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Protein

Putative outer membrane porin protein NmpC

Gene

nmpC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

GO - Molecular functioni

  • porin activity Source: EcoCyc

GO - Biological processi

  • ion transport Source: UniProtKB-KW
  • transmembrane transport Source: GOC
  • transport Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Porin

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:EG10659-MONOMER.

Protein family/group databases

TCDBi1.B.1.1.4. the general bacterial porin (gbp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative outer membrane porin protein NmpC
Gene namesi
Name:nmpC
Synonyms:phmA
Ordered Locus Names:b0553
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10659. nmpC.

Subcellular locationi

GO - Cellular componenti

  • cell outer membrane Source: EcoCyc
  • pore complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 365342Putative outer membrane porin protein NmpCPRO_0000025248Add
BLAST

Proteomic databases

EPDiP21420.
PRIDEiP21420.

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

IntActiP21420. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP21420.
SMRiP21420. Positions 24-365.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Gram-negative porin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

HOGENOMiHOG000272406.
InParanoidiP21420.
PhylomeDBiP21420.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR001897. Porin_gammaproteobac.
IPR001702. Porin_Gram-ve.
IPR013793. Porin_Gram-ve_CS.
[Graphical view]
PfamiPF00267. Porin_1. 1 hit.
[Graphical view]
PRINTSiPR00183. ECOLIPORIN.
PR00182. ECOLNEIPORIN.
PROSITEiPS00576. GRAM_NEG_PORIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21420-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKLTVAISA VAASVLMAMS AQAAEIYNKD SNKLDLYGKV NAKHYFSSND
60 70 80 90 100
ADDGDTTYAR LGFKGETQIN DQLTGFGQWE YEFKGNRAES QGSSKDKTRL
110 120 130 140 150
AFAGLKFGDY GSIDYGRNYG VAYDIGAWTD VLPEFGGDTW TQTDVFMTQR
160 170 180 190 200
ATGVATYRNN DFFGLVDGLN FAAQYQGKND RSDFDNYTEG NGDGFGFSAT
210 220 230 240 250
YEYEGFGIGA TYAKSDRTDT QVNAGKVLPE VFASGKNAEV WAAGLKYDAN
260 270 280 290 300
NIYLATTYSE TQNMTVFADH FVANKAQNFE AVAQYQFDFG LRPSVAYLQS
310 320 330 340 350
KGKDLGVWGD QDLVKYVDVG ATYYFNKNMS TFVDYKINLL DKNDFTKALG
360
VSTDDIVAVG LVYQF
Length:365
Mass (Da):40,302
Last modified:July 19, 2003 - v2
Checksum:i6A0069D4847FB4FF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti326 – 3261N → K in AAA23728 (PubMed:3017988).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13457 Genomic DNA. Translation: AAA23728.1. Sequence problems.
U82598 Genomic DNA. Translation: AAB40749.1. Sequence problems.
U00096 Genomic DNA. No translation available.
Z35442 Genomic DNA. Translation: CAA84594.1.
X92587 Genomic DNA. Translation: CAA63325.1.
PIRiA25647. MMECNC.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13457 Genomic DNA. Translation: AAA23728.1. Sequence problems.
U82598 Genomic DNA. Translation: AAB40749.1. Sequence problems.
U00096 Genomic DNA. No translation available.
Z35442 Genomic DNA. Translation: CAA84594.1.
X92587 Genomic DNA. Translation: CAA63325.1.
PIRiA25647. MMECNC.

3D structure databases

ProteinModelPortaliP21420.
SMRiP21420. Positions 24-365.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP21420. 1 interaction.

Protein family/group databases

TCDBi1.B.1.1.4. the general bacterial porin (gbp) family.

Proteomic databases

EPDiP21420.
PRIDEiP21420.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

EchoBASEiEB0653.
EcoGeneiEG10659. nmpC.

Phylogenomic databases

HOGENOMiHOG000272406.
InParanoidiP21420.
PhylomeDBiP21420.

Enzyme and pathway databases

BioCyciEcoCyc:EG10659-MONOMER.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR001897. Porin_gammaproteobac.
IPR001702. Porin_Gram-ve.
IPR013793. Porin_Gram-ve_CS.
[Graphical view]
PfamiPF00267. Porin_1. 1 hit.
[Graphical view]
PRINTSiPR00183. ECOLIPORIN.
PR00182. ECOLNEIPORIN.
PROSITEiPS00576. GRAM_NEG_PORIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure of the lc and nmpC outer membrane porin protein genes of lambdoid bacteriophage."
    Blasband A.J., Marcotte W.R. Jr., Schnaitman C.A.
    J. Biol. Chem. 261:12723-12732(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Mutant CS384.
  2. "Sequence of minutes 4-25 of Escherichia coli."
    Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Expression of the nmpC gene of Escherichia coli K-12 is modulated by external pH. Identification of cis-acting regulatory sequences involved in this regulation."
    Coll J.L., Heyde M., Portalier R.
    Mol. Microbiol. 12:83-93(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-17.
    Strain: JL5502.
  5. "Holliday junction resolvases encoded by homologous rusA genes in Escherichia coli K-12 and phage 82."
    Mahdi A.A., Sharples G.J., Mandal T.N., Lloyd R.G.
    J. Mol. Biol. 257:561-573(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 347-365.
    Strain: K12.

Entry informationi

Entry nameiNMPC_ECOLI
AccessioniPrimary (citable) accession number: P21420
Secondary accession number(s): P77189
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: July 19, 2003
Last modified: March 16, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Encoded by the cryptic lambdoid prophage DLP12.

Caution

Could be the product of a pseudogene, as in E.coli K12 the nmpC open reading frame is interrupted by an IS5 insertion and generates a hybrid open reading frame that is not expressed. In strains which have undergone selection for suppressors of ompB mutations (for example, mutant strain CS384) nmpC is expressed.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.