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P21414

- POL_GALV

UniProt

P21414 - POL_GALV

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Protein

Pol polyprotein

Gene

pol

Organism
Gibbon ape leukemia virus (GALV)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).PROSITE-ProRule annotation
Endonucleolytic cleavage to 5'-phosphomonoester.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei27 – 271PROSITE-ProRule annotation

GO - Molecular functioni

  1. aspartic-type endopeptidase activity Source: UniProtKB-KW
  2. nucleic acid binding Source: InterPro
  3. RNA-directed DNA polymerase activity Source: UniProtKB-KW
  4. RNA-DNA hybrid ribonuclease activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA integration Source: UniProtKB-KW
  2. DNA recombination Source: UniProtKB-KW
  3. establishment of integrated proviral latency Source: UniProtKB-KW
  4. viral entry into host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Endonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Protease, RNA-directed DNA polymerase, Transferase

Keywords - Biological processi

DNA integration, DNA recombination, Viral genome integration, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Pol polyprotein
Cleaved into the following 3 chains:
Gene namesi
Name:pol
OrganismiGibbon ape leukemia virus (GALV)
Taxonomic identifieri11840 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeGammaretrovirus
Virus hostiHylobatidae (gibbons) [TaxID: 9577]
ProteomesiUP000008231: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 1165IntegrasePRO_0000259721
Chaini1 – 11651165Pol polyproteinPRO_0000259719Add
BLAST
Chaini1 – 103103ProteasePRO_0000026128Add
BLAST
Chaini106 – ?Reverse transcriptase/ribonuclease HPRO_0000259720

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins.

Structurei

3D structure databases

ProteinModelPortaliP21414.
SMRiP21414. Positions 141-590.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 9271Peptidase A2PROSITE-ProRule annotationAdd
BLAST
Domaini199 – 390192Reverse transcriptasePROSITE-ProRule annotationAdd
BLAST
Domaini631 – 777147RNase HPROSITE-ProRule annotationAdd
BLAST
Domaini872 – 1030159Integrase catalyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the retroviral Pol polyprotein family.Curated
Contains 1 integrase catalytic domain.PROSITE-ProRule annotation
Contains 1 peptidase A2 domain.PROSITE-ProRule annotation
Contains 1 reverse transcriptase domain.PROSITE-ProRule annotation
Contains 1 RNase H domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di2.40.70.10. 1 hit.
3.30.420.10. 2 hits.
InterProiIPR001969. Aspartic_peptidase_AS.
IPR001584. Integrase_cat-core.
IPR018061. Pept_A2A_retrovirus_sg.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR012337. RNaseH-like_dom.
IPR002156. RNaseH_domain.
IPR000477. RT_dom.
[Graphical view]
PfamiPF00075. RNase_H. 1 hit.
PF00665. rve. 1 hit.
PF00077. RVP. 1 hit.
PF00078. RVT_1. 1 hit.
[Graphical view]
SUPFAMiSSF50630. SSF50630. 1 hit.
SSF53098. SSF53098. 2 hits.
PROSITEiPS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50994. INTEGRASE. 1 hit.
PS50879. RNASE_H. 1 hit.
PS50878. RT_POL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21414-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
GSQGSDPLPE PRVTLTVEGT PIEFLVDTGA EHSVLTQPMG KVGSRRTVVE
60 70 80 90 100
GATGSKVYPW TTKRLLKIGH KQVTHSFLVI PECPAPLLGR DLLTKLKAQI
110 120 130 140 150
QFSAEGPQVT WGERPTMCLV LNLEEEYRLH EKPVPSSIDP SWLQLFPTVW
160 170 180 190 200
AERAGMGLAN QVPPVVVELR SGASPVAVRQ YPMSKEAREG IRPHIQKFLD
210 220 230 240 250
LGVLVPCRSP WNTPLLPVKK PGTNDYRPVQ DLREINKRVQ DIHPTVPNPY
260 270 280 290 300
NLLSSLPPSY TWYSVLDLKD AFFCLRLHPN SQPLFAFEWK DPEKGNTGQL
310 320 330 340 350
TWTRLPQGFK NSPTLFDEAL HRDLAPFRAL NPQVVLLQYV DDLLVAAPTY
360 370 380 390 400
EDCKKGTQKL LQELSKLGYR VSAKKAQLCQ REVTYLGYLL KEGKRWLTPA
410 420 430 440 450
RKATVMKIPV PTTPRQVREF LGTAGFCRLW IPGFASLAAP LYPLTKESIP
460 470 480 490 500
FIWTEEHQQA FDHIKKALLS APALALPDLT KPFTLYIDER AGVARGVLTQ
510 520 530 540 550
TLGPWRRPVA YLSKKLDPVA SGWPTCLKAV AAVALLLKDA DKLTLGQNVT
560 570 580 590 600
VIASHSLESI VRQPPDRWMT NARMTHYQSL LLNERVSFAP PAVLNPATLL
610 620 630 640 650
PVESEATPVH RCSEILAEET GTRRDLEDQP LPGVPTWYTD GSSFITEGKR
660 670 680 690 700
RAGAPIVDGK RTVWASSLPE GTSAQKAELV ALTQALRLAE GKNINIYTDS
710 720 730 740 750
RYAFATAHIH GAIYKQRGLL TSAGKDIKNK EEILALLEAI HLPRRVAIIH
760 770 780 790 800
CPGHQRGSNP VATGNRRADE AAKQAALSTR VLAGTTKPQE PIEPAQEKTR
810 820 830 840 850
PRELTPDRGK EFIKRLHQLT HLGPEKLLQL VNRTSLLIPN LQSAVREVTS
860 870 880 890 900
QCQACAMTNA VTTYRETGKR QRGDRPGVYW EVDFTEIKPG RYGNKYLLVF
910 920 930 940 950
IDTFSGWVEA FPTKTETALI VCKKILEEIL PRFGIPKVLG SDNGPAFVAQ
960 970 980 990 1000
VSQGLATQLG INWKLHCAYR PQSSGQVERM NRTIKETLTK LALETGGKDW
1010 1020 1030 1040 1050
VTLLPLALLR ARNTPGRFGL TPYEILYGGP PPILESGETL GPDDRFLPVL
1060 1070 1080 1090 1100
FTHLKALEIV RTQIWDQIKE VYKPGTVTIP HPFQVGDQVL VRRHRPSSLE
1110 1120 1130 1140 1150
PRWKGPYLVL LTTPTAVKVD GIAAWVHASH LKPAPPSAPD ESWELEKTDH
1160
PLKLRIRRRR DESAK
Length:1,165
Mass (Da):129,887
Last modified:May 1, 1991 - v1
Checksum:i8B7AFD54812B7E1A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M26927 Genomic RNA. Translation: AAA46810.1.
PIRiB32595. GNLJGL.
RefSeqiNP_056790.1. NC_001885.2.

Genome annotation databases

GeneIDi1491893.

Keywords - Coding sequence diversityi

RNA suppression of termination

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M26927 Genomic RNA. Translation: AAA46810.1 .
PIRi B32595. GNLJGL.
RefSeqi NP_056790.1. NC_001885.2.

3D structure databases

ProteinModelPortali P21414.
SMRi P21414. Positions 141-590.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1491893.

Family and domain databases

Gene3Di 2.40.70.10. 1 hit.
3.30.420.10. 2 hits.
InterProi IPR001969. Aspartic_peptidase_AS.
IPR001584. Integrase_cat-core.
IPR018061. Pept_A2A_retrovirus_sg.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
IPR012337. RNaseH-like_dom.
IPR002156. RNaseH_domain.
IPR000477. RT_dom.
[Graphical view ]
Pfami PF00075. RNase_H. 1 hit.
PF00665. rve. 1 hit.
PF00077. RVP. 1 hit.
PF00078. RVT_1. 1 hit.
[Graphical view ]
SUPFAMi SSF50630. SSF50630. 1 hit.
SSF53098. SSF53098. 2 hits.
PROSITEi PS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50994. INTEGRASE. 1 hit.
PS50879. RNASE_H. 1 hit.
PS50878. RT_POL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genetic organization of gibbon ape leukemia virus."
    Delassus S., Sonigo P., Wain-Hobson S.
    Virology 173:205-213(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiPOL_GALV
AccessioniPrimary (citable) accession number: P21414
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: October 29, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is synthesized as a Gag-Pol polyprotein.

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3