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Protein

Malate synthase, glyoxysomal

Gene

MAS

Organism
Pichia angusta (Yeast) (Hansenula polymorpha)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.

Pathwayi: glyoxylate cycle

This protein is involved in step 2 of the subpathway that synthesizes (S)-malate from isocitrate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Malate synthase, glyoxysomal (MAS)
This subpathway is part of the pathway glyoxylate cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-malate from isocitrate, the pathway glyoxylate cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei179Proton acceptorBy similarity1
Active sitei460Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processGlyoxylate bypass, Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase, glyoxysomal (EC:2.3.3.9)
Gene namesi
Name:MAS
OrganismiPichia angusta (Yeast) (Hansenula polymorpha)
Taxonomic identifieri870730 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPichiaceaeOgataea

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Glyoxysome, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001668631 – 555Malate synthase, glyoxysomalAdd BLAST555

Proteomic databases

PRIDEiP21360.

Expressioni

Inductioni

By ethanol.

Structurei

3D structure databases

ProteinModelPortaliP21360.
SMRiP21360.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the malate synthase family.Curated

Phylogenomic databases

PhylomeDBiP21360.

Family and domain databases

CDDicd00727. malate_synt_A. 1 hit.
InterProiView protein in InterPro
IPR011076. Malate_synth-like_sf.
IPR006252. Malate_synthA.
IPR001465. Malate_synthase.
IPR019830. Malate_synthase_CS.
PANTHERiPTHR42902. PTHR42902. 1 hit.
PfamiView protein in Pfam
PF01274. Malate_synthase. 1 hit.
PIRSFiPIRSF001363. Malate_synth. 1 hit.
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01344. malate_syn_A. 1 hit.
PROSITEiView protein in PROSITE
PS00510. MALATE_SYNTHASE. 1 hit.

Sequencei

Sequence statusi: Complete.

P21360-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQINPTTLD NVKILGEVSD KPLLSKATPR DILTKDALKF IVLLHRSFNE
60 70 80 90 100
TRKQLLENRQ KVQERLDAGE SLHFLEETKY IREDPNWKCL PTHPKLQCRK
110 120 130 140 150
IEITGPPDAK MIVNAFNTDV FTYMTDFEDS CSPTWNNMIY GQVNLYDAIR
160 170 180 190 200
DRIDFTNEAT GKRYKINREG RRVPVMIVRP RGWHMVDKHI LVDGEPISAS
210 220 230 240 250
IMDFGLFFFH NAKFLLSQGL APFFYLPKME HYKEAQLWND IFCVAQDCLE
260 270 280 290 300
IPRGTIKATV LIETLPISYQ LDEVLYALRD HSAGLNCGRW DYMFSTIKRL
310 320 330 340 350
RNQKQHILPD RHQVTMTVPF MTNYVKQLIK ICHKRGVHAM GGMAATIPIK
360 370 380 390 400
DDPEKNAAAM EAVRQDKLRE VLAGHDGTWI AHPGLLPTAL SVFQEHMPTP
410 420 430 440 450
NQIHVQKNVE ITEADLVDTN IPDGKITMKG VSANIYIGLN YMESWLRGLG
460 470 480 490 500
CVPINNLMED AATAEVSRLQ LYSWCKHAVK MDDTGKTITP EFISKLIDEE
510 520 530 540 550
AERCAANKPN NKFKIAADCL KKEINGHTEV AEFLTTLLYD DIVTIGPEVD

ISSLK
Length:555
Mass (Da):63,255
Last modified:May 1, 1991 - v1
Checksum:i88137B77B2ECE303
GO

Sequence databases

PIRiS09294. SYHQMA.

Similar proteinsi

Entry informationi

Entry nameiMASY_PICAN
AccessioniPrimary (citable) accession number: P21360
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: November 22, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families