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P21400

- GP_PUUMG

UniProt

P21400 - GP_PUUMG

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Protein

Envelope glycoprotein

Gene

GP

Organism
Puumala virus (strain Bank vole/Russia/CG1820/1984)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion. G1 contains an ITAM motif which is likely to dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei658 – 6592Cleavage; by host signal peptidaseBy similarity

GO - Biological processi

  1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  2. signal transduction Source: InterPro
  3. suppression by virus of host innate immune response Source: UniProtKB-KW
  4. suppression by virus of host TRAF activity Source: UniProtKB-KW
  5. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host RLR pathway by virus, Inhibition of host TRAFs by virus, Viral attachment to host cell, Viral immunoevasion, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein
Short name:
GP
Alternative name(s):
M polyprotein
Cleaved into the following 2 chains:
Gene namesi
Name:GP
OrganismiPuumala virus (strain Bank vole/Russia/CG1820/1984)
Taxonomic identifieri1337063 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeHantavirus
ProteomesiUP000008481: Genome

Subcellular locationi

Chain Glycoprotein G1 : Virion membrane Curated; Single-pass type I membrane protein Curated. Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated. Host endoplasmic reticulum membrane Curated; Single-pass type I membrane protein Curated
Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs.By similarity

GO - Cellular componenti

  1. host cell endoplasmic reticulum Source: UniProtKB-KW
  2. host cell Golgi apparatus Source: UniProtKB-KW
  3. host cell membrane Source: UniProtKB-KW
  4. integral component of membrane Source: UniProtKB-KW
  5. virion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 11481125Envelope glycoproteinPRO_0000036822Add
BLAST
Chaini24 – 658635Glycoprotein G1By similarityPRO_0000036823Add
BLAST
Chaini659 – 1148490Glycoprotein G2By similarityPRO_0000036824Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi142 – 1421N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi357 – 3571N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi409 – 4091N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi898 – 8981N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi937 – 9371N-linked (GlcNAc...); by hostSequence Analysis

Post-translational modificationi

Specific enzymatic cleavages yield mature proteins including glycoprotein G1 and glycoprotein G2.

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

G1 and G2 interacts with each other.By similarity

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 495472LumenalSequence AnalysisAdd
BLAST
Topological domaini517 – 658142CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini659 – 1114456LumenalSequence AnalysisAdd
BLAST
Topological domaini1136 – 114813CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei496 – 51621HelicalSequence AnalysisAdd
BLAST
Transmembranei1115 – 113521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini621 – 64424ITAMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ITAM domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR016402. Envelope_gylcoprot_Hantavirus.
IPR002534. Hanta_G1.
IPR002532. Hanta_G2.
IPR012316. ITAM_motif_hantavir-typ.
[Graphical view]
PfamiPF01567. Hanta_G1. 1 hit.
PF01561. Hanta_G2. 1 hit.
PF10538. ITAM_Cys-rich. 1 hit.
[Graphical view]
PIRSFiPIRSF003945. M_poly_HantaV. 1 hit.
ProDomiPD001813. Hanta_G2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS51056. ITAM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21400 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MGELSPVCLY LLLQGLLLCN TGAARNLNEL KMECPHTIRL GQGLVVGSVE
60 70 80 90 100
LPSLPIQQVE TLKLESSCNF DLHTSTAGQQ SFTKWTWEIK GDLAENTQAS
110 120 130 140 150
STSFQTKSSE VNLRGLCLIP TLVVETAARM RKTIACYDLS CNQTVCQPTV
160 170 180 190 200
YLMGPIQTCI TTKSCLLSLG DQRIQVNYEK TYCVSGDLVE GICFNPIHTM
210 220 230 240 250
ALSQPSHTYD IMTMMVRCFL VIKKVTSGDS MKIEKNFETL VQKNGCTANN
260 270 280 290 300
FQGYYICLIG SSSEPLYVPA LDDYRSAEVL SRMAFAPHGE DHDIEKNAVS
310 320 330 340 350
AMRIAGKVTG KVPSTESSDT VQGIAFSGSP LYTSTGVLTS KDDPVYIWAP
360 370 380 390 400
GIIMEGNHSI CEKKTLPLTW TGFISLPGEI EKTTQCTVFC TLAGPGADCE
410 420 430 440 450
AYSETGIFNI SSPTCLINRV QRFRGSEQQI KFVCQRVDMD ITVYCNGMKK
460 470 480 490 500
VILTKTLVIG QCIYTFTSIF SLIPGVAHSL AVELCVPGLH GWATMLLLLT
510 520 530 540 550
FCFGWVLIPT ITMILLKILI AFAYLCSKYN TDSKFRILIE KVKREYQKTM
560 570 580 590 600
GSMVCEVCQY ECETAKELES HRKSCSIGSC PYCLNPSEAT TSALQAHFKV
610 620 630 640 650
CKLRSRFQEN LRKSLTVYEP MQGCYRTLSL FRYRSRFFVG LVWCVLLVHH
660 670 680 690 700
LIVWAASAET QNLNAGWTDT AHGSRIIPMK TDLELDFSLQ SSASYTYRRQ
710 720 730 740 750
LQNPANEQEK IPFHLQLSKQ VIHAEIQHLG HWMDATFNLK TAFHCYGSCE
760 770 780 790 800
KYAYPWQTAG CFIEKDYEYE TGWGCNPPDC PGVGTGCTAC GVYLDKLKSV
810 820 830 840 850
GKVFKIVSLR YTRKVCIQLG TEQTCKTVDS NDCLITTSVK VCLIGTISKF
860 870 880 890 900
QPSDTLLFLG PLQQGGLIFK QWCTTTCQFG DPGDIMSTPT GMKCPELNGS
910 920 930 940 950
FRKKCAFATT PVCQFDGNTI SGYKRMIATK DSFQSFNVTE PHISTSALEW
960 970 980 990 1000
IDPDSSLRDH INVIVSRDLS FQDLSETPCQ IDLATASIDG AWGSGVGFNL
1010 1020 1030 1040 1050
VCTVSLTECS AFLTSIKACD AAMCYGSTTA NLVRGQNTIH IVGKGGHSGS
1060 1070 1080 1090 1100
KFMCCHDTKC SSTGLVAAAP HLDRVTPYNQ ADSDKIFDDG APECGMSCWF
1110 1120 1130 1140
KKSGEWILGV LNGNWMVVAV LVVLLILSIL LFTLCCPRRP SYRKEHKP
Length:1,148
Mass (Da):126,907
Last modified:August 1, 1992 - v2
Checksum:i52FE60F120C01AAB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M29979 Genomic RNA. No translation available.
PIRiA33077. GNVUNE.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M29979 Genomic RNA. No translation available.
PIRi A33077. GNVUNE.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR016402. Envelope_gylcoprot_Hantavirus.
IPR002534. Hanta_G1.
IPR002532. Hanta_G2.
IPR012316. ITAM_motif_hantavir-typ.
[Graphical view ]
Pfami PF01567. Hanta_G1. 1 hit.
PF01561. Hanta_G2. 1 hit.
PF10538. ITAM_Cys-rich. 1 hit.
[Graphical view ]
PIRSFi PIRSF003945. M_poly_HantaV. 1 hit.
ProDomi PD001813. Hanta_G2. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
PROSITEi PS51056. ITAM_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Determination of the coding capacity of the M genome segment of nephropathia epidemica virus strain Hallnas B1 by molecular cloning and nucleotide sequence analysis."
    Giebel L.B., Stohwasser R., Zoeller L., Bautz E.K.F., Darai G.
    Virology 172:498-505(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Comparison of the deduced gene products of the L, M and S genome segments of hantaviruses."
    Antic D., Kang C.Y., Spik K., Schmaljohn C.S., Vapalahti O., Vaheri A.
    Virus Res. 24:35-46(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION TO 802-803.

Entry informationi

Entry nameiGP_PUUMG
AccessioniPrimary (citable) accession number: P21400
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: August 1, 1992
Last modified: October 29, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Caution

The sequence was wrongly described as Hallnas B1 strain.1 Publication

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3