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P21414

- POL_GALV

UniProt

P21414 - POL_GALV

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Protein
Pol polyprotein
Gene
pol
Organism
Gibbon ape leukemia virus (GALV)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
Endonucleolytic cleavage to 5'-phosphomonoester.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei27 – 271 By similarity

GO - Molecular functioni

  1. RNA binding Source: InterPro
  2. RNA-DNA hybrid ribonuclease activity Source: UniProtKB-EC
  3. RNA-directed DNA polymerase activity Source: UniProtKB-KW
  4. aspartic-type endopeptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. DNA integration Source: UniProtKB-KW
  2. DNA recombination Source: UniProtKB-KW
  3. establishment of integrated proviral latency Source: UniProtKB-KW
  4. viral entry into host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Endonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Protease, RNA-directed DNA polymerase, Transferase

Keywords - Biological processi

DNA integration, DNA recombination, Viral genome integration, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Pol polyprotein
Cleaved into the following 3 chains:
Gene namesi
Name:pol
OrganismiGibbon ape leukemia virus (GALV)
Taxonomic identifieri11840 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
Virus hostiHylobatidae (gibbons) [TaxID: 9577]
ProteomesiUP000008231: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 1165IntegrasePRO_0000259721
Chaini1 – 11651165Pol polyprotein
PRO_0000259719Add
BLAST
Chaini1 – 103103Protease
PRO_0000026128Add
BLAST
Chaini106 – ?Reverse transcriptase/ribonuclease HPRO_0000259720

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins.

Structurei

3D structure databases

ProteinModelPortaliP21414.
SMRiP21414. Positions 141-590.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 9271Peptidase A2
Add
BLAST
Domaini199 – 390192Reverse transcriptase
Add
BLAST
Domaini631 – 777147RNase H
Add
BLAST
Domaini872 – 1030159Integrase catalytic
Add
BLAST

Sequence similaritiesi

Contains 1 RNase H domain.

Family and domain databases

Gene3Di2.40.70.10. 1 hit.
3.30.420.10. 2 hits.
InterProiIPR001969. Aspartic_peptidase_AS.
IPR001584. Integrase_cat-core.
IPR018061. Pept_A2A_retrovirus_sg.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR012337. RNaseH-like_dom.
IPR002156. RNaseH_domain.
IPR000477. RT_dom.
[Graphical view]
PfamiPF00075. RNase_H. 1 hit.
PF00665. rve. 1 hit.
PF00077. RVP. 1 hit.
PF00078. RVT_1. 1 hit.
[Graphical view]
SUPFAMiSSF50630. SSF50630. 1 hit.
SSF53098. SSF53098. 2 hits.
PROSITEiPS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50994. INTEGRASE. 1 hit.
PS50879. RNASE_H. 1 hit.
PS50878. RT_POL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21414-1 [UniParc]FASTAAdd to Basket

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GSQGSDPLPE PRVTLTVEGT PIEFLVDTGA EHSVLTQPMG KVGSRRTVVE     50
GATGSKVYPW TTKRLLKIGH KQVTHSFLVI PECPAPLLGR DLLTKLKAQI 100
QFSAEGPQVT WGERPTMCLV LNLEEEYRLH EKPVPSSIDP SWLQLFPTVW 150
AERAGMGLAN QVPPVVVELR SGASPVAVRQ YPMSKEAREG IRPHIQKFLD 200
LGVLVPCRSP WNTPLLPVKK PGTNDYRPVQ DLREINKRVQ DIHPTVPNPY 250
NLLSSLPPSY TWYSVLDLKD AFFCLRLHPN SQPLFAFEWK DPEKGNTGQL 300
TWTRLPQGFK NSPTLFDEAL HRDLAPFRAL NPQVVLLQYV DDLLVAAPTY 350
EDCKKGTQKL LQELSKLGYR VSAKKAQLCQ REVTYLGYLL KEGKRWLTPA 400
RKATVMKIPV PTTPRQVREF LGTAGFCRLW IPGFASLAAP LYPLTKESIP 450
FIWTEEHQQA FDHIKKALLS APALALPDLT KPFTLYIDER AGVARGVLTQ 500
TLGPWRRPVA YLSKKLDPVA SGWPTCLKAV AAVALLLKDA DKLTLGQNVT 550
VIASHSLESI VRQPPDRWMT NARMTHYQSL LLNERVSFAP PAVLNPATLL 600
PVESEATPVH RCSEILAEET GTRRDLEDQP LPGVPTWYTD GSSFITEGKR 650
RAGAPIVDGK RTVWASSLPE GTSAQKAELV ALTQALRLAE GKNINIYTDS 700
RYAFATAHIH GAIYKQRGLL TSAGKDIKNK EEILALLEAI HLPRRVAIIH 750
CPGHQRGSNP VATGNRRADE AAKQAALSTR VLAGTTKPQE PIEPAQEKTR 800
PRELTPDRGK EFIKRLHQLT HLGPEKLLQL VNRTSLLIPN LQSAVREVTS 850
QCQACAMTNA VTTYRETGKR QRGDRPGVYW EVDFTEIKPG RYGNKYLLVF 900
IDTFSGWVEA FPTKTETALI VCKKILEEIL PRFGIPKVLG SDNGPAFVAQ 950
VSQGLATQLG INWKLHCAYR PQSSGQVERM NRTIKETLTK LALETGGKDW 1000
VTLLPLALLR ARNTPGRFGL TPYEILYGGP PPILESGETL GPDDRFLPVL 1050
FTHLKALEIV RTQIWDQIKE VYKPGTVTIP HPFQVGDQVL VRRHRPSSLE 1100
PRWKGPYLVL LTTPTAVKVD GIAAWVHASH LKPAPPSAPD ESWELEKTDH 1150
PLKLRIRRRR DESAK 1165
Length:1,165
Mass (Da):129,887
Last modified:May 1, 1991 - v1
Checksum:i8B7AFD54812B7E1A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M26927 Genomic RNA. Translation: AAA46810.1.
PIRiB32595. GNLJGL.
RefSeqiNP_056790.1. NC_001885.2.

Genome annotation databases

GeneIDi1491893.

Keywords - Coding sequence diversityi

RNA suppression of termination

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M26927 Genomic RNA. Translation: AAA46810.1 .
PIRi B32595. GNLJGL.
RefSeqi NP_056790.1. NC_001885.2.

3D structure databases

ProteinModelPortali P21414.
SMRi P21414. Positions 141-590.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1491893.

Family and domain databases

Gene3Di 2.40.70.10. 1 hit.
3.30.420.10. 2 hits.
InterProi IPR001969. Aspartic_peptidase_AS.
IPR001584. Integrase_cat-core.
IPR018061. Pept_A2A_retrovirus_sg.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR012337. RNaseH-like_dom.
IPR002156. RNaseH_domain.
IPR000477. RT_dom.
[Graphical view ]
Pfami PF00075. RNase_H. 1 hit.
PF00665. rve. 1 hit.
PF00077. RVP. 1 hit.
PF00078. RVT_1. 1 hit.
[Graphical view ]
SUPFAMi SSF50630. SSF50630. 1 hit.
SSF53098. SSF53098. 2 hits.
PROSITEi PS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50994. INTEGRASE. 1 hit.
PS50879. RNASE_H. 1 hit.
PS50878. RT_POL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genetic organization of gibbon ape leukemia virus."
    Delassus S., Sonigo P., Wain-Hobson S.
    Virology 173:205-213(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiPOL_GALV
AccessioniPrimary (citable) accession number: P21414
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: May 14, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is synthesized as a Gag-Pol polyprotein.

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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