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P21414 (POL_GALV) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Pol polyprotein

Cleaved into the following 3 chains:

  1. Protease
    EC=3.4.23.-
  2. Reverse transcriptase/ribonuclease H
    Short name=RT
    EC=2.7.7.49
    EC=3.1.26.4
  3. Integrase
    Short name=IN
Gene names
Name:pol
OrganismGibbon ape leukemia virus (GALV) [Complete proteome]
Taxonomic identifier11840 [NCBI]
Taxonomic lineageViruses › Retro-transcribing viruses › Retroviridae › Orthoretrovirinae › Gammaretrovirus ›
Virus hostHylobatidae (gibbons) [TaxID: 9577]

Protein attributes

Sequence length1165 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.

Catalytic activity

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Endonucleolytic cleavage to 5'-phosphomonoester.

Post-translational modification

Specific enzymatic cleavages in vivo yield mature proteins.

Miscellaneous

This protein is synthesized as a Gag-Pol polyprotein.

Sequence similarities

Belongs to the retroviral Pol polyprotein family.

Contains 1 integrase catalytic domain.

Contains 1 peptidase A2 domain.

Contains 1 reverse transcriptase domain.

Contains 1 RNase H domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11651165Pol polyprotein
PRO_0000259719
Chain1 – 103103Protease
PRO_0000026128
Chain106 – ?Reverse transcriptase/ribonuclease HPRO_0000259720
Chain? – 1165IntegrasePRO_0000259721

Regions

Domain22 – 9271Peptidase A2
Domain199 – 390192Reverse transcriptase
Domain631 – 777147RNase H
Domain872 – 1030159Integrase catalytic

Sites

Active site271 By similarity

Sequences

Sequence LengthMass (Da)Tools
P21414 [UniParc].

Last modified May 1, 1991. Version 1.
Checksum: 8B7AFD54812B7E1A

FASTA1,165129,887
        10         20         30         40         50         60 
GSQGSDPLPE PRVTLTVEGT PIEFLVDTGA EHSVLTQPMG KVGSRRTVVE GATGSKVYPW 

        70         80         90        100        110        120 
TTKRLLKIGH KQVTHSFLVI PECPAPLLGR DLLTKLKAQI QFSAEGPQVT WGERPTMCLV 

       130        140        150        160        170        180 
LNLEEEYRLH EKPVPSSIDP SWLQLFPTVW AERAGMGLAN QVPPVVVELR SGASPVAVRQ 

       190        200        210        220        230        240 
YPMSKEAREG IRPHIQKFLD LGVLVPCRSP WNTPLLPVKK PGTNDYRPVQ DLREINKRVQ 

       250        260        270        280        290        300 
DIHPTVPNPY NLLSSLPPSY TWYSVLDLKD AFFCLRLHPN SQPLFAFEWK DPEKGNTGQL 

       310        320        330        340        350        360 
TWTRLPQGFK NSPTLFDEAL HRDLAPFRAL NPQVVLLQYV DDLLVAAPTY EDCKKGTQKL 

       370        380        390        400        410        420 
LQELSKLGYR VSAKKAQLCQ REVTYLGYLL KEGKRWLTPA RKATVMKIPV PTTPRQVREF 

       430        440        450        460        470        480 
LGTAGFCRLW IPGFASLAAP LYPLTKESIP FIWTEEHQQA FDHIKKALLS APALALPDLT 

       490        500        510        520        530        540 
KPFTLYIDER AGVARGVLTQ TLGPWRRPVA YLSKKLDPVA SGWPTCLKAV AAVALLLKDA 

       550        560        570        580        590        600 
DKLTLGQNVT VIASHSLESI VRQPPDRWMT NARMTHYQSL LLNERVSFAP PAVLNPATLL 

       610        620        630        640        650        660 
PVESEATPVH RCSEILAEET GTRRDLEDQP LPGVPTWYTD GSSFITEGKR RAGAPIVDGK 

       670        680        690        700        710        720 
RTVWASSLPE GTSAQKAELV ALTQALRLAE GKNINIYTDS RYAFATAHIH GAIYKQRGLL 

       730        740        750        760        770        780 
TSAGKDIKNK EEILALLEAI HLPRRVAIIH CPGHQRGSNP VATGNRRADE AAKQAALSTR 

       790        800        810        820        830        840 
VLAGTTKPQE PIEPAQEKTR PRELTPDRGK EFIKRLHQLT HLGPEKLLQL VNRTSLLIPN 

       850        860        870        880        890        900 
LQSAVREVTS QCQACAMTNA VTTYRETGKR QRGDRPGVYW EVDFTEIKPG RYGNKYLLVF 

       910        920        930        940        950        960 
IDTFSGWVEA FPTKTETALI VCKKILEEIL PRFGIPKVLG SDNGPAFVAQ VSQGLATQLG 

       970        980        990       1000       1010       1020 
INWKLHCAYR PQSSGQVERM NRTIKETLTK LALETGGKDW VTLLPLALLR ARNTPGRFGL 

      1030       1040       1050       1060       1070       1080 
TPYEILYGGP PPILESGETL GPDDRFLPVL FTHLKALEIV RTQIWDQIKE VYKPGTVTIP 

      1090       1100       1110       1120       1130       1140 
HPFQVGDQVL VRRHRPSSLE PRWKGPYLVL LTTPTAVKVD GIAAWVHASH LKPAPPSAPD 

      1150       1160 
ESWELEKTDH PLKLRIRRRR DESAK

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References

[1]"Genetic organization of gibbon ape leukemia virus."
Delassus S., Sonigo P., Wain-Hobson S.
Virology 173:205-213(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M26927 Genomic RNA. Translation: AAA46810.1.
PIRGNLJGL. B32595.
RefSeqNP_056790.1. NC_001885.2.

3D structure databases

ProteinModelPortalP21414.
SMRP21414. Positions 141-590.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.40.70.10. 1 hit.
InterProIPR001584. Integrase_cat-core.
IPR018061. Pept_A2A_retrovirus_sg.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic.
IPR001969. Peptidase_aspartic_AS.
IPR012337. RNaseH-like_dom.
IPR002156. RNaseH_domain.
IPR000477. RVT.
[Graphical view]
PfamPF00075. RNase_H. 1 hit.
PF00665. rve. 1 hit.
PF00077. RVP. 1 hit.
PF00078. RVT_1. 1 hit.
[Graphical view]
SUPFAMSSF50630. Pept_Aspartic. 1 hit.
SSF53098. RNaseH_fold. 2 hits.
PROSITEPS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
PS50994. INTEGRASE. 1 hit.
PS50879. RNASE_H. 1 hit.
PS50878. RT_POL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePOL_GALV
AccessionPrimary (citable) accession number: P21414
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: April 3, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

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