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P21339

- MSB1_YEAST

UniProt

P21339 - MSB1_YEAST

Protein

Morphogenesis-related protein MSB1

Gene

MSB1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 May 1991)
      Previous versions | rss
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    Functioni

    May play a role in polarity establishment and bud formation. The MSB1 gene may be functionally redundant.

    GO - Biological processi

    1. establishment of cell polarity Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-33698-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Morphogenesis-related protein MSB1
    Alternative name(s):
    Multicopy suppressor of bud emergence 1
    Gene namesi
    Name:MSB1
    Ordered Locus Names:YOR188W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XV

    Organism-specific databases

    CYGDiYOR188w.
    SGDiS000005714. MSB1.

    Subcellular locationi

    GO - Cellular componenti

    1. cellular bud neck Source: SGD
    2. cellular bud tip Source: SGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11371137Morphogenesis-related protein MSB1PRO_0000096588Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei538 – 5381Phosphoserine2 Publications
    Modified residuei776 – 7761Phosphoserine1 Publication
    Modified residuei816 – 8161Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP21339.
    PaxDbiP21339.
    PeptideAtlasiP21339.

    Expressioni

    Gene expression databases

    GenevestigatoriP21339.

    Interactioni

    Protein-protein interaction databases

    BioGridi34583. 33 interactions.
    DIPiDIP-2687N.
    IntActiP21339. 3 interactions.
    MINTiMINT-582498.
    STRINGi4932.YOR188W.

    Structurei

    3D structure databases

    ProteinModelPortaliP21339.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG39513.
    HOGENOMiHOG000113660.
    OMAiCIENISH.
    OrthoDBiEOG7P8PH5.

    Family and domain databases

    InterProiIPR012965. DUF1708.
    [Graphical view]
    PfamiPF08101. DUF1708. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P21339-1 [UniParc]FASTAAdd to Basket

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    MNDMAKPLPT PPTAEIRKSR SNSPKKAQKT NLSPNKNQNN EKNVPRSNGR     50
    TKNEHNSMDD EEFEFFHQFS REKVKGVIHV ITAELKEKGP DVEFLMIPFR 100
    PEQTNDKLLT LLNQLFPLGN GQPVNEKKQL RIVSKADVWT LFQCLKYIWC 150
    RLPNSEIIGW KSYLEFKFRE EDKKFPRKSF LEIMPQCLAS PNHASIVYDF 200
    FDLIISISSN SRVNKMSARK ISKMCAIWAF SKQIPNSDIQ DYDFESAAMK 250
    SFAPNNSIQD GLDQWIPASD AMFHLLLAFL RSFVPQDLES AKLPRTLKSL 300
    LFNNQYPPRK STAYTSETIL TIPLVTLKTD VFSRKPWQLL ERCNDLLDFS 350
    DHDAFEARED YALLKSLFRK KNTVEGISRK MSQESRRLMK AMSTKHSTFQ 400
    PGWAPRECIE NISHLKECIE VKRLDIDDYF IWTWLSSLSF EQTSEKKKIF 450
    GRSIILEFEF DGFKKWVVFQ ECDITLDYNK KGQLKKKTSA QSPTTEKELP 500
    PDDFELEDPP LSKSPTLSQT YKKFQAEVPQ QSTVRRDSAP DNQGIYHTVI 550
    SKNALTKNKH NVNLHSFEHK ISKWNPLNNL RKKSGSNSSS SSFEEKSKDA 600
    PIREEYHTNK NHKSKKEERV LSQFSTLNPD EYQLPVIETG SSNFKIEIPE 650
    LMYEHDDDDS DKLKNSQKRA TDSAIEELNG MVEEMMINEP DDVKISITEA 700
    ETFESLTKFD QYKPSNITDD DLQSSHSSAV HSLKLSTNTN DSCADSSKYT 750
    ADRKLAEPRK ISEESKVNDD SSSYYSPNIN NLPASRMPSQ PTYSNSDSKK 800
    AFTNESRLNV LQGAVSPSQQ VTPKPYKNAP GDCVSPVQQK YYQNDRRNEM 850
    SPASAPVPPS AYSPARSPQF STNSAGFKQN TINVPVGYND PAHVLANQPH 900
    MTYRDQHNYP SHQQKQRPFQ NNIVPPELKS RNQRADASPI PQHMVPVKQG 950
    VPNLPSNVPL YQQMERMNPN HQHPVNTYKV TQPPYHNNTT NAYGNSRAGN 1000
    AHMLDGKWSN NPPQMVPKGV RPNQYPQQHV NRYSPQAQPV VPAEYYNGPP 1050
    PMRAPPMMSH MVPAQEPIRY TAGANRRSFP QGMQQNAYSV PAQPMGAVNS 1100
    EFYLPEAPQG NKLHGNINKR QERKKLYDNI RSGNFGI 1137
    Length:1,137
    Mass (Da):129,971
    Last modified:May 1, 1991 - v1
    Checksum:i59CDD6E0F1E43F8A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M37767 Genomic DNA. Translation: AAA34797.1.
    Z75096 Genomic DNA. Translation: CAA99397.1.
    BK006948 Genomic DNA. Translation: DAA10960.1.
    PIRiS13759.
    RefSeqiNP_014831.3. NM_001183607.3.

    Genome annotation databases

    EnsemblFungiiYOR188W; YOR188W; YOR188W.
    GeneIDi854360.
    KEGGisce:YOR188W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M37767 Genomic DNA. Translation: AAA34797.1 .
    Z75096 Genomic DNA. Translation: CAA99397.1 .
    BK006948 Genomic DNA. Translation: DAA10960.1 .
    PIRi S13759.
    RefSeqi NP_014831.3. NM_001183607.3.

    3D structure databases

    ProteinModelPortali P21339.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34583. 33 interactions.
    DIPi DIP-2687N.
    IntActi P21339. 3 interactions.
    MINTi MINT-582498.
    STRINGi 4932.YOR188W.

    Proteomic databases

    MaxQBi P21339.
    PaxDbi P21339.
    PeptideAtlasi P21339.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YOR188W ; YOR188W ; YOR188W .
    GeneIDi 854360.
    KEGGi sce:YOR188W.

    Organism-specific databases

    CYGDi YOR188w.
    SGDi S000005714. MSB1.

    Phylogenomic databases

    eggNOGi NOG39513.
    HOGENOMi HOG000113660.
    OMAi CIENISH.
    OrthoDBi EOG7P8PH5.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-33698-MONOMER.

    Miscellaneous databases

    NextBioi 976467.

    Gene expression databases

    Genevestigatori P21339.

    Family and domain databases

    InterProi IPR012965. DUF1708.
    [Graphical view ]
    Pfami PF08101. DUF1708. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Use of a screen for synthetic lethal and multicopy suppressee mutants to identify two new genes involved in morphogenesis in Saccharomyces cerevisiae."
      Bender A., Pringle J.R.
      Mol. Cell. Biol. 11:1295-1305(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV."
      Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J., Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A., Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B., Dang V.-D.
      , de Haan M., Delius H., Durand P., Fairhead C., Feldmann H., Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E., Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U., Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B., Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A., Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C., Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G., Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B., Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B., Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F., Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E., Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I., Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H., Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.
      Nature 387:98-102(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-538 AND SER-816, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-538 AND SER-776, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMSB1_YEAST
    AccessioniPrimary (citable) accession number: P21339
    Secondary accession number(s): D6W2P4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: May 1, 1991
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 172 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome XV
      Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names

    External Data

    Dasty 3