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P21360 (MASY_PICAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Malate synthase, glyoxysomal
EC=2.3.3.9
Gene names
Name:MAS
OrganismPichia angusta (Yeast) (Hansenula polymorpha)
Taxonomic identifier870730 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetales incertae sedis › Ogataea

Protein attributes

Sequence length555 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.

Pathway

Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2.

Subcellular location

Glyoxysome.

Induction

By ethanol.

Sequence similarities

Belongs to the malate synthase family.

Ontologies

Keywords
   Biological processGlyoxylate bypass
Tricarboxylic acid cycle
   Cellular componentGlyoxysome
Peroxisome
   Molecular functionTransferase
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processglyoxylate cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentglyoxysome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmalate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 555555Malate synthase, glyoxysomal
PRO_0000166863

Sites

Active site1791Proton acceptor By similarity
Active site4601Proton donor By similarity

Sequences

Sequence LengthMass (Da)Tools
P21360 [UniParc].

Last modified May 1, 1991. Version 1.
Checksum: 88137B77B2ECE303

FASTA55563,255
        10         20         30         40         50         60 
MAQINPTTLD NVKILGEVSD KPLLSKATPR DILTKDALKF IVLLHRSFNE TRKQLLENRQ 

        70         80         90        100        110        120 
KVQERLDAGE SLHFLEETKY IREDPNWKCL PTHPKLQCRK IEITGPPDAK MIVNAFNTDV 

       130        140        150        160        170        180 
FTYMTDFEDS CSPTWNNMIY GQVNLYDAIR DRIDFTNEAT GKRYKINREG RRVPVMIVRP 

       190        200        210        220        230        240 
RGWHMVDKHI LVDGEPISAS IMDFGLFFFH NAKFLLSQGL APFFYLPKME HYKEAQLWND 

       250        260        270        280        290        300 
IFCVAQDCLE IPRGTIKATV LIETLPISYQ LDEVLYALRD HSAGLNCGRW DYMFSTIKRL 

       310        320        330        340        350        360 
RNQKQHILPD RHQVTMTVPF MTNYVKQLIK ICHKRGVHAM GGMAATIPIK DDPEKNAAAM 

       370        380        390        400        410        420 
EAVRQDKLRE VLAGHDGTWI AHPGLLPTAL SVFQEHMPTP NQIHVQKNVE ITEADLVDTN 

       430        440        450        460        470        480 
IPDGKITMKG VSANIYIGLN YMESWLRGLG CVPINNLMED AATAEVSRLQ LYSWCKHAVK 

       490        500        510        520        530        540 
MDDTGKTITP EFISKLIDEE AERCAANKPN NKFKIAADCL KKEINGHTEV AEFLTTLLYD 

       550 
DIVTIGPEVD ISSLK

« Hide

References

[1]"Cloning and sequencing of the malate synthase gene from Hansenula polymorpha."
Bruinenberg P.G., Blaauw M., Kazemier B., Ab G.
Yeast 6:245-254(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE, PROTEIN SEQUENCE OF 234-253.
Strain: ATCC 34438 / CBS 4732 / DSM 70277 / JCM 3621 / NBRC 1476 / NRRL Y-5445.

Cross-references

Sequence databases

PIRSYHQMA. S09294.

3D structure databases

ProteinModelPortalP21360.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00703; UER00720.

Family and domain databases

InterProIPR011076. Malate_synth-like.
IPR006252. Malate_synthA.
IPR001465. Malate_synthase.
IPR019830. Malate_synthase_CS.
[Graphical view]
PANTHERPTHR21631:SF1. PTHR21631:SF1. 1 hit.
PfamPF01274. Malate_synthase. 1 hit.
[Graphical view]
PIRSFPIRSF001363. Malate_synth. 1 hit.
SUPFAMSSF51645. Malat_synth_like. 1 hit.
TIGRFAMsTIGR01344. malate_syn_A. 1 hit.
PROSITEPS00510. MALATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMASY_PICAN
AccessionPrimary (citable) accession number: P21360
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: April 3, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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