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P21451

- EDNRB_RAT

UniProt

P21451 - EDNRB_RAT

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Protein

Endothelin B receptor

Gene

Ednrb

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  1. endothelin receptor activity Source: RGD
  2. G-protein coupled receptor activity Source: RGD
  3. peptide hormone binding Source: Ensembl
  4. receptor activity Source: RGD
  5. type 1 angiotensin receptor binding Source: RGD

GO - Biological processi

  1. aging Source: RGD
  2. cellular response to lipopolysaccharide Source: RGD
  3. cGMP-mediated signaling Source: RGD
  4. endothelin receptor signaling pathway Source: GOC
  5. enteric nervous system development Source: RGD
  6. enteric smooth muscle cell differentiation Source: Ensembl
  7. epithelial fluid transport Source: RGD
  8. macrophage chemotaxis Source: Ensembl
  9. melanocyte differentiation Source: RGD
  10. negative regulation of apoptotic process Source: RGD
  11. negative regulation of cellular protein metabolic process Source: Ensembl
  12. negative regulation of neuron maturation Source: Ensembl
  13. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  14. neural crest cell migration Source: Ensembl
  15. peripheral nervous system development Source: Ensembl
  16. phospholipase C-activating G-protein coupled receptor signaling pathway Source: RGD
  17. pigmentation Source: RGD
  18. positive regulation of cell proliferation Source: RGD
  19. positive regulation of cytosolic calcium ion concentration Source: RGD
  20. positive regulation of penile erection Source: RGD
  21. positive regulation of protein phosphorylation Source: RGD
  22. positive regulation of renal sodium excretion Source: RGD
  23. positive regulation of urine volume Source: RGD
  24. posterior midgut development Source: Ensembl
  25. regulation of blood pressure Source: RGD
  26. regulation of epithelial cell proliferation Source: RGD
  27. regulation of fever generation Source: RGD
  28. regulation of pH Source: Ensembl
  29. regulation of sensory perception of pain Source: RGD
  30. response to lipopolysaccharide Source: RGD
  31. response to organic cyclic compound Source: RGD
  32. response to pain Source: RGD
  33. sensory perception of pain Source: RGD
  34. vasoconstriction Source: RGD
  35. vasodilation Source: RGD
  36. vein smooth muscle contraction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin B receptor
Short name:
ET-B
Short name:
ET-BR
Alternative name(s):
Endothelin receptor non-selective type
Gene namesi
Name:Ednrb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 15

Organism-specific databases

RGDi2536. Ednrb.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane Source: RGD
  3. membrane raft Source: RGD
  4. nuclear membrane Source: RGD
  5. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 442416Endothelin B receptorPRO_0000012733Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi60 – 601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi97 – 971N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi174 ↔ 255PROSITE-ProRule annotation
Modified residuei305 – 3051PhosphoserineBy similarity
Lipidationi402 – 4021S-palmitoyl cysteineSequence Analysis
Lipidationi403 – 4031S-palmitoyl cysteineSequence Analysis
Lipidationi405 – 4051S-palmitoyl cysteineSequence Analysis
Modified residuei419 – 4191PhosphoserineBy similarity
Modified residuei439 – 4391PhosphotyrosineBy similarity
Modified residuei440 – 4401PhosphoserineBy similarity
Modified residuei441 – 4411PhosphoserineBy similarity
Modified residuei442 – 4421PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

PTM databases

PhosphoSiteiP21451.

Expressioni

Tissue specificityi

Widely distributed in cell types of a variety of tissues.

Gene expression databases

ExpressionAtlasiP21451. baseline and differential.
GenevestigatoriP21451.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliP21451.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 10175ExtracellularSequence AnalysisAdd
BLAST
Topological domaini127 – 13711CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini164 – 17512ExtracellularSequence AnalysisAdd
BLAST
Topological domaini198 – 21821CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini244 – 27128ExtracellularSequence AnalysisAdd
BLAST
Topological domaini297 – 32428CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini351 – 36212ExtracellularSequence AnalysisAdd
BLAST
Topological domaini390 – 44253CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei102 – 12625Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei138 – 16326Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei176 – 19722Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei219 – 24325Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei272 – 29625Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei325 – 35026Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei363 – 38927Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG278704.
GeneTreeiENSGT00760000119177.
HOVERGENiHBG051443.
InParanoidiP21451.
KOiK04198.
OMAiLHIVIDI.
OrthoDBiEOG7HHWS4.
PhylomeDBiP21451.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000499. Endthln_rcpt.
IPR001112. ETB_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00571. ENDOTHELINBR.
PR00366. ENDOTHELINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21451 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQSSASRCGR ALVALLLACG LLGVWGEKRG FPPAQATPSL LGTKEVMTPP
60 70 80 90 100
TKTSWTRGSN SSLMRSSAPA EVTKGGRVAG VPPRSFPPPC QRKIEINKTF
110 120 130 140 150
KYINTIVSCL VFVLGIIGNS TLLRIIYKNK CMRNGPNILI ASLALGDLLH
160 170 180 190 200
IIIDIPINAY KLLAGDWPFG AEMCKLVPFI QKASVGITVL SLCALSIDRY
210 220 230 240 250
RAVASWSRIK GIGVPKWTAV EIVLIWVVSV VLAVPEAIGF DVITSDYKGK
260 270 280 290 300
PLRVCMLNPF QKTAFMQFYK TAKDWWLFSF YFCLPLAITA IFYTLMTCEM
310 320 330 340 350
LRKKSGMQIA LNDHLKQRRE VAKTVFCLVL VFALCWLPLH LSRILKLTLY
360 370 380 390 400
DQSNPQRCEL LSFLLVLDYI GINMASLNSC INPIALYLVS KRFKNCFKSC
410 420 430 440
LCCWCQTFEE KQSLEEKQSC LKFKANDHGY DNFRSSNKYS SS
Length:442
Mass (Da):49,455
Last modified:July 1, 1993 - v2
Checksum:iBDA628D78E8071CB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti66 – 694SSAP → FRT in CAA40916. (PubMed:2175397)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X57764 mRNA. Translation: CAA40916.1.
S65355 mRNA. Translation: AAB28172.1.
PIRiS13425.
RefSeqiNP_059029.1. NM_017333.1.
XP_006252493.1. XM_006252431.2.
UniGeneiRn.11412.

Genome annotation databases

EnsembliENSRNOT00000014747; ENSRNOP00000014747; ENSRNOG00000010997.
GeneIDi50672.
KEGGirno:50672.
UCSCiRGD:2536. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X57764 mRNA. Translation: CAA40916.1 .
S65355 mRNA. Translation: AAB28172.1 .
PIRi S13425.
RefSeqi NP_059029.1. NM_017333.1.
XP_006252493.1. XM_006252431.2.
UniGenei Rn.11412.

3D structure databases

ProteinModelPortali P21451.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi P21451.
ChEMBLi CHEMBL2111453.
GuidetoPHARMACOLOGYi 220.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P21451.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000014747 ; ENSRNOP00000014747 ; ENSRNOG00000010997 .
GeneIDi 50672.
KEGGi rno:50672.
UCSCi RGD:2536. rat.

Organism-specific databases

CTDi 1910.
RGDi 2536. Ednrb.

Phylogenomic databases

eggNOGi NOG278704.
GeneTreei ENSGT00760000119177.
HOVERGENi HBG051443.
InParanoidi P21451.
KOi K04198.
OMAi LHIVIDI.
OrthoDBi EOG7HHWS4.
PhylomeDBi P21451.

Miscellaneous databases

NextBioi 610502.
PROi P21451.

Gene expression databases

ExpressionAtlasi P21451. baseline and differential.
Genevestigatori P21451.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000499. Endthln_rcpt.
IPR001112. ETB_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00571. ENDOTHELINBR.
PR00366. ENDOTHELINR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Distinct tissue distribution and cellular localization of two messenger ribonucleic acids encoding different subtypes of rat endothelin receptors."
    Hori S., Komatsu Y., Shigemoto R., Mizuno N., Nakanishi S.
    Endocrinology 130:1885-1895(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  2. "Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor."
    Sakurai T., Yanagisawa M., Takuwa Y., Miyazaki H., Kimura S., Goto K., Masaki T.
    Nature 348:732-735(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  3. "Alternative transcript of the nonselective-type endothelin receptor from rat brain."
    Cheng H.F., Su Y.M., Yeh J.R., Chang K.J.
    Mol. Pharmacol. 44:533-538(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiEDNRB_RAT
AccessioniPrimary (citable) accession number: P21451
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: July 1, 1993
Last modified: October 29, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3