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P21398

- AOFA_BOVIN

UniProt

P21398 - AOFA_BOVIN

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Protein

Amine oxidase [flavin-containing] A

Gene
MAOA
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.

Catalytic activityi

RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.

Cofactori

FAD.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei335 – 3351Important for substrate specificity By similarity
Sitei374 – 3741Important for catalytic activity By similarity

GO - Molecular functioni

  1. oxidoreductase activity Source: UniProtKB-KW

GO - Biological processi

  1. dopamine catabolic process Source: Ensembl
  2. neurotransmitter catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Catecholamine metabolism, Neurotransmitter degradation

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BRENDAi1.4.3.4. 908.
ReactomeiREACT_209234. Enzymatic degradation of dopamine by COMT.
REACT_215107. Enzymatic degradation of Dopamine by monoamine oxidase.
REACT_223515. Monoamines are oxidized to aldehydes by MAOA and MAOB, producing NH3 and H2O2.
REACT_224508. Norepinephrine Neurotransmitter Release Cycle.
REACT_227135. Metabolism of serotonin.

Names & Taxonomyi

Protein namesi
Recommended name:
Amine oxidase [flavin-containing] A (EC:1.4.3.4)
Alternative name(s):
Monoamine oxidase type A
Short name:
MAO-A
Gene namesi
Name:MAOA
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome X

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 497497Cytoplasmic By similarityAdd
BLAST
Transmembranei498 – 51821Helical; Anchor for type IV membrane protein; By similarityAdd
BLAST
Topological domaini519 – 5279Mitochondrial intermembrane By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial outer membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 527527Amine oxidase [flavin-containing] APRO_0000099847Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity
Modified residuei406 – 4061S-8alpha-FAD cysteine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP21398.
PRIDEiP21398.

Interactioni

Subunit structurei

Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer By similarity.

Structurei

3D structure databases

ProteinModelPortaliP21398.
SMRiP21398. Positions 12-524.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni520 – 5223Interaction with membrane phospholipid headgroups By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1231.
GeneTreeiENSGT00730000110903.
HOGENOMiHOG000221615.
HOVERGENiHBG004255.
InParanoidiP21398.
KOiK00274.
OMAiMEITHTF.
OrthoDBiEOG7K6PTP.
TreeFamiTF313314.

Family and domain databases

InterProiIPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
PRINTSiPR00757. AMINEOXDASEF.

Sequencei

Sequence statusi: Complete.

P21398-1 [UniParc]FASTAAdd to Basket

« Hide

MESLQKTSDA GQMFDVVVIG GGISGLSAAK LLAEHEVNVL VLEARERVGG    50
RTYTVRNEHV DYVDVGGAYV GPTQNRILRL SKQLGLETYK VNVNERLVHY 100
VKGKTYPFRG AFPPVWNPIA YLDYNNLWRT MDNMGKEIPA DAPWEAPHAV 150
EWDKMTMKDL IEKICWTKTA RQFASLFVNI NVTSEPHEVS ALWFLWYVKQ 200
CGGTTRIFSI TNGGQERKFV GGSGQVSERI MQLLGDRVKL RSPVTYVDQS 250
SENITVETLN RELYECRYVI SAIPPTLTAK IHFRPELPSE RNQLIQRLPM 300
GAVIKCMMYY KEAFWKKKDY CGCMIIEDEE APISITLDDT KPDGSLPAIM 350
GFILARKADR LAKVHKDIRK RKICELYAKV LGSQEALHPV HYEEKNWCQE 400
QYSGGCYTAY FPPGIMTQYG RVIRQPVGRI YFAGTETATQ WSGYMEGAVE 450
AGERAAREVL NALGKLSAKD IWIQEPEAED VPAVEITPSF WERNLPSVSG 500
LLKIVGFSTS ITALWFVMYR FRLLSRS 527
Length:527
Mass (Da):59,758
Last modified:January 23, 2007 - v2
Checksum:iBC69ED43644DAF37
GO

Sequence cautioni

The sequence CAA33633.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti376 – 3761L → R in CAA33632. 1 Publication
Sequence conflicti376 – 3761L → R in CAA33633. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15609 mRNA. Translation: CAA33632.1.
X15609 mRNA. Translation: CAA33633.1. Different initiation.
BC122682 mRNA. Translation: AAI22683.1.
PIRiS03974.
RefSeqiNP_851357.2. NM_181014.2.
UniGeneiBt.91572.

Genome annotation databases

EnsembliENSBTAT00000021570; ENSBTAP00000021570; ENSBTAG00000016206.
GeneIDi281293.
KEGGibta:281293.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15609 mRNA. Translation: CAA33632.1 .
X15609 mRNA. Translation: CAA33633.1 . Different initiation.
BC122682 mRNA. Translation: AAI22683.1 .
PIRi S03974.
RefSeqi NP_851357.2. NM_181014.2.
UniGenei Bt.91572.

3D structure databases

ProteinModelPortali P21398.
SMRi P21398. Positions 12-524.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi P21398.
ChEMBLi CHEMBL3254.

Proteomic databases

PaxDbi P21398.
PRIDEi P21398.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000021570 ; ENSBTAP00000021570 ; ENSBTAG00000016206 .
GeneIDi 281293.
KEGGi bta:281293.

Organism-specific databases

CTDi 4128.

Phylogenomic databases

eggNOGi COG1231.
GeneTreei ENSGT00730000110903.
HOGENOMi HOG000221615.
HOVERGENi HBG004255.
InParanoidi P21398.
KOi K00274.
OMAi MEITHTF.
OrthoDBi EOG7K6PTP.
TreeFami TF313314.

Enzyme and pathway databases

BRENDAi 1.4.3.4. 908.
Reactomei REACT_209234. Enzymatic degradation of dopamine by COMT.
REACT_215107. Enzymatic degradation of Dopamine by monoamine oxidase.
REACT_223515. Monoamines are oxidized to aldehydes by MAOA and MAOB, producing NH3 and H2O2.
REACT_224508. Norepinephrine Neurotransmitter Release Cycle.
REACT_227135. Metabolism of serotonin.

Miscellaneous databases

NextBioi 20805322.

Family and domain databases

InterProi IPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
[Graphical view ]
Pfami PF01593. Amino_oxidase. 1 hit.
[Graphical view ]
PRINTSi PR00757. AMINEOXDASEF.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The primary structure of bovine monoamine oxidase type A. Comparison with peptide sequences of bovine monoamine oxidase type B and other flavoenzymes."
    Powell J.F., Hsu Y.-P.P., Weyler W., Chen S.A., Salach J., Andrikopoulos K., Mallet J., Breakefield X.O.
    Biochem. J. 259:407-413(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Thalamus.

Entry informationi

Entry nameiAOFA_BOVIN
AccessioniPrimary (citable) accession number: P21398
Secondary accession number(s): Q0IIE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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