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P21451 (EDNRB_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Endothelin B receptor

Short name=ET-B
Short name=ET-BR
Alternative name(s):
Endothelin receptor non-selective type
Gene names
Name:Ednrb
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length442 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Widely distributed in cell types of a variety of tissues.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
Lipoprotein
Palmitate
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaging

Inferred from expression pattern PubMed 16803983. Source: RGD

cGMP-mediated signaling

Inferred from mutant phenotype PubMed 17585504. Source: RGD

cellular response to lipopolysaccharide

Inferred from expression pattern PubMed 18091567. Source: RGD

enteric nervous system development

Inferred from genetic interaction PubMed 15026112. Source: RGD

enteric smooth muscle cell differentiation

Inferred from electronic annotation. Source: Ensembl

epithelial fluid transport

Inferred from mutant phenotype PubMed 18948426. Source: RGD

macrophage chemotaxis

Inferred from electronic annotation. Source: Ensembl

melanocyte differentiation

Inferred from direct assay PubMed 11709437. Source: RGD

negative regulation of apoptotic process

Inferred from mutant phenotype PubMed 18683040. Source: RGD

negative regulation of cellular protein metabolic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of neuron maturation

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

neural crest cell migration

Inferred from electronic annotation. Source: Ensembl

peripheral nervous system development

Inferred from electronic annotation. Source: Ensembl

phospholipase C-activating G-protein coupled receptor signaling pathway

Inferred from mutant phenotype PubMed 15245872. Source: RGD

pigmentation

Inferred from mutant phenotype PubMed 8570650. Source: RGD

positive regulation of cell proliferation

Inferred from mutant phenotype PubMed 18683040PubMed 19628632. Source: RGD

positive regulation of cytosolic calcium ion concentration

Inferred from direct assay Ref.2. Source: RGD

positive regulation of penile erection

Inferred from mutant phenotype PubMed 19884966. Source: RGD

positive regulation of protein phosphorylation

Inferred from direct assay PubMed 16014039. Source: RGD

positive regulation of renal sodium excretion

Inferred from mutant phenotype PubMed 18305094. Source: RGD

positive regulation of urine volume

Inferred from mutant phenotype PubMed 18305094. Source: RGD

posterior midgut development

Inferred from electronic annotation. Source: Ensembl

regulation of blood pressure

Inferred from mutant phenotype PubMed 16763077. Source: RGD

regulation of epithelial cell proliferation

Inferred from mutant phenotype PubMed 12538737. Source: RGD

regulation of fever generation

Inferred from mutant phenotype PubMed 16123229. Source: RGD

regulation of pH

Inferred from electronic annotation. Source: Ensembl

regulation of sensory perception of pain

Inferred from mutant phenotype PubMed 12847519. Source: RGD

response to lipopolysaccharide

Inferred from mutant phenotype PubMed 20888431. Source: RGD

response to organic cyclic compound

Inferred from expression pattern PubMed 19851775. Source: RGD

response to pain

Inferred from mutant phenotype PubMed 12847519. Source: RGD

sensory perception of pain

Inferred from mutant phenotype PubMed 20450894. Source: RGD

vasoconstriction

Inferred from mutant phenotype PubMed 14678950. Source: RGD

vasodilation

Inferred from mutant phenotype PubMed 14678950. Source: RGD

vein smooth muscle contraction

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

membrane

Inferred from direct assay PubMed 11709437. Source: RGD

membrane raft

Inferred from direct assay PubMed 18288637. Source: RGD

nuclear membrane

Inferred from direct assay PubMed 12756260. Source: RGD

plasma membrane

Inferred from direct assay PubMed 16014039. Source: RGD

   Molecular_functionG-protein coupled receptor activity

Traceable author statement PubMed 11709437. Source: RGD

endothelin receptor activity

Inferred from direct assay Ref.2. Source: RGD

peptide hormone binding

Inferred from electronic annotation. Source: Ensembl

receptor activity

Traceable author statement PubMed 11709437. Source: RGD

type 1 angiotensin receptor binding

Inferred from physical interaction PubMed 16014039. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 442416Endothelin B receptor
PRO_0000012733

Regions

Topological domain27 – 10175Extracellular Potential
Transmembrane102 – 12625Helical; Name=1; Potential
Topological domain127 – 13711Cytoplasmic Potential
Transmembrane138 – 16326Helical; Name=2; Potential
Topological domain164 – 17512Extracellular Potential
Transmembrane176 – 19722Helical; Name=3; Potential
Topological domain198 – 21821Cytoplasmic Potential
Transmembrane219 – 24325Helical; Name=4; Potential
Topological domain244 – 27128Extracellular Potential
Transmembrane272 – 29625Helical; Name=5; Potential
Topological domain297 – 32428Cytoplasmic Potential
Transmembrane325 – 35026Helical; Name=6; Potential
Topological domain351 – 36212Extracellular Potential
Transmembrane363 – 38927Helical; Name=7; Potential
Topological domain390 – 44253Cytoplasmic Potential

Amino acid modifications

Modified residue3051Phosphoserine By similarity
Modified residue4191Phosphoserine By similarity
Modified residue4391Phosphotyrosine By similarity
Modified residue4401Phosphoserine By similarity
Modified residue4411Phosphoserine By similarity
Modified residue4421Phosphoserine By similarity
Lipidation4021S-palmitoyl cysteine Potential
Lipidation4031S-palmitoyl cysteine Potential
Lipidation4051S-palmitoyl cysteine Potential
Glycosylation601N-linked (GlcNAc...) Potential
Glycosylation971N-linked (GlcNAc...) Potential
Disulfide bond174 ↔ 255 By similarity

Experimental info

Sequence conflict66 – 694SSAP → FRT in CAA40916. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P21451 [UniParc].

Last modified July 1, 1993. Version 2.
Checksum: BDA628D78E8071CB

FASTA44249,455
        10         20         30         40         50         60 
MQSSASRCGR ALVALLLACG LLGVWGEKRG FPPAQATPSL LGTKEVMTPP TKTSWTRGSN 

        70         80         90        100        110        120 
SSLMRSSAPA EVTKGGRVAG VPPRSFPPPC QRKIEINKTF KYINTIVSCL VFVLGIIGNS 

       130        140        150        160        170        180 
TLLRIIYKNK CMRNGPNILI ASLALGDLLH IIIDIPINAY KLLAGDWPFG AEMCKLVPFI 

       190        200        210        220        230        240 
QKASVGITVL SLCALSIDRY RAVASWSRIK GIGVPKWTAV EIVLIWVVSV VLAVPEAIGF 

       250        260        270        280        290        300 
DVITSDYKGK PLRVCMLNPF QKTAFMQFYK TAKDWWLFSF YFCLPLAITA IFYTLMTCEM 

       310        320        330        340        350        360 
LRKKSGMQIA LNDHLKQRRE VAKTVFCLVL VFALCWLPLH LSRILKLTLY DQSNPQRCEL 

       370        380        390        400        410        420 
LSFLLVLDYI GINMASLNSC INPIALYLVS KRFKNCFKSC LCCWCQTFEE KQSLEEKQSC 

       430        440 
LKFKANDHGY DNFRSSNKYS SS 

« Hide

References

[1]"Distinct tissue distribution and cellular localization of two messenger ribonucleic acids encoding different subtypes of rat endothelin receptors."
Hori S., Komatsu Y., Shigemoto R., Mizuno N., Nakanishi S.
Endocrinology 130:1885-1895(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung.
[2]"Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor."
Sakurai T., Yanagisawa M., Takuwa Y., Miyazaki H., Kimura S., Goto K., Masaki T.
Nature 348:732-735(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung.
[3]"Alternative transcript of the nonselective-type endothelin receptor from rat brain."
Cheng H.F., Su Y.M., Yeh J.R., Chang K.J.
Mol. Pharmacol. 44:533-538(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X57764 mRNA. Translation: CAA40916.1.
S65355 mRNA. Translation: AAB28172.1.
PIRS13425.
RefSeqNP_059029.1. NM_017333.1.
XP_006252492.1. XM_006252430.1.
XP_006252493.1. XM_006252431.1.
UniGeneRn.11412.

3D structure databases

ProteinModelPortalP21451.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBP21451.
ChEMBLCHEMBL2111453.
GuidetoPHARMACOLOGY220.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP21451.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000014747; ENSRNOP00000014747; ENSRNOG00000010997.
GeneID50672.
KEGGrno:50672.
UCSCRGD:2536. rat.

Organism-specific databases

CTD1910.
RGD2536. Ednrb.

Phylogenomic databases

eggNOGNOG278704.
GeneTreeENSGT00690000101856.
HOVERGENHBG051443.
KOK04198.
OMALHIVIDI.
OrthoDBEOG7HHWS4.
PhylomeDBP21451.

Gene expression databases

ArrayExpressP21451.
GenevestigatorP21451.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000499. Endthln_rcpt.
IPR001112. ETB_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00571. ENDOTHELINBR.
PR00366. ENDOTHELINR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio610502.
PROP21451.

Entry information

Entry nameEDNRB_RAT
AccessionPrimary (citable) accession number: P21451
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: July 1, 1993
Last modified: April 16, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries