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P21438

- MYC_FLVTT

UniProt

P21438 - MYC_FLVTT

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Protein

Viral myc transforming protein

Gene

MYC

Organism
Feline leukemia virus FTT
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence CAC[GA]TG. Seems to activate the transcription of growth-related genes (By similarity).By similarity

GO - Molecular functioni

  1. E-box binding Source: UniProtKB
  2. protein complex binding Source: UniProtKB
  3. sequence-specific DNA binding transcription factor activity Source: UniProtKB

GO - Biological processi

  1. canonical Wnt signaling pathway Source: UniProtKB
  2. cellular iron ion homeostasis Source: UniProtKB
  3. cellular response to DNA damage stimulus Source: UniProtKB
  4. chromatin remodeling Source: UniProtKB
  5. chromosome organization Source: UniProtKB
  6. MAPK cascade Source: UniProtKB
  7. negative regulation of cell division Source: UniProtKB
  8. negative regulation of monocyte differentiation Source: UniProtKB
  9. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
  10. positive regulation of DNA biosynthetic process Source: UniProtKB
  11. positive regulation of epithelial cell proliferation Source: UniProtKB
  12. positive regulation of fibroblast proliferation Source: UniProtKB
  13. positive regulation of response to DNA damage stimulus Source: UniProtKB
  14. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  15. regulation of telomere maintenance Source: UniProtKB
  16. response to gamma radiation Source: UniProtKB
  17. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Viral myc transforming protein
Short name:
v-Myc
Gene namesi
Name:MYC
OrganismiFeline leukemia virus FTT
Taxonomic identifieri11923 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
Virus hostiFelidae (cat family) [TaxID: 9681]

Subcellular locationi

Host nucleus Curated

GO - Cellular componenti

  1. host cell nucleus Source: UniProtKB-KW
  2. nucleus Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Host nucleus

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 437437Viral myc transforming proteinPRO_0000127312Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP21438.
SMRiP21438. Positions 353-434.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini354 – 40653bHLHPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni413 – 43422Leucine-zipperAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi33 – 375Poly-Gln
Compositional biasi88 – 914Poly-Gly
Compositional biasi253 – 2619Poly-Glu

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR003327. Myc-LZ.
IPR002418. Tscrpt_reg_Myc.
IPR012682. Tscrpt_reg_Myc_N.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
PF02344. Myc-LZ. 1 hit.
PF01056. Myc_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001705. Myc_protein. 1 hit.
PRINTSiPR00044. LEUZIPPRMYC.
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21438-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPLNVSFANR NYDLDYDSVQ PYFYCDEEEN FYQQQQQSEL QPPAPSEDIW
60 70 80 90 100
KKFELLPTPP LSPSRRSGLC SPSYVAFASF SPRGDDDGGG GSFSTADQLE
110 120 130 140 150
MVTELLGGDM VNQSFICDPD DETFIKNIII QDCMWSGFSA AAKLVSEKLA
160 170 180 190 200
SYQAARKDSG SPSPARGPGG CPTSSLYLQD LTAAASECID PSVVFPYPLN
210 220 230 240 250
DSSSPKPCAS PDSAAFSPSS DSLLSSAESS PRASPKPLGL HEETPPTTSS
260 270 280 290 300
DSEEEQEEEE EIDVVSVEKR QPPAKRSESG SPSAGGHSKP PHSPLVLKRC
310 320 330 340 350
HVPTHQHNYA APPSTRKDYP AAKRAKLDSG RVLKQISNNR KCISPRSSDT
360 370 380 390 400
EENDKRRTDN VLERQRRNEL KRSFFALRDQ IPELENNEKA PKVVILKKAT
410 420 430
AYILSVQAGE QKLISEKDLL RKRREQLKHK LEQLRNS
Length:437
Mass (Da):48,309
Last modified:February 1, 1996 - v2
Checksum:i1C39AD24B1CEB4D7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M10973 Genomic DNA. Translation: AAA43059.1. Sequence problems.
M25762 Genomic DNA. Translation: AAA30812.1.
PIRiA26268. TVMVFT.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M10973 Genomic DNA. Translation: AAA43059.1 . Sequence problems.
M25762 Genomic DNA. Translation: AAA30812.1 .
PIRi A26268. TVMVFT.

3D structure databases

ProteinModelPortali P21438.
SMRi P21438. Positions 353-434.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 4.10.280.10. 1 hit.
InterProi IPR011598. bHLH_dom.
IPR003327. Myc-LZ.
IPR002418. Tscrpt_reg_Myc.
IPR012682. Tscrpt_reg_Myc_N.
[Graphical view ]
Pfami PF00010. HLH. 1 hit.
PF02344. Myc-LZ. 1 hit.
PF01056. Myc_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF001705. Myc_protein. 1 hit.
PRINTSi PR00044. LEUZIPPRMYC.
SMARTi SM00353. HLH. 1 hit.
[Graphical view ]
SUPFAMi SSF47459. SSF47459. 1 hit.
PROSITEi PS50888. BHLH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of a transduced myc gene from a defective feline leukemia provirus."
    Braun M.J., Deininger P.L., Casey J.W.
    J. Virol. 55:177-183(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Structure, origin, and transforming activity of feline leukemia virus-myc recombinant provirus FTT."
    Doggett D.L., Drake A.L., Hirsch V., Rowe M.E., Stallard V., Mullins J.I.
    J. Virol. 63:2108-2117(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiMYC_FLVTT
AccessioniPrimary (citable) accession number: P21438
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is synthesized as a Gag-vMyc chimeric protein. The sequence shown here corresponds to the Myc homolog fragment of the chimera.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3