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P21401

- GP_RVFVZ

UniProt

P21401 - GP_RVFVZ

Protein

Envelope glycoprotein

Gene

GP

Organism
Rift valley fever virus (strain ZH-548 M12) (RVFV)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 May 1991)
      Previous versions | rss
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    Functioni

    Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei690 – 6912Cleavage; by host signal peptidaseBy similarity

    GO - Biological processi

    1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
    2. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Biological processi

    Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Envelope glycoprotein
    Short name:
    GP
    Alternative name(s):
    M polyprotein
    Cleaved into the following 3 chains:
    Gene namesi
    Name:GP
    OrganismiRift valley fever virus (strain ZH-548 M12) (RVFV)
    Taxonomic identifieri11589 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaePhlebovirus
    Virus hostiAedes [TaxID: 7158]
    Bos taurus (Bovine) [TaxID: 9913]
    Bos taurus x Bison bison (beefalo) [TaxID: 297284]
    Camelus bactrianus (Bactrian camel) [TaxID: 9837]
    Capra hircus (Goat) [TaxID: 9925]
    Homo sapiens (Human) [TaxID: 9606]
    Ovis aries (Sheep) [TaxID: 9940]
    Phlebotomus papatasi (Sandfly) [TaxID: 29031]
    ProteomesiUP000002477: Genome

    Subcellular locationi

    Chain Glycoprotein G1 : Virion membrane Curated; Single-pass type I membrane protein Curated. Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated. Host endoplasmic reticulum membrane Curated; Single-pass type I membrane protein Curated
    Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs.By similarity

    GO - Cellular componenti

    1. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. host cell Golgi membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Chaini17 – 11971181Envelope glycoproteinPRO_0000247010Add
    BLAST
    Chaini17 – 153137Non-structural protein NSmPRO_0000036850Add
    BLAST
    Chaini154 – 690537Glycoprotein G1Sequence AnalysisPRO_0000036851Add
    BLAST
    Chaini691 – 1197507Glycoprotein G2Sequence AnalysisPRO_0000036852Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi88 – 881N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi438 – 4381N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi794 – 7941N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi1035 – 10351N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi1077 – 10771N-linked (GlcNAc...); by hostSequence Analysis

    Post-translational modificationi

    Specific enzymatic cleavages in vivo yield mature proteins including nonstructural protein NSm, glycoprotein G1, and glycoprotein G2.

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiP21401.

    Interactioni

    Subunit structurei

    G1 and G2 interacts with each other.By similarity

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini17 – 582566LumenalSequence AnalysisAdd
    BLAST
    Topological domaini604 – 69087CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini691 – 1159469LumenalSequence AnalysisAdd
    BLAST
    Topological domaini1181 – 119717CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei583 – 60321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1160 – 118021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Family and domain databases

    InterProiIPR016404. M_polyprot_prcur_phlebovir.
    IPR010826. Phlebovirus_G1.
    IPR009878. Phlebovirus_G2.
    IPR009879. Phlebovirus_NSM.
    [Graphical view]
    PfamiPF07243. Phlebovirus_G1. 1 hit.
    PF07245. Phlebovirus_G2. 1 hit.
    PF07246. Phlebovirus_NSM. 2 hits.
    [Graphical view]
    PIRSFiPIRSF003961. M_poly_PhleboV. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P21401-1 [UniParc]FASTAAdd to Basket

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    MYVLLTILTS VLVCEAIIRV SLSSTREETC FGDSTNPEMI EGAWDSLREE     50
    EMPEELSCSI SGIREVKTSS QELYRALKAI IAADGLNNIT CHGKDPEDKI 100
    SLIKGPPHKK RVGIVRCERR RDAKQIGRKT MAGIAMTVLP ALAVFALAPV 150
    VFAEDPHLRN RPGKGHNYID GMTQEDATCK PVTYAGACSS FDVLLEKGKF 200
    PLFQSYAHHR TLLEAVHDTI IAKADPPSCD LLSAHGNPCM KEKLVMKTHC 250
    PNDYQSAHHL NNDGKMASVK CPPKYELTED CNFCRQMTGA SLKKGSYPLQ 300
    DLFCQSSEDD GSKLKTKMKG VCEVGVQALK KCDGQLSTAH EVVPFAVFKN 350
    SKKVYLDKLD LKTEENLLPD SFVCFEHKGQ YKGTMDSGQT KRELKSFDIS 400
    QCPKIGGHGS KKCTGDAAFC SAYECTAQYA NAYCSHANGS GIVQIQVSGV 450
    WKKPLCVGYE RVVVKRELSA KPIQRVEPCT TCITKCEPHG LVVRSTGFKI 500
    SSAVACASGV CVTGSQSPST EITLKYPGIS QSSGGDIGVH MAHDDQSVSS 550
    KIVAHCPPQD PCLVHDCIVC AHGLINYQCH TALSAFVVVF VFSSIAIICL 600
    AILYRVLKCL KIAPRKVLNP LMWITAFIRW IYKKMVARVA DNINQVNREI 650
    GWMEGGQLVL GNPAPIPRHA PIPRYSTYLM LLLIVSYASA CSELIQASSR 700
    ITTCSTEGVN TKCRLSGTAL IRAGSVGAEA CLMLKGVKED QTKFLKLKTV 750
    SSELSCREGQ SYWTGSFSPK CLSSRRCHLV GECHVNRCLS WRDNETSAEF 800
    SFVGESTTMR ENKCFEQCGG WGCGCFNVNP SCLFVHTYLQ SVRKEALRVF 850
    NCIDWVHKLT LEITDFDGSV STIDLGASSS RFTNWGSVSL SLDAEGISGS 900
    NSFSFIESPG KGYAIVDEPF SEIPRQGFLG EIRCNSESSV LSAHESCLRA 950
    PNLISYKPMI DQLECTTNLI DPFVVFERGS LPQTRNDKTF AASKGNRGVQ 1000
    AFSKGSVQAD LTLMFDNFEV DFVGAAVSCD AAFLNLTGCY SCNAGARVCL 1050
    SITSTGTGSL SAHNKDGSLH IVLPSENGTK DQCQILHFTV PEVEEEFMYS 1100
    CDGDERPLLV KGTLIAIDPF DDRREAGGES TVVNPKSGSW NFFDWFSGLM 1150
    SWFGGPLKTI LLICLYVALS IGLFFLLIYL GGTGLSKMWL AATKKAS 1197
    Length:1,197
    Mass (Da):130,805
    Last modified:May 1, 1991 - v1
    Checksum:i860B822CD968767F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M25276 Genomic RNA. Translation: AAA47449.1.
    PIRiA30183. VGVURF.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M25276 Genomic RNA. Translation: AAA47449.1 .
    PIRi A30183. VGVURF.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P21401.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR016404. M_polyprot_prcur_phlebovir.
    IPR010826. Phlebovirus_G1.
    IPR009878. Phlebovirus_G2.
    IPR009879. Phlebovirus_NSM.
    [Graphical view ]
    Pfami PF07243. Phlebovirus_G1. 1 hit.
    PF07245. Phlebovirus_G2. 1 hit.
    PF07246. Phlebovirus_NSM. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF003961. M_poly_PhleboV. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of mutations in the M RNA of a candidate vaccine strain of Rift Valley fever virus."
      Takehara K., Min M.K., Battles J.K., Sugiyama K., Emery V.C., Dalrymple J.M., Bishop D.H.L.
      Virology 169:452-457(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiGP_RVFVZ
    AccessioniPrimary (citable) accession number: P21401
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: May 1, 1991
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3