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Protein

Amine oxidase [flavin-containing] A

Gene

MAOA

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.

Catalytic activityi

RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei335Important for substrate specificityBy similarity1
Sitei374Important for catalytic activityBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCatecholamine metabolism, Neurotransmitter degradation
LigandFAD, Flavoprotein

Enzyme and pathway databases

BRENDAi1.4.3.4 908
ReactomeiR-BTA-141333 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB
R-BTA-181430 Norepinephrine Neurotransmitter Release Cycle
R-BTA-379397 Enzymatic degradation of dopamine by COMT
R-BTA-379398 Enzymatic degradation of Dopamine by monoamine oxidase
R-BTA-380612 Metabolism of serotonin

Names & Taxonomyi

Protein namesi
Recommended name:
Amine oxidase [flavin-containing] A (EC:1.4.3.4)
Alternative name(s):
Monoamine oxidase type A
Short name:
MAO-A
Gene namesi
Name:MAOA
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome X

Organism-specific databases

VGNCiVGNC:31174 MAOA

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 497CytoplasmicBy similarityAdd BLAST497
Transmembranei498 – 518Helical; Anchor for type IV membrane proteinBy similarityAdd BLAST21
Topological domaini519 – 527Mitochondrial intermembraneBy similarity9

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3254

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000998471 – 527Amine oxidase [flavin-containing] AAdd BLAST527

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei383PhosphoserineBy similarity1
Modified residuei406S-8alpha-FAD cysteineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP21398
PeptideAtlasiP21398
PRIDEiP21398

Expressioni

Gene expression databases

BgeeiENSBTAG00000016206

Interactioni

Subunit structurei

Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021570

Chemistry databases

BindingDBiP21398

Structurei

3D structure databases

ProteinModelPortaliP21398
SMRiP21398
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni520 – 522Interaction with membrane phospholipid headgroupsBy similarity3

Sequence similaritiesi

Belongs to the flavin monoamine oxidase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0029 Eukaryota
ENOG410XSNC LUCA
GeneTreeiENSGT00730000110903
HOGENOMiHOG000221615
HOVERGENiHBG004255
InParanoidiP21398
KOiK00274
OMAiEWTRGAY
OrthoDBiEOG091G0G7P
TreeFamiTF313314

Family and domain databases

Gene3Di3.50.50.604 hits
InterProiView protein in InterPro
IPR002937 Amino_oxidase
IPR036188 FAD/NAD-bd_sf
IPR001613 Flavin_amine_oxidase
PfamiView protein in Pfam
PF01593 Amino_oxidase, 1 hit
PRINTSiPR00757 AMINEOXDASEF
SUPFAMiSSF51905 SSF51905, 2 hits

Sequencei

Sequence statusi: Complete.

P21398-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESLQKTSDA GQMFDVVVIG GGISGLSAAK LLAEHEVNVL VLEARERVGG
60 70 80 90 100
RTYTVRNEHV DYVDVGGAYV GPTQNRILRL SKQLGLETYK VNVNERLVHY
110 120 130 140 150
VKGKTYPFRG AFPPVWNPIA YLDYNNLWRT MDNMGKEIPA DAPWEAPHAV
160 170 180 190 200
EWDKMTMKDL IEKICWTKTA RQFASLFVNI NVTSEPHEVS ALWFLWYVKQ
210 220 230 240 250
CGGTTRIFSI TNGGQERKFV GGSGQVSERI MQLLGDRVKL RSPVTYVDQS
260 270 280 290 300
SENITVETLN RELYECRYVI SAIPPTLTAK IHFRPELPSE RNQLIQRLPM
310 320 330 340 350
GAVIKCMMYY KEAFWKKKDY CGCMIIEDEE APISITLDDT KPDGSLPAIM
360 370 380 390 400
GFILARKADR LAKVHKDIRK RKICELYAKV LGSQEALHPV HYEEKNWCQE
410 420 430 440 450
QYSGGCYTAY FPPGIMTQYG RVIRQPVGRI YFAGTETATQ WSGYMEGAVE
460 470 480 490 500
AGERAAREVL NALGKLSAKD IWIQEPEAED VPAVEITPSF WERNLPSVSG
510 520
LLKIVGFSTS ITALWFVMYR FRLLSRS
Length:527
Mass (Da):59,758
Last modified:January 23, 2007 - v2
Checksum:iBC69ED43644DAF37
GO

Sequence cautioni

The sequence CAA33633 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti376L → R in CAA33632 (PubMed:2719656).Curated1
Sequence conflicti376L → R in CAA33633 (PubMed:2719656).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15609 mRNA Translation: CAA33632.1
X15609 mRNA Translation: CAA33633.1 Different initiation.
BC122682 mRNA Translation: AAI22683.1
PIRiS03974
RefSeqiNP_851357.2, NM_181014.2
UniGeneiBt.91572

Genome annotation databases

EnsembliENSBTAT00000021570; ENSBTAP00000021570; ENSBTAG00000016206
GeneIDi281293
KEGGibta:281293

Similar proteinsi

Entry informationi

Entry nameiAOFA_BOVIN
AccessioniPrimary (citable) accession number: P21398
Secondary accession number(s): Q0IIE7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome