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Protein

Endothelin-1 receptor

Gene

EDNRA

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-BTA-375276. Peptide ligand-binding receptors.
R-BTA-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-1 receptor
Alternative name(s):
Endothelin A receptor
Short name:
ET-A
Short name:
ET-AR
Gene namesi
Name:EDNRA
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 17

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 8060ExtracellularSequence analysisAdd
BLAST
Transmembranei81 – 10222Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini103 – 11210CytoplasmicSequence analysis
Transmembranei113 – 13220Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini133 – 15927ExtracellularSequence analysisAdd
BLAST
Transmembranei160 – 18122Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini182 – 20524CytoplasmicSequence analysisAdd
BLAST
Transmembranei206 – 22924Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini230 – 25627ExtracellularSequence analysisAdd
BLAST
Transmembranei257 – 27822Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini279 – 30628CytoplasmicSequence analysisAdd
BLAST
Transmembranei307 – 32822Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini329 – 34719ExtracellularSequence analysisAdd
BLAST
Transmembranei348 – 37225Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini373 – 42755CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2806.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 427407Endothelin-1 receptorPRO_0000012719Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence analysis
Glycosylationi62 – 621N-linked (GlcNAc...)Sequence analysis
Disulfide bondi158 ↔ 239PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP21450.
PRIDEiP21450.

Expressioni

Gene expression databases

BgeeiENSBTAG00000013674.

Interactioni

Subunit structurei

Interacts with HDAC7 and KAT5.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018173.

Chemistry

BindingDBiP21450.

Structurei

3D structure databases

ProteinModelPortaliP21450.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119177.
HOGENOMiHOG000272623.
HOVERGENiHBG051443.
InParanoidiP21450.
KOiK04197.
OMAiSIQWKNQ.
OrthoDBiEOG091G0CJV.
TreeFamiTF331292.

Family and domain databases

InterProiIPR000499. Endthln_rcpt.
IPR002175. ETA_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00570. ENDOTHELINAR.
PR00366. ENDOTHELINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21450-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METFWLRLSF WVALVGGVIS DNPESYSTNL SIHVDSVATF HGTELSFVVT
60 70 80 90 100
THQPTNLALP SNGSMHNYCP QQTKITSAFK YINTVISCTI FIVGMVGNAT
110 120 130 140 150
LLRIIYQNKC MRNGPNALIA SLALGDLIYV VIDLPINVFK LLAGRWPFEQ
160 170 180 190 200
NDFGVFLCKL FPFLQKSSVG ITVLNLCALS VDRYRAVASW SRVQGIGIPL
210 220 230 240 250
VTAIEIVSIW ILSFILAIPE AIGFVMVPFE YKGAQHRTCM LNATSKFMEF
260 270 280 290 300
YQDVKDWWLF GFYFCMPLVC TAIFYTLMTC EMLNRRNGSL RIALSEHLKQ
310 320 330 340 350
RREVAKTVFC LVVIFALCWF PLHLSRILKK TVYDEMDTNR CELLSFLLLM
360 370 380 390 400
DYIGINLATM NSCINPIALY FVSKKFKNCF QSCLCCCCYQ SKSLMTSVPM
410 420
NGTSIQWKNH EQNNHNTERS SHKDSIN
Length:427
Mass (Da):48,515
Last modified:August 1, 1991 - v2
Checksum:i73CF44404CD9AC14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57765 mRNA. Translation: CAA40917.1.
BC133407 mRNA. Translation: AAI33408.1.
BC142309 mRNA. Translation: AAI42310.1.
PIRiS13424.
RefSeqiNP_776733.1. NM_174308.2.
UniGeneiBt.4719.

Genome annotation databases

EnsembliENSBTAT00000018173; ENSBTAP00000018173; ENSBTAG00000013674.
GeneIDi281749.
KEGGibta:281749.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57765 mRNA. Translation: CAA40917.1.
BC133407 mRNA. Translation: AAI33408.1.
BC142309 mRNA. Translation: AAI42310.1.
PIRiS13424.
RefSeqiNP_776733.1. NM_174308.2.
UniGeneiBt.4719.

3D structure databases

ProteinModelPortaliP21450.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018173.

Chemistry

BindingDBiP21450.
ChEMBLiCHEMBL2806.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiP21450.
PRIDEiP21450.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000018173; ENSBTAP00000018173; ENSBTAG00000013674.
GeneIDi281749.
KEGGibta:281749.

Organism-specific databases

CTDi1909.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119177.
HOGENOMiHOG000272623.
HOVERGENiHBG051443.
InParanoidiP21450.
KOiK04197.
OMAiSIQWKNQ.
OrthoDBiEOG091G0CJV.
TreeFamiTF331292.

Enzyme and pathway databases

ReactomeiR-BTA-375276. Peptide ligand-binding receptors.
R-BTA-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiP21450.

Gene expression databases

BgeeiENSBTAG00000013674.

Family and domain databases

InterProiIPR000499. Endthln_rcpt.
IPR002175. ETA_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00570. ENDOTHELINAR.
PR00366. ENDOTHELINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEDNRA_BOVIN
AccessioniPrimary (citable) accession number: P21450
Secondary accession number(s): A3KMY5, A5PK08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: August 1, 1991
Last modified: September 7, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.