SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P21452

- NK2R_HUMAN

UniProt

P21452 - NK2R_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Substance-K receptor
Gene
TACR2, NK2R, NKNAR, TAC2R
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P.1 Publication

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. substance K receptor activity Source: Ensembl
  3. tachykinin receptor activity Source: ProtInc
Complete GO annotation...

GO - Biological processi

  1. excretion Source: ProtInc
  2. intestine smooth muscle contraction Source: Ensembl
  3. muscle contraction Source: ProtInc
  4. negative regulation of luteinizing hormone secretion Source: Ensembl
  5. operant conditioning Source: Ensembl
  6. positive regulation of acetylcholine secretion, neurotransmission Source: Ensembl
  7. positive regulation of uterine smooth muscle contraction Source: Ensembl
  8. positive regulation of vascular permeability Source: Ensembl
  9. prolactin secretion Source: Ensembl
  10. tachykinin receptor signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_16963. Tachykinin receptors bind tachykinins.
REACT_18283. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Substance-K receptor
Short name:
SKR
Alternative name(s):
NK-2 receptor
Short name:
NK-2R
Neurokinin A receptor
Tachykinin receptor 2
Gene namesi
Name:TACR2
Synonyms:NK2R, NKNAR, TAC2R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:11527. TACR2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232Extracellular Reviewed prediction
Add
BLAST
Transmembranei33 – 5624Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini57 – 6913Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei70 – 9021Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini91 – 10717Extracellular Reviewed prediction
Add
BLAST
Transmembranei108 – 12922Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini130 – 14920Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei150 – 17021Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini171 – 19626Extracellular Reviewed prediction
Add
BLAST
Transmembranei197 – 21822Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini219 – 25133Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei252 – 27221Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini273 – 29018Extracellular Reviewed prediction
Add
BLAST
Transmembranei291 – 31020Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini311 – 39888Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36303.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 398398Substance-K receptor
PRO_0000069893Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi11 – 111N-linked (GlcNAc...) Reviewed prediction
Glycosylationi19 – 191N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi106 ↔ 181 By similarity
Lipidationi324 – 3241S-palmitoyl cysteine Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP21452.
PRIDEiP21452.

PTM databases

PhosphoSiteiP21452.

Expressioni

Gene expression databases

ArrayExpressiP21452.
BgeeiP21452.
CleanExiHS_TACR2.
GenevestigatoriP21452.

Organism-specific databases

HPAiHPA012084.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TAC1P203662EBI-6655413,EBI-6655449

Protein-protein interaction databases

BioGridi112728. 2 interactions.
IntActiP21452. 1 interaction.
STRINGi9606.ENSP00000362403.

Structurei

3D structure databases

ProteinModelPortaliP21452.
SMRiP21452. Positions 9-347.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG331485.
HOGENOMiHOG000013018.
HOVERGENiHBG103412.
InParanoidiP21452.
KOiK04223.
OMAiLCMAAFN.
PhylomeDBiP21452.
TreeFamiTF315303.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001681. Neurokn_rcpt.
IPR000913. NK2_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01025. NEUROKININ2R.
PR00244. NEUROKININR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21452-1 [UniParc]FASTAAdd to Basket

« Hide

MGTCDIVTEA NISSGPESNT TGITAFSMPS WQLALWATAY LALVLVAVTG    50
NAIVIWIILA HRRMRTVTNY FIVNLALADL CMAAFNAAFN FVYASHNIWY 100
FGRAFCYFQN LFPITAMFVS IYSMTAIAAD RYMAIVHPFQ PRLSAPSTKA 150
VIAGIWLVAL ALASPQCFYS TVTMDQGATK CVVAWPEDSG GKTLLLYHLV 200
VIALIYFLPL AVMFVAYSVI GLTLWRRAVP GHQAHGANLR HLQAMKKFVK 250
TMVLVVLTFA ICWLPYHLYF ILGSFQEDIY CHKFIQQVYL ALFWLAMSST 300
MYNPIIYCCL NHRFRSGFRL AFRCCPWVTP TKEDKLELTP TTSLSTRVNR 350
CHTKETLFMA GDTAPSEATS GEAGRPQDGS GLWFGYGLLA PTKTHVEI 398
Length:398
Mass (Da):44,442
Last modified:May 5, 2009 - v3
Checksum:i20AD618EF74263A7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti23 – 231I → T.2 Publications
Corresponds to variant rs5030920 [ dbSNP | Ensembl ].
VAR_016159
Natural varianti47 – 471A → T.
Corresponds to variant rs57500981 [ dbSNP | Ensembl ].
VAR_061221
Natural varianti245 – 2451M → K.7 Publications
Corresponds to variant rs55953810 [ dbSNP | Ensembl ].
VAR_061222
Natural varianti363 – 3631T → A.
Corresponds to variant rs57900755 [ dbSNP | Ensembl ].
VAR_061223
Natural varianti375 – 3751R → H.1 Publication
Corresponds to variant rs2229170 [ dbSNP | Ensembl ].
VAR_014680
Natural varianti395 – 3951H → R.
Corresponds to variant rs58692969 [ dbSNP | Ensembl ].
VAR_061224

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti38 – 381T → P in AAC31760. 1 Publication
Sequence conflicti38 – 381T → P in AAA60347. 1 Publication
Sequence conflicti40 – 40 Error
SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

500 Internal Server Error

The server was not able to handle your request.

If this error occurs repeatedly, please contact us and indicate the page you were trying to access.