P21438 (MYC_FLVTT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Viral myc transforming protein
Short name=v-Myc

Gene names

Name:

MYC

Organism

Feline leukemia virus FTT

Taxonomic identifier

11923 [NCBI]

Taxonomic lineage

Viruses › Retro-transcribing viruses › Retroviridae › Orthoretrovirinae › Gammaretrovirus › Mammalian virus group › Replication competent viruses › Feline leukemia virus

Virus host

Felidae (cat family) [TaxID: 9681]

Protein attributes

Sequence length	437 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence CAC[GA]TG. Seems to activate the transcription of growth-related genes By similarity.
Subcellular location	Host nucleus Potential.
Miscellaneous	This protein is synthesized as a Gag-vMyc chimeric protein. The sequence shown here corresponds to the Myc homolog fragment of the chimera.
Sequence similarities	Contains 1 bHLH (basic helix-loop-helix) domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Host nucleus
Disease	Oncogene
Ligand	DNA-binding
Molecular function	Activator
Gene Ontology (GO)
Biological_process	MAPK cascade Inferred from sequence or structural similarity. Source: UniProtKB canonical Wnt receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB cellular iron ion homeostasis Inferred from sequence or structural similarity. Source: UniProtKB chromatin remodeling Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of cell division Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of monocyte differentiation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of DNA biosynthetic process Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of epithelial cell proliferation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of fibroblast proliferation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of response to DNA damage stimulus Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of transcription from RNA polymerase II promoter Inferred from sequence or structural similarity. Source: UniProtKB regulation of telomere maintenance Inferred from sequence or structural similarity. Source: UniProtKB response to DNA damage stimulus Inferred from sequence or structural similarity. Source: UniProtKB response to gamma radiation Inferred from sequence or structural similarity. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	host cell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	E-box binding Inferred from sequence or structural similarity. Source: UniProtKB protein complex binding Inferred from sequence or structural similarity. Source: UniProtKB sequence-specific DNA binding transcription factor activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 437	437	Viral myc transforming protein		PRO_0000127312
Regions
	Domain	354 – 406	53	bHLH
	Region	413 – 434	22	Leucine-zipper
	Compositional bias	33 – 37	5	Poly-Gln
	Compositional bias	88 – 91	4	Poly-Gly
	Compositional bias	253 – 261	9	Poly-Glu

Sequences

	Sequence		Length	Mass (Da)
	P21438 [UniParc]. Last modified February 1, 1996. Version 2. Checksum: 1C39AD24B1CEB4D7	FASTA	437	48,309
	10 20 30 40 50 60 MPLNVSFANR NYDLDYDSVQ PYFYCDEEEN FYQQQQQSEL QPPAPSEDIW KKFELLPTPP 70 80 90 100 110 120 LSPSRRSGLC SPSYVAFASF SPRGDDDGGG GSFSTADQLE MVTELLGGDM VNQSFICDPD 130 140 150 160 170 180 DETFIKNIII QDCMWSGFSA AAKLVSEKLA SYQAARKDSG SPSPARGPGG CPTSSLYLQD 190 200 210 220 230 240 LTAAASECID PSVVFPYPLN DSSSPKPCAS PDSAAFSPSS DSLLSSAESS PRASPKPLGL 250 260 270 280 290 300 HEETPPTTSS DSEEEQEEEE EIDVVSVEKR QPPAKRSESG SPSAGGHSKP PHSPLVLKRC 310 320 330 340 350 360 HVPTHQHNYA APPSTRKDYP AAKRAKLDSG RVLKQISNNR KCISPRSSDT EENDKRRTDN 370 380 390 400 410 420 VLERQRRNEL KRSFFALRDQ IPELENNEKA PKVVILKKAT AYILSVQAGE QKLISEKDLL 430 RKRREQLKHK LEQLRNS

References

[1]	"Nucleotide sequence of a transduced myc gene from a defective feline leukemia provirus." Braun M.J., Deininger P.L., Casey J.W. J. Virol. 55:177-183(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Structure, origin, and transforming activity of feline leukemia virus-myc recombinant provirus FTT." Doggett D.L., Drake A.L., Hirsch V., Rowe M.E., Stallard V., Mullins J.I. J. Virol. 63:2108-2117(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M10973 Genomic DNA. Translation: AAA43059.1. Sequence problems. M25762 Genomic DNA. Translation: AAA30812.1.
PIR	TVMVFT. A26268.
3D structure databases
ProteinModelPortal	P21438.
SMR	P21438. Positions 353-434.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	4.10.280.10. 1 hit.
InterPro	IPR011598. bHLH_dom. IPR003327. Myc-LZ. IPR002418. Tscrpt_reg_Myc. IPR012682. Tscrpt_reg_Myc_N. [Graphical view]
Pfam	PF00010. HLH. 1 hit. PF02344. Myc-LZ. 1 hit. PF01056. Myc_N. 1 hit. [Graphical view]
PIRSF	PIRSF001705. Myc_protein. 1 hit.
PRINTS	PR00044. LEUZIPPRMYC.
SMART	SM00353. HLH. 1 hit. [Graphical view]
SUPFAM	SSF47459. HLH_basic. 1 hit.
PROSITE	PS50888. BHLH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MYC_FLVTT

Accession

Primary (citable) accession number: P21438

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
Last sequence update:	February 1, 1996
Last modified:	May 1, 2013
This is version 90 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program