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P21398

- AOFA_BOVIN

UniProt

P21398 - AOFA_BOVIN

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Protein

Amine oxidase [flavin-containing] A

Gene

MAOA

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.

Catalytic activityi

RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.

Cofactori

FAD.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei335 – 3351Important for substrate specificityBy similarity
Sitei374 – 3741Important for catalytic activityBy similarity

GO - Molecular functioni

  1. primary amine oxidase activity Source: Ensembl

GO - Biological processi

  1. dopamine catabolic process Source: Ensembl
  2. neurotransmitter catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Catecholamine metabolism, Neurotransmitter degradation

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BRENDAi1.4.3.4. 908.
ReactomeiREACT_209234. Enzymatic degradation of dopamine by COMT.
REACT_215107. Enzymatic degradation of Dopamine by monoamine oxidase.
REACT_223515. Monoamines are oxidized to aldehydes by MAOA and MAOB, producing NH3 and H2O2.
REACT_224508. Norepinephrine Neurotransmitter Release Cycle.
REACT_227135. Metabolism of serotonin.

Names & Taxonomyi

Protein namesi
Recommended name:
Amine oxidase [flavin-containing] A (EC:1.4.3.4)
Alternative name(s):
Monoamine oxidase type A
Short name:
MAO-A
Gene namesi
Name:MAOA
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome X

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial outer membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 527527Amine oxidase [flavin-containing] APRO_0000099847Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei406 – 4061S-8alpha-FAD cysteineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP21398.
PRIDEiP21398.

Expressioni

Gene expression databases

ExpressionAtlasiP21398. baseline.

Interactioni

Subunit structurei

Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP21398.
SMRiP21398. Positions 12-524.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 497497CytoplasmicBy similarityAdd
BLAST
Topological domaini519 – 5279Mitochondrial intermembraneBy similarity

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei498 – 51821Helical; Anchor for type IV membrane proteinBy similarityAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni520 – 5223Interaction with membrane phospholipid headgroupsBy similarity

Sequence similaritiesi

Belongs to the flavin monoamine oxidase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1231.
GeneTreeiENSGT00730000110903.
HOGENOMiHOG000221615.
HOVERGENiHBG004255.
InParanoidiP21398.
KOiK00274.
OMAiMEITHTF.
OrthoDBiEOG7K6PTP.
TreeFamiTF313314.

Family and domain databases

InterProiIPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
PRINTSiPR00757. AMINEOXDASEF.

Sequencei

Sequence statusi: Complete.

P21398-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESLQKTSDA GQMFDVVVIG GGISGLSAAK LLAEHEVNVL VLEARERVGG
60 70 80 90 100
RTYTVRNEHV DYVDVGGAYV GPTQNRILRL SKQLGLETYK VNVNERLVHY
110 120 130 140 150
VKGKTYPFRG AFPPVWNPIA YLDYNNLWRT MDNMGKEIPA DAPWEAPHAV
160 170 180 190 200
EWDKMTMKDL IEKICWTKTA RQFASLFVNI NVTSEPHEVS ALWFLWYVKQ
210 220 230 240 250
CGGTTRIFSI TNGGQERKFV GGSGQVSERI MQLLGDRVKL RSPVTYVDQS
260 270 280 290 300
SENITVETLN RELYECRYVI SAIPPTLTAK IHFRPELPSE RNQLIQRLPM
310 320 330 340 350
GAVIKCMMYY KEAFWKKKDY CGCMIIEDEE APISITLDDT KPDGSLPAIM
360 370 380 390 400
GFILARKADR LAKVHKDIRK RKICELYAKV LGSQEALHPV HYEEKNWCQE
410 420 430 440 450
QYSGGCYTAY FPPGIMTQYG RVIRQPVGRI YFAGTETATQ WSGYMEGAVE
460 470 480 490 500
AGERAAREVL NALGKLSAKD IWIQEPEAED VPAVEITPSF WERNLPSVSG
510 520
LLKIVGFSTS ITALWFVMYR FRLLSRS
Length:527
Mass (Da):59,758
Last modified:January 23, 2007 - v2
Checksum:iBC69ED43644DAF37
GO

Sequence cautioni

The sequence CAA33633.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti376 – 3761L → R in CAA33632. (PubMed:2719656)Curated
Sequence conflicti376 – 3761L → R in CAA33633. (PubMed:2719656)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15609 mRNA. Translation: CAA33632.1.
X15609 mRNA. Translation: CAA33633.1. Different initiation.
BC122682 mRNA. Translation: AAI22683.1.
PIRiS03974.
RefSeqiNP_851357.2. NM_181014.2.
UniGeneiBt.91572.

Genome annotation databases

EnsembliENSBTAT00000021570; ENSBTAP00000021570; ENSBTAG00000016206.
GeneIDi281293.
KEGGibta:281293.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15609 mRNA. Translation: CAA33632.1 .
X15609 mRNA. Translation: CAA33633.1 . Different initiation.
BC122682 mRNA. Translation: AAI22683.1 .
PIRi S03974.
RefSeqi NP_851357.2. NM_181014.2.
UniGenei Bt.91572.

3D structure databases

ProteinModelPortali P21398.
SMRi P21398. Positions 12-524.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi P21398.
ChEMBLi CHEMBL2111399.

Proteomic databases

PaxDbi P21398.
PRIDEi P21398.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000021570 ; ENSBTAP00000021570 ; ENSBTAG00000016206 .
GeneIDi 281293.
KEGGi bta:281293.

Organism-specific databases

CTDi 4128.

Phylogenomic databases

eggNOGi COG1231.
GeneTreei ENSGT00730000110903.
HOGENOMi HOG000221615.
HOVERGENi HBG004255.
InParanoidi P21398.
KOi K00274.
OMAi MEITHTF.
OrthoDBi EOG7K6PTP.
TreeFami TF313314.

Enzyme and pathway databases

BRENDAi 1.4.3.4. 908.
Reactomei REACT_209234. Enzymatic degradation of dopamine by COMT.
REACT_215107. Enzymatic degradation of Dopamine by monoamine oxidase.
REACT_223515. Monoamines are oxidized to aldehydes by MAOA and MAOB, producing NH3 and H2O2.
REACT_224508. Norepinephrine Neurotransmitter Release Cycle.
REACT_227135. Metabolism of serotonin.

Miscellaneous databases

NextBioi 20805322.

Gene expression databases

ExpressionAtlasi P21398. baseline.

Family and domain databases

InterProi IPR002937. Amino_oxidase.
IPR001613. Flavin_amine_oxidase.
[Graphical view ]
Pfami PF01593. Amino_oxidase. 1 hit.
[Graphical view ]
PRINTSi PR00757. AMINEOXDASEF.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The primary structure of bovine monoamine oxidase type A. Comparison with peptide sequences of bovine monoamine oxidase type B and other flavoenzymes."
    Powell J.F., Hsu Y.-P.P., Weyler W., Chen S.A., Salach J., Andrikopoulos K., Mallet J., Breakefield X.O.
    Biochem. J. 259:407-413(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Thalamus.

Entry informationi

Entry nameiAOFA_BOVIN
AccessioniPrimary (citable) accession number: P21398
Secondary accession number(s): Q0IIE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3