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Protein

ATP synthase subunit epsilon, mitochondrial

Gene

ATP15

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F1 domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha3beta3 subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

GO - Molecular functioni

GO - Biological processi

  • ATP synthesis coupled proton transport Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-34153-MONOMER.

Protein family/group databases

TCDBi3.A.2.1.3. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit epsilon, mitochondrial
Short name:
ATPase subunit epsilon
Gene namesi
Name:ATP15
Ordered Locus Names:YPL271W
ORF Names:P0345
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL271W.
SGDiS000006192. ATP15.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial proton-transporting ATP synthase, central stalk Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

CF(1), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000716672 – 62ATP synthase subunit epsilon, mitochondrialAdd BLAST61

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei52PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP21306.
PRIDEiP21306.

PTM databases

iPTMnetiP21306.

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c.

Protein-protein interaction databases

BioGridi35942. 58 interactors.
DIPiDIP-3031N.
IntActiP21306. 7 interactors.
MINTiMINT-547186.

Structurei

Secondary structure

162
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni4 – 6Combined sources3
Helixi11 – 24Combined sources14
Helixi28 – 30Combined sources3
Helixi33 – 37Combined sources5
Beta strandi44 – 47Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HLDX-ray2.801/I/R2-62[»]
2WPDX-ray3.43I2-62[»]
3FKSX-ray3.591/I/R2-62[»]
3OE7X-ray3.191/I/R2-62[»]
3OEEX-ray2.741/I/R2-62[»]
3OEHX-ray3.001/I/R2-62[»]
3OFNX-ray3.20I/R2-62[»]
3ZIAX-ray2.50I/S2-62[»]
4B2Qelectron microscopy37.00I/i2-60[»]
ProteinModelPortaliP21306.
SMRiP21306.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP21306.

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic ATPase epsilon family.Curated

Phylogenomic databases

HOGENOMiHOG000214506.
InParanoidiP21306.
KOiK02135.
OMAiPELQTNS.
OrthoDBiEOG092C5WS2.

Family and domain databases

CDDicd12153. F1-ATPase_epsilon. 1 hit.
Gene3Di1.10.1620.20. 1 hit.
InterProiIPR006721. ATP_synth_F1_esu_mt.
[Graphical view]
PANTHERiPTHR12448. PTHR12448. 1 hit.
PfamiPF04627. ATP-synt_Eps. 1 hit.
[Graphical view]
SUPFAMiSSF48690. SSF48690. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21306-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAWRKAGIS YAAYLNVAAQ AIRSSLKTEL QTASVLNRSQ TDAFYTQYKN
60
GTAASEPTPI TK
Length:62
Mass (Da):6,743
Last modified:January 23, 2007 - v2
Checksum:i0CD754A9DEFFD08C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64767 Genomic DNA. Translation: CAA46014.1.
Z73627 Genomic DNA. Translation: CAA98007.1.
AY558140 Genomic DNA. Translation: AAS56466.1.
BK006949 Genomic DNA. Translation: DAA11165.1.
PIRiA45315.
RefSeqiNP_015052.1. NM_001184085.1.

Genome annotation databases

EnsemblFungiiYPL271W; YPL271W; YPL271W.
GeneIDi855857.
KEGGisce:YPL271W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64767 Genomic DNA. Translation: CAA46014.1.
Z73627 Genomic DNA. Translation: CAA98007.1.
AY558140 Genomic DNA. Translation: AAS56466.1.
BK006949 Genomic DNA. Translation: DAA11165.1.
PIRiA45315.
RefSeqiNP_015052.1. NM_001184085.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HLDX-ray2.801/I/R2-62[»]
2WPDX-ray3.43I2-62[»]
3FKSX-ray3.591/I/R2-62[»]
3OE7X-ray3.191/I/R2-62[»]
3OEEX-ray2.741/I/R2-62[»]
3OEHX-ray3.001/I/R2-62[»]
3OFNX-ray3.20I/R2-62[»]
3ZIAX-ray2.50I/S2-62[»]
4B2Qelectron microscopy37.00I/i2-60[»]
ProteinModelPortaliP21306.
SMRiP21306.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35942. 58 interactors.
DIPiDIP-3031N.
IntActiP21306. 7 interactors.
MINTiMINT-547186.

Protein family/group databases

TCDBi3.A.2.1.3. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

PTM databases

iPTMnetiP21306.

Proteomic databases

MaxQBiP21306.
PRIDEiP21306.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL271W; YPL271W; YPL271W.
GeneIDi855857.
KEGGisce:YPL271W.

Organism-specific databases

EuPathDBiFungiDB:YPL271W.
SGDiS000006192. ATP15.

Phylogenomic databases

HOGENOMiHOG000214506.
InParanoidiP21306.
KOiK02135.
OMAiPELQTNS.
OrthoDBiEOG092C5WS2.

Enzyme and pathway databases

BioCyciYEAST:G3O-34153-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP21306.
PROiP21306.

Family and domain databases

CDDicd12153. F1-ATPase_epsilon. 1 hit.
Gene3Di1.10.1620.20. 1 hit.
InterProiIPR006721. ATP_synth_F1_esu_mt.
[Graphical view]
PANTHERiPTHR12448. PTHR12448. 1 hit.
PfamiPF04627. ATP-synt_Eps. 1 hit.
[Graphical view]
SUPFAMiSSF48690. SSF48690. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiATP5E_YEAST
AccessioniPrimary (citable) accession number: P21306
Secondary accession number(s): D6W399
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 150 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 4280 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.