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Protein

Periodic tryptophan protein 1

Gene

PWP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • rRNA processing Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-32317-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Periodic tryptophan protein 1
Gene namesi
Name:PWP1
Ordered Locus Names:YLR196W
ORF Names:L8167.10
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR196W.
SGDiS000004186. PWP1.

Subcellular locationi

GO - Cellular componenti

  • nucleolus Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000511731 – 576Periodic tryptophan protein 1Add BLAST576

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei52PhosphoserineCombined sources1
Modified residuei131PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP21304.
PRIDEiP21304.

PTM databases

iPTMnetiP21304.

Interactioni

Protein-protein interaction databases

BioGridi31466. 100 interactors.
DIPiDIP-4203N.
IntActiP21304. 62 interactors.
MINTiMINT-503691.

Structurei

3D structure databases

ProteinModelPortaliP21304.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati207 – 252WD 1Add BLAST46
Repeati284 – 324WD 2Add BLAST41
Repeati329 – 369WD 3Add BLAST41
Repeati376 – 414WD 4Add BLAST39
Repeati420 – 461WD 5Add BLAST42
Repeati472 – 514WD 6Add BLAST43

Sequence similaritiesi

Belongs to the WD repeat PWP1 family.Curated
Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

GeneTreeiENSGT00390000017324.
HOGENOMiHOG000212580.
InParanoidiP21304.
KOiK14791.
OMAiSQWHPTE.
OrthoDBiEOG092C1EOT.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21304-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISATNWVPR GFSSEFPEKY VLDDEEVERI NQLAQLNLDD AKATLEEAEG
60 70 80 90 100
ESGVEDDAAT GSSNKLKDQL DIDDDLKEYN LEEYDDEEIA DNEGGKDVSM
110 120 130 140 150
FPGLSNDSDV KFHEGEKGED PYISLPNQED SQEEKQELQV YPSDNLVLAA
160 170 180 190 200
RTEDDVSYLD IYVYDDGAGF HSSDIPVEEG DEADPDVARG LVRDPALYVH
210 220 230 240 250
HDLMLPAFPL CVEWLDYKVG SNSEEAANYA AIGTFDPQIE IWNLDCVDKA
260 270 280 290 300
FPDMILGEPL DNSMVSLKSK KKKKKSKTGH ITTHHTDAVL SMAHNKYFRS
310 320 330 340 350
VLASTSADHT VKLWDLNSGN AARSLASIHS NKNVSSSEWH MLNGSILLTG
360 370 380 390 400
GYDSRVALTD VRISDESQMS KYWSAMAGEE IETVTFASEN IILCGTDSGN
410 420 430 440 450
VYSFDIRNNE NRKPVWTLKA HDAGISTLCS NKFIPGMMST GAMGEKTVKL
460 470 480 490 500
WKFPLDDATN TKGPSMVLSR DFDVGNVLTS SFAPDIEVAG TMVIGGVNKV
510 520 530 540 550
LKLWDVFTNR SVRKSFKSEL ENVQARAKEE AQKIGKSSRI ARKYTSNDNP
560 570
DTVITIDDQG EDEEEREGGD EHDDMA
Length:576
Mass (Da):63,803
Last modified:May 1, 1991 - v1
Checksum:iFC0189B289494AB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37578 Genomic DNA. Translation: AAA34926.1.
U14913 Genomic DNA. Translation: AAB67432.1.
BK006945 Genomic DNA. Translation: DAA09515.1.
PIRiS29367.
RefSeqiNP_013297.1. NM_001182083.1.

Genome annotation databases

EnsemblFungiiYLR196W; YLR196W; YLR196W.
GeneIDi850893.
KEGGisce:YLR196W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37578 Genomic DNA. Translation: AAA34926.1.
U14913 Genomic DNA. Translation: AAB67432.1.
BK006945 Genomic DNA. Translation: DAA09515.1.
PIRiS29367.
RefSeqiNP_013297.1. NM_001182083.1.

3D structure databases

ProteinModelPortaliP21304.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31466. 100 interactors.
DIPiDIP-4203N.
IntActiP21304. 62 interactors.
MINTiMINT-503691.

PTM databases

iPTMnetiP21304.

Proteomic databases

MaxQBiP21304.
PRIDEiP21304.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR196W; YLR196W; YLR196W.
GeneIDi850893.
KEGGisce:YLR196W.

Organism-specific databases

EuPathDBiFungiDB:YLR196W.
SGDiS000004186. PWP1.

Phylogenomic databases

GeneTreeiENSGT00390000017324.
HOGENOMiHOG000212580.
InParanoidiP21304.
KOiK14791.
OMAiSQWHPTE.
OrthoDBiEOG092C1EOT.

Enzyme and pathway databases

BioCyciYEAST:G3O-32317-MONOMER.

Miscellaneous databases

PROiP21304.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPWP1_YEAST
AccessioniPrimary (citable) accession number: P21304
Secondary accession number(s): D6VYJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: November 2, 2016
This is version 154 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 43800 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.