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Protein

Fe(3+)-binding periplasmic protein

Gene

fbpA

Organism
Serratia marcescens
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex FbpABC (TC 3.A.1.10.1) involved in Fe3+ ions import. This protein specifically binds Fe3+ and is involved in its transmembrane transport (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi40IronBy similarity1
Metal bindingi88IronBy similarity1
Metal bindingi224IronBy similarity1
Metal bindingi225IronBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron, Metal-binding

Protein family/group databases

TCDBi3.A.1.10.1. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Fe(3+)-binding periplasmic protein
Alternative name(s):
Iron(III)-binding periplasmic protein
Gene namesi
Name:fbpA
Synonyms:sfuA
OrganismiSerratia marcescens
Taxonomic identifieri615 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeSerratia

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000003170427 – 338Fe(3+)-binding periplasmic proteinAdd BLAST312

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (FbpC), two transmembrane proteins (FbpB) and a solute-binding protein (FbpA).Curated

Structurei

Secondary structure

1338
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi33 – 37Combined sources5
Helixi41 – 55Combined sources15
Beta strandi59 – 63Combined sources5
Helixi66 – 76Combined sources11
Helixi77 – 79Combined sources3
Beta strandi83 – 86Combined sources4
Beta strandi88 – 90Combined sources3
Helixi91 – 98Combined sources8
Helixi107 – 110Combined sources4
Helixi115 – 117Combined sources3
Beta strandi123 – 136Combined sources14
Turni138 – 140Combined sources3
Helixi143 – 145Combined sources3
Helixi150 – 154Combined sources5
Helixi156 – 158Combined sources3
Beta strandi161 – 164Combined sources4
Helixi169 – 197Combined sources29
Beta strandi198 – 200Combined sources3
Helixi204 – 212Combined sources9
Beta strandi215 – 222Combined sources8
Helixi224 – 231Combined sources8
Turni235 – 239Combined sources5
Beta strandi241 – 243Combined sources3
Helixi250 – 252Combined sources3
Beta strandi254 – 262Combined sources9
Helixi268 – 279Combined sources12
Helixi281 – 289Combined sources9
Beta strandi290 – 292Combined sources3
Helixi310 – 313Combined sources4
Helixi320 – 322Combined sources3
Helixi325 – 334Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XVYX-ray1.74A30-338[»]
ProteinModelPortaliP21408.
SMRiP21408.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP21408.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR026045. Ferric-bd.
IPR006061. SBP_1_CS.
[Graphical view]
PIRSFiPIRSF002825. CfbpA. 1 hit.
PROSITEiPS01037. SBP_BACTERIAL_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21408-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLRISSLGP VALLASSMML AFGAQAASAD QGIVIYNAQH ENLVKSWVDG
60 70 80 90 100
FTKDTGIKVT LRNGGDSELG NQLVQEGSAS PADVFLTENS PAMVLVDNAK
110 120 130 140 150
LFAPLDAATL AQVEPQYRPS HGRWIGIAAR STVFVYNPAK LSDAQLPKSL
160 170 180 190 200
LDLAKPEWKG RWAASPSGAD FQAIVSALLE LKGEKATLAW LKAMKTNFTA
210 220 230 240 250
YKGNSTVMKA VNAGQVDSGV IYHYYPFVDG AKTGENSNNI KLYYFKHQDP
260 270 280 290 300
GAFVSISGGG VLASSKHQQQ AQAFIKWITG KQGQEILRTN NAFEYAVGVG
310 320 330
AASNPKLVPL KDLDAPKVDA AQLNSKKVVE LMTEAGLL
Length:338
Mass (Da):36,157
Last modified:May 1, 1991 - v1
Checksum:iDD5FAA452301A716
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33815 Genomic DNA. Translation: AAA26573.1.
PIRiA35108. QRSEUA.
RefSeqiWP_016927639.1. NZ_KN050642.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33815 Genomic DNA. Translation: AAA26573.1.
PIRiA35108. QRSEUA.
RefSeqiWP_016927639.1. NZ_KN050642.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XVYX-ray1.74A30-338[»]
ProteinModelPortaliP21408.
SMRiP21408.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi3.A.1.10.1. the atp-binding cassette (abc) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP21408.

Family and domain databases

InterProiIPR026045. Ferric-bd.
IPR006061. SBP_1_CS.
[Graphical view]
PIRSFiPIRSF002825. CfbpA. 1 hit.
PROSITEiPS01037. SBP_BACTERIAL_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFBPA_SERMA
AccessioniPrimary (citable) accession number: P21408
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: November 30, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.