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Protein

Retron EC67 DNA adenine methylase

Gene
N/A
Organism
Escherichia coli
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Methylates DNA within the sequence GATC and protects the DNA from cleavage by the restriction endonuclease MboI. May play a regulatory role in the functions of the retron.

Catalytic activityi

S-adenosyl-L-methionine + adenine in DNA = S-adenosyl-L-homocysteine + N-6-methyladenine in DNA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei7S-adenosyl-L-methionineBy similarity1
Binding sitei11S-adenosyl-L-methionine; via amide nitrogenBy similarity1
Binding sitei51S-adenosyl-L-methionineBy similarity1
Binding sitei179S-adenosyl-L-methionineBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processDNA replication
LigandS-adenosyl-L-methionine

Protein family/group databases

REBASEi2846 M.EcoEc67Dam

Names & Taxonomyi

Protein namesi
Recommended name:
Retron EC67 DNA adenine methylase (EC:2.1.1.72)
Alternative name(s):
M.Eco67Dam
ORF1-EC67 DAM
OrganismiEscherichia coli
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000879951 – 285Retron EC67 DNA adenine methylaseAdd BLAST285

Structurei

3D structure databases

ProteinModelPortaliP21311
SMRiP21311
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the N(4)/N(6)-methyltransferase family.Curated

Phylogenomic databases

eggNOGiENOG4105DFE Bacteria
COG0338 LUCA

Family and domain databases

Gene3Di1.10.1020.10, 1 hit
InterProiView protein in InterPro
IPR023095 Ade_MeTrfase_dom_2
IPR002052 DNA_methylase_N6_adenine_CS
IPR012263 M_m6A_EcoRV
IPR012327 MeTrfase_D12
IPR029063 SAM-dependent_MTases
PANTHERiPTHR30481 PTHR30481, 1 hit
PfamiView protein in Pfam
PF02086 MethyltransfD12, 1 hit
PIRSFiPIRSF000398 M_m6A_EcoRV, 1 hit
PRINTSiPR00505 D12N6MTFRASE
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00571 dam, 1 hit
PROSITEiView protein in PROSITE
PS00092 N6_MTASE, 1 hit

Sequencei

Sequence statusi: Complete.

P21311-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTILKWAGN KTAIMSELKK HLPAGPRLVE PFAGSCAVMM ATDYPSYLVA
60 70 80 90 100
DINPDLINLY KKIAADCEAF ISRARVLFEI ANREVAYYNI RQEFNYSTEI
110 120 130 140 150
TDFMKAVYFL YLNRHGYRGL CRYNKSGHFN IPYGNYKNPY FPEKEIRKFA
160 170 180 190 200
EKAQRATFIC ASFDETLAML QVGDVVYCDP PYDGTFSGYH TDGFTEDDQY
210 220 230 240 250
HLASVLEYRS SEGHPVIVSN SDTSLIRSLY RNFTHHYIKA KRSIGVSAGE
260 270 280
SKSATEIIAV SGARCWVGFD PSRGVDSSAV YEVRV
Length:285
Mass (Da):32,255
Last modified:May 1, 1991 - v1
Checksum:i2F7F5FF2804F4841
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55249 Genomic DNA Translation: AAA23396.1
PIRiJQ0851
RefSeqiWP_001522695.1, NZ_PENP01000001.1

Similar proteinsi

Entry informationi

Entry nameiDMA7_ECOLX
AccessioniPrimary (citable) accession number: P21311
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: March 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Transposable element

Documents

  1. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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