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Protein

NAD(+) kinase

Gene

UTR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Specifically phosphorylates NAD in the presence of ATP, dATP, or CTP as phosphoryl donors.1 Publication

Miscellaneous

Present with 5040 molecules/cell in log phase SD medium.1 Publication

Caution

Was briefly thought to be FRE2.Curated

Catalytic activityi

ATP + NAD+ = ADP + NADP+.

Kineticsi

  1. KM=0.50 mM for NAD1 Publication
  2. KM=0.60 mM for ATP1 Publication

    pH dependencei

    Optimum pH is 8.0.1 Publication

    GO - Molecular functioni

    • ATP binding Source: UniProtKB-KW
    • NAD+ kinase activity Source: SGD
    • NADH kinase activity Source: SGD

    GO - Biological processi

    • cellular iron ion homeostasis Source: SGD
    • NAD metabolic process Source: InterPro
    • NADP biosynthetic process Source: SGD

    Keywordsi

    Molecular functionKinase, Transferase
    LigandATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:G3O-31684-MONOMER
    YEAST:G3O-31684-MONOMER
    BRENDAi2.7.1.23 984
    ReactomeiR-SCE-196807 Nicotinate metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD(+) kinase (EC:2.7.1.23)
    Alternative name(s):
    Unknown transcript 1 protein
    Gene namesi
    Name:UTR1
    Ordered Locus Names:YJR049C
    ORF Names:J1655
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    Proteomesi
    • UP000002311 Componenti: Chromosome X

    Organism-specific databases

    EuPathDBiFungiDB:YJR049C
    SGDiS000003810 UTR1

    Subcellular locationi

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00001207161 – 530NAD(+) kinaseAdd BLAST530

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei499PhosphoserineCombined sources1
    Modified residuei503PhosphoserineCombined sources1

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP21373
    PaxDbiP21373
    PRIDEiP21373

    PTM databases

    iPTMnetiP21373

    Interactioni

    Subunit structurei

    Homohexamer.1 Publication

    Protein-protein interaction databases

    BioGridi33802, 85 interactors
    DIPiDIP-4479N
    IntActiP21373, 5 interactors
    MINTiP21373
    STRINGi4932.YJR049C

    Structurei

    3D structure databases

    ProteinModelPortaliP21373
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.Curated

    Phylogenomic databases

    GeneTreeiENSGT00390000013792
    HOGENOMiHOG000176769
    InParanoidiP21373
    KOiK00858
    OMAiIHNKLYC
    OrthoDBiEOG092C2G28

    Family and domain databases

    Gene3Di2.60.200.30, 1 hit
    HAMAPiMF_00361 NAD_kinase, 1 hit
    InterProiView protein in InterPro
    IPR017437 ATP-NAD_kinase_PpnK-typ_C
    IPR016064 NAD/diacylglycerol_kinase_sf
    IPR002504 NADK
    PANTHERiPTHR20275 PTHR20275, 1 hit
    PfamiView protein in Pfam
    PF01513 NAD_kinase, 1 hit
    SUPFAMiSSF111331 SSF111331, 1 hit

    Sequencei

    Sequence statusi: Complete.

    P21373-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MKENDMNNGV DKWVNEEDGR NDHHNNNNNL MKKAMMNNEQ IDRTQDIDNA
    60 70 80 90 100
    KEMLRKISSE SSSRRSSLLN KDSSLVNGNA NSGGGTSING TRGSSKSSNT
    110 120 130 140 150
    HFQYASTAYG VRMLSKDISN TKVELDVENL MIVTKLNDVS LYFLTRELVE
    160 170 180 190 200
    WVLVHFPRVT VYVDSELKNS KKFAAGELCE DSKCRESRIK YWTKDFIREH
    210 220 230 240 250
    DVFFDLVVTL GGDGTVLFVS SIFQRHVPPV MSFSLGSLGF LTNFKFEHFR
    260 270 280 290 300
    EDLPRIMNHK IKTNLRLRLE CTIYRRHRPE VDPNTGKKIC VVEKLSTHHI
    310 320 330 340 350
    LNEVTIDRGP SPFLSMLELY GDGSLMTVAQ ADGLIAATPT GSTAYSLSAG
    360 370 380 390 400
    GSLVCPTVNA IALTPICPHA LSFRPIILPE SINLKVKVSM KSRAPAWAAF
    410 420 430 440 450
    DGKDRIELQK GDFITICASP YAFPTVEASP DEFINSISRQ LNWNVREQQK
    460 470 480 490 500
    SFTHILSQKN QEKYAHEANK VRNQAEPLEV IRDKYSLEAD ATKENNNGSD
    510 520 530
    DESDDESVNC EACKLKPSSV PKPSQARFSV
    Length:530
    Mass (Da):59,469
    Last modified:February 1, 1995 - v2
    Checksum:i1BF4F01D7213B94B
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti337A → V in AAT92918 (PubMed:17322287).Curated1

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB044344 Genomic DNA Translation: BAB83863.1
    L26347 Genomic DNA Translation: AAA62857.1
    L36344 Genomic DNA Translation: AAA88752.1
    M37696 Genomic DNA No translation available.
    Z49549 Genomic DNA Translation: CAA89577.1
    AY692899 Genomic DNA Translation: AAT92918.1
    BK006943 Genomic DNA Translation: DAA08836.1
    PIRiS46589
    RefSeqiNP_012583.1, NM_001181707.1

    Genome annotation databases

    EnsemblFungiiYJR049C; YJR049C; YJR049C
    GeneIDi853508
    KEGGisce:YJR049C

    Similar proteinsi

    Entry informationi

    Entry nameiUTR1_YEAST
    AccessioniPrimary (citable) accession number: P21373
    Secondary accession number(s): D6VWM0, E9P8Y8, Q54AD8
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: February 1, 1995
    Last modified: March 28, 2018
    This is version 151 of the entry and version 2 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

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