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Protein

UPF0259 membrane protein YciC

Gene

yciC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciEcoCyc:EG11123-MONOMER.
ECOL316407:JW1247-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0259 membrane protein YciC
Gene namesi
Name:yciC
Ordered Locus Names:b1255, JW1247
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11123. yciC.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919CytoplasmicSequence analysisAdd
BLAST
Transmembranei20 – 4021HelicalSequence analysisAdd
BLAST
Topological domaini41 – 8646PeriplasmicSequence analysisAdd
BLAST
Transmembranei87 – 10721HelicalSequence analysisAdd
BLAST
Topological domaini108 – 11710CytoplasmicSequence analysis
Transmembranei118 – 14023HelicalSequence analysisAdd
BLAST
Topological domaini141 – 15111PeriplasmicSequence analysisAdd
BLAST
Transmembranei152 – 17221HelicalSequence analysisAdd
BLAST
Topological domaini173 – 18614CytoplasmicSequence analysisAdd
BLAST
Transmembranei187 – 20923HelicalSequence analysisAdd
BLAST
Topological domaini210 – 22415PeriplasmicSequence analysisAdd
BLAST
Transmembranei225 – 24521HelicalSequence analysisAdd
BLAST
Topological domaini246 – 2472CytoplasmicSequence analysis

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 247247UPF0259 membrane protein YciCPRO_0000206514Add
BLAST

Proteomic databases

PaxDbiP21365.

Interactioni

Protein-protein interaction databases

BioGridi4262999. 21 interactions.
STRINGi511145.b1255.

Structurei

3D structure databases

ProteinModelPortaliP21365.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0259 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108S3I. Bacteria.
ENOG410XRTM. LUCA.
OMAiFFRNQFV.
OrthoDBiEOG6XM7B7.

Family and domain databases

HAMAPiMF_01067. UPF0259.
InterProiIPR009627. UPF0259.
[Graphical view]
PfamiPF06790. UPF0259. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21365-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSITAQSVYR DTGNFFRNQF MTILLVSLLC AFITVVLGHV FSPSDAQLAQ
60 70 80 90 100
LNDGVPVSGS SGLFDLVQNM SPEQQQILLQ ASAASTFSGL IGNAILAGGV
110 120 130 140 150
ILIIQLVSAG QRVSALRAIG ASAPILPKLF ILIFLTTLLV QIGIMLVVVP
160 170 180 190 200
GIIMAILLAL APVMLVQDKM GVFASMRSSM RLTWANMRLV APAVLSWLLA
210 220 230 240
KTLLLLFASS FAALTPEIGA VLANTLSNLI SAILLIYLFR LYMLIRQ
Length:247
Mass (Da):26,419
Last modified:July 11, 2003 - v2
Checksum:iC2750BF3A8ECF069
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti100 – 11415VILII…GQRVS → RNINYPAGVCGSESQ (PubMed:3058546).CuratedAdd
BLAST
Sequence conflicti100 – 11415VILII…GQRVS → RNINYPAGVCGSESQ (Ref. 2) CuratedAdd
BLAST
Sequence conflicti191 – 1911A → T (PubMed:3058546).Curated
Sequence conflicti191 – 1911A → T (Ref. 2) Curated
Sequence conflicti202 – 2021T → P (PubMed:3058546).Curated
Sequence conflicti202 – 2021T → P (Ref. 2) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti26 – 261V → I in strain: ECOR 52.
Natural varianti46 – 461A → V in strain: ECOR 31.
Natural varianti65 – 651D → N in strain: ECOR 16.
Natural varianti119 – 1191I → V in strain: ECOR 60.
Natural varianti172 – 1721V → I in strain: ECOR 16, ECOR 28, ECOR 31, ECOR 37, ECOR 50 and ECOR 71.
Natural varianti233 – 2331I → V in strain: ECOR 31, ECOR 46, ECOR 50, ECOR 52 and ECOR 60.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13583 Genomic DNA. Translation: CAA31923.1.
U24195 Genomic DNA. Translation: AAB60066.1.
U24196 Genomic DNA. Translation: AAB60074.1.
U24197 Genomic DNA. Translation: AAB60082.1.
U24198 Genomic DNA. Translation: AAB60090.1.
U24199 Genomic DNA. Translation: AAB60098.1.
U24200 Genomic DNA. Translation: AAB60106.1.
U24201 Genomic DNA. Translation: AAB60114.1.
U24202 Genomic DNA. Translation: AAB60122.1.
U24203 Genomic DNA. Translation: AAB60130.1.
U24204 Genomic DNA. Translation: AAB60138.1.
U24205 Genomic DNA. Translation: AAB60146.1.
U24206 Genomic DNA. Translation: AAB60154.1.
U00096 Genomic DNA. Translation: AAC74337.1.
AP009048 Genomic DNA. Translation: BAA14787.1.
PIRiB64873.
T45502.
RefSeqiNP_415771.1. NC_000913.3.
WP_000028545.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74337; AAC74337; b1255.
BAA14787; BAA14787; BAA14787.
GeneIDi945844.
KEGGiecj:JW1247.
eco:b1255.
PATRICi32117770. VBIEscCol129921_1305.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13583 Genomic DNA. Translation: CAA31923.1.
U24195 Genomic DNA. Translation: AAB60066.1.
U24196 Genomic DNA. Translation: AAB60074.1.
U24197 Genomic DNA. Translation: AAB60082.1.
U24198 Genomic DNA. Translation: AAB60090.1.
U24199 Genomic DNA. Translation: AAB60098.1.
U24200 Genomic DNA. Translation: AAB60106.1.
U24201 Genomic DNA. Translation: AAB60114.1.
U24202 Genomic DNA. Translation: AAB60122.1.
U24203 Genomic DNA. Translation: AAB60130.1.
U24204 Genomic DNA. Translation: AAB60138.1.
U24205 Genomic DNA. Translation: AAB60146.1.
U24206 Genomic DNA. Translation: AAB60154.1.
U00096 Genomic DNA. Translation: AAC74337.1.
AP009048 Genomic DNA. Translation: BAA14787.1.
PIRiB64873.
T45502.
RefSeqiNP_415771.1. NC_000913.3.
WP_000028545.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP21365.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262999. 21 interactions.
STRINGi511145.b1255.

Proteomic databases

PaxDbiP21365.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74337; AAC74337; b1255.
BAA14787; BAA14787; BAA14787.
GeneIDi945844.
KEGGiecj:JW1247.
eco:b1255.
PATRICi32117770. VBIEscCol129921_1305.

Organism-specific databases

EchoBASEiEB1113.
EcoGeneiEG11123. yciC.

Phylogenomic databases

eggNOGiENOG4108S3I. Bacteria.
ENOG410XRTM. LUCA.
OMAiFFRNQFV.
OrthoDBiEOG6XM7B7.

Enzyme and pathway databases

BioCyciEcoCyc:EG11123-MONOMER.
ECOL316407:JW1247-MONOMER.

Miscellaneous databases

PROiP21365.

Family and domain databases

HAMAPiMF_01067. UPF0259.
InterProiIPR009627. UPF0259.
[Graphical view]
PfamiPF06790. UPF0259. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular evolution of the Escherichia coli chromosome. I. Analysis of structure and natural variation in a previously uncharacterized region between trp and tonB."
    Stoltzfus A., Leslie J.F., Milkman R.
    Genetics 120:345-358(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. Milkman R.
    Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ECOR 1, ECOR 16, ECOR 28, ECOR 31, ECOR 37, ECOR 4, ECOR 46, ECOR 52, ECOR 60, ECOR 71, K12 and O2:HN / ECOR 50 / P97 / UPEC.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  5. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  6. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiYCIC_ECOLI
AccessioniPrimary (citable) accession number: P21365
Secondary accession number(s): P77207
, P94718, P94724, P94727, P94731, P94734, P94737, P97230
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: July 11, 2003
Last modified: January 20, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.