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P21398

- AOFA_BOVIN

UniProt

P21398 - AOFA_BOVIN

Protein

Amine oxidase [flavin-containing] A

Gene

MAOA

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.

    Catalytic activityi

    RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2.

    Cofactori

    FAD.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei335 – 3351Important for substrate specificityBy similarity
    Sitei374 – 3741Important for catalytic activityBy similarity

    GO - Molecular functioni

    1. oxidoreductase activity Source: UniProtKB-KW

    GO - Biological processi

    1. dopamine catabolic process Source: Ensembl
    2. neurotransmitter catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Catecholamine metabolism, Neurotransmitter degradation

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    BRENDAi1.4.3.4. 908.
    ReactomeiREACT_209234. Enzymatic degradation of dopamine by COMT.
    REACT_215107. Enzymatic degradation of Dopamine by monoamine oxidase.
    REACT_223515. Monoamines are oxidized to aldehydes by MAOA and MAOB, producing NH3 and H2O2.
    REACT_224508. Norepinephrine Neurotransmitter Release Cycle.
    REACT_227135. Metabolism of serotonin.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Amine oxidase [flavin-containing] A (EC:1.4.3.4)
    Alternative name(s):
    Monoamine oxidase type A
    Short name:
    MAO-A
    Gene namesi
    Name:MAOA
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome X

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial outer membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 527527Amine oxidase [flavin-containing] APRO_0000099847Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei406 – 4061S-8alpha-FAD cysteineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiP21398.
    PRIDEiP21398.

    Interactioni

    Subunit structurei

    Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP21398.
    SMRiP21398. Positions 12-524.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 497497CytoplasmicBy similarityAdd
    BLAST
    Topological domaini519 – 5279Mitochondrial intermembraneBy similarity

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei498 – 51821Helical; Anchor for type IV membrane proteinBy similarityAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni520 – 5223Interaction with membrane phospholipid headgroupsBy similarity

    Sequence similaritiesi

    Belongs to the flavin monoamine oxidase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1231.
    GeneTreeiENSGT00730000110903.
    HOGENOMiHOG000221615.
    HOVERGENiHBG004255.
    InParanoidiP21398.
    KOiK00274.
    OMAiMEITHTF.
    OrthoDBiEOG7K6PTP.
    TreeFamiTF313314.

    Family and domain databases

    InterProiIPR002937. Amino_oxidase.
    IPR001613. Flavin_amine_oxidase.
    [Graphical view]
    PfamiPF01593. Amino_oxidase. 1 hit.
    [Graphical view]
    PRINTSiPR00757. AMINEOXDASEF.

    Sequencei

    Sequence statusi: Complete.

    P21398-1 [UniParc]FASTAAdd to Basket

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    MESLQKTSDA GQMFDVVVIG GGISGLSAAK LLAEHEVNVL VLEARERVGG    50
    RTYTVRNEHV DYVDVGGAYV GPTQNRILRL SKQLGLETYK VNVNERLVHY 100
    VKGKTYPFRG AFPPVWNPIA YLDYNNLWRT MDNMGKEIPA DAPWEAPHAV 150
    EWDKMTMKDL IEKICWTKTA RQFASLFVNI NVTSEPHEVS ALWFLWYVKQ 200
    CGGTTRIFSI TNGGQERKFV GGSGQVSERI MQLLGDRVKL RSPVTYVDQS 250
    SENITVETLN RELYECRYVI SAIPPTLTAK IHFRPELPSE RNQLIQRLPM 300
    GAVIKCMMYY KEAFWKKKDY CGCMIIEDEE APISITLDDT KPDGSLPAIM 350
    GFILARKADR LAKVHKDIRK RKICELYAKV LGSQEALHPV HYEEKNWCQE 400
    QYSGGCYTAY FPPGIMTQYG RVIRQPVGRI YFAGTETATQ WSGYMEGAVE 450
    AGERAAREVL NALGKLSAKD IWIQEPEAED VPAVEITPSF WERNLPSVSG 500
    LLKIVGFSTS ITALWFVMYR FRLLSRS 527
    Length:527
    Mass (Da):59,758
    Last modified:January 23, 2007 - v2
    Checksum:iBC69ED43644DAF37
    GO

    Sequence cautioni

    The sequence CAA33633.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti376 – 3761L → R in CAA33632. (PubMed:2719656)Curated
    Sequence conflicti376 – 3761L → R in CAA33633. (PubMed:2719656)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15609 mRNA. Translation: CAA33632.1.
    X15609 mRNA. Translation: CAA33633.1. Different initiation.
    BC122682 mRNA. Translation: AAI22683.1.
    PIRiS03974.
    RefSeqiNP_851357.2. NM_181014.2.
    UniGeneiBt.91572.

    Genome annotation databases

    EnsembliENSBTAT00000021570; ENSBTAP00000021570; ENSBTAG00000016206.
    GeneIDi281293.
    KEGGibta:281293.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15609 mRNA. Translation: CAA33632.1 .
    X15609 mRNA. Translation: CAA33633.1 . Different initiation.
    BC122682 mRNA. Translation: AAI22683.1 .
    PIRi S03974.
    RefSeqi NP_851357.2. NM_181014.2.
    UniGenei Bt.91572.

    3D structure databases

    ProteinModelPortali P21398.
    SMRi P21398. Positions 12-524.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi P21398.
    ChEMBLi CHEMBL3254.

    Proteomic databases

    PaxDbi P21398.
    PRIDEi P21398.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000021570 ; ENSBTAP00000021570 ; ENSBTAG00000016206 .
    GeneIDi 281293.
    KEGGi bta:281293.

    Organism-specific databases

    CTDi 4128.

    Phylogenomic databases

    eggNOGi COG1231.
    GeneTreei ENSGT00730000110903.
    HOGENOMi HOG000221615.
    HOVERGENi HBG004255.
    InParanoidi P21398.
    KOi K00274.
    OMAi MEITHTF.
    OrthoDBi EOG7K6PTP.
    TreeFami TF313314.

    Enzyme and pathway databases

    BRENDAi 1.4.3.4. 908.
    Reactomei REACT_209234. Enzymatic degradation of dopamine by COMT.
    REACT_215107. Enzymatic degradation of Dopamine by monoamine oxidase.
    REACT_223515. Monoamines are oxidized to aldehydes by MAOA and MAOB, producing NH3 and H2O2.
    REACT_224508. Norepinephrine Neurotransmitter Release Cycle.
    REACT_227135. Metabolism of serotonin.

    Miscellaneous databases

    NextBioi 20805322.

    Family and domain databases

    InterProi IPR002937. Amino_oxidase.
    IPR001613. Flavin_amine_oxidase.
    [Graphical view ]
    Pfami PF01593. Amino_oxidase. 1 hit.
    [Graphical view ]
    PRINTSi PR00757. AMINEOXDASEF.
    ProtoNeti Search...

    Publicationsi

    1. "The primary structure of bovine monoamine oxidase type A. Comparison with peptide sequences of bovine monoamine oxidase type B and other flavoenzymes."
      Powell J.F., Hsu Y.-P.P., Weyler W., Chen S.A., Salach J., Andrikopoulos K., Mallet J., Breakefield X.O.
      Biochem. J. 259:407-413(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Thalamus.

    Entry informationi

    Entry nameiAOFA_BOVIN
    AccessioniPrimary (citable) accession number: P21398
    Secondary accession number(s): Q0IIE7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3