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P21401

- GP_RVFVZ

UniProt

P21401 - GP_RVFVZ

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Protein
Envelope glycoprotein
Gene
GP
Organism
Rift valley fever virus (strain ZH-548 M12) (RVFV)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei690 – 6912Cleavage; by host signal peptidase By similarity

GO - Biological processi

  1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  2. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein
Short name:
GP
Alternative name(s):
M polyprotein
Cleaved into the following 3 chains:
Gene namesi
Name:GP
OrganismiRift valley fever virus (strain ZH-548 M12) (RVFV)
Taxonomic identifieri11589 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaePhlebovirus
Virus hostiAedes [TaxID: 7158]
Bos taurus (Bovine) [TaxID: 9913]
Bos taurus x Bison bison (beefalo) [TaxID: 297284]
Camelus bactrianus (Bactrian camel) [TaxID: 9837]
Capra hircus (Goat) [TaxID: 9925]
Homo sapiens (Human) [TaxID: 9606]
Ovis aries (Sheep) [TaxID: 9940]
Phlebotomus papatasi (Sandfly) [TaxID: 29031]
ProteomesiUP000002477: Genome

Subcellular locationi

Chain Glycoprotein G1 : Virion membrane; Single-pass type I membrane protein Reviewed prediction. Host Golgi apparatus membrane; Single-pass type I membrane protein Reviewed prediction. Host endoplasmic reticulum membrane; Single-pass type I membrane protein Reviewed prediction
Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 582566Lumenal Reviewed prediction
Add
BLAST
Transmembranei583 – 60321Helical; Reviewed prediction
Add
BLAST
Topological domaini604 – 69087Cytoplasmic Reviewed prediction
Add
BLAST
Topological domaini691 – 1159469Lumenal Reviewed prediction
Add
BLAST
Transmembranei1160 – 118021Helical; Reviewed prediction
Add
BLAST
Topological domaini1181 – 119717Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. host cell Golgi membrane Source: UniProtKB-SubCell
  2. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616 Reviewed prediction
Add
BLAST
Chaini17 – 11971181Envelope glycoprotein
PRO_0000247010Add
BLAST
Chaini17 – 153137Non-structural protein NSm
PRO_0000036850Add
BLAST
Chaini154 – 690537Glycoprotein G1 Reviewed prediction
PRO_0000036851Add
BLAST
Chaini691 – 1197507Glycoprotein G2 Reviewed prediction
PRO_0000036852Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi88 – 881N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi438 – 4381N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi794 – 7941N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi1035 – 10351N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi1077 – 10771N-linked (GlcNAc...); by host Reviewed prediction

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins including nonstructural protein NSm, glycoprotein G1, and glycoprotein G2.

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP21401.

Interactioni

Subunit structurei

G1 and G2 interacts with each other By similarity.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR016404. M_polyprot_prcur_phlebovir.
IPR010826. Phlebovirus_G1.
IPR009878. Phlebovirus_G2.
IPR009879. Phlebovirus_NSM.
[Graphical view]
PfamiPF07243. Phlebovirus_G1. 1 hit.
PF07245. Phlebovirus_G2. 1 hit.
PF07246. Phlebovirus_NSM. 2 hits.
[Graphical view]
PIRSFiPIRSF003961. M_poly_PhleboV. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21401-1 [UniParc]FASTAAdd to Basket

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MYVLLTILTS VLVCEAIIRV SLSSTREETC FGDSTNPEMI EGAWDSLREE     50
EMPEELSCSI SGIREVKTSS QELYRALKAI IAADGLNNIT CHGKDPEDKI 100
SLIKGPPHKK RVGIVRCERR RDAKQIGRKT MAGIAMTVLP ALAVFALAPV 150
VFAEDPHLRN RPGKGHNYID GMTQEDATCK PVTYAGACSS FDVLLEKGKF 200
PLFQSYAHHR TLLEAVHDTI IAKADPPSCD LLSAHGNPCM KEKLVMKTHC 250
PNDYQSAHHL NNDGKMASVK CPPKYELTED CNFCRQMTGA SLKKGSYPLQ 300
DLFCQSSEDD GSKLKTKMKG VCEVGVQALK KCDGQLSTAH EVVPFAVFKN 350
SKKVYLDKLD LKTEENLLPD SFVCFEHKGQ YKGTMDSGQT KRELKSFDIS 400
QCPKIGGHGS KKCTGDAAFC SAYECTAQYA NAYCSHANGS GIVQIQVSGV 450
WKKPLCVGYE RVVVKRELSA KPIQRVEPCT TCITKCEPHG LVVRSTGFKI 500
SSAVACASGV CVTGSQSPST EITLKYPGIS QSSGGDIGVH MAHDDQSVSS 550
KIVAHCPPQD PCLVHDCIVC AHGLINYQCH TALSAFVVVF VFSSIAIICL 600
AILYRVLKCL KIAPRKVLNP LMWITAFIRW IYKKMVARVA DNINQVNREI 650
GWMEGGQLVL GNPAPIPRHA PIPRYSTYLM LLLIVSYASA CSELIQASSR 700
ITTCSTEGVN TKCRLSGTAL IRAGSVGAEA CLMLKGVKED QTKFLKLKTV 750
SSELSCREGQ SYWTGSFSPK CLSSRRCHLV GECHVNRCLS WRDNETSAEF 800
SFVGESTTMR ENKCFEQCGG WGCGCFNVNP SCLFVHTYLQ SVRKEALRVF 850
NCIDWVHKLT LEITDFDGSV STIDLGASSS RFTNWGSVSL SLDAEGISGS 900
NSFSFIESPG KGYAIVDEPF SEIPRQGFLG EIRCNSESSV LSAHESCLRA 950
PNLISYKPMI DQLECTTNLI DPFVVFERGS LPQTRNDKTF AASKGNRGVQ 1000
AFSKGSVQAD LTLMFDNFEV DFVGAAVSCD AAFLNLTGCY SCNAGARVCL 1050
SITSTGTGSL SAHNKDGSLH IVLPSENGTK DQCQILHFTV PEVEEEFMYS 1100
CDGDERPLLV KGTLIAIDPF DDRREAGGES TVVNPKSGSW NFFDWFSGLM 1150
SWFGGPLKTI LLICLYVALS IGLFFLLIYL GGTGLSKMWL AATKKAS 1197
Length:1,197
Mass (Da):130,805
Last modified:May 1, 1991 - v1
Checksum:i860B822CD968767F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M25276 Genomic RNA. Translation: AAA47449.1.
PIRiA30183. VGVURF.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M25276 Genomic RNA. Translation: AAA47449.1 .
PIRi A30183. VGVURF.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P21401.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR016404. M_polyprot_prcur_phlebovir.
IPR010826. Phlebovirus_G1.
IPR009878. Phlebovirus_G2.
IPR009879. Phlebovirus_NSM.
[Graphical view ]
Pfami PF07243. Phlebovirus_G1. 1 hit.
PF07245. Phlebovirus_G2. 1 hit.
PF07246. Phlebovirus_NSM. 2 hits.
[Graphical view ]
PIRSFi PIRSF003961. M_poly_PhleboV. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Identification of mutations in the M RNA of a candidate vaccine strain of Rift Valley fever virus."
    Takehara K., Min M.K., Battles J.K., Sugiyama K., Emery V.C., Dalrymple J.M., Bishop D.H.L.
    Virology 169:452-457(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiGP_RVFVZ
AccessioniPrimary (citable) accession number: P21401
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: February 19, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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