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P21398 (AOFA_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Amine oxidase [flavin-containing] A

EC=1.4.3.4
Alternative name(s):
Monoamine oxidase type A
Short name=MAO-A
Gene names
Name:MAOA
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length527 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.

Catalytic activity

RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.

Cofactor

FAD.

Subunit structure

Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer By similarity.

Subcellular location

Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side.

Sequence similarities

Belongs to the flavin monoamine oxidase family.

Sequence caution

The sequence CAA33633.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 527527Amine oxidase [flavin-containing] A
PRO_0000099847

Regions

Topological domain1 – 497497Cytoplasmic By similarity
Transmembrane498 – 51821Helical; Anchor for type IV membrane protein; By similarity
Topological domain519 – 5279Mitochondrial intermembrane By similarity
Region520 – 5223Interaction with membrane phospholipid headgroups By similarity

Sites

Site3351Important for substrate specificity By similarity
Site3741Important for catalytic activity By similarity

Amino acid modifications

Modified residue11N-acetylmethionine By similarity
Modified residue4061S-8alpha-FAD cysteine By similarity

Experimental info

Sequence conflict3761L → R in CAA33632. Ref.1
Sequence conflict3761L → R in CAA33633. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P21398 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: BC69ED43644DAF37

FASTA52759,758
        10         20         30         40         50         60 
MESLQKTSDA GQMFDVVVIG GGISGLSAAK LLAEHEVNVL VLEARERVGG RTYTVRNEHV 

        70         80         90        100        110        120 
DYVDVGGAYV GPTQNRILRL SKQLGLETYK VNVNERLVHY VKGKTYPFRG AFPPVWNPIA 

       130        140        150        160        170        180 
YLDYNNLWRT MDNMGKEIPA DAPWEAPHAV EWDKMTMKDL IEKICWTKTA RQFASLFVNI 

       190        200        210        220        230        240 
NVTSEPHEVS ALWFLWYVKQ CGGTTRIFSI TNGGQERKFV GGSGQVSERI MQLLGDRVKL 

       250        260        270        280        290        300 
RSPVTYVDQS SENITVETLN RELYECRYVI SAIPPTLTAK IHFRPELPSE RNQLIQRLPM 

       310        320        330        340        350        360 
GAVIKCMMYY KEAFWKKKDY CGCMIIEDEE APISITLDDT KPDGSLPAIM GFILARKADR 

       370        380        390        400        410        420 
LAKVHKDIRK RKICELYAKV LGSQEALHPV HYEEKNWCQE QYSGGCYTAY FPPGIMTQYG 

       430        440        450        460        470        480 
RVIRQPVGRI YFAGTETATQ WSGYMEGAVE AGERAAREVL NALGKLSAKD IWIQEPEAED 

       490        500        510        520 
VPAVEITPSF WERNLPSVSG LLKIVGFSTS ITALWFVMYR FRLLSRS 

« Hide

References

« Hide 'large scale' references
[1]"The primary structure of bovine monoamine oxidase type A. Comparison with peptide sequences of bovine monoamine oxidase type B and other flavoenzymes."
Powell J.F., Hsu Y.-P.P., Weyler W., Chen S.A., Salach J., Andrikopoulos K., Mallet J., Breakefield X.O.
Biochem. J. 259:407-413(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Thalamus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X15609 mRNA. Translation: CAA33632.1.
X15609 mRNA. Translation: CAA33633.1. Different initiation.
BC122682 mRNA. Translation: AAI22683.1.
PIRS03974.
RefSeqNP_851357.2. NM_181014.2.
UniGeneBt.91572.

3D structure databases

ProteinModelPortalP21398.
SMRP21398. Positions 12-524.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBP21398.
ChEMBLCHEMBL3254.

Proteomic databases

PaxDbP21398.
PRIDEP21398.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000021570; ENSBTAP00000021570; ENSBTAG00000016206.
GeneID281293.
KEGGbta:281293.

Organism-specific databases

CTD4128.

Phylogenomic databases

eggNOGCOG1231.
GeneTreeENSGT00730000110903.
HOGENOMHOG000221615.
HOVERGENHBG004255.
InParanoidP21398.
KOK00274.
OMAMEITHTF.
OrthoDBEOG7K6PTP.
TreeFamTF313314.

Enzyme and pathway databases

BRENDA1.4.3.4. 908.

Family and domain databases

InterProIPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
[Graphical view]
PfamPF01593. Amino_oxidase. 1 hit.
[Graphical view]
PRINTSPR00757. AMINEOXDASEF.
ProtoNetSearch...

Other

NextBio20805322.

Entry information

Entry nameAOFA_BOVIN
AccessionPrimary (citable) accession number: P21398
Secondary accession number(s): Q0IIE7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families