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Protein

Inositol polyphosphate 1-phosphatase

Gene

INPP1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate.

Cofactori

Enzyme regulationi

Inhibited by Li+.

Pathwayi: phosphatidylinositol signaling pathway

This protein is involved in the pathway phosphatidylinositol signaling pathway, which is part of Signal transduction.
View all proteins of this organism that are known to be involved in the pathway phosphatidylinositol signaling pathway and in Signal transduction.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi79Magnesium 11
Binding sitei119SubstrateBy similarity1
Metal bindingi153Magnesium 1By similarity1
Metal bindingi153Magnesium 21
Metal bindingi155Magnesium 1; via carbonyl oxygen1
Metal bindingi156Magnesium 21
Metal bindingi317Magnesium 21
Binding sitei317SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Lithium, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-BTA-1855183. Synthesis of IP2, IP, and Ins in the cytosol.
SABIO-RKP21327.
UniPathwayiUPA00944.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol polyphosphate 1-phosphatase (EC:3.1.3.57)
Short name:
IPP
Short name:
IPPase
Gene namesi
Name:INPP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001425091 – 400Inositol polyphosphate 1-phosphataseAdd BLAST400

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei318PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP21327.
PeptideAtlasiP21327.
PRIDEiP21327.

Expressioni

Gene expression databases

BgeeiENSBTAG00000007584.

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000009977.

Structurei

Secondary structure

1400
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 24Combined sources21
Helixi26 – 29Combined sources4
Turni40 – 43Combined sources4
Helixi48 – 68Combined sources21
Helixi72 – 75Combined sources4
Beta strandi76 – 80Combined sources5
Beta strandi82 – 85Combined sources4
Beta strandi91 – 93Combined sources3
Helixi103 – 110Combined sources8
Turni111 – 113Combined sources3
Helixi117 – 125Combined sources9
Beta strandi134 – 138Combined sources5
Helixi145 – 147Combined sources3
Beta strandi148 – 156Combined sources9
Helixi158 – 163Combined sources6
Beta strandi176 – 178Combined sources3
Helixi179 – 181Combined sources3
Beta strandi183 – 190Combined sources8
Turni191 – 193Combined sources3
Beta strandi196 – 208Combined sources13
Turni210 – 212Combined sources3
Beta strandi215 – 230Combined sources16
Turni240 – 242Combined sources3
Beta strandi258 – 261Combined sources4
Beta strandi264 – 267Combined sources4
Turni278 – 281Combined sources4
Beta strandi284 – 287Combined sources4
Helixi291 – 299Combined sources9
Beta strandi304 – 308Combined sources5
Helixi315 – 326Combined sources12
Turni327 – 329Combined sources3
Beta strandi331 – 334Combined sources4
Helixi335 – 340Combined sources6
Turni359 – 364Combined sources6
Beta strandi373 – 377Combined sources5
Helixi379 – 385Combined sources7
Turni390 – 392Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1INPX-ray2.30A1-400[»]
ProteinModelPortaliP21327.
SMRiP21327.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP21327.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni155 – 158Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the inositol monophosphatase family.Curated

Phylogenomic databases

eggNOGiKOG3099. Eukaryota.
ENOG410XNMV. LUCA.
GeneTreeiENSGT00850000132413.
HOGENOMiHOG000007839.
HOVERGENiHBG006163.
InParanoidiP21327.
KOiK01107.
OMAiAGYKSLC.
OrthoDBiEOG091G0LNK.
TreeFamiTF314300.

Family and domain databases

InterProiIPR020583. Inositol_monoP_metal-BS.
IPR000760. Inositol_monophosphatase-like.
IPR020550. Inositol_monophosphatase_CS.
[Graphical view]
PANTHERiPTHR20854. PTHR20854. 2 hits.
PfamiPF00459. Inositol_P. 1 hit.
[Graphical view]
PROSITEiPS00629. IMP_1. 1 hit.
PS00630. IMP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21327-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDILQELLR VSEKAANIAR ACRQQETLFQ LLIEEKKEGE KNKKFAVDFK
60 70 80 90 100
TLADVLVQEV IKENMENKFP GLGKKIFGEE SNEFTNDLGE KIIMRLGPTE
110 120 130 140 150
EETVALLSKV LNGNKLASEA LAKVVHQDVF FSDPALDSVE INIPQDILGI
160 170 180 190 200
WVDPIDSTYQ YIKGSADITP NQGIFPSGLQ CVTVLIGVYD IQTGVPLMGV
210 220 230 240 250
INQPFVSQDL HTRRWKGQCY WGLSYLGTNI HSLLPPVSTR SNSEAQSQGT
260 270 280 290 300
QNPSSEGSCR FSVVISTSEK ETIKGALSHV CGERIFRAAG AGYKSLCVIL
310 320 330 340 350
GLADIYIFSE DTTFKWDSCA AHAILRAMGG GMVDLKECLE RNPDTGLDLP
360 370 380 390 400
QLVYHVGNEG AAGVDQWANK GGLIAYRSEK QLETFLSRLL QHLAPVATHT
Length:400
Mass (Da):43,965
Last modified:October 17, 2006 - v2
Checksum:i27917063A224D6A8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti84F → L in AAA30588 (PubMed:2175905).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55916 mRNA. Translation: AAA30588.1.
BC114863 mRNA. Translation: AAI14864.1.
PIRiA39254.
RefSeqiNP_776789.1. NM_174364.2.
XP_005202248.1. XM_005202191.3.
XP_005202249.1. XM_005202192.2.
XP_010800089.1. XM_010801787.2.
XP_010800090.1. XM_010801788.2.
XP_010800091.1. XM_010801789.2.
XP_010800092.1. XM_010801790.2.
UniGeneiBt.5174.

Genome annotation databases

EnsembliENSBTAT00000009977; ENSBTAP00000009977; ENSBTAG00000007584.
GeneIDi281869.
KEGGibta:281869.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55916 mRNA. Translation: AAA30588.1.
BC114863 mRNA. Translation: AAI14864.1.
PIRiA39254.
RefSeqiNP_776789.1. NM_174364.2.
XP_005202248.1. XM_005202191.3.
XP_005202249.1. XM_005202192.2.
XP_010800089.1. XM_010801787.2.
XP_010800090.1. XM_010801788.2.
XP_010800091.1. XM_010801789.2.
XP_010800092.1. XM_010801790.2.
UniGeneiBt.5174.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1INPX-ray2.30A1-400[»]
ProteinModelPortaliP21327.
SMRiP21327.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000009977.

Proteomic databases

PaxDbiP21327.
PeptideAtlasiP21327.
PRIDEiP21327.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000009977; ENSBTAP00000009977; ENSBTAG00000007584.
GeneIDi281869.
KEGGibta:281869.

Organism-specific databases

CTDi3628.

Phylogenomic databases

eggNOGiKOG3099. Eukaryota.
ENOG410XNMV. LUCA.
GeneTreeiENSGT00850000132413.
HOGENOMiHOG000007839.
HOVERGENiHBG006163.
InParanoidiP21327.
KOiK01107.
OMAiAGYKSLC.
OrthoDBiEOG091G0LNK.
TreeFamiTF314300.

Enzyme and pathway databases

UniPathwayiUPA00944.
ReactomeiR-BTA-1855183. Synthesis of IP2, IP, and Ins in the cytosol.
SABIO-RKP21327.

Miscellaneous databases

EvolutionaryTraceiP21327.

Gene expression databases

BgeeiENSBTAG00000007584.

Family and domain databases

InterProiIPR020583. Inositol_monoP_metal-BS.
IPR000760. Inositol_monophosphatase-like.
IPR020550. Inositol_monophosphatase_CS.
[Graphical view]
PANTHERiPTHR20854. PTHR20854. 2 hits.
PfamiPF00459. Inositol_P. 1 hit.
[Graphical view]
PROSITEiPS00629. IMP_1. 1 hit.
PS00630. IMP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiINPP_BOVIN
AccessioniPrimary (citable) accession number: P21327
Secondary accession number(s): Q1RMJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: October 17, 2006
Last modified: November 30, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Acts on inositol 1,4-bisphosphate and inositol 1,3,4-trisphosphate (forming inositol 3,4-bisphosphate) with a 4-fold higher affinity for the bisphosphate.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.