Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P21451

- EDNRB_RAT

UniProt

P21451 - EDNRB_RAT

Protein

Endothelin B receptor

Gene

Ednrb

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (01 Jul 1993)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

    GO - Molecular functioni

    1. endothelin receptor activity Source: RGD
    2. G-protein coupled receptor activity Source: RGD
    3. peptide hormone binding Source: Ensembl
    4. receptor activity Source: RGD
    5. type 1 angiotensin receptor binding Source: RGD

    GO - Biological processi

    1. aging Source: RGD
    2. cellular response to lipopolysaccharide Source: RGD
    3. cGMP-mediated signaling Source: RGD
    4. enteric nervous system development Source: RGD
    5. enteric smooth muscle cell differentiation Source: Ensembl
    6. epithelial fluid transport Source: RGD
    7. macrophage chemotaxis Source: Ensembl
    8. melanocyte differentiation Source: RGD
    9. negative regulation of apoptotic process Source: RGD
    10. negative regulation of cellular protein metabolic process Source: Ensembl
    11. negative regulation of neuron maturation Source: Ensembl
    12. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    13. neural crest cell migration Source: Ensembl
    14. peripheral nervous system development Source: Ensembl
    15. phospholipase C-activating G-protein coupled receptor signaling pathway Source: RGD
    16. pigmentation Source: RGD
    17. positive regulation of cell proliferation Source: RGD
    18. positive regulation of cytosolic calcium ion concentration Source: RGD
    19. positive regulation of penile erection Source: RGD
    20. positive regulation of protein phosphorylation Source: RGD
    21. positive regulation of renal sodium excretion Source: RGD
    22. positive regulation of urine volume Source: RGD
    23. posterior midgut development Source: Ensembl
    24. regulation of blood pressure Source: RGD
    25. regulation of epithelial cell proliferation Source: RGD
    26. regulation of fever generation Source: RGD
    27. regulation of pH Source: Ensembl
    28. regulation of sensory perception of pain Source: RGD
    29. response to lipopolysaccharide Source: RGD
    30. response to organic cyclic compound Source: RGD
    31. response to pain Source: RGD
    32. sensory perception of pain Source: RGD
    33. vasoconstriction Source: RGD
    34. vasodilation Source: RGD
    35. vein smooth muscle contraction Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endothelin B receptor
    Short name:
    ET-B
    Short name:
    ET-BR
    Alternative name(s):
    Endothelin receptor non-selective type
    Gene namesi
    Name:Ednrb
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 15

    Organism-specific databases

    RGDi2536. Ednrb.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. membrane Source: RGD
    3. membrane raft Source: RGD
    4. nuclear membrane Source: RGD
    5. plasma membrane Source: RGD

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 442416Endothelin B receptorPRO_0000012733Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi60 – 601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi97 – 971N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi174 ↔ 255PROSITE-ProRule annotation
    Modified residuei305 – 3051PhosphoserineBy similarity
    Lipidationi402 – 4021S-palmitoyl cysteineSequence Analysis
    Lipidationi403 – 4031S-palmitoyl cysteineSequence Analysis
    Lipidationi405 – 4051S-palmitoyl cysteineSequence Analysis
    Modified residuei419 – 4191PhosphoserineBy similarity
    Modified residuei439 – 4391PhosphotyrosineBy similarity
    Modified residuei440 – 4401PhosphoserineBy similarity
    Modified residuei441 – 4411PhosphoserineBy similarity
    Modified residuei442 – 4421PhosphoserineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

    PTM databases

    PhosphoSiteiP21451.

    Expressioni

    Tissue specificityi

    Widely distributed in cell types of a variety of tissues.

    Gene expression databases

    ArrayExpressiP21451.
    GenevestigatoriP21451.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliP21451.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 10175ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini127 – 13711CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini164 – 17512ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini198 – 21821CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini244 – 27128ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini297 – 32428CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini351 – 36212ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini390 – 44253CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei102 – 12625Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei138 – 16326Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei176 – 19722Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei219 – 24325Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei272 – 29625Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei325 – 35026Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei363 – 38927Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG278704.
    GeneTreeiENSGT00690000101856.
    HOVERGENiHBG051443.
    KOiK04198.
    OMAiLHIVIDI.
    OrthoDBiEOG7HHWS4.
    PhylomeDBiP21451.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000499. Endthln_rcpt.
    IPR001112. ETB_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00571. ENDOTHELINBR.
    PR00366. ENDOTHELINR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P21451-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQSSASRCGR ALVALLLACG LLGVWGEKRG FPPAQATPSL LGTKEVMTPP    50
    TKTSWTRGSN SSLMRSSAPA EVTKGGRVAG VPPRSFPPPC QRKIEINKTF 100
    KYINTIVSCL VFVLGIIGNS TLLRIIYKNK CMRNGPNILI ASLALGDLLH 150
    IIIDIPINAY KLLAGDWPFG AEMCKLVPFI QKASVGITVL SLCALSIDRY 200
    RAVASWSRIK GIGVPKWTAV EIVLIWVVSV VLAVPEAIGF DVITSDYKGK 250
    PLRVCMLNPF QKTAFMQFYK TAKDWWLFSF YFCLPLAITA IFYTLMTCEM 300
    LRKKSGMQIA LNDHLKQRRE VAKTVFCLVL VFALCWLPLH LSRILKLTLY 350
    DQSNPQRCEL LSFLLVLDYI GINMASLNSC INPIALYLVS KRFKNCFKSC 400
    LCCWCQTFEE KQSLEEKQSC LKFKANDHGY DNFRSSNKYS SS 442
    Length:442
    Mass (Da):49,455
    Last modified:July 1, 1993 - v2
    Checksum:iBDA628D78E8071CB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti66 – 694SSAP → FRT in CAA40916. (PubMed:2175397)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X57764 mRNA. Translation: CAA40916.1.
    S65355 mRNA. Translation: AAB28172.1.
    PIRiS13425.
    RefSeqiNP_059029.1. NM_017333.1.
    XP_006252492.1. XM_006252430.1.
    XP_006252493.1. XM_006252431.1.
    UniGeneiRn.11412.

    Genome annotation databases

    EnsembliENSRNOT00000014747; ENSRNOP00000014747; ENSRNOG00000010997.
    GeneIDi50672.
    KEGGirno:50672.
    UCSCiRGD:2536. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X57764 mRNA. Translation: CAA40916.1 .
    S65355 mRNA. Translation: AAB28172.1 .
    PIRi S13425.
    RefSeqi NP_059029.1. NM_017333.1.
    XP_006252492.1. XM_006252430.1.
    XP_006252493.1. XM_006252431.1.
    UniGenei Rn.11412.

    3D structure databases

    ProteinModelPortali P21451.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi P21451.
    ChEMBLi CHEMBL4631.
    GuidetoPHARMACOLOGYi 220.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P21451.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000014747 ; ENSRNOP00000014747 ; ENSRNOG00000010997 .
    GeneIDi 50672.
    KEGGi rno:50672.
    UCSCi RGD:2536. rat.

    Organism-specific databases

    CTDi 1910.
    RGDi 2536. Ednrb.

    Phylogenomic databases

    eggNOGi NOG278704.
    GeneTreei ENSGT00690000101856.
    HOVERGENi HBG051443.
    KOi K04198.
    OMAi LHIVIDI.
    OrthoDBi EOG7HHWS4.
    PhylomeDBi P21451.

    Miscellaneous databases

    NextBioi 610502.
    PROi P21451.

    Gene expression databases

    ArrayExpressi P21451.
    Genevestigatori P21451.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000499. Endthln_rcpt.
    IPR001112. ETB_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00571. ENDOTHELINBR.
    PR00366. ENDOTHELINR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Distinct tissue distribution and cellular localization of two messenger ribonucleic acids encoding different subtypes of rat endothelin receptors."
      Hori S., Komatsu Y., Shigemoto R., Mizuno N., Nakanishi S.
      Endocrinology 130:1885-1895(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.
    2. "Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor."
      Sakurai T., Yanagisawa M., Takuwa Y., Miyazaki H., Kimura S., Goto K., Masaki T.
      Nature 348:732-735(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.
    3. "Alternative transcript of the nonselective-type endothelin receptor from rat brain."
      Cheng H.F., Su Y.M., Yeh J.R., Chang K.J.
      Mol. Pharmacol. 44:533-538(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiEDNRB_RAT
    AccessioniPrimary (citable) accession number: P21451
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3