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P21360

- MASY_PICAN

UniProt

P21360 - MASY_PICAN

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Protein

Malate synthase, glyoxysomal

Gene

MAS

Organism
Pichia angusta (Yeast) (Hansenula polymorpha)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei179 – 1791Proton acceptorBy similarity
Active sitei460 – 4601Proton donorBy similarity

GO - Molecular functioni

  1. malate synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-UniPathway
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase, glyoxysomal (EC:2.3.3.9)
Gene namesi
Name:MAS
OrganismiPichia angusta (Yeast) (Hansenula polymorpha)
Taxonomic identifieri870730 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPichiaceaeOgataea

Subcellular locationi

GO - Cellular componenti

  1. glyoxysome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Glyoxysome, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Malate synthase, glyoxysomalPRO_0000166863Add
BLAST

Expressioni

Inductioni

By ethanol.

Structurei

3D structure databases

ProteinModelPortaliP21360.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the malate synthase family.Curated

Phylogenomic databases

PhylomeDBiP21360.

Family and domain databases

InterProiIPR011076. Malate_synth-like.
IPR006252. Malate_synthA.
IPR001465. Malate_synthase.
IPR019830. Malate_synthase_CS.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF001363. Malate_synth. 1 hit.
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01344. malate_syn_A. 1 hit.
PROSITEiPS00510. MALATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21360 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQINPTTLD NVKILGEVSD KPLLSKATPR DILTKDALKF IVLLHRSFNE
60 70 80 90 100
TRKQLLENRQ KVQERLDAGE SLHFLEETKY IREDPNWKCL PTHPKLQCRK
110 120 130 140 150
IEITGPPDAK MIVNAFNTDV FTYMTDFEDS CSPTWNNMIY GQVNLYDAIR
160 170 180 190 200
DRIDFTNEAT GKRYKINREG RRVPVMIVRP RGWHMVDKHI LVDGEPISAS
210 220 230 240 250
IMDFGLFFFH NAKFLLSQGL APFFYLPKME HYKEAQLWND IFCVAQDCLE
260 270 280 290 300
IPRGTIKATV LIETLPISYQ LDEVLYALRD HSAGLNCGRW DYMFSTIKRL
310 320 330 340 350
RNQKQHILPD RHQVTMTVPF MTNYVKQLIK ICHKRGVHAM GGMAATIPIK
360 370 380 390 400
DDPEKNAAAM EAVRQDKLRE VLAGHDGTWI AHPGLLPTAL SVFQEHMPTP
410 420 430 440 450
NQIHVQKNVE ITEADLVDTN IPDGKITMKG VSANIYIGLN YMESWLRGLG
460 470 480 490 500
CVPINNLMED AATAEVSRLQ LYSWCKHAVK MDDTGKTITP EFISKLIDEE
510 520 530 540 550
AERCAANKPN NKFKIAADCL KKEINGHTEV AEFLTTLLYD DIVTIGPEVD

ISSLK
Length:555
Mass (Da):63,255
Last modified:May 1, 1991 - v1
Checksum:i88137B77B2ECE303
GO

Sequence databases

PIRiS09294. SYHQMA.

Cross-referencesi

Sequence databases

PIRi S09294. SYHQMA.

3D structure databases

ProteinModelPortali P21360.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

PhylomeDBi P21360.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00720 .

Family and domain databases

InterProi IPR011076. Malate_synth-like.
IPR006252. Malate_synthA.
IPR001465. Malate_synthase.
IPR019830. Malate_synthase_CS.
[Graphical view ]
Pfami PF01274. Malate_synthase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001363. Malate_synth. 1 hit.
SUPFAMi SSF51645. SSF51645. 1 hit.
TIGRFAMsi TIGR01344. malate_syn_A. 1 hit.
PROSITEi PS00510. MALATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and sequencing of the malate synthase gene from Hansenula polymorpha."
    Bruinenberg P.G., Blaauw M., Kazemier B., Ab G.
    Yeast 6:245-254(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE, PROTEIN SEQUENCE OF 234-253.
    Strain: ATCC 34438 / CBS 4732 / DSM 70277 / JCM 3621 / NBRC 1476 / NRRL Y-5445.

Entry informationi

Entry nameiMASY_PICAN
AccessioniPrimary (citable) accession number: P21360
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3