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P21333

- FLNA_HUMAN

UniProt

P21333 - FLNA_HUMAN

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Protein

Filamin-A

Gene

FLNA

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis.By similarity1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei1761 – 17622Cleavage; by calpain

GO - Molecular functioni

  1. actin filament binding Source: BHF-UCL
  2. Fc-gamma receptor I complex binding Source: BHF-UCL
  3. glycoprotein binding Source: BHF-UCL
  4. poly(A) RNA binding Source: UniProtKB
  5. protein homodimerization activity Source: BHF-UCL
  6. Rac GTPase binding Source: BHF-UCL
  7. Ral GTPase binding Source: BHF-UCL
  8. Rho GTPase binding Source: BHF-UCL
  9. signal transducer activity Source: UniProtKB
  10. small GTPase binding Source: BHF-UCL
  11. transcription factor binding Source: UniProtKB

GO - Biological processi

  1. actin crosslink formation Source: BHF-UCL
  2. actin cytoskeleton reorganization Source: BHF-UCL
  3. adenylate cyclase-inhibiting dopamine receptor signaling pathway Source: BHF-UCL
  4. blood coagulation Source: Reactome
  5. cell junction assembly Source: Reactome
  6. cilium assembly Source: UniProtKB
  7. cytoplasmic sequestering of protein Source: BHF-UCL
  8. early endosome to late endosome transport Source: Ensembl
  9. epithelial to mesenchymal transition Source: Ensembl
  10. establishment of protein localization Source: BHF-UCL
  11. mRNA transcription from RNA polymerase II promoter Source: Ensembl
  12. negative regulation of protein catabolic process Source: BHF-UCL
  13. negative regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
  14. platelet activation Source: Reactome
  15. platelet aggregation Source: UniProtKB
  16. platelet degranulation Source: Reactome
  17. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  18. positive regulation of transcription factor import into nucleus Source: UniProtKB
  19. protein localization to cell surface Source: BHF-UCL
  20. protein stabilization Source: BHF-UCL
  21. receptor clustering Source: BHF-UCL
  22. spindle assembly involved in mitosis Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

ReactomeiREACT_20649. Cell-extracellular matrix interactions.
REACT_23847. GP1b-IX-V activation signalling.
SignaLinkiP21333.

Names & Taxonomyi

Protein namesi
Recommended name:
Filamin-A
Short name:
FLN-A
Alternative name(s):
Actin-binding protein 280
Short name:
ABP-280
Alpha-filamin
Endothelial actin-binding protein
Filamin-1
Non-muscle filamin
Gene namesi
Name:FLNA
Synonyms:FLN, FLN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:3754. FLNA.

Subcellular locationi

GO - Cellular componenti

  1. actin cytoskeleton Source: BHF-UCL
  2. actin filament Source: Ensembl
  3. apical dendrite Source: Ensembl
  4. cortical cytoskeleton Source: Ensembl
  5. cytoplasm Source: UniProtKB
  6. cytosol Source: Reactome
  7. dendritic shaft Source: Ensembl
  8. extracellular region Source: Reactome
  9. extracellular vesicular exosome Source: UniProtKB
  10. focal adhesion Source: UniProtKB
  11. membrane Source: UniProtKB
  12. Myb complex Source: MGI
  13. neuronal cell body Source: Ensembl
  14. nucleus Source: UniProtKB
  15. perinuclear region of cytoplasm Source: Ensembl
  16. plasma membrane Source: BHF-UCL
  17. trans-Golgi network Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Involvement in diseasei

Periventricular nodular heterotopia 1 (PVNH1) [MIM:300049]: A developmental disorder characterized by the presence of periventricular nodules of cerebral gray matter, resulting from a failure of neurons to migrate normally from the lateral ventricular proliferative zone, where they are formed, to the cerebral cortex. PVNH1 is an X-linked dominant form. Heterozygous females have normal intelligence but suffer from seizures and various manifestations outside the central nervous system, especially related to the vascular system. Hemizygous affected males die in the prenatal or perinatal period.5 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti82 – 821E → V in PVNH1. 1 Publication
Corresponds to variant rs28935169 [ dbSNP | Ensembl ].
VAR_015699
Natural varianti102 – 1021M → V in PVNH1. 1 Publication
VAR_031305
Natural varianti149 – 1491S → F in PVNH1. 1 Publication
VAR_031307
Natural varianti528 – 5281V → M in PVNH1. 1 Publication
Corresponds to variant rs143873938 [ dbSNP | Ensembl ].
VAR_031309
Natural varianti656 – 6561L → F in PVNH1. 1 Publication
VAR_012834
Periventricular nodular heterotopia 4 (PVNH4) [MIM:300537]: A disorder characterized by nodular brain heterotopia, joint hypermobility and development of aortic dilation in early adulthood.2 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti39 – 391A → G in PVNH4. 1 Publication
VAR_022734
Natural varianti128 – 1281A → V in PVNH4. 1 Publication
VAR_031306
Otopalatodigital syndrome 1 (OPD1) [MIM:311300]: X-linked dominant multiple congenital anomalies disease mainly characterized by a generalized skeletal dysplasia, mild mental retardation, hearing loss, cleft palate, and typical facial anomalies. OPD1 belongs to a group of X-linked skeletal dysplasias known as oto-palato-digital syndrome spectrum disorders that also include OPD2, Melnick-Needles syndrome (MNS), and frontometaphyseal dysplasia (FMD). Remodeling of the cytoskeleton is central to the modulation of cell shape and migration. FLNA is a widely expressed protein that regulates re-organization of the actin cytoskeleton by interacting with integrins, transmembrane receptor complexes and second messengers. Males with OPD1 have cleft palate, malformations of the ossicles causing deafness and milder bone and limb defects than those associated with OPD2. Obligate female carriers of mutations causing both OPD1 and OPD2 have variable (often milder) expression of a similar phenotypic spectrum.2 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti172 – 1721L → F in OPD1. 1 Publication
VAR_015714
Natural varianti196 – 1961R → W in OPD1. 1 Publication
VAR_015716
Natural varianti203 – 2031D → Y in OPD1. 1 Publication
VAR_031308
Natural varianti207 – 2071P → L in OPD1. 1 Publication
Corresponds to variant rs28935469 [ dbSNP | Ensembl ].
VAR_015700
Otopalatodigital syndrome 2 (OPD2) [MIM:304120]: Congenital bone disorder that is characterized by abnormally modeled, bowed bones, small or absent first digits and, more variably, cleft palate, posterior fossa brain anomalies, omphalocele and cardiac defects.2 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti170 – 1701Q → P in OPD2. 1 Publication
VAR_015713
Natural varianti196 – 1961R → G in OPD2. 1 Publication
VAR_015715
Natural varianti200 – 2001A → S in OPD2. 1 Publication
VAR_015717
Natural varianti210 – 2101C → F in OPD2. 1 Publication
VAR_058720
Natural varianti254 – 2541E → K in OPD2. 1 Publication
Corresponds to variant rs28935470 [ dbSNP | Ensembl ].
VAR_015701
Natural varianti273 – 2731A → P in OPD2. 1 Publication
VAR_015718
Natural varianti555 – 5551T → K in OPD2. 1 Publication
VAR_015719
Natural varianti1645 – 16451C → F in OPD2. 1 Publication
VAR_015723
Frontometaphyseal dysplasia (FMD) [MIM:305620]: Congenital bone disease characterized by supraorbital hyperostosis, deafness and digital anomalies.2 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1159 – 11591D → A in FMD; does not inhibit interaction with MIS18BP1. 1 Publication
Corresponds to variant rs28935471 [ dbSNP | Ensembl ].
VAR_015702
Natural varianti1186 – 11861S → L in FMD. 2 Publications
VAR_015721
Natural varianti1620 – 16201Missing in FMD. 1 Publication
VAR_015722
Natural varianti1728 – 17281G → C in FMD. 1 Publication
VAR_031312
Melnick-Needles syndrome (MNS) [MIM:309350]: Severe congenital bone disorder characterized by typical facies (exophthalmos, full cheeks, micrognathia and malalignment of teeth), flaring of the metaphyses of long bones, s-like curvature of bones of legs, irregular constrictions in the ribs, and sclerosis of base of skull.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1184 – 11841D → E in MNS. 1 Publication
VAR_015720
Natural varianti1188 – 11881A → T in MNS; does not inhibit interaction with MIS18BP1. 1 Publication
Corresponds to variant rs28935472 [ dbSNP | Ensembl ].
VAR_015703
Natural varianti1199 – 11991S → L in MNS; does not inhibit interaction with MIS18BP1. 1 Publication
Corresponds to variant rs28935473 [ dbSNP | Ensembl ].
VAR_015704
Intestinal pseudoobstruction, neuronal, chronic idiopathic, X-linked (IPOX) [MIM:300048]: A disease characterized by a severe abnormality of gastrointestinal motility due to primary qualitative defects of enteric ganglia and nerve fibers. Affected individuals manifest recurrent signs of intestinal obstruction in the absence of any mechanical lesion.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
FG syndrome 2 (FGS2) [MIM:300321]: FG syndrome (FGS) is an X-linked disorder characterized by mental retardation, relative macrocephaly, hypotonia and constipation.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1291 – 12911P → L in FGS2. 1 Publication
VAR_058721
Terminal osseous dysplasia (TOD) [MIM:300244]: A rare X-linked dominant male-lethal disease characterized by skeletal dysplasia of the limbs, pigmentary defects of the skin and recurrent digital fibroma during infancy. A significant phenotypic variability is observed in affected females.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1724 – 173916Missing in TOD. 1 Publication
VAR_064159Add
BLAST
Cardiac valvular dysplasia X-linked (CVDX) [MIM:314400]: A rare X-linked heart disease characterized by mitral and/or aortic valve regurgitation. The histologic features include fragmentation of collagenous bundles within the valve fibrosa and accumulation of proteoglycans, which produces excessive valve tissue leading to billowing of the valve leaflets.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti288 – 2881G → R in CVDX. 1 Publication
VAR_064156
Natural varianti637 – 6371P → Q in CVDX. 1 Publication
VAR_064157
Natural varianti711 – 7111V → D in CVDX. 1 Publication
VAR_064158
Defects in FLNA may be a cause of macrothrombocytopenia, a disorder characterized by subnormal levels of blood platelets. Blood platelets are abnormally enlarged.
Congenital short bowel syndrome, X-linked (CSBSX) [MIM:300048]: A disease characterized by a shortened small intestine, and malabsorption. The mean length of the small intestine in affected individuals is approximately 50 cm, compared with a normal length at birth of 190-280 cm. It is associated with significant mortality and morbidity. Infants usually present with failure to thrive, recurrent vomiting, and diarrhea.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi42 – 421K → R: Abrogates ASB2alpha-mediated degradation without altering ASB2alpha binding; when associated with R-43 and R-135. 1 Publication
Mutagenesisi43 – 431K → R: Abrogates ASB2alpha-mediated degradation without altering ASB2alpha binding; when associated with R-42 and R-135. 1 Publication
Mutagenesisi135 – 1351K → R: Abrogates ASB2alpha-mediated degradation without altering ASB2alpha binding; when associated with R-42 and R-43. 1 Publication

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi300048. phenotype.
300049. phenotype.
300244. phenotype.
300321. phenotype.
300537. phenotype.
304120. phenotype.
305620. phenotype.
309350. phenotype.
311300. phenotype.
314400. phenotype.
Orphaneti2978. Chronic intestinal pseudoobstruction.
2301. Congenital short bowel syndrome.
1864. Congenital valvular dysplasia.
82004. Ehlers-Danlos syndrome with periventricular heterotopia.
323. FG syndrome.
1826. Frontometaphyseal dysplasia.
2484. Osteodysplasty, Melnick-Needles type.
90650. Otopalatodigital syndrome type 1.
90652. Otopalatodigital syndrome type 2.
98892. Periventricular nodular heterotopia.
88630. Terminal osseous dysplasia - pigmentary defects.
PharmGKBiPA28172.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 26472646Filamin-APRO_0000087296Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine2 Publications
Modified residuei11 – 111Phosphoserine1 Publication
Cross-linki42 – 42Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki43 – 43Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki135 – 135Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei376 – 3761N6-acetyllysineBy similarity
Modified residuei508 – 5081N6-acetyllysine1 Publication
Modified residuei700 – 7001N6-acetyllysine1 Publication
Modified residuei781 – 7811N6-acetyllysine1 Publication
Modified residuei837 – 8371N6-acetyllysine1 Publication
Modified residuei865 – 8651N6-acetyllysineBy similarity
Modified residuei906 – 9061N6-acetyllysineBy similarity
Modified residuei1071 – 10711N6-acetyllysine; alternateBy similarity
Modified residuei1071 – 10711N6-succinyllysine; alternateBy similarity
Modified residuei1081 – 10811Phosphoserine3 Publications
Modified residuei1084 – 10841Phosphoserine8 Publications
Modified residuei1089 – 10891Phosphothreonine1 Publication
Modified residuei1338 – 13381Phosphoserine1 Publication
Modified residuei1372 – 13721N6-acetyllysineBy similarity
Modified residuei1459 – 14591Phosphoserine7 Publications
Modified residuei1533 – 15331Phosphoserine2 Publications
Modified residuei1538 – 15381N6-acetyllysineBy similarity
Modified residuei1630 – 16301Phosphoserine1 Publication
Modified residuei1734 – 17341Phosphoserine1 Publication
Modified residuei2053 – 20531Phosphoserine2 Publications
Modified residuei2152 – 21521Phosphoserine5 Publications
Modified residuei2158 – 21581Phosphoserine1 Publication
Modified residuei2284 – 22841Phosphoserine2 Publications
Modified residuei2327 – 23271Phosphoserine3 Publications
Modified residuei2336 – 23361Phosphothreonine1 Publication
Modified residuei2414 – 24141Phosphoserine2 Publications
Modified residuei2510 – 25101Phosphoserine1 Publication
Modified residuei2569 – 25691N6-acetyllysine; alternateBy similarity
Modified residuei2569 – 25691N6-succinyllysine; alternateBy similarity
Modified residuei2575 – 25751N6-acetyllysineBy similarity
Modified residuei2607 – 26071N6-acetyllysine1 Publication
Modified residuei2621 – 26211N6-acetyllysine1 Publication

Post-translational modificationi

Phosphorylation extent changes in response to cell activation.11 Publications
Polyubiquitination in the CH1 domain by a SCF-like complex containing ASB2 leads to proteasomal degradation. Prior dissociation from actin may be required to expose the target lysines.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP21333.
PaxDbiP21333.
PRIDEiP21333.

2D gel databases

OGPiP21333.

PTM databases

PhosphoSiteiP21333.

Miscellaneous databases

PMAP-CutDBP21333.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiP21333.
CleanExiHS_FLNA.
ExpressionAtlasiP21333. baseline and differential.
GenevestigatoriP21333.

Organism-specific databases

HPAiCAB000356.
HPA000368.
HPA001115.
HPA002925.

Interactioni

Subunit structurei

Homodimer. Interacts with PDLIM2 (By similarity). Interacts with FAM101A and FAM101B (By similarity). Interacts with FCGR1A, FLNB, FURIN, HSPB7, INPPL1, KCND2, MYOT, MYOZ1, ARHGAP24, PSEN1, PSEN2 and ECSCR. Interacts also with various other binding partners in addition to filamentous actin. Interacts (via N-terminus) with MIS18BP1 (via N-terminus). Interacts (via N-terminus) with TAF1B. Interacts with TMEM67 (via C-terminus) and MKS1. Interacts (via actin-binding domain) with MICALL2 (via CH domain).By similarity12 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Q9WMX26EBI-350432,EBI-6863748From a different organism.
ARHGAP24Q8N2646EBI-350432,EBI-988764
CCNB2O950678EBI-350432,EBI-375024
CRKP461083EBI-350432,EBI-886
FLNBO753695EBI-350432,EBI-352089
FOXC1Q129488EBI-350432,EBI-1175253
GRB2P629932EBI-350432,EBI-401755
ITGB1P055565EBI-350432,EBI-703066
ITGB1P05556-12EBI-350432,EBI-6082935
ITGB1P072282EBI-350432,EBI-5606437From a different organism.
ITGB7P260106EBI-350432,EBI-702932
NRP1O147862EBI-350432,EBI-1187100
OPRM1P353725EBI-350432,EBI-2624570
PHLDB2Q86SQ02EBI-350432,EBI-2798483

Protein-protein interaction databases

BioGridi108605. 111 interactions.
DIPiDIP-1136N.
IntActiP21333. 61 interactions.
MINTiMINT-118283.
STRINGi9606.ENSP00000358866.

Structurei

Secondary structure

1
2647
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi40 – 434Combined sources
Helixi44 – 5714Combined sources
Helixi58 – 603Combined sources
Turni67 – 737Combined sources
Helixi75 – 8511Combined sources
Helixi100 – 11617Combined sources
Helixi126 – 1305Combined sources
Helixi134 – 14916Combined sources
Helixi168 – 17912Combined sources
Beta strandi181 – 1833Combined sources
Helixi190 – 1923Combined sources
Beta strandi193 – 1953Combined sources
Helixi196 – 20510Combined sources
Helixi213 – 2153Combined sources
Helixi221 – 23616Combined sources
Helixi244 – 2474Combined sources
Helixi254 – 2618Combined sources
Helixi263 – 2664Combined sources
Helixi480 – 4823Combined sources
Beta strandi484 – 4874Combined sources
Helixi488 – 4903Combined sources
Beta strandi501 – 5066Combined sources
Beta strandi515 – 5217Combined sources
Beta strandi529 – 5346Combined sources
Beta strandi537 – 5426Combined sources
Beta strandi548 – 5569Combined sources
Beta strandi565 – 5717Combined sources
Beta strandi579 – 5835Combined sources
Helixi584 – 5863Combined sources
Beta strandi588 – 5903Combined sources
Beta strandi595 – 60410Combined sources
Beta strandi609 – 6179Combined sources
Beta strandi620 – 6256Combined sources
Beta strandi627 – 63610Combined sources
Beta strandi639 – 64911Combined sources
Beta strandi658 – 6647Combined sources
Helixi672 – 6743Combined sources
Beta strandi676 – 6794Combined sources
Helixi680 – 6823Combined sources
Beta strandi683 – 6853Combined sources
Beta strandi693 – 6986Combined sources
Beta strandi707 – 7126Combined sources
Beta strandi714 – 7163Combined sources
Beta strandi721 – 7255Combined sources
Beta strandi727 – 7359Combined sources
Beta strandi739 – 74911Combined sources
Beta strandi758 – 7625Combined sources
Helixi1160 – 11623Combined sources
Beta strandi1164 – 11674Combined sources
Helixi1168 – 11703Combined sources
Beta strandi1172 – 11743Combined sources
Beta strandi1179 – 11846Combined sources
Beta strandi1193 – 11986Combined sources
Beta strandi1206 – 12116Combined sources
Beta strandi1213 – 122210Combined sources
Beta strandi1225 – 123511Combined sources
Beta strandi1244 – 12507Combined sources
Turni1785 – 17873Combined sources
Beta strandi1791 – 17966Combined sources
Beta strandi1804 – 18096Combined sources
Beta strandi1819 – 18224Combined sources
Beta strandi1824 – 18329Combined sources
Beta strandi1838 – 18469Combined sources
Beta strandi1855 – 18606Combined sources
Beta strandi1865 – 18673Combined sources
Beta strandi1869 – 18724Combined sources
Helixi1873 – 18753Combined sources
Beta strandi1877 – 18793Combined sources
Beta strandi1884 – 18896Combined sources
Turni1891 – 18933Combined sources
Beta strandi1895 – 190612Combined sources
Beta strandi1909 – 19146Combined sources
Beta strandi1916 – 192510Combined sources
Beta strandi1930 – 19389Combined sources
Beta strandi1947 – 19537Combined sources
Beta strandi1959 – 19679Combined sources
Beta strandi1980 – 19889Combined sources
Beta strandi1998 – 20014Combined sources
Beta strandi2007 – 20104Combined sources
Beta strandi2014 – 202512Combined sources
Beta strandi2034 – 20396Combined sources
Helixi2041 – 20433Combined sources
Helixi2047 – 20493Combined sources
Beta strandi2051 – 20544Combined sources
Helixi2055 – 20573Combined sources
Beta strandi2059 – 20613Combined sources
Beta strandi2066 – 20716Combined sources
Beta strandi2075 – 20773Combined sources
Beta strandi2080 – 20889Combined sources
Beta strandi2091 – 20966Combined sources
Beta strandi2100 – 21078Combined sources
Beta strandi2112 – 21209Combined sources
Beta strandi2129 – 21368Combined sources
Beta strandi2139 – 214810Combined sources
Beta strandi2174 – 21796Combined sources
Beta strandi2185 – 21895Combined sources
Beta strandi2208 – 22169Combined sources
Beta strandi2225 – 22317Combined sources
Helixi2238 – 22403Combined sources
Beta strandi2242 – 22454Combined sources
Helixi2246 – 22483Combined sources
Beta strandi2257 – 22626Combined sources
Helixi2264 – 22663Combined sources
Beta strandi2271 – 22799Combined sources
Beta strandi2282 – 22876Combined sources
Beta strandi2293 – 22986Combined sources
Beta strandi2303 – 23119Combined sources
Beta strandi2320 – 23267Combined sources
Turni2429 – 24313Combined sources
Beta strandi2433 – 24364Combined sources
Helixi2437 – 24393Combined sources
Beta strandi2441 – 24433Combined sources
Beta strandi2448 – 24536Combined sources
Turni2455 – 24573Combined sources
Beta strandi2462 – 24709Combined sources
Beta strandi2472 – 24798Combined sources
Beta strandi2482 – 24898Combined sources
Beta strandi2491 – 250616Combined sources
Beta strandi2511 – 25188Combined sources
Beta strandi2561 – 25644Combined sources
Helixi2565 – 25673Combined sources
Beta strandi2576 – 25816Combined sources
Beta strandi2590 – 25956Combined sources
Beta strandi2597 – 25993Combined sources
Beta strandi2602 – 26109Combined sources
Beta strandi2613 – 26197Combined sources
Beta strandi2624 – 26329Combined sources
Beta strandi2641 – 26466Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2AAVNMR-A1863-1956[»]
2BP3X-ray2.32A/B1863-1956[»]
2BRQX-ray2.10A/B2236-2329[»]
2J3SX-ray2.50A/B2045-2329[»]
2JF1X-ray2.20A2236-2329[»]
2K3TNMR-A2427-2522[»]
2K7PNMR-A1772-1956[»]
2K7QNMR-A1954-2141[»]
2W0PX-ray1.90A/B2236-2329[»]
2WFNX-ray3.20A/B1-278[»]
3CNKX-ray1.65A/B2559-2647[»]
3HOCX-ray2.30A/B2-269[»]
3HOPX-ray2.30A/B2-269[»]
3HORX-ray2.70A/B2-269[»]
3ISWX-ray2.80A/B2236-2329[»]
3RGHX-ray2.44A/B1158-1252[»]
4M9PX-ray1.72A478-766[»]
ProteinModelPortaliP21333.
SMRiP21333. Positions 39-269, 277-2647.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP21333.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 274273Actin-bindingAdd
BLAST
Domaini43 – 149107CH 1PROSITE-ProRule annotationAdd
BLAST
Domaini166 – 266101CH 2PROSITE-ProRule annotationAdd
BLAST
Repeati276 – 37499Filamin 1Add
BLAST
Repeati376 – 47499Filamin 2Add
BLAST
Repeati475 – 57096Filamin 3Add
BLAST
Repeati571 – 66393Filamin 4Add
BLAST
Repeati667 – 76397Filamin 5Add
BLAST
Repeati764 – 866103Filamin 6Add
BLAST
Repeati867 – 96599Filamin 7Add
BLAST
Repeati966 – 106196Filamin 8Add
BLAST
Repeati1062 – 115493Filamin 9Add
BLAST
Repeati1155 – 124995Filamin 10Add
BLAST
Repeati1250 – 1349100Filamin 11Add
BLAST
Repeati1350 – 144293Filamin 12Add
BLAST
Repeati1443 – 153997Filamin 13Add
BLAST
Repeati1540 – 163697Filamin 14Add
BLAST
Repeati1649 – 174092Filamin 15Add
BLAST
Repeati1779 – 186082Filamin 16Add
BLAST
Repeati1861 – 195090Filamin 17Add
BLAST
Repeati1951 – 203989Filamin 18Add
BLAST
Repeati2042 – 213190Filamin 19Add
BLAST
Repeati2132 – 223099Filamin 20Add
BLAST
Repeati2233 – 232593Filamin 21Add
BLAST
Repeati2327 – 242094Filamin 22Add
BLAST
Repeati2424 – 251693Filamin 23Add
BLAST
Repeati2552 – 264695Filamin 24Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1490 – 1607118Interaction with furinBy similarityAdd
BLAST
Regioni1741 – 177838Hinge 1Add
BLAST
Regioni2517 – 2647131Self-association site, tailAdd
BLAST
Regioni2517 – 255135Hinge 2Add
BLAST

Domaini

Comprised of a NH2-terminal actin-binding domain, 24 immunoglobulin-like internally homologous repeats and two hinge regions. Repeat 24 and the second hinge domain are important for dimer formation.

Sequence similaritiesi

Belongs to the filamin family.Curated
Contains 1 actin-binding domain.Curated
Contains 2 CH (calponin-homology) domains.PROSITE-ProRule annotation
Contains 24 filamin repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5069.
GeneTreeiENSGT00660000095431.
HOGENOMiHOG000044235.
HOVERGENiHBG004163.
InParanoidiP21333.
KOiK04437.
OMAiVQVQDNE.
PhylomeDBiP21333.
TreeFamiTF313685.

Family and domain databases

Gene3Di1.10.418.10. 2 hits.
2.60.40.10. 24 hits.
InterProiIPR001589. Actinin_actin-bd_CS.
IPR001715. CH-domain.
IPR017868. Filamin/ABP280_repeat-like.
IPR001298. Filamin/ABP280_rpt.
IPR028559. FLN_A/C.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
[Graphical view]
PANTHERiPTHR11915:SF173. PTHR11915:SF173. 1 hit.
PfamiPF00307. CH. 2 hits.
PF00630. Filamin. 23 hits.
[Graphical view]
SMARTiSM00033. CH. 2 hits.
SM00557. IG_FLMN. 24 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF81296. SSF81296. 24 hits.
PROSITEiPS00019. ACTININ_1. 1 hit.
PS00020. ACTININ_2. 1 hit.
PS50021. CH. 2 hits.
PS50194. FILAMIN_REPEAT. 24 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P21333-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSSHSRAGQ SAAGAAPGGG VDTRDAEMPA TEKDLAEDAP WKKIQQNTFT
60 70 80 90 100
RWCNEHLKCV SKRIANLQTD LSDGLRLIAL LEVLSQKKMH RKHNQRPTFR
110 120 130 140 150
QMQLENVSVA LEFLDRESIK LVSIDSKAIV DGNLKLILGL IWTLILHYSI
160 170 180 190 200
SMPMWDEEED EEAKKQTPKQ RLLGWIQNKL PQLPITNFSR DWQSGRALGA
210 220 230 240 250
LVDSCAPGLC PDWDSWDASK PVTNAREAMQ QADDWLGIPQ VITPEEIVDP
260 270 280 290 300
NVDEHSVMTY LSQFPKAKLK PGAPLRPKLN PKKARAYGPG IEPTGNMVKK
310 320 330 340 350
RAEFTVETRS AGQGEVLVYV EDPAGHQEEA KVTANNDKNR TFSVWYVPEV
360 370 380 390 400
TGTHKVTVLF AGQHIAKSPF EVYVDKSQGD ASKVTAQGPG LEPSGNIANK
410 420 430 440 450
TTYFEIFTAG AGTGEVEVVI QDPMGQKGTV EPQLEARGDS TYRCSYQPTM
460 470 480 490 500
EGVHTVHVTF AGVPIPRSPY TVTVGQACNP SACRAVGRGL QPKGVRVKET
510 520 530 540 550
ADFKVYTKGA GSGELKVTVK GPKGEERVKQ KDLGDGVYGF EYYPMVPGTY
560 570 580 590 600
IVTITWGGQN IGRSPFEVKV GTECGNQKVR AWGPGLEGGV VGKSADFVVE
610 620 630 640 650
AIGDDVGTLG FSVEGPSQAK IECDDKGDGS CDVRYWPQEA GEYAVHVLCN
660 670 680 690 700
SEDIRLSPFM ADIRDAPQDF HPDRVKARGP GLEKTGVAVN KPAEFTVDAK
710 720 730 740 750
HGGKAPLRVQ VQDNEGCPVE ALVKDNGNGT YSCSYVPRKP VKHTAMVSWG
760 770 780 790 800
GVSIPNSPFR VNVGAGSHPN KVKVYGPGVA KTGLKAHEPT YFTVDCAEAG
810 820 830 840 850
QGDVSIGIKC APGVVGPAEA DIDFDIIRND NDTFTVKYTP RGAGSYTIMV
860 870 880 890 900
LFADQATPTS PIRVKVEPSH DASKVKAEGP GLSRTGVELG KPTHFTVNAK
910 920 930 940 950
AAGKGKLDVQ FSGLTKGDAV RDVDIIDHHD NTYTVKYTPV QQGPVGVNVT
960 970 980 990 1000
YGGDPIPKSP FSVAVSPSLD LSKIKVSGLG EKVDVGKDQE FTVKSKGAGG
1010 1020 1030 1040 1050
QGKVASKIVG PSGAAVPCKV EPGLGADNSV VRFLPREEGP YEVEVTYDGV
1060 1070 1080 1090 1100
PVPGSPFPLE AVAPTKPSKV KAFGPGLQGG SAGSPARFTI DTKGAGTGGL
1110 1120 1130 1140 1150
GLTVEGPCEA QLECLDNGDG TCSVSYVPTE PGDYNINILF ADTHIPGSPF
1160 1170 1180 1190 1200
KAHVVPCFDA SKVKCSGPGL ERATAGEVGQ FQVDCSSAGS AELTIEICSE
1210 1220 1230 1240 1250
AGLPAEVYIQ DHGDGTHTIT YIPLCPGAYT VTIKYGGQPV PNFPSKLQVE
1260 1270 1280 1290 1300
PAVDTSGVQC YGPGIEGQGV FREATTEFSV DARALTQTGG PHVKARVANP
1310 1320 1330 1340 1350
SGNLTETYVQ DRGDGMYKVE YTPYEEGLHS VDVTYDGSPV PSSPFQVPVT
1360 1370 1380 1390 1400
EGCDPSRVRV HGPGIQSGTT NKPNKFTVET RGAGTGGLGL AVEGPSEAKM
1410 1420 1430 1440 1450
SCMDNKDGSC SVEYIPYEAG TYSLNVTYGG HQVPGSPFKV PVHDVTDASK
1460 1470 1480 1490 1500
VKCSGPGLSP GMVRANLPQS FQVDTSKAGV APLQVKVQGP KGLVEPVDVV
1510 1520 1530 1540 1550
DNADGTQTVN YVPSREGPYS ISVLYGDEEV PRSPFKVKVL PTHDASKVKA
1560 1570 1580 1590 1600
SGPGLNTTGV PASLPVEFTI DAKDAGEGLL AVQITDPEGK PKKTHIQDNH
1610 1620 1630 1640 1650
DGTYTVAYVP DVTGRYTILI KYGGDEIPFS PYRVRAVPTG DASKCTVTVS
1660 1670 1680 1690 1700
IGGHGLGAGI GPTIQIGEET VITVDTKAAG KGKVTCTVCT PDGSEVDVDV
1710 1720 1730 1740 1750
VENEDGTFDI FYTAPQPGKY VICVRFGGEH VPNSPFQVTA LAGDQPSVQP
1760 1770 1780 1790 1800
PLRSQQLAPQ YTYAQGGQQT WAPERPLVGV NGLDVTSLRP FDLVIPFTIK
1810 1820 1830 1840 1850
KGEITGEVRM PSGKVAQPTI TDNKDGTVTV RYAPSEAGLH EMDIRYDNMH
1860 1870 1880 1890 1900
IPGSPLQFYV DYVNCGHVTA YGPGLTHGVV NKPATFTVNT KDAGEGGLSL
1910 1920 1930 1940 1950
AIEGPSKAEI SCTDNQDGTC SVSYLPVLPG DYSILVKYNE QHVPGSPFTA
1960 1970 1980 1990 2000
RVTGDDSMRM SHLKVGSAAD IPINISETDL SLLTATVVPP SGREEPCLLK
2010 2020 2030 2040 2050
RLRNGHVGIS FVPKETGEHL VHVKKNGQHV ASSPIPVVIS QSEIGDASRV
2060 2070 2080 2090 2100
RVSGQGLHEG HTFEPAEFII DTRDAGYGGL SLSIEGPSKV DINTEDLEDG
2110 2120 2130 2140 2150
TCRVTYCPTE PGNYIINIKF ADQHVPGSPF SVKVTGEGRV KESITRRRRA
2160 2170 2180 2190 2200
PSVANVGSHC DLSLKIPEIS IQDMTAQVTS PSGKTHEAEI VEGENHTYCI
2210 2220 2230 2240 2250
RFVPAEMGTH TVSVKYKGQH VPGSPFQFTV GPLGEGGAHK VRAGGPGLER
2260 2270 2280 2290 2300
AEAGVPAEFS IWTREAGAGG LAIAVEGPSK AEISFEDRKD GSCGVAYVVQ
2310 2320 2330 2340 2350
EPGDYEVSVK FNEEHIPDSP FVVPVASPSG DARRLTVSSL QESGLKVNQP
2360 2370 2380 2390 2400
ASFAVSLNGA KGAIDAKVHS PSGALEECYV TEIDQDKYAV RFIPRENGVY
2410 2420 2430 2440 2450
LIDVKFNGTH IPGSPFKIRV GEPGHGGDPG LVSAYGAGLE GGVTGNPAEF
2460 2470 2480 2490 2500
VVNTSNAGAG ALSVTIDGPS KVKMDCQECP EGYRVTYTPM APGSYLISIK
2510 2520 2530 2540 2550
YGGPYHIGGS PFKAKVTGPR LVSNHSLHET SSVFVDSLTK ATCAPQHGAP
2560 2570 2580 2590 2600
GPGPADASKV VAKGLGLSKA YVGQKSSFTV DCSKAGNNML LVGVHGPRTP
2610 2620 2630 2640
CEEILVKHVG SRLYSVSYLL KDKGEYTLVV KWGDEHIPGS PYRVVVP
Length:2,647
Mass (Da):280,739
Last modified:January 23, 2007 - v4
Checksum:i6C1A07041DF50142
GO
Isoform 2 (identifier: P21333-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1649-1656: Missing.

Note: No experimental confirmation available.

Show »
Length:2,639
Mass (Da):280,018
Checksum:i862625C6FEA39075
GO

Sequence cautioni

The sequence BAC03408.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti44 – 441I → T AA sequence (PubMed:2248958)Curated
Sequence conflicti1772 – 17721A → G in CAA49687. (PubMed:7689010)Curated
Sequence conflicti2341 – 23411Q → R in BAC03408. (PubMed:14702039)Curated
Sequence conflicti2634 – 26341D → H in CAA37495. (PubMed:8088819)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti39 – 391A → G in PVNH4. 1 Publication
VAR_022734
Natural varianti82 – 821E → V in PVNH1. 1 Publication
Corresponds to variant rs28935169 [ dbSNP | Ensembl ].
VAR_015699
Natural varianti102 – 1021M → V in PVNH1. 1 Publication
VAR_031305
Natural varianti128 – 1281A → V in PVNH4. 1 Publication
VAR_031306
Natural varianti149 – 1491S → F in PVNH1. 1 Publication
VAR_031307
Natural varianti170 – 1701Q → P in OPD2. 1 Publication
VAR_015713
Natural varianti172 – 1721L → F in OPD1. 1 Publication
VAR_015714
Natural varianti196 – 1961R → G in OPD2. 1 Publication
VAR_015715
Natural varianti196 – 1961R → W in OPD1. 1 Publication
VAR_015716
Natural varianti200 – 2001A → S in OPD2. 1 Publication
VAR_015717
Natural varianti203 – 2031D → Y in OPD1. 1 Publication
VAR_031308
Natural varianti207 – 2071P → L in OPD1. 1 Publication
Corresponds to variant rs28935469 [ dbSNP | Ensembl ].
VAR_015700
Natural varianti210 – 2101C → F in OPD2. 1 Publication
VAR_058720
Natural varianti254 – 2541E → K in OPD2. 1 Publication
Corresponds to variant rs28935470 [ dbSNP | Ensembl ].
VAR_015701
Natural varianti273 – 2731A → P in OPD2. 1 Publication
VAR_015718
Natural varianti288 – 2881G → R in CVDX. 1 Publication
VAR_064156
Natural varianti320 – 3201V → A.
Corresponds to variant rs1064816 [ dbSNP | Ensembl ].
VAR_012831
Natural varianti370 – 3701F → L.
Corresponds to variant rs1064817 [ dbSNP | Ensembl ].
VAR_012832
Natural varianti429 – 4291T → M.1 Publication
VAR_069803
Natural varianti528 – 5281V → M in PVNH1. 1 Publication
Corresponds to variant rs143873938 [ dbSNP | Ensembl ].
VAR_031309
Natural varianti552 – 5521V → A.
Corresponds to variant rs730319 [ dbSNP | Ensembl ].
VAR_012833
Natural varianti555 – 5551T → K in OPD2. 1 Publication
VAR_015719
Natural varianti637 – 6371P → Q in CVDX. 1 Publication
VAR_064157
Natural varianti656 – 6561L → F in PVNH1. 1 Publication
VAR_012834
Natural varianti711 – 7111V → D in CVDX. 1 Publication
VAR_064158
Natural varianti1012 – 10121S → L.
Corresponds to variant rs17091204 [ dbSNP | Ensembl ].
VAR_031310
Natural varianti1159 – 11591D → A in FMD; does not inhibit interaction with MIS18BP1. 1 Publication
Corresponds to variant rs28935471 [ dbSNP | Ensembl ].
VAR_015702
Natural varianti1184 – 11841D → E in MNS. 1 Publication
VAR_015720
Natural varianti1186 – 11861S → L in FMD. 2 Publications
VAR_015721
Natural varianti1188 – 11881A → T in MNS; does not inhibit interaction with MIS18BP1. 1 Publication
Corresponds to variant rs28935472 [ dbSNP | Ensembl ].
VAR_015703
Natural varianti1199 – 11991S → L in MNS; does not inhibit interaction with MIS18BP1. 1 Publication
Corresponds to variant rs28935473 [ dbSNP | Ensembl ].
VAR_015704
Natural varianti1291 – 12911P → L in FGS2. 1 Publication
VAR_058721
Natural varianti1419 – 14191A → G.
Corresponds to variant rs35504556 [ dbSNP | Ensembl ].
VAR_032083
Natural varianti1620 – 16201Missing in FMD. 1 Publication
VAR_015722
Natural varianti1635 – 16373Missing in otopalatodigital spectrum disorder. 1 Publication
VAR_031311
Natural varianti1645 – 16451C → F in OPD2. 1 Publication
VAR_015723
Natural varianti1724 – 173916Missing in TOD. 1 Publication
VAR_064159Add
BLAST
Natural varianti1728 – 17281G → C in FMD. 1 Publication
VAR_031312
Natural varianti1764 – 17641A → T.2 Publications
Corresponds to variant rs57108893 [ dbSNP | Ensembl ].
VAR_012835
Natural varianti1803 – 18031E → K Probable disease-associated mutation found in a patient with macrothrombocytopenia. 1 Publication
VAR_067251

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1649 – 16568Missing in isoform 2. 1 PublicationVSP_035454

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53416 mRNA. Translation: CAA37495.1.
L44140 Genomic DNA. Translation: AAA92644.1.
X70082 Genomic DNA. Translation: CAA49687.1.
X70085 Genomic DNA. Translation: CAA49690.1.
GU727643 mRNA. Translation: ADU87644.1.
AK090427 mRNA. Translation: BAC03408.2. Different initiation.
AB593010 mRNA. Translation: BAJ83965.1.
BX664723, BX936346 Genomic DNA. Translation: CAI43197.1.
BX664723, BX936346 Genomic DNA. Translation: CAI43199.1.
BX936346, BX664723 Genomic DNA. Translation: CAI43225.1.
BX936346, BX664723 Genomic DNA. Translation: CAI43227.1.
CH471172 Genomic DNA. Translation: EAW72745.1.
CH471172 Genomic DNA. Translation: EAW72746.1.
CCDSiCCDS44021.1. [P21333-2]
CCDS48194.1. [P21333-1]
PIRiA37098.
RefSeqiNP_001104026.1. NM_001110556.1. [P21333-1]
NP_001447.2. NM_001456.3. [P21333-2]
UniGeneiHs.195464.

Genome annotation databases

EnsembliENST00000360319; ENSP00000353467; ENSG00000196924. [P21333-2]
ENST00000369850; ENSP00000358866; ENSG00000196924. [P21333-1]
ENST00000422373; ENSP00000416926; ENSG00000196924. [P21333-2]
GeneIDi2316.
KEGGihsa:2316.
UCSCiuc004fkk.2. human. [P21333-1]
uc010nuu.1. human. [P21333-2]

Polymorphism databases

DMDMi116241365.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53416 mRNA. Translation: CAA37495.1 .
L44140 Genomic DNA. Translation: AAA92644.1 .
X70082 Genomic DNA. Translation: CAA49687.1 .
X70085 Genomic DNA. Translation: CAA49690.1 .
GU727643 mRNA. Translation: ADU87644.1 .
AK090427 mRNA. Translation: BAC03408.2 . Different initiation.
AB593010 mRNA. Translation: BAJ83965.1 .
BX664723 , BX936346 Genomic DNA. Translation: CAI43197.1 .
BX664723 , BX936346 Genomic DNA. Translation: CAI43199.1 .
BX936346 , BX664723 Genomic DNA. Translation: CAI43225.1 .
BX936346 , BX664723 Genomic DNA. Translation: CAI43227.1 .
CH471172 Genomic DNA. Translation: EAW72745.1 .
CH471172 Genomic DNA. Translation: EAW72746.1 .
CCDSi CCDS44021.1. [P21333-2 ]
CCDS48194.1. [P21333-1 ]
PIRi A37098.
RefSeqi NP_001104026.1. NM_001110556.1. [P21333-1 ]
NP_001447.2. NM_001456.3. [P21333-2 ]
UniGenei Hs.195464.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2AAV NMR - A 1863-1956 [» ]
2BP3 X-ray 2.32 A/B 1863-1956 [» ]
2BRQ X-ray 2.10 A/B 2236-2329 [» ]
2J3S X-ray 2.50 A/B 2045-2329 [» ]
2JF1 X-ray 2.20 A 2236-2329 [» ]
2K3T NMR - A 2427-2522 [» ]
2K7P NMR - A 1772-1956 [» ]
2K7Q NMR - A 1954-2141 [» ]
2W0P X-ray 1.90 A/B 2236-2329 [» ]
2WFN X-ray 3.20 A/B 1-278 [» ]
3CNK X-ray 1.65 A/B 2559-2647 [» ]
3HOC X-ray 2.30 A/B 2-269 [» ]
3HOP X-ray 2.30 A/B 2-269 [» ]
3HOR X-ray 2.70 A/B 2-269 [» ]
3ISW X-ray 2.80 A/B 2236-2329 [» ]
3RGH X-ray 2.44 A/B 1158-1252 [» ]
4M9P X-ray 1.72 A 478-766 [» ]
ProteinModelPortali P21333.
SMRi P21333. Positions 39-269, 277-2647.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108605. 111 interactions.
DIPi DIP-1136N.
IntActi P21333. 61 interactions.
MINTi MINT-118283.
STRINGi 9606.ENSP00000358866.

PTM databases

PhosphoSitei P21333.

Polymorphism databases

DMDMi 116241365.

2D gel databases

OGPi P21333.

Proteomic databases

MaxQBi P21333.
PaxDbi P21333.
PRIDEi P21333.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000360319 ; ENSP00000353467 ; ENSG00000196924 . [P21333-2 ]
ENST00000369850 ; ENSP00000358866 ; ENSG00000196924 . [P21333-1 ]
ENST00000422373 ; ENSP00000416926 ; ENSG00000196924 . [P21333-2 ]
GeneIDi 2316.
KEGGi hsa:2316.
UCSCi uc004fkk.2. human. [P21333-1 ]
uc010nuu.1. human. [P21333-2 ]

Organism-specific databases

CTDi 2316.
GeneCardsi GC0XM153576.
GeneReviewsi FLNA.
H-InvDB HIX0017150.
HGNCi HGNC:3754. FLNA.
HPAi CAB000356.
HPA000368.
HPA001115.
HPA002925.
MIMi 300017. gene.
300048. phenotype.
300049. phenotype.
300244. phenotype.
300321. phenotype.
300537. phenotype.
304120. phenotype.
305620. phenotype.
309350. phenotype.
311300. phenotype.
314400. phenotype.
neXtProti NX_P21333.
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