMTAIAAD RYMAIVHPFQ PRLSAPSTKA
160 170 180 190 200
VIAGIWLVAL ALASPQCFYS TVTMDQGATK CVVAWPEDSG GKTLLLYHLV
210 220 230 240 250
VIALIYFLPL AVMFVAYSVI GLTLWRRAVP GHQAHGANLR HLQAMKKFVK
260 270 280 290 300
TMVLVVLTFA ICWLPYHLYF ILGSFQEDIY CHKFIQQVYL ALFWLAMSST
310 320 330 340 350
MYNPIIYCCL NHRFRSGFRL AFRCCPWVTP TKEDKLELTP TTSLSTRVNR
360 370 380 390
CHTKETLFMA GDTAPSEATS GEAGRPQDGS GLWFGYGLLA PTKTHVEI
Length:398
Mass (Da):44,442
Last modified:May 4, 2009 - v3
Checksum:i20AD618EF74263A7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti38 – 381T → P in AAC31760 (PubMed:2173708).Curated
Sequence conflicti38 – 381T → P in AAA60347 (PubMed:2173708).Curated
Sequence conflicti40 – 401Y → V (PubMed:1659297).Curated
Sequence conflicti264 – 2641L → P in AAH96842 (PubMed:15489334).Curated
Sequence conflicti293 – 2931F → FF (PubMed:1848773).Curated
Sequence conflicti340 – 3401P → R in AAH96842 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti23 – 231I → T.2 Publications
Corresponds to variant rs5030920 [ dbSNP | Ensembl ].
VAR_016159
Natural varianti47 – 471A → T.
Corresponds to variant rs57500981 [ dbSNP | Ensembl ].
VAR_061221
Natural varianti245 – 2451M → K.7 Publications
Corresponds to variant rs55953810 [ dbSNP | Ensembl ].
VAR_061222
Natural varianti363 – 3631T → A.
Corresponds to variant rs57900755 [ dbSNP | Ensembl ].
VAR_061223
Natural varianti375 – 3751R → H.1 Publication
Corresponds to variant rs2229170 [ dbSNP | Ensembl ].
VAR_014680
Natural varianti395 – 3951H → R.
Corresponds to variant rs58692969 [ dbSNP | Ensembl ].
VAR_061224

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57414 mRNA. Translation: AAC31760.1.
M60284
, M57415, M60281, M60282, M60283 Genomic DNA. Translation: AAA60347.1.
M75105
, M75101, M75102, M75103, M75104 Genomic DNA. Translation: AAB05897.1.
AB065731 Genomic DNA. Translation: BAC05952.1.
AK291996 mRNA. Translation: BAF84685.1.
AY322545 mRNA. Translation: AAP84358.1.
CH471083 Genomic DNA. Translation: EAW54324.1.
BC096842 mRNA. Translation: AAH96842.1.
CCDSiCCDS7293.1.
PIRiJQ1059.
RefSeqiNP_001048.2. NM_001057.2.
UniGeneiHs.88372.

Genome annotation databases

EnsembliENST00000373306; ENSP00000362403; ENSG00000075073.
GeneIDi6865.
KEGGihsa:6865.
UCSCiuc001jpn.2. human.

Polymorphism databases

DMDMi229462950.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57414 mRNA. Translation: AAC31760.1.
M60284
, M57415, M60281, M60282, M60283 Genomic DNA. Translation: AAA60347.1.
M75105
, M75101, M75102, M75103, M75104 Genomic DNA. Translation: AAB05897.1.
AB065731 Genomic DNA. Translation: BAC05952.1.
AK291996 mRNA. Translation: BAF84685.1.
AY322545 mRNA. Translation: AAP84358.1.
CH471083 Genomic DNA. Translation: EAW54324.1.
BC096842 mRNA. Translation: AAH96842.1.
CCDSiCCDS7293.1.
PIRiJQ1059.
RefSeqiNP_001048.2. NM_001057.2.
UniGeneiHs.88372.

3D structure databases

ProteinModelPortaliP21452.
SMRiP21452. Positions 9-347.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112728. 2 interactions.
IntActiP21452. 1 interaction.
STRINGi9606.ENSP00000362403.

Chemistry

BindingDBiP21452.
ChEMBLiCHEMBL2327.
GuidetoPHARMACOLOGYi361.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP21452.

Polymorphism databases

DMDMi229462950.

Proteomic databases

PaxDbiP21452.
PRIDEiP21452.

Protocols and materials databases

DNASUi6865.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373306; ENSP00000362403; ENSG00000075073.
GeneIDi6865.
KEGGihsa:6865.
UCSCiuc001jpn.2. human.

Organism-specific databases

CTDi6865.
GeneCardsiGC10M071163.
H-InvDBHIX0008887.
HGNCiHGNC:11527. TACR2.
HPAiHPA012084.
MIMi162321. gene.
neXtProtiNX_P21452.
PharmGKBiPA36303.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG331485.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000013018.
HOVERGENiHBG103412.
InParanoidiP21452.
KOiK04223.
OMAiLCMAAFN.
PhylomeDBiP21452.
TreeFamiTF315303.

Enzyme and pathway databases

ReactomeiREACT_16963. Tachykinin receptors bind tachykinins.
REACT_18283. G alpha (q) signalling events.

Miscellaneous databases

GeneWikiiTachykinin_receptor_2.
GenomeRNAii6865.
NextBioi26793.
PROiP21452.
SOURCEiSearch...

Gene expression databases

BgeeiP21452.
CleanExiHS_TACR2.
ExpressionAtlasiP21452. baseline.
GenevestigatoriP21452.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001681. Neurokn_rcpt.
IPR000913. NK2_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01025. NEUROKININ2R.
PR00244. NEUROKININR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The human neurokinin A (substance K) receptor. Molecular cloning of the gene, chromosome localization, and isolation of cDNA from tracheal and gastric tissues."
    Gerard N.P., Eddy R.L. Jr., Shows T.B., Gerard C.
    J. Biol. Chem. 265:20455-20462(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT LYS-245.
    Tissue: Stomach and Trachea.
  2. Erratum
    Gerard N.P., Eddy R.L. Jr., Shows T.B., Gerard C.
    J. Biol. Chem. 266:1354-1354(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning of the human neurokinin-2 receptor cDNA by polymerase chain reaction and isolation of the gene."
    Gerard N.P., Gerard C.
    Ann. N. Y. Acad. Sci. 632:389-390(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Cloning, expression of the human substance K receptor, and analysis of its role in mitogenesis."
    Cyr C., South V., Saltzman A., Felder S., Ricca G.A., Jaye M., Huebner K., Kagan J., Croce C.M., Schlessinger J.
    Ann. N. Y. Acad. Sci. 632:426-427(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, VARIANTS THR-23 AND LYS-245.
    Tissue: Jejunum.
  5. "Isolation and characterisation of the human lung NK-2 receptor gene using rapid amplification of cDNA ends."
    Graham A., Hopkins B., Powell S.J., Danks P., Briggs I.
    Biochem. Biophys. Res. Commun. 177:8-16(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-23 AND LYS-245.
    Tissue: Lung.
  6. "Cloning and expression of the human substance K receptor and analysis of its role in mitogenesis."
    Kris R.M., South V., Saltzman A., Felder S., Ricca G.A., Jaye M., Huebner K., Kagan J., Croce C.M., Schlessinger J.
    Cell Growth Differ. 2:15-22(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-375.
  7. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-245.
    Tissue: Small intestine.
  9. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-245.
    Tissue: Stomach.
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LYS-245.
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-245.

Entry informationi

Entry nameiNK2R_HUMAN
AccessioniPrimary (citable) accession number: P21452
Secondary accession number(s): A8K7I1
, Q4QRI5, Q8NGQ8, Q9UDE6, Q9UDE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 1991
Last sequence update: May 4, 2009
Last modified: January 6, 2015
This is version 140 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.