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Protein

Substance-K receptor

Gene

TACR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P.1 Publication

GO - Molecular functioni

  • substance K receptor activity Source: GO_Central
  • tachykinin receptor activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000075073-MONOMER.
ReactomeiR-HSA-380095. Tachykinin receptors bind tachykinins.
R-HSA-416476. G alpha (q) signalling events.
SIGNORiP21452.

Names & Taxonomyi

Protein namesi
Recommended name:
Substance-K receptor
Short name:
SKR
Alternative name(s):
NK-2 receptor
Short name:
NK-2R
Neurokinin A receptor
Tachykinin receptor 2
Gene namesi
Name:TACR2
Synonyms:NK2R, NKNAR, TAC2R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:11527. TACR2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32ExtracellularSequence analysisAdd BLAST32
Transmembranei33 – 56Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini57 – 69CytoplasmicSequence analysisAdd BLAST13
Transmembranei70 – 90Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini91 – 107ExtracellularSequence analysisAdd BLAST17
Transmembranei108 – 129Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini130 – 149CytoplasmicSequence analysisAdd BLAST20
Transmembranei150 – 170Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini171 – 196ExtracellularSequence analysisAdd BLAST26
Transmembranei197 – 218Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini219 – 251CytoplasmicSequence analysisAdd BLAST33
Transmembranei252 – 272Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini273 – 290ExtracellularSequence analysisAdd BLAST18
Transmembranei291 – 310Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini311 – 398CytoplasmicSequence analysisAdd BLAST88

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6865.
OpenTargetsiENSG00000075073.
PharmGKBiPA36303.

Chemistry databases

ChEMBLiCHEMBL2327.
GuidetoPHARMACOLOGYi361.

Polymorphism and mutation databases

BioMutaiTACR2.
DMDMi229462950.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000698931 – 398Substance-K receptorAdd BLAST398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi11N-linked (GlcNAc...)Sequence analysis1
Glycosylationi19N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi106 ↔ 181PROSITE-ProRule annotation
Lipidationi324S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP21452.
PRIDEiP21452.

PTM databases

iPTMnetiP21452.
PhosphoSitePlusiP21452.

Expressioni

Gene expression databases

BgeeiENSG00000075073.
CleanExiHS_TACR2.
ExpressionAtlasiP21452. baseline and differential.
GenevisibleiP21452. HS.

Organism-specific databases

HPAiHPA012084.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TAC1P203662EBI-6655413,EBI-6655449

Protein-protein interaction databases

BioGridi112728. 3 interactors.
IntActiP21452. 1 interactor.
STRINGi9606.ENSP00000362403.

Chemistry databases

BindingDBiP21452.

Structurei

3D structure databases

ProteinModelPortaliP21452.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4219. Eukaryota.
ENOG410XSC5. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000013018.
HOVERGENiHBG103412.
InParanoidiP21452.
KOiK04223.
OMAiLCMAAFN.
OrthoDBiEOG091G0WYG.
PhylomeDBiP21452.
TreeFamiTF315303.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001681. Neurokn_rcpt.
IPR000913. NK2_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01025. NEUROKININ2R.
PR00244. NEUROKININR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21452-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTCDIVTEA NISSGPESNT TGITAFSMPS WQLALWATAY LALVLVAVTG
60 70 80 90 100
NAIVIWIILA HRRMRTVTNY FIVNLALADL CMAAFNAAFN FVYASHNIWY
110 120 130 140 150
FGRAFCYFQN LFPITAMFVS IYSMTAIAAD RYMAIVHPFQ PRLSAPSTKA
160 170 180 190 200
VIAGIWLVAL ALASPQCFYS TVTMDQGATK CVVAWPEDSG GKTLLLYHLV
210 220 230 240 250
VIALIYFLPL AVMFVAYSVI GLTLWRRAVP GHQAHGANLR HLQAMKKFVK
260 270 280 290 300
TMVLVVLTFA ICWLPYHLYF ILGSFQEDIY CHKFIQQVYL ALFWLAMSST
310 320 330 340 350
MYNPIIYCCL NHRFRSGFRL AFRCCPWVTP TKEDKLELTP TTSLSTRVNR
360 370 380 390
CHTKETLFMA GDTAPSEATS GEAGRPQDGS GLWFGYGLLA PTKTHVEI
Length:398
Mass (Da):44,442
Last modified:May 5, 2009 - v3
Checksum:i20AD618EF74263A7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38T → P in AAC31760 (PubMed:2173708).Curated1
Sequence conflicti38T → P in AAA60347 (PubMed:2173708).Curated1
Sequence conflicti40Y → V (PubMed:1659297).Curated1
Sequence conflicti264L → P in AAH96842 (PubMed:15489334).Curated1
Sequence conflicti293F → FF (PubMed:1848773).Curated1
Sequence conflicti340P → R in AAH96842 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01615923I → T.2 PublicationsCorresponds to variant rs5030920dbSNPEnsembl.1
Natural variantiVAR_06122147A → T.Corresponds to variant rs57500981dbSNPEnsembl.1
Natural variantiVAR_061222245M → K.7 PublicationsCorresponds to variant rs55953810dbSNPEnsembl.1
Natural variantiVAR_061223363T → A.Corresponds to variant rs57900755dbSNPEnsembl.1
Natural variantiVAR_014680375R → H.1 PublicationCorresponds to variant rs2229170dbSNPEnsembl.1
Natural variantiVAR_061224395H → R.Corresponds to variant rs58692969dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57414 mRNA. Translation: AAC31760.1.
M60284
, M57415, M60281, M60282, M60283 Genomic DNA. Translation: AAA60347.1.
M75105
, M75101, M75102, M75103, M75104 Genomic DNA. Translation: AAB05897.1.
AB065731 Genomic DNA. Translation: BAC05952.1.
AK291996 mRNA. Translation: BAF84685.1.
AY322545 mRNA. Translation: AAP84358.1.
CH471083 Genomic DNA. Translation: EAW54324.1.
BC096842 mRNA. Translation: AAH96842.1.
CCDSiCCDS7293.1.
PIRiJQ1059.
RefSeqiNP_001048.2. NM_001057.2.
UniGeneiHs.88372.

Genome annotation databases

EnsembliENST00000373306; ENSP00000362403; ENSG00000075073.
GeneIDi6865.
KEGGihsa:6865.
UCSCiuc001jpn.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57414 mRNA. Translation: AAC31760.1.
M60284
, M57415, M60281, M60282, M60283 Genomic DNA. Translation: AAA60347.1.
M75105
, M75101, M75102, M75103, M75104 Genomic DNA. Translation: AAB05897.1.
AB065731 Genomic DNA. Translation: BAC05952.1.
AK291996 mRNA. Translation: BAF84685.1.
AY322545 mRNA. Translation: AAP84358.1.
CH471083 Genomic DNA. Translation: EAW54324.1.
BC096842 mRNA. Translation: AAH96842.1.
CCDSiCCDS7293.1.
PIRiJQ1059.
RefSeqiNP_001048.2. NM_001057.2.
UniGeneiHs.88372.

3D structure databases

ProteinModelPortaliP21452.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112728. 3 interactors.
IntActiP21452. 1 interactor.
STRINGi9606.ENSP00000362403.

Chemistry databases

BindingDBiP21452.
ChEMBLiCHEMBL2327.
GuidetoPHARMACOLOGYi361.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP21452.
PhosphoSitePlusiP21452.

Polymorphism and mutation databases

BioMutaiTACR2.
DMDMi229462950.

Proteomic databases

PaxDbiP21452.
PRIDEiP21452.

Protocols and materials databases

DNASUi6865.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373306; ENSP00000362403; ENSG00000075073.
GeneIDi6865.
KEGGihsa:6865.
UCSCiuc001jpn.3. human.

Organism-specific databases

CTDi6865.
DisGeNETi6865.
GeneCardsiTACR2.
H-InvDBHIX0008887.
HGNCiHGNC:11527. TACR2.
HPAiHPA012084.
MIMi162321. gene.
neXtProtiNX_P21452.
OpenTargetsiENSG00000075073.
PharmGKBiPA36303.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4219. Eukaryota.
ENOG410XSC5. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000013018.
HOVERGENiHBG103412.
InParanoidiP21452.
KOiK04223.
OMAiLCMAAFN.
OrthoDBiEOG091G0WYG.
PhylomeDBiP21452.
TreeFamiTF315303.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000075073-MONOMER.
ReactomeiR-HSA-380095. Tachykinin receptors bind tachykinins.
R-HSA-416476. G alpha (q) signalling events.
SIGNORiP21452.

Miscellaneous databases

GeneWikiiTachykinin_receptor_2.
GenomeRNAii6865.
PROiP21452.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000075073.
CleanExiHS_TACR2.
ExpressionAtlasiP21452. baseline and differential.
GenevisibleiP21452. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001681. Neurokn_rcpt.
IPR000913. NK2_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01025. NEUROKININ2R.
PR00244. NEUROKININR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNK2R_HUMAN
AccessioniPrimary (citable) accession number: P21452
Secondary accession number(s): A8K7I1
, Q4QRI5, Q8NGQ8, Q9UDE6, Q9UDE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 5, 2009
Last modified: November 2, 2016
This is version 151 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.