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Protein

Protease synthase and sporulation protein PAI 2

Gene

paiB

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the reduction of extracellular and cell-associated protease levels, as well as in the reduced levels of alpha-amylase, levansucrase, alkaline phosphatase and sporulation inhibition, when present in high copy number.

GO - Molecular functioni

  1. FMN binding Source: InterPro
  2. oxidoreductase activity Source: InterPro

GO - Biological processi

  1. sporulation resulting in formation of a cellular spore Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Sporulation

Enzyme and pathway databases

BioCyciBSUB:BSU32140-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protease synthase and sporulation protein PAI 2
Gene namesi
Name:paiB
Synonyms:yumE
Ordered Locus Names:BSU32140
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570 Componenti: Chromosome

Organism-specific databases

GenoListiBSU32140. [Micado]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 207207Protease synthase and sporulation protein PAI 2PRO_0000058176Add
BLAST

Proteomic databases

PaxDbiP21341.

Interactioni

Protein-protein interaction databases

STRINGi224308.BSU32140.

Structurei

3D structure databases

ProteinModelPortaliP21341.
SMRiP21341. Positions 10-200.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PaiB family.Curated

Phylogenomic databases

eggNOGiCOG2808.
HOGENOMiHOG000218797.
InParanoidiP21341.
KOiK07734.
OMAiVMFQGPH.
OrthoDBiEOG6CS040.
PhylomeDBiP21341.

Family and domain databases

Gene3Di2.30.110.10. 1 hit.
InterProiIPR012349. Split_barrel_FMN-bd.
IPR007396. TR_PAI2-type.
[Graphical view]
PfamiPF04299. FMN_bind_2. 1 hit.
[Graphical view]
PIRSFiPIRSF010372. PaiB. 1 hit.
SUPFAMiSSF50475. SSF50475. 1 hit.

Sequencei

Sequence statusi: Complete.

P21341-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYIPKYFKVT NAEEIWNFVQ ENSFGTVVTT EQGKPIATHL PLGFNKKDDH
60 70 80 90 100
YYITGHFAYG NPQWRTFEAC EDVLVMFQGP HAYISSSWYS RENVPTWNYQ
110 120 130 140 150
AVHMYGKASM LEKDELAEEL TIMLEKYEKH RDNPVLWDKL SPKLLESELK
160 170 180 190 200
GIVGFKIKVE DIQAAYKLSQ NRNETDYMNV IEQLQNEENP NAKQMAELME

DKLKKQI
Length:207
Mass (Da):24,284
Last modified:July 7, 2009 - v3
Checksum:iA0C5425B9B97D93D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti126 – 1349KYEKHRDNP → QKTPTQAFS in CAB07956 (Ref. 4) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36471 Genomic DNA. Translation: AAA22639.1.
AL009126 Genomic DNA. Translation: CAB15204.2.
Z93939 Genomic DNA. Translation: CAB07956.1.
PIRiB35145.
F69671.
RefSeqiNP_391094.2. NC_000964.3.
WP_003244329.1. NZ_JNCM01000033.1.

Genome annotation databases

EnsemblBacteriaiCAB15204; CAB15204; BSU32140.
GeneIDi936588.
KEGGibsu:BSU32140.
PATRICi18978400. VBIBacSub10457_3363.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36471 Genomic DNA. Translation: AAA22639.1.
AL009126 Genomic DNA. Translation: CAB15204.2.
Z93939 Genomic DNA. Translation: CAB07956.1.
PIRiB35145.
F69671.
RefSeqiNP_391094.2. NC_000964.3.
WP_003244329.1. NZ_JNCM01000033.1.

3D structure databases

ProteinModelPortaliP21341.
SMRiP21341. Positions 10-200.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.BSU32140.

Proteomic databases

PaxDbiP21341.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB15204; CAB15204; BSU32140.
GeneIDi936588.
KEGGibsu:BSU32140.
PATRICi18978400. VBIBacSub10457_3363.

Organism-specific databases

GenoListiBSU32140. [Micado]

Phylogenomic databases

eggNOGiCOG2808.
HOGENOMiHOG000218797.
InParanoidiP21341.
KOiK07734.
OMAiVMFQGPH.
OrthoDBiEOG6CS040.
PhylomeDBiP21341.

Enzyme and pathway databases

BioCyciBSUB:BSU32140-MONOMER.

Family and domain databases

Gene3Di2.30.110.10. 1 hit.
InterProiIPR012349. Split_barrel_FMN-bd.
IPR007396. TR_PAI2-type.
[Graphical view]
PfamiPF04299. FMN_bind_2. 1 hit.
[Graphical view]
PIRSFiPIRSF010372. PaiB. 1 hit.
SUPFAMiSSF50475. SSF50475. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel Bacillus subtilis gene involved in negative control of sporulation and degradative-enzyme production."
    Honjo M., Nakayama A., Fukazawa K., Kawamura K., Ando K., Hori M., Furutani Y.
    J. Bacteriol. 172:1783-1790(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-5.
    Strain: 168 / DB104.
  2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  3. "From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later."
    Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.
    Microbiology 155:1758-1775(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION TO 126-134.
  4. Oudega B., Koningstein G., de Sales Ramon M., Rodrigues L.
    Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 76-207.
    Strain: 168.

Entry informationi

Entry nameiPAIB_BACSU
AccessioniPrimary (citable) accession number: P21341
Secondary accession number(s): O05270
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: July 7, 2009
Last modified: January 7, 2015
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.