P21408 (FBPA_SERMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fe(3+)-binding periplasmic protein

Alternative name(s):
Iron(III)-binding periplasmic protein

Gene names

Name:	fbpA
Synonyms:	sfuA

Organism

Serratia marcescens

Taxonomic identifier

615 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Serratia

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Part of the ABC transporter complex fbpABC (TC 3.A.1.10.1) involved in Fe3+ ions import. This protein specifically binds Fe3+ and is involved in its transmembrane transport By similarity.
Subunit structure	The complex is composed of two ATP-binding proteins (fbpC), two transmembrane proteins (fbpB) and a solute-binding protein (fbpA) Probable.
Subcellular location	Periplasm Probable.
Sequence similarities	Belongs to the bacterial solute-binding protein 1 family.

Ontologies

Keywords
Biological process	Ion transport Iron transport Transport
Cellular component	Periplasm
Domain	Signal
Ligand	Iron Metal-binding
Technical term	3D-structure
Gene Ontology (GO)
Biological process	ion transport Inferred from electronic annotation. Source: UniProtKB-KW iron ion homeostasis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	periplasmic space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 26

26

Potential

Chain

27 – 338

312

Fe(3+)-binding periplasmic protein

PRO_0000031704

Sites

Metal binding

40

1

Iron By similarity

Metal binding

88

1

Iron By similarity

Metal binding

224

1

Iron By similarity

Metal binding

225

1

Iron By similarity

Secondary structure

1

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338

Helix Strand Turn

Details...

Beta strand

33 – 37

5

Helix

41 – 55

15

Beta strand

59 – 63

5

Helix

66 – 76

11

Helix

77 – 79

3

Beta strand

83 – 86

4

Beta strand

88 – 90

3

Helix

91 – 98

8

Helix

107 – 110

4

Helix

115 – 117

3

Beta strand

123 – 136

14

Turn

138 – 140

3

Helix

143 – 145

3

Helix

150 – 154

5

Helix

156 – 158

3

Beta strand

161 – 164

4

Helix

169 – 197

29

Beta strand

198 – 200

3

Helix

204 – 212

9

Beta strand

215 – 222

8

Helix

224 – 231

8

Turn

235 – 239

5

Beta strand

241 – 243

3

Helix

250 – 252

3

Beta strand

254 – 262

9

Helix

268 – 279

12

Helix

281 – 289

9

Beta strand

290 – 292

3

Helix

310 – 313

4

Helix

320 – 322

3

Helix

325 – 334

10

Sequences

	Sequence		Length	Mass (Da)
	P21408 [UniParc]. Last modified May 1, 1991. Version 1. Checksum: DD5FAA452301A716	FASTA	338	36,157
	10 20 30 40 50 60 MKLRISSLGP VALLASSMML AFGAQAASAD QGIVIYNAQH ENLVKSWVDG FTKDTGIKVT 70 80 90 100 110 120 LRNGGDSELG NQLVQEGSAS PADVFLTENS PAMVLVDNAK LFAPLDAATL AQVEPQYRPS 130 140 150 160 170 180 HGRWIGIAAR STVFVYNPAK LSDAQLPKSL LDLAKPEWKG RWAASPSGAD FQAIVSALLE 190 200 210 220 230 240 LKGEKATLAW LKAMKTNFTA YKGNSTVMKA VNAGQVDSGV IYHYYPFVDG AKTGENSNNI 250 260 270 280 290 300 KLYYFKHQDP GAFVSISGGG VLASSKHQQQ AQAFIKWITG KQGQEILRTN NAFEYAVGVG 310 320 330 AASNPKLVPL KDLDAPKVDA AQLNSKKVVE LMTEAGLL

References

[1]	"Nucleotide sequences of the sfuA, sfuB, and sfuC genes of Serratia marcescens suggest a periplasmic-binding-protein-dependent iron transport mechanism." Angerer A., Gaisser S., Braun V. J. Bacteriol. 172:572-578(1990) [PubMed: 2404942] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M33815 Genomic DNA. Translation: AAA26573.1.

PIR

QRSEUA. A35108.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1XVY	X-ray	1.74	A	30-338	[»]

ProteinModelPortal

P21408.

SMR

P21408. Positions 32-338.

ModBase

Search...

Protein family/group databases

TCDB

3.A.1.10.1. ATP-binding cassette (ABC) superfamily.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

InterPro

IPR006059. Solute-bd_1_bac.
IPR006061. Solute-bd_1_bac_CS.
[Graphical view]

Pfam

PF01547. SBP_bac_1. 1 hit.
[Graphical view]

PROSITE

PS01037. SBP_BACTERIAL_1. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

FBPA_SERMA

Accession

Primary (citable) accession number: P21408

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
Last sequence update:	May 1, 1991
Last modified:	May 31, 2011
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program