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P21400

- GP_PUUMG

UniProt

P21400 - GP_PUUMG

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Protein
Envelope glycoprotein
Gene
GP
Organism
Puumala virus (strain Bank vole/Russia/CG1820/1984)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion. G1 contains an ITAM motif which is likely to dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei658 – 6592Cleavage; by host signal peptidase By similarity

GO - Biological processi

  1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  2. signal transduction Source: InterPro
  3. suppression by virus of host TRAF activity Source: UniProtKB-KW
  4. suppression by virus of host innate immune response Source: UniProtKB-KW
  5. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host RLR pathway by virus, Inhibition of host TRAFs by virus, Viral attachment to host cell, Viral immunoevasion, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein
Short name:
GP
Alternative name(s):
M polyprotein
Cleaved into the following 2 chains:
Gene namesi
Name:GP
OrganismiPuumala virus (strain Bank vole/Russia/CG1820/1984)
Taxonomic identifieri1337063 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeHantavirus
ProteomesiUP000008481: Genome

Subcellular locationi

Chain Glycoprotein G1 : Virion membrane; Single-pass type I membrane protein Reviewed prediction. Host Golgi apparatus membrane; Single-pass type I membrane protein Reviewed prediction. Host endoplasmic reticulum membrane; Single-pass type I membrane protein Reviewed prediction
Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 495472Lumenal Reviewed prediction
Add
BLAST
Transmembranei496 – 51621Helical; Reviewed prediction
Add
BLAST
Topological domaini517 – 658142Cytoplasmic Reviewed prediction
Add
BLAST
Topological domaini659 – 1114456Lumenal Reviewed prediction
Add
BLAST
Transmembranei1115 – 113521Helical; Reviewed prediction
Add
BLAST
Topological domaini1136 – 114813Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. host cell Golgi membrane Source: UniProtKB-SubCell
  2. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 11481125Envelope glycoprotein
PRO_0000036822Add
BLAST
Chaini24 – 658635Glycoprotein G1 By similarity
PRO_0000036823Add
BLAST
Chaini659 – 1148490Glycoprotein G2 By similarity
PRO_0000036824Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi142 – 1421N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi357 – 3571N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi409 – 4091N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi898 – 8981N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi937 – 9371N-linked (GlcNAc...); by host Reviewed prediction

Post-translational modificationi

Specific enzymatic cleavages yield mature proteins including glycoprotein G1 and glycoprotein G2.

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

G1 and G2 interacts with each other By similarity.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini621 – 64424ITAM
Add
BLAST

Sequence similaritiesi

Contains 1 ITAM domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR016402. Envelope_gylcoprot_Hantavirus.
IPR002534. Hanta_G1.
IPR002532. Hanta_G2.
IPR012316. ITAM_motif_hantavir-typ.
[Graphical view]
PfamiPF01567. Hanta_G1. 1 hit.
PF01561. Hanta_G2. 1 hit.
PF10538. ITAM_Cys-rich. 1 hit.
[Graphical view]
PIRSFiPIRSF003945. M_poly_HantaV. 1 hit.
ProDomiPD001813. Hanta_G2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS51056. ITAM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21400-1 [UniParc]FASTAAdd to Basket

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MGELSPVCLY LLLQGLLLCN TGAARNLNEL KMECPHTIRL GQGLVVGSVE     50
LPSLPIQQVE TLKLESSCNF DLHTSTAGQQ SFTKWTWEIK GDLAENTQAS 100
STSFQTKSSE VNLRGLCLIP TLVVETAARM RKTIACYDLS CNQTVCQPTV 150
YLMGPIQTCI TTKSCLLSLG DQRIQVNYEK TYCVSGDLVE GICFNPIHTM 200
ALSQPSHTYD IMTMMVRCFL VIKKVTSGDS MKIEKNFETL VQKNGCTANN 250
FQGYYICLIG SSSEPLYVPA LDDYRSAEVL SRMAFAPHGE DHDIEKNAVS 300
AMRIAGKVTG KVPSTESSDT VQGIAFSGSP LYTSTGVLTS KDDPVYIWAP 350
GIIMEGNHSI CEKKTLPLTW TGFISLPGEI EKTTQCTVFC TLAGPGADCE 400
AYSETGIFNI SSPTCLINRV QRFRGSEQQI KFVCQRVDMD ITVYCNGMKK 450
VILTKTLVIG QCIYTFTSIF SLIPGVAHSL AVELCVPGLH GWATMLLLLT 500
FCFGWVLIPT ITMILLKILI AFAYLCSKYN TDSKFRILIE KVKREYQKTM 550
GSMVCEVCQY ECETAKELES HRKSCSIGSC PYCLNPSEAT TSALQAHFKV 600
CKLRSRFQEN LRKSLTVYEP MQGCYRTLSL FRYRSRFFVG LVWCVLLVHH 650
LIVWAASAET QNLNAGWTDT AHGSRIIPMK TDLELDFSLQ SSASYTYRRQ 700
LQNPANEQEK IPFHLQLSKQ VIHAEIQHLG HWMDATFNLK TAFHCYGSCE 750
KYAYPWQTAG CFIEKDYEYE TGWGCNPPDC PGVGTGCTAC GVYLDKLKSV 800
GKVFKIVSLR YTRKVCIQLG TEQTCKTVDS NDCLITTSVK VCLIGTISKF 850
QPSDTLLFLG PLQQGGLIFK QWCTTTCQFG DPGDIMSTPT GMKCPELNGS 900
FRKKCAFATT PVCQFDGNTI SGYKRMIATK DSFQSFNVTE PHISTSALEW 950
IDPDSSLRDH INVIVSRDLS FQDLSETPCQ IDLATASIDG AWGSGVGFNL 1000
VCTVSLTECS AFLTSIKACD AAMCYGSTTA NLVRGQNTIH IVGKGGHSGS 1050
KFMCCHDTKC SSTGLVAAAP HLDRVTPYNQ ADSDKIFDDG APECGMSCWF 1100
KKSGEWILGV LNGNWMVVAV LVVLLILSIL LFTLCCPRRP SYRKEHKP 1148
Length:1,148
Mass (Da):126,907
Last modified:August 1, 1992 - v2
Checksum:i52FE60F120C01AAB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M29979 Genomic RNA. No translation available.
PIRiA33077. GNVUNE.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M29979 Genomic RNA. No translation available.
PIRi A33077. GNVUNE.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR016402. Envelope_gylcoprot_Hantavirus.
IPR002534. Hanta_G1.
IPR002532. Hanta_G2.
IPR012316. ITAM_motif_hantavir-typ.
[Graphical view ]
Pfami PF01567. Hanta_G1. 1 hit.
PF01561. Hanta_G2. 1 hit.
PF10538. ITAM_Cys-rich. 1 hit.
[Graphical view ]
PIRSFi PIRSF003945. M_poly_HantaV. 1 hit.
ProDomi PD001813. Hanta_G2. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
PROSITEi PS51056. ITAM_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Determination of the coding capacity of the M genome segment of nephropathia epidemica virus strain Hallnas B1 by molecular cloning and nucleotide sequence analysis."
    Giebel L.B., Stohwasser R., Zoeller L., Bautz E.K.F., Darai G.
    Virology 172:498-505(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Comparison of the deduced gene products of the L, M and S genome segments of hantaviruses."
    Antic D., Kang C.Y., Spik K., Schmaljohn C.S., Vapalahti O., Vaheri A.
    Virus Res. 24:35-46(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION TO 802-803.

Entry informationi

Entry nameiGP_PUUMG
AccessioniPrimary (citable) accession number: P21400
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: August 1, 1992
Last modified: February 19, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Caution

The sequence was wrongly described (1 Publication) as Hallnas B1 strain.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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