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P21414

- POL_GALV

UniProt

P21414 - POL_GALV

Protein

Pol polyprotein

Gene

pol

Organism
Gibbon ape leukemia virus (GALV)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 May 1991)
      Previous versions | rss
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    Functioni

    During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.

    Catalytic activityi

    Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).PROSITE-ProRule annotation
    Endonucleolytic cleavage to 5'-phosphomonoester.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei27 – 271PROSITE-ProRule annotation

    GO - Molecular functioni

    1. aspartic-type endopeptidase activity Source: UniProtKB-KW
    2. RNA binding Source: InterPro
    3. RNA-directed DNA polymerase activity Source: UniProtKB-KW
    4. RNA-DNA hybrid ribonuclease activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA integration Source: UniProtKB-KW
    2. DNA recombination Source: UniProtKB-KW
    3. establishment of integrated proviral latency Source: UniProtKB-KW
    4. viral entry into host cell Source: UniProtKB-KW

    Keywords - Molecular functioni

    Aspartyl protease, Endonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Protease, RNA-directed DNA polymerase, Transferase

    Keywords - Biological processi

    DNA integration, DNA recombination, Viral genome integration, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pol polyprotein
    Cleaved into the following 3 chains:
    Gene namesi
    Name:pol
    OrganismiGibbon ape leukemia virus (GALV)
    Taxonomic identifieri11840 [NCBI]
    Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
    Virus hostiHylobatidae (gibbons) [TaxID: 9577]
    ProteomesiUP000008231: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 1165IntegrasePRO_0000259721
    Chaini1 – 11651165Pol polyproteinPRO_0000259719Add
    BLAST
    Chaini1 – 103103ProteasePRO_0000026128Add
    BLAST
    Chaini106 – ?Reverse transcriptase/ribonuclease HPRO_0000259720

    Post-translational modificationi

    Specific enzymatic cleavages in vivo yield mature proteins.

    Structurei

    3D structure databases

    ProteinModelPortaliP21414.
    SMRiP21414. Positions 141-590.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 9271Peptidase A2PROSITE-ProRule annotationAdd
    BLAST
    Domaini199 – 390192Reverse transcriptasePROSITE-ProRule annotationAdd
    BLAST
    Domaini631 – 777147RNase HPROSITE-ProRule annotationAdd
    BLAST
    Domaini872 – 1030159Integrase catalyticPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the retroviral Pol polyprotein family.Curated
    Contains 1 integrase catalytic domain.PROSITE-ProRule annotation
    Contains 1 peptidase A2 domain.PROSITE-ProRule annotation
    Contains 1 reverse transcriptase domain.PROSITE-ProRule annotation
    Contains 1 RNase H domain.PROSITE-ProRule annotation

    Family and domain databases

    Gene3Di2.40.70.10. 1 hit.
    3.30.420.10. 2 hits.
    InterProiIPR001969. Aspartic_peptidase_AS.
    IPR001584. Integrase_cat-core.
    IPR018061. Pept_A2A_retrovirus_sg.
    IPR001995. Peptidase_A2_cat.
    IPR021109. Peptidase_aspartic_dom.
    IPR012337. RNaseH-like_dom.
    IPR002156. RNaseH_domain.
    IPR000477. RT_dom.
    [Graphical view]
    PfamiPF00075. RNase_H. 1 hit.
    PF00665. rve. 1 hit.
    PF00077. RVP. 1 hit.
    PF00078. RVT_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF50630. SSF50630. 1 hit.
    SSF53098. SSF53098. 2 hits.
    PROSITEiPS50175. ASP_PROT_RETROV. 1 hit.
    PS00141. ASP_PROTEASE. 1 hit.
    PS50994. INTEGRASE. 1 hit.
    PS50879. RNASE_H. 1 hit.
    PS50878. RT_POL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P21414-1 [UniParc]FASTAAdd to Basket

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    GSQGSDPLPE PRVTLTVEGT PIEFLVDTGA EHSVLTQPMG KVGSRRTVVE     50
    GATGSKVYPW TTKRLLKIGH KQVTHSFLVI PECPAPLLGR DLLTKLKAQI 100
    QFSAEGPQVT WGERPTMCLV LNLEEEYRLH EKPVPSSIDP SWLQLFPTVW 150
    AERAGMGLAN QVPPVVVELR SGASPVAVRQ YPMSKEAREG IRPHIQKFLD 200
    LGVLVPCRSP WNTPLLPVKK PGTNDYRPVQ DLREINKRVQ DIHPTVPNPY 250
    NLLSSLPPSY TWYSVLDLKD AFFCLRLHPN SQPLFAFEWK DPEKGNTGQL 300
    TWTRLPQGFK NSPTLFDEAL HRDLAPFRAL NPQVVLLQYV DDLLVAAPTY 350
    EDCKKGTQKL LQELSKLGYR VSAKKAQLCQ REVTYLGYLL KEGKRWLTPA 400
    RKATVMKIPV PTTPRQVREF LGTAGFCRLW IPGFASLAAP LYPLTKESIP 450
    FIWTEEHQQA FDHIKKALLS APALALPDLT KPFTLYIDER AGVARGVLTQ 500
    TLGPWRRPVA YLSKKLDPVA SGWPTCLKAV AAVALLLKDA DKLTLGQNVT 550
    VIASHSLESI VRQPPDRWMT NARMTHYQSL LLNERVSFAP PAVLNPATLL 600
    PVESEATPVH RCSEILAEET GTRRDLEDQP LPGVPTWYTD GSSFITEGKR 650
    RAGAPIVDGK RTVWASSLPE GTSAQKAELV ALTQALRLAE GKNINIYTDS 700
    RYAFATAHIH GAIYKQRGLL TSAGKDIKNK EEILALLEAI HLPRRVAIIH 750
    CPGHQRGSNP VATGNRRADE AAKQAALSTR VLAGTTKPQE PIEPAQEKTR 800
    PRELTPDRGK EFIKRLHQLT HLGPEKLLQL VNRTSLLIPN LQSAVREVTS 850
    QCQACAMTNA VTTYRETGKR QRGDRPGVYW EVDFTEIKPG RYGNKYLLVF 900
    IDTFSGWVEA FPTKTETALI VCKKILEEIL PRFGIPKVLG SDNGPAFVAQ 950
    VSQGLATQLG INWKLHCAYR PQSSGQVERM NRTIKETLTK LALETGGKDW 1000
    VTLLPLALLR ARNTPGRFGL TPYEILYGGP PPILESGETL GPDDRFLPVL 1050
    FTHLKALEIV RTQIWDQIKE VYKPGTVTIP HPFQVGDQVL VRRHRPSSLE 1100
    PRWKGPYLVL LTTPTAVKVD GIAAWVHASH LKPAPPSAPD ESWELEKTDH 1150
    PLKLRIRRRR DESAK 1165
    Length:1,165
    Mass (Da):129,887
    Last modified:May 1, 1991 - v1
    Checksum:i8B7AFD54812B7E1A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M26927 Genomic RNA. Translation: AAA46810.1.
    PIRiB32595. GNLJGL.
    RefSeqiNP_056790.1. NC_001885.2.

    Genome annotation databases

    GeneIDi1491893.

    Keywords - Coding sequence diversityi

    RNA suppression of termination

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M26927 Genomic RNA. Translation: AAA46810.1 .
    PIRi B32595. GNLJGL.
    RefSeqi NP_056790.1. NC_001885.2.

    3D structure databases

    ProteinModelPortali P21414.
    SMRi P21414. Positions 141-590.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1491893.

    Family and domain databases

    Gene3Di 2.40.70.10. 1 hit.
    3.30.420.10. 2 hits.
    InterProi IPR001969. Aspartic_peptidase_AS.
    IPR001584. Integrase_cat-core.
    IPR018061. Pept_A2A_retrovirus_sg.
    IPR001995. Peptidase_A2_cat.
    IPR021109. Peptidase_aspartic_dom.
    IPR012337. RNaseH-like_dom.
    IPR002156. RNaseH_domain.
    IPR000477. RT_dom.
    [Graphical view ]
    Pfami PF00075. RNase_H. 1 hit.
    PF00665. rve. 1 hit.
    PF00077. RVP. 1 hit.
    PF00078. RVT_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50630. SSF50630. 1 hit.
    SSF53098. SSF53098. 2 hits.
    PROSITEi PS50175. ASP_PROT_RETROV. 1 hit.
    PS00141. ASP_PROTEASE. 1 hit.
    PS50994. INTEGRASE. 1 hit.
    PS50879. RNASE_H. 1 hit.
    PS50878. RT_POL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genetic organization of gibbon ape leukemia virus."
      Delassus S., Sonigo P., Wain-Hobson S.
      Virology 173:205-213(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiPOL_GALV
    AccessioniPrimary (citable) accession number: P21414
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: May 1, 1991
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    This protein is synthesized as a Gag-Pol polyprotein.

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3