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Protein

Multidrug resistance protein 1A

Gene

Abcb1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.1 Publication

Catalytic activityi

ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi423 – 4308ATP 1PROSITE-ProRule annotation
Nucleotide bindingi1066 – 10738ATP 2PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_272600. Abacavir transmembrane transport.
REACT_293350. ABC-family proteins mediated transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein 1A (EC:3.6.3.44)
Alternative name(s):
ATP-binding cassette sub-family B member 1A
MDR1A
Multidrug resistance protein 3
P-glycoprotein 3
Gene namesi
Name:Abcb1a
Synonyms:Abcb4, Mdr1a, Mdr3, Pgy-3, Pgy3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:97570. Abcb1a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4343CytoplasmicBy similarityAdd
BLAST
Transmembranei44 – 6623HelicalAdd
BLAST
Topological domaini67 – 11246ExtracellularBy similarityAdd
BLAST
Transmembranei113 – 13321HelicalAdd
BLAST
Topological domaini134 – 18249CytoplasmicBy similarityAdd
BLAST
Transmembranei183 – 20422HelicalAdd
BLAST
Topological domaini205 – 2117ExtracellularBy similarity
Transmembranei212 – 23221HelicalAdd
BLAST
Topological domaini233 – 29058CytoplasmicBy similarityAdd
BLAST
Transmembranei291 – 31222HelicalAdd
BLAST
Topological domaini313 – 32614ExtracellularBy similarityAdd
BLAST
Transmembranei327 – 34822HelicalAdd
BLAST
Topological domaini349 – 707359CytoplasmicBy similarityAdd
BLAST
Transmembranei708 – 72821HelicalAdd
BLAST
Topological domaini729 – 75224ExtracellularBy similarityAdd
BLAST
Transmembranei753 – 77321HelicalAdd
BLAST
Topological domaini774 – 82855CytoplasmicBy similarityAdd
BLAST
Transmembranei829 – 84921HelicalAdd
BLAST
Topological domaini850 – 8501ExtracellularBy similarity
Transmembranei851 – 87020HelicalAdd
BLAST
Topological domaini871 – 93060CytoplasmicBy similarityAdd
BLAST
Transmembranei931 – 95323HelicalAdd
BLAST
Topological domaini954 – 96916ExtracellularBy similarityAdd
BLAST
Transmembranei970 – 99122HelicalAdd
BLAST
Topological domaini992 – 1276285CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12761276Multidrug resistance protein 1APRO_0000093336Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi83 – 831N-linked (GlcNAc...)Sequence Analysis
Glycosylationi87 – 871N-linked (GlcNAc...)Sequence Analysis
Glycosylationi90 – 901N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP21447.
PaxDbiP21447.
PRIDEiP21447.

PTM databases

PhosphoSiteiP21447.

Expressioni

Gene expression databases

BgeeiP21447.
ExpressionAtlasiP21447. baseline and differential.
GenevisibleiP21447. MM.

Interactioni

Subunit structurei

Interacts with PSMB5.By similarity

Protein-protein interaction databases

IntActiP21447. 1 interaction.
MINTiMINT-4101695.
STRINGi10090.ENSMUSP00000041204.

Structurei

Secondary structure

1
1276
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni35 – 417Combined sources
Helixi45 – 8642Combined sources
Turni93 – 975Combined sources
Helixi98 – 15356Combined sources
Helixi156 – 1605Combined sources
Helixi164 – 18118Combined sources
Helixi184 – 20623Combined sources
Helixi209 – 26254Combined sources
Turni263 – 2653Combined sources
Helixi266 – 31853Combined sources
Helixi324 – 36643Combined sources
Beta strandi388 – 3958Combined sources
Helixi400 – 4023Combined sources
Beta strandi410 – 4134Combined sources
Beta strandi418 – 4225Combined sources
Helixi428 – 4358Combined sources
Turni436 – 4383Combined sources
Beta strandi443 – 45311Combined sources
Turni454 – 4563Combined sources
Helixi459 – 4646Combined sources
Beta strandi466 – 4727Combined sources
Helixi480 – 4856Combined sources
Helixi493 – 50210Combined sources
Helixi506 – 5116Combined sources
Helixi515 – 5173Combined sources
Beta strandi521 – 5244Combined sources
Helixi529 – 54214Combined sources
Beta strandi546 – 5527Combined sources
Beta strandi555 – 5573Combined sources
Helixi559 – 57214Combined sources
Beta strandi574 – 5818Combined sources
Turni585 – 5906Combined sources
Beta strandi592 – 5987Combined sources
Beta strandi601 – 6066Combined sources
Helixi608 – 6147Combined sources
Helixi617 – 6259Combined sources
Helixi695 – 7006Combined sources
Helixi707 – 73630Combined sources
Helixi741 – 7433Combined sources
Helixi744 – 79451Combined sources
Helixi797 – 8004Combined sources
Helixi807 – 82519Combined sources
Helixi827 – 84923Combined sources
Beta strandi850 – 8523Combined sources
Helixi853 – 89846Combined sources
Helixi900 – 9067Combined sources
Helixi909 – 95648Combined sources
Turni957 – 9615Combined sources
Beta strandi962 – 9643Combined sources
Helixi967 – 100943Combined sources
Beta strandi1031 – 10388Combined sources
Beta strandi1048 – 10569Combined sources
Beta strandi1060 – 106910Combined sources
Helixi1070 – 107910Combined sources
Beta strandi1086 – 109611Combined sources
Helixi1097 – 10993Combined sources
Helixi1102 – 11065Combined sources
Beta strandi1109 – 11124Combined sources
Beta strandi1120 – 11223Combined sources
Helixi1123 – 11275Combined sources
Helixi1128 – 11303Combined sources
Helixi1138 – 114710Combined sources
Helixi1151 – 11566Combined sources
Beta strandi1157 – 11593Combined sources
Helixi1160 – 11623Combined sources
Beta strandi1164 – 11696Combined sources
Helixi1174 – 118714Combined sources
Beta strandi1191 – 11955Combined sources
Helixi1204 – 121714Combined sources
Beta strandi1218 – 12258Combined sources
Beta strandi1230 – 12356Combined sources
Beta strandi1237 – 12437Combined sources
Helixi1253 – 12586Combined sources
Helixi1262 – 127211Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3G5UX-ray3.80A/B1-1276[»]
3G60X-ray4.40A/B1-1276[»]
3G61X-ray4.35A/B1-1276[»]
4KSBX-ray3.80A1-1276[»]
4KSCX-ray4.00A1-1276[»]
4KSDX-ray4.10A1-1276[»]
4LSGX-ray3.80A/B1-1276[»]
4M1MX-ray3.80A/B1-1276[»]
4M2SX-ray4.40A/B1-1276[»]
4M2TX-ray4.35A/B1-1276[»]
4Q9HX-ray3.40A1-1276[»]
4Q9IX-ray3.78A1-1276[»]
4Q9JX-ray3.60A1-1276[»]
4Q9KX-ray3.80A1-1276[»]
4Q9LX-ray3.80A1-1276[»]
ProteinModelPortaliP21447.
SMRiP21447. Positions 31-626.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP21447.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini50 – 353304ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini388 – 624237ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini707 – 996290ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini1031 – 1269239ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1132.
GeneTreeiENSGT00530000062896.
HOVERGENiHBG080809.
InParanoidiP21447.
KOiK05658.
OMAiRTINVRH.
OrthoDBiEOG7Z3F4H.
PhylomeDBiP21447.
TreeFamiTF105193.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030258. MDR1.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24221:SF155. PTHR24221:SF155. 1 hit.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21447-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELEEDLKGR ADKNFSKMGK KSKKEKKEKK PAVSVLTMFR YAGWLDRLYM
60 70 80 90 100
LVGTLAAIIH GVALPLMMLI FGDMTDSFAS VGNVSKNSTN MSEADKRAMF
110 120 130 140 150
AKLEEEMTTY AYYYTGIGAG VLIVAYIQVS FWCLAAGRQI HKIRQKFFHA
160 170 180 190 200
IMNQEIGWFD VHDVGELNTR LTDDVSKINE GIGDKIGMFF QAMATFFGGF
210 220 230 240 250
IIGFTRGWKL TLVILAISPV LGLSAGIWAK ILSSFTDKEL HAYAKAGAVA
260 270 280 290 300
EEVLAAIRTV IAFGGQKKEL ERYNNNLEEA KRLGIKKAIT ANISMGAAFL
310 320 330 340 350
LIYASYALAF WYGTSLVISK EYSIGQVLTV FFSVLIGAFS VGQASPNIEA
360 370 380 390 400
FANARGAAYE VFKIIDNKPS IDSFSKSGHK PDNIQGNLEF KNIHFSYPSR
410 420 430 440 450
KEVQILKGLN LKVKSGQTVA LVGNSGCGKS TTVQLMQRLY DPLDGMVSID
460 470 480 490 500
GQDIRTINVR YLREIIGVVS QEPVLFATTI AENIRYGRED VTMDEIEKAV
510 520 530 540 550
KEANAYDFIM KLPHQFDTLV GERGAQLSGG QKQRIAIARA LVRNPKILLL
560 570 580 590 600
DEATSALDTE SEAVVQAALD KAREGRTTIV IAHRLSTVRN ADVIAGFDGG
610 620 630 640 650
VIVEQGNHDE LMREKGIYFK LVMTQTAGNE IELGNEACKS KDEIDNLDMS
660 670 680 690 700
SKDSGSSLIR RRSTRKSICG PHDQDRKLST KEALDEDVPP ASFWRILKLN
710 720 730 740 750
STEWPYFVVG IFCAIINGGL QPAFSVIFSK VVGVFTNGGP PETQRQNSNL
760 770 780 790 800
FSLLFLILGI ISFITFFLQG FTFGKAGEIL TKRLRYMVFK SMLRQDVSWF
810 820 830 840 850
DDPKNTTGAL TTRLANDAAQ VKGATGSRLA VIFQNIANLG TGIIISLIYG
860 870 880 890 900
WQLTLLLLAI VPIIAIAGVV EMKMLSGQAL KDKKELEGSG KIATEAIENF
910 920 930 940 950
RTVVSLTREQ KFETMYAQSL QIPYRNAMKK AHVFGITFSF TQAMMYFSYA
960 970 980 990 1000
ACFRFGAYLV TQQLMTFENV LLVFSAIVFG AMAVGQVSSF APDYAKATVS
1010 1020 1030 1040 1050
ASHIIRIIEK TPEIDSYSTQ GLKPNMLEGN VQFSGVVFNY PTRPSIPVLQ
1060 1070 1080 1090 1100
GLSLEVKKGQ TLALVGSSGC GKSTVVQLLE RFYDPMAGSV FLDGKEIKQL
1110 1120 1130 1140 1150
NVQWLRAQLG IVSQEPILFD CSIAENIAYG DNSRVVSYEE IVRAAKEANI
1160 1170 1180 1190 1200
HQFIDSLPDK YNTRVGDKGT QLSGGQKQRI AIARALVRQP HILLLDEATS
1210 1220 1230 1240 1250
ALDTESEKVV QEALDKAREG RTCIVIAHRL STIQNADLIV VIQNGKVKEH
1260 1270
GTHQQLLAQK GIYFSMVSVQ AGAKRS
Length:1,276
Mass (Da):140,647
Last modified:June 16, 2009 - v3
Checksum:i542E101DF18DDC52
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti526 – 5272QL → HV in AAA39514 (PubMed:1972547).Curated
Sequence conflicti526 – 5272QL → HV in AAA03243 (PubMed:2473069).Curated
Sequence conflicti939 – 9391S → F in AAA39517 (PubMed:1969610).Curated
Sequence conflicti1036 – 10361V → F in AAA39517 (PubMed:1969610).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30697 mRNA. Translation: AAA39517.1.
M33581 mRNA. Translation: AAA39514.1.
M33580 Genomic DNA. Translation: AAA39518.1.
AY864315 mRNA. Translation: AAW56448.1.
CH466600 Genomic DNA. Translation: EDL14677.1.
M24417 mRNA. Translation: AAA03243.1.
CCDSiCCDS19084.1.
PIRiA34175. DVMS1A.
A34786.
RefSeqiNP_035206.2. NM_011076.2.
XP_006503618.1. XM_006503555.2.
XP_006503619.1. XM_006503556.2.
UniGeneiMm.207354.

Genome annotation databases

EnsembliENSMUST00000047753; ENSMUSP00000041204; ENSMUSG00000040584.
GeneIDi18671.
KEGGimmu:18671.
UCSCiuc008wkl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30697 mRNA. Translation: AAA39517.1.
M33581 mRNA. Translation: AAA39514.1.
M33580 Genomic DNA. Translation: AAA39518.1.
AY864315 mRNA. Translation: AAW56448.1.
CH466600 Genomic DNA. Translation: EDL14677.1.
M24417 mRNA. Translation: AAA03243.1.
CCDSiCCDS19084.1.
PIRiA34175. DVMS1A.
A34786.
RefSeqiNP_035206.2. NM_011076.2.
XP_006503618.1. XM_006503555.2.
XP_006503619.1. XM_006503556.2.
UniGeneiMm.207354.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3G5UX-ray3.80A/B1-1276[»]
3G60X-ray4.40A/B1-1276[»]
3G61X-ray4.35A/B1-1276[»]
4KSBX-ray3.80A1-1276[»]
4KSCX-ray4.00A1-1276[»]
4KSDX-ray4.10A1-1276[»]
4LSGX-ray3.80A/B1-1276[»]
4M1MX-ray3.80A/B1-1276[»]
4M2SX-ray4.40A/B1-1276[»]
4M2TX-ray4.35A/B1-1276[»]
4Q9HX-ray3.40A1-1276[»]
4Q9IX-ray3.78A1-1276[»]
4Q9JX-ray3.60A1-1276[»]
4Q9KX-ray3.80A1-1276[»]
4Q9LX-ray3.80A1-1276[»]
ProteinModelPortaliP21447.
SMRiP21447. Positions 31-626.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP21447. 1 interaction.
MINTiMINT-4101695.
STRINGi10090.ENSMUSP00000041204.

Chemistry

BindingDBiP21447.
ChEMBLiCHEMBL2573.

PTM databases

PhosphoSiteiP21447.

Proteomic databases

MaxQBiP21447.
PaxDbiP21447.
PRIDEiP21447.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047753; ENSMUSP00000041204; ENSMUSG00000040584.
GeneIDi18671.
KEGGimmu:18671.
UCSCiuc008wkl.1. mouse.

Organism-specific databases

CTDi18671.
MGIiMGI:97570. Abcb1a.

Phylogenomic databases

eggNOGiCOG1132.
GeneTreeiENSGT00530000062896.
HOVERGENiHBG080809.
InParanoidiP21447.
KOiK05658.
OMAiRTINVRH.
OrthoDBiEOG7Z3F4H.
PhylomeDBiP21447.
TreeFamiTF105193.

Enzyme and pathway databases

ReactomeiREACT_272600. Abacavir transmembrane transport.
REACT_293350. ABC-family proteins mediated transport.

Miscellaneous databases

EvolutionaryTraceiP21447.
NextBioi294686.
PROiP21447.
SOURCEiSearch...

Gene expression databases

BgeeiP21447.
ExpressionAtlasiP21447. baseline and differential.
GenevisibleiP21447. MM.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030258. MDR1.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24221:SF155. PTHR24221:SF155. 1 hit.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities."
    Devault A., Gros P.
    Mol. Cell. Biol. 10:1652-1663(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structural analysis of the mouse mdr1a (P-glycoprotein) promoter reveals the basis for differential transcript heterogeneity in multidrug-resistant J774.2 cells."
    Hsu S.I.H., Cohen D., Kirschner L.S., Lothstein L., Hartstein M., Horwitz S.B.
    Mol. Cell. Biol. 10:3596-3606(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  3. "Heterologus expression of mouse mdr1a (Abcb1a), (P-glycoprotein), using the insect cell baculovirus expression system."
    Pimprale S.S., Xiao G., Patten C., Crespi C.
    Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells. Evidence that distinct P-glycoprotein precursors are encoded by unique mdr genes."
    Hsu S.I.H., Lothstein L., Horwitz S.B.
    J. Biol. Chem. 264:12053-12062(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 173-1276.
    Strain: BALB/c.
  6. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 273-282, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  7. "Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding."
    Aller S.G., Yu J., Ward A., Weng Y., Chittaboina S., Zhuo R., Harrell P.M., Trinh Y.T., Zhang Q., Urbatsch I.L., Chang G.
    Science 323:1718-1722(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.8 ANGSTROMS) IN COMPLEXES WITH INHIBITORS, FUNCTION, TOPOLOGY.

Entry informationi

Entry nameiMDR1A_MOUSE
AccessioniPrimary (citable) accession number: P21447
Secondary accession number(s): Q5I1Y5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: June 16, 2009
Last modified: June 24, 2015
This is version 140 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

In mouse the MDR gene family includes three or more related but distinct cellular genes.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.