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Protein

Endothelin B receptor

Gene

Ednrb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  • endothelin receptor activity Source: RGD
  • G-protein coupled receptor activity Source: RGD
  • peptide hormone binding Source: Ensembl
  • receptor activity Source: RGD
  • type 1 angiotensin receptor binding Source: RGD

GO - Biological processi

  • aging Source: RGD
  • cellular response to lipopolysaccharide Source: RGD
  • cGMP-mediated signaling Source: RGD
  • enteric nervous system development Source: RGD
  • enteric smooth muscle cell differentiation Source: Ensembl
  • epithelial fluid transport Source: RGD
  • macrophage chemotaxis Source: Ensembl
  • melanocyte differentiation Source: RGD
  • negative regulation of apoptotic process Source: RGD
  • negative regulation of cellular protein metabolic process Source: Ensembl
  • negative regulation of neuron maturation Source: Ensembl
  • negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  • neural crest cell migration Source: Ensembl
  • peripheral nervous system development Source: Ensembl
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: RGD
  • pigmentation Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of penile erection Source: RGD
  • positive regulation of protein phosphorylation Source: RGD
  • positive regulation of renal sodium excretion Source: RGD
  • positive regulation of urine volume Source: RGD
  • posterior midgut development Source: Ensembl
  • regulation of blood pressure Source: RGD
  • regulation of epithelial cell proliferation Source: RGD
  • regulation of fever generation Source: RGD
  • regulation of pH Source: Ensembl
  • regulation of sensory perception of pain Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to pain Source: RGD
  • sensory perception of pain Source: RGD
  • vasoconstriction Source: RGD
  • vasodilation Source: RGD
  • vein smooth muscle contraction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin B receptor
Short name:
ET-B
Short name:
ET-BR
Alternative name(s):
Endothelin receptor non-selective type
Gene namesi
Name:Ednrb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi2536. Ednrb.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 101ExtracellularSequence analysisAdd BLAST75
Transmembranei102 – 126Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini127 – 137CytoplasmicSequence analysisAdd BLAST11
Transmembranei138 – 163Helical; Name=2Sequence analysisAdd BLAST26
Topological domaini164 – 175ExtracellularSequence analysisAdd BLAST12
Transmembranei176 – 197Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini198 – 218CytoplasmicSequence analysisAdd BLAST21
Transmembranei219 – 243Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini244 – 271ExtracellularSequence analysisAdd BLAST28
Transmembranei272 – 296Helical; Name=5Sequence analysisAdd BLAST25
Topological domaini297 – 324CytoplasmicSequence analysisAdd BLAST28
Transmembranei325 – 350Helical; Name=6Sequence analysisAdd BLAST26
Topological domaini351 – 362ExtracellularSequence analysisAdd BLAST12
Transmembranei363 – 389Helical; Name=7Sequence analysisAdd BLAST27
Topological domaini390 – 442CytoplasmicSequence analysisAdd BLAST53

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: RGD
  • membrane raft Source: RGD
  • nuclear membrane Source: RGD
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4631.
GuidetoPHARMACOLOGYi220.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001273327 – 442Endothelin B receptorAdd BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi60N-linked (GlcNAc...)Sequence analysis1
Glycosylationi97N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi174 ↔ 255PROSITE-ProRule annotation
Modified residuei305PhosphoserineBy similarity1
Lipidationi402S-palmitoyl cysteineSequence analysis1
Lipidationi403S-palmitoyl cysteineSequence analysis1
Lipidationi405S-palmitoyl cysteineSequence analysis1
Modified residuei419PhosphoserineBy similarity1
Modified residuei439PhosphotyrosineBy similarity1
Modified residuei440PhosphoserineBy similarity1
Modified residuei441PhosphoserineBy similarity1
Modified residuei442PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP21451.
PRIDEiP21451.

PTM databases

PhosphoSitePlusiP21451.

Expressioni

Tissue specificityi

Widely distributed in cell types of a variety of tissues.

Gene expression databases

BgeeiENSRNOG00000010997.
GenevisibleiP21451. RN.

Interactioni

GO - Molecular functioni

  • type 1 angiotensin receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014747.

Chemistry databases

BindingDBiP21451.

Structurei

3D structure databases

ProteinModelPortaliP21451.
SMRiP21451.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119177.
HOVERGENiHBG051443.
InParanoidiP21451.
KOiK04198.
OMAiTAEIMTP.
OrthoDBiEOG091G0CJV.
PhylomeDBiP21451.

Family and domain databases

InterProiIPR000499. Endthln_rcpt.
IPR001112. ETB_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00571. ENDOTHELINBR.
PR00366. ENDOTHELINR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21451-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSSASRCGR ALVALLLACG LLGVWGEKRG FPPAQATPSL LGTKEVMTPP
60 70 80 90 100
TKTSWTRGSN SSLMRSSAPA EVTKGGRVAG VPPRSFPPPC QRKIEINKTF
110 120 130 140 150
KYINTIVSCL VFVLGIIGNS TLLRIIYKNK CMRNGPNILI ASLALGDLLH
160 170 180 190 200
IIIDIPINAY KLLAGDWPFG AEMCKLVPFI QKASVGITVL SLCALSIDRY
210 220 230 240 250
RAVASWSRIK GIGVPKWTAV EIVLIWVVSV VLAVPEAIGF DVITSDYKGK
260 270 280 290 300
PLRVCMLNPF QKTAFMQFYK TAKDWWLFSF YFCLPLAITA IFYTLMTCEM
310 320 330 340 350
LRKKSGMQIA LNDHLKQRRE VAKTVFCLVL VFALCWLPLH LSRILKLTLY
360 370 380 390 400
DQSNPQRCEL LSFLLVLDYI GINMASLNSC INPIALYLVS KRFKNCFKSC
410 420 430 440
LCCWCQTFEE KQSLEEKQSC LKFKANDHGY DNFRSSNKYS SS
Length:442
Mass (Da):49,455
Last modified:July 1, 1993 - v2
Checksum:iBDA628D78E8071CB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66 – 69SSAP → FRT in CAA40916 (PubMed:2175397).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57764 mRNA. Translation: CAA40916.1.
S65355 mRNA. Translation: AAB28172.1.
PIRiS13425.
RefSeqiNP_059029.1. NM_017333.1.
XP_006252493.1. XM_006252431.3.
XP_017455275.1. XM_017599786.1.
UniGeneiRn.11412.

Genome annotation databases

EnsembliENSRNOT00000014747; ENSRNOP00000014747; ENSRNOG00000010997.
GeneIDi50672.
KEGGirno:50672.
UCSCiRGD:2536. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57764 mRNA. Translation: CAA40916.1.
S65355 mRNA. Translation: AAB28172.1.
PIRiS13425.
RefSeqiNP_059029.1. NM_017333.1.
XP_006252493.1. XM_006252431.3.
XP_017455275.1. XM_017599786.1.
UniGeneiRn.11412.

3D structure databases

ProteinModelPortaliP21451.
SMRiP21451.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014747.

Chemistry databases

BindingDBiP21451.
ChEMBLiCHEMBL4631.
GuidetoPHARMACOLOGYi220.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP21451.

Proteomic databases

PaxDbiP21451.
PRIDEiP21451.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000014747; ENSRNOP00000014747; ENSRNOG00000010997.
GeneIDi50672.
KEGGirno:50672.
UCSCiRGD:2536. rat.

Organism-specific databases

CTDi1910.
RGDi2536. Ednrb.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119177.
HOVERGENiHBG051443.
InParanoidiP21451.
KOiK04198.
OMAiTAEIMTP.
OrthoDBiEOG091G0CJV.
PhylomeDBiP21451.

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiP21451.

Gene expression databases

BgeeiENSRNOG00000010997.
GenevisibleiP21451. RN.

Family and domain databases

InterProiIPR000499. Endthln_rcpt.
IPR001112. ETB_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00571. ENDOTHELINBR.
PR00366. ENDOTHELINR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEDNRB_RAT
AccessioniPrimary (citable) accession number: P21451
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: July 1, 1993
Last modified: November 30, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.