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P21360

- MASY_PICAN

UniProt

P21360 - MASY_PICAN

Protein

Malate synthase, glyoxysomal

Gene

MAS

Organism
Pichia angusta (Yeast) (Hansenula polymorpha)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 May 1991)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei179 – 1791Proton acceptorBy similarity
    Active sitei460 – 4601Proton donorBy similarity

    GO - Molecular functioni

    1. malate synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-UniPathway
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Glyoxylate bypass, Tricarboxylic acid cycle

    Enzyme and pathway databases

    UniPathwayiUPA00703; UER00720.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate synthase, glyoxysomal (EC:2.3.3.9)
    Gene namesi
    Name:MAS
    OrganismiPichia angusta (Yeast) (Hansenula polymorpha)
    Taxonomic identifieri870730 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetales incertae sedisOgataea

    Subcellular locationi

    GO - Cellular componenti

    1. glyoxysome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Glyoxysome, Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 555555Malate synthase, glyoxysomalPRO_0000166863Add
    BLAST

    Expressioni

    Inductioni

    By ethanol.

    Structurei

    3D structure databases

    ProteinModelPortaliP21360.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the malate synthase family.Curated

    Phylogenomic databases

    PhylomeDBiP21360.

    Family and domain databases

    InterProiIPR011076. Malate_synth-like.
    IPR006252. Malate_synthA.
    IPR001465. Malate_synthase.
    IPR019830. Malate_synthase_CS.
    [Graphical view]
    PfamiPF01274. Malate_synthase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001363. Malate_synth. 1 hit.
    SUPFAMiSSF51645. SSF51645. 1 hit.
    TIGRFAMsiTIGR01344. malate_syn_A. 1 hit.
    PROSITEiPS00510. MALATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P21360-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQINPTTLD NVKILGEVSD KPLLSKATPR DILTKDALKF IVLLHRSFNE    50
    TRKQLLENRQ KVQERLDAGE SLHFLEETKY IREDPNWKCL PTHPKLQCRK 100
    IEITGPPDAK MIVNAFNTDV FTYMTDFEDS CSPTWNNMIY GQVNLYDAIR 150
    DRIDFTNEAT GKRYKINREG RRVPVMIVRP RGWHMVDKHI LVDGEPISAS 200
    IMDFGLFFFH NAKFLLSQGL APFFYLPKME HYKEAQLWND IFCVAQDCLE 250
    IPRGTIKATV LIETLPISYQ LDEVLYALRD HSAGLNCGRW DYMFSTIKRL 300
    RNQKQHILPD RHQVTMTVPF MTNYVKQLIK ICHKRGVHAM GGMAATIPIK 350
    DDPEKNAAAM EAVRQDKLRE VLAGHDGTWI AHPGLLPTAL SVFQEHMPTP 400
    NQIHVQKNVE ITEADLVDTN IPDGKITMKG VSANIYIGLN YMESWLRGLG 450
    CVPINNLMED AATAEVSRLQ LYSWCKHAVK MDDTGKTITP EFISKLIDEE 500
    AERCAANKPN NKFKIAADCL KKEINGHTEV AEFLTTLLYD DIVTIGPEVD 550
    ISSLK 555
    Length:555
    Mass (Da):63,255
    Last modified:May 1, 1991 - v1
    Checksum:i88137B77B2ECE303
    GO

    Sequence databases

    PIRiS09294. SYHQMA.

    Cross-referencesi

    Sequence databases

    PIRi S09294. SYHQMA.

    3D structure databases

    ProteinModelPortali P21360.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    PhylomeDBi P21360.

    Enzyme and pathway databases

    UniPathwayi UPA00703 ; UER00720 .

    Family and domain databases

    InterProi IPR011076. Malate_synth-like.
    IPR006252. Malate_synthA.
    IPR001465. Malate_synthase.
    IPR019830. Malate_synthase_CS.
    [Graphical view ]
    Pfami PF01274. Malate_synthase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001363. Malate_synth. 1 hit.
    SUPFAMi SSF51645. SSF51645. 1 hit.
    TIGRFAMsi TIGR01344. malate_syn_A. 1 hit.
    PROSITEi PS00510. MALATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing of the malate synthase gene from Hansenula polymorpha."
      Bruinenberg P.G., Blaauw M., Kazemier B., Ab G.
      Yeast 6:245-254(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE, PROTEIN SEQUENCE OF 234-253.
      Strain: ATCC 34438 / CBS 4732 / DSM 70277 / JCM 3621 / NBRC 1476 / NRRL Y-5445.

    Entry informationi

    Entry nameiMASY_PICAN
    AccessioniPrimary (citable) accession number: P21360
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: May 1, 1991
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3