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P21401 (GP_RVFVZ) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Envelope glycoprotein

Short name=GP
Alternative name(s):
M polyprotein
Gene names
Name:GP
OrganismRift valley fever virus (strain ZH-548 M12) (RVFV) [Reference proteome]
Taxonomic identifier11589 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesBunyaviridaePhlebovirus
Virus hostAedes [TaxID: 7158]
Bos taurus (Bovine) [TaxID: 9913]
Bos taurus x Bison bison (beefalo) [TaxID: 297284]
Camelus bactrianus (Bactrian camel) [TaxID: 9837]
Capra hircus (Goat) [TaxID: 9925]
Homo sapiens (Human) [TaxID: 9606]
Ovis aries (Sheep) [TaxID: 9940]
Phlebotomus papatasi (Sandfly) [TaxID: 29031]

Protein attributes

Sequence length1197 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion By similarity.

Subunit structure

G1 and G2 interacts with each other By similarity.

Subcellular location

Glycoprotein G1: Virion membrane; Single-pass type I membrane protein Potential. Host Golgi apparatus membrane; Single-pass type I membrane protein Potential. Host endoplasmic reticulum membrane; Single-pass type I membrane protein Potential. Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs By similarity.

Glycoprotein G2: Virion membrane; Single-pass type I membrane protein Potential. Host Golgi apparatus membrane; Single-pass type I membrane protein Potential.

Post-translational modification

Specific enzymatic cleavages in vivo yield mature proteins including nonstructural protein NSm, glycoprotein G1, and glycoprotein G2.

Sequence similarities

Belongs to the phlebovirus envelope glycoprotein family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Chain17 – 11971181Envelope glycoprotein
PRO_0000247010
Chain17 – 153137Non-structural protein NSm
PRO_0000036850
Chain154 – 690537Glycoprotein G1 Potential
PRO_0000036851
Chain691 – 1197507Glycoprotein G2 Potential
PRO_0000036852

Regions

Topological domain17 – 582566Lumenal Potential
Transmembrane583 – 60321Helical; Potential
Topological domain604 – 69087Cytoplasmic Potential
Topological domain691 – 1159469Lumenal Potential
Transmembrane1160 – 118021Helical; Potential
Topological domain1181 – 119717Cytoplasmic Potential

Sites

Site690 – 6912Cleavage; by host signal peptidase By similarity

Amino acid modifications

Glycosylation881N-linked (GlcNAc...); by host Potential
Glycosylation4381N-linked (GlcNAc...); by host Potential
Glycosylation7941N-linked (GlcNAc...); by host Potential
Glycosylation10351N-linked (GlcNAc...); by host Potential
Glycosylation10771N-linked (GlcNAc...); by host Potential

Sequences

Sequence LengthMass (Da)Tools
P21401 [UniParc].

Last modified May 1, 1991. Version 1.
Checksum: 860B822CD968767F

FASTA1,197130,805
        10         20         30         40         50         60 
MYVLLTILTS VLVCEAIIRV SLSSTREETC FGDSTNPEMI EGAWDSLREE EMPEELSCSI 

        70         80         90        100        110        120 
SGIREVKTSS QELYRALKAI IAADGLNNIT CHGKDPEDKI SLIKGPPHKK RVGIVRCERR 

       130        140        150        160        170        180 
RDAKQIGRKT MAGIAMTVLP ALAVFALAPV VFAEDPHLRN RPGKGHNYID GMTQEDATCK 

       190        200        210        220        230        240 
PVTYAGACSS FDVLLEKGKF PLFQSYAHHR TLLEAVHDTI IAKADPPSCD LLSAHGNPCM 

       250        260        270        280        290        300 
KEKLVMKTHC PNDYQSAHHL NNDGKMASVK CPPKYELTED CNFCRQMTGA SLKKGSYPLQ 

       310        320        330        340        350        360 
DLFCQSSEDD GSKLKTKMKG VCEVGVQALK KCDGQLSTAH EVVPFAVFKN SKKVYLDKLD 

       370        380        390        400        410        420 
LKTEENLLPD SFVCFEHKGQ YKGTMDSGQT KRELKSFDIS QCPKIGGHGS KKCTGDAAFC 

       430        440        450        460        470        480 
SAYECTAQYA NAYCSHANGS GIVQIQVSGV WKKPLCVGYE RVVVKRELSA KPIQRVEPCT 

       490        500        510        520        530        540 
TCITKCEPHG LVVRSTGFKI SSAVACASGV CVTGSQSPST EITLKYPGIS QSSGGDIGVH 

       550        560        570        580        590        600 
MAHDDQSVSS KIVAHCPPQD PCLVHDCIVC AHGLINYQCH TALSAFVVVF VFSSIAIICL 

       610        620        630        640        650        660 
AILYRVLKCL KIAPRKVLNP LMWITAFIRW IYKKMVARVA DNINQVNREI GWMEGGQLVL 

       670        680        690        700        710        720 
GNPAPIPRHA PIPRYSTYLM LLLIVSYASA CSELIQASSR ITTCSTEGVN TKCRLSGTAL 

       730        740        750        760        770        780 
IRAGSVGAEA CLMLKGVKED QTKFLKLKTV SSELSCREGQ SYWTGSFSPK CLSSRRCHLV 

       790        800        810        820        830        840 
GECHVNRCLS WRDNETSAEF SFVGESTTMR ENKCFEQCGG WGCGCFNVNP SCLFVHTYLQ 

       850        860        870        880        890        900 
SVRKEALRVF NCIDWVHKLT LEITDFDGSV STIDLGASSS RFTNWGSVSL SLDAEGISGS 

       910        920        930        940        950        960 
NSFSFIESPG KGYAIVDEPF SEIPRQGFLG EIRCNSESSV LSAHESCLRA PNLISYKPMI 

       970        980        990       1000       1010       1020 
DQLECTTNLI DPFVVFERGS LPQTRNDKTF AASKGNRGVQ AFSKGSVQAD LTLMFDNFEV 

      1030       1040       1050       1060       1070       1080 
DFVGAAVSCD AAFLNLTGCY SCNAGARVCL SITSTGTGSL SAHNKDGSLH IVLPSENGTK 

      1090       1100       1110       1120       1130       1140 
DQCQILHFTV PEVEEEFMYS CDGDERPLLV KGTLIAIDPF DDRREAGGES TVVNPKSGSW 

      1150       1160       1170       1180       1190 
NFFDWFSGLM SWFGGPLKTI LLICLYVALS IGLFFLLIYL GGTGLSKMWL AATKKAS 

« Hide

References

[1]"Identification of mutations in the M RNA of a candidate vaccine strain of Rift Valley fever virus."
Takehara K., Min M.K., Battles J.K., Sugiyama K., Emery V.C., Dalrymple J.M., Bishop D.H.L.
Virology 169:452-457(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M25276 Genomic RNA. Translation: AAA47449.1.
PIRVGVURF. A30183.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP21401.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR016404. M_polyprot_prcur_phlebovir.
IPR010826. Phlebovirus_G1.
IPR009878. Phlebovirus_G2.
IPR009879. Phlebovirus_NSM.
[Graphical view]
PfamPF07243. Phlebovirus_G1. 1 hit.
PF07245. Phlebovirus_G2. 1 hit.
PF07246. Phlebovirus_NSM. 2 hits.
[Graphical view]
PIRSFPIRSF003961. M_poly_PhleboV. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGP_RVFVZ
AccessionPrimary (citable) accession number: P21401
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: February 19, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families