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Protein

Viral myc transforming protein

Gene

MYC

Organism
Feline leukemia virus FTT
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence CAC[GA]TG. Seems to activate the transcription of growth-related genes (By similarity).By similarity

Miscellaneous

This protein is synthesized as a Gag-vMyc chimeric protein. The sequence shown here corresponds to the Myc homolog fragment of the chimera.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Viral myc transforming protein
Short name:
v-Myc
Gene namesi
Name:MYC
OrganismiFeline leukemia virus FTT
Taxonomic identifieri11923 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
Virus hostiFelidae (cat family) [TaxID: 9681]

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001273121 – 437Viral myc transforming proteinAdd BLAST437

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP21438
SMRiP21438
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini354 – 406bHLHPROSITE-ProRule annotationAdd BLAST53

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni413 – 434Leucine-zipperAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi33 – 37Poly-Gln5
Compositional biasi88 – 91Poly-Gly4
Compositional biasi253 – 261Poly-Glu9

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR003327 Myc-LZ
IPR002418 Tscrpt_reg_Myc
IPR012682 Tscrpt_reg_Myc_N
PfamiView protein in Pfam
PF00010 HLH, 1 hit
PF02344 Myc-LZ, 1 hit
PF01056 Myc_N, 1 hit
PIRSFiPIRSF001705 Myc_protein, 1 hit
PRINTSiPR00044 LEUZIPPRMYC
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

P21438-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLNVSFANR NYDLDYDSVQ PYFYCDEEEN FYQQQQQSEL QPPAPSEDIW
60 70 80 90 100
KKFELLPTPP LSPSRRSGLC SPSYVAFASF SPRGDDDGGG GSFSTADQLE
110 120 130 140 150
MVTELLGGDM VNQSFICDPD DETFIKNIII QDCMWSGFSA AAKLVSEKLA
160 170 180 190 200
SYQAARKDSG SPSPARGPGG CPTSSLYLQD LTAAASECID PSVVFPYPLN
210 220 230 240 250
DSSSPKPCAS PDSAAFSPSS DSLLSSAESS PRASPKPLGL HEETPPTTSS
260 270 280 290 300
DSEEEQEEEE EIDVVSVEKR QPPAKRSESG SPSAGGHSKP PHSPLVLKRC
310 320 330 340 350
HVPTHQHNYA APPSTRKDYP AAKRAKLDSG RVLKQISNNR KCISPRSSDT
360 370 380 390 400
EENDKRRTDN VLERQRRNEL KRSFFALRDQ IPELENNEKA PKVVILKKAT
410 420 430
AYILSVQAGE QKLISEKDLL RKRREQLKHK LEQLRNS
Length:437
Mass (Da):48,309
Last modified:February 1, 1996 - v2
Checksum:i1C39AD24B1CEB4D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10973 Genomic DNA Translation: AAA43059.1 Sequence problems.
M25762 Genomic DNA Translation: AAA30812.1
PIRiA26268 TVMVFT

Similar proteinsi

Entry informationi

Entry nameiMYC_FLVTT
AccessioniPrimary (citable) accession number: P21438
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: February 1, 1996
Last modified: April 25, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health