P21342 (PFPA_SOLTU) Reviewed, UniProtKB/Swiss-Prot
Last modified
September 21, 2011.
Version 66.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha Short name=PFP EC=2.7.1.90 Alternative name(s): 6-phosphofructokinase, pyrophosphate dependent PPi-PFK Pyrophosphate-dependent 6-phosphofructose-1-kinase |
| Organism | Solanum tuberosum (Potato) |
| Taxonomic identifier | 4113 [NCBI] |
| Taxonomic lineage | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › lamiids › Solanales › Solanaceae › Solanoideae › Solaneae › Solanum |
Protein attributes
| Sequence length | 616 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | The alpha subunit may be involved in the regulation of PFP by Fru-2,6-P. |
| Catalytic activity | Diphosphate + D-fructose 6-phosphate = phosphate + D-fructose 1,6-bisphosphate. |
| Enzyme regulation | Fru-2,6-P is an activator of the plant enzyme. |
| Subunit structure | Tetramer of two alpha and two beta chains. |
| Miscellaneous | The active site might be on the beta subunit. |
| Sequence similarities | Belongs to the pyrophosphate-dependent phosphofructokinase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Glycolysis |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| Technical term | Allosteric enzyme Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | glycolysis Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | 6-phosphofructokinase complex Inferred from electronic annotation. Source: InterPro |
| Molecular function | 6-phosphofructokinase activity Inferred from electronic annotation. Source: InterPro ATP bindingInferred from electronic annotation. Source: UniProtKB-KW diphosphate-fructose-6-phosphate 1-phosphotransferase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 616 | 616 | Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha | PRO_0000112048 | |||
Sequences
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References
| [1] | "Pyrophosphate-dependent phosphofructokinase. Conservation of protein sequence between the alpha- and beta-subunits and with the ATP-dependent phosphofructokinase." Carlisle S.M., Blakeley S.D., Hemmingsen S.M., Trevanion S.J., Hiyoshi T., Kruger N.J., Dennis D.T. J. Biol. Chem. 265:18366-18371(1990) [PubMed: 2170409] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 277-295. Strain: cv. Kennebec. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | M55190 mRNA. Translation: AAA63451.1. |
| PIR | A36094. |
3D structure databases | |
| ProteinModelPortal | P21342. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Family and domain databases | |
| InterPro | IPR011183. PfpB_PPi_PFK. IPR000023. Phosphofructokinase_dom. IPR013981. PPi-dep_PFK_a-hlx. [Graphical view] |
| Gene3D | G3DSA:1.10.10.480. PPi-dep_PFK_a-hlx. 1 hit. |
| Pfam | PF00365. PFK. 1 hit. [Graphical view] |
| PIRSF | PIRSF005677. PPi_PFK_PfpB. 1 hit. |
| SUPFAM | SSF53784. Ppfruckinase. 1 hit. |
| TIGRFAMs | TIGR02477. PFKA_PPi. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | PFPA_SOLTU | ||||||||
| Accession | Primary (citable) accession number: P21342 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Plant Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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