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Protein

Periodic tryptophan protein 1

Gene

PWP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 43800 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • rRNA processing Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-32317-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Periodic tryptophan protein 1
Gene namesi
Name:PWP1
Ordered Locus Names:YLR196W
ORF Names:L8167.10
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR196W
SGDiS000004186 PWP1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000511731 – 576Periodic tryptophan protein 1Add BLAST576

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei52PhosphoserineCombined sources1
Modified residuei131PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP21304
PaxDbiP21304
PRIDEiP21304

PTM databases

iPTMnetiP21304

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi31466, 185 interactors
DIPiDIP-4203N
IntActiP21304, 99 interactors
MINTiP21304
STRINGi4932.YLR196W

Structurei

3D structure databases

ProteinModelPortaliP21304
SMRiP21304
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati207 – 252WD 1Add BLAST46
Repeati284 – 324WD 2Add BLAST41
Repeati329 – 369WD 3Add BLAST41
Repeati376 – 414WD 4Add BLAST39
Repeati420 – 461WD 5Add BLAST42
Repeati472 – 514WD 6Add BLAST43

Sequence similaritiesi

Belongs to the WD repeat PWP1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

GeneTreeiENSGT00390000017324
HOGENOMiHOG000212580
InParanoidiP21304
KOiK14791
OMAiPLCVEWL
OrthoDBiEOG092C1EOT

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 2 hits
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 3 hits
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

P21304-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISATNWVPR GFSSEFPEKY VLDDEEVERI NQLAQLNLDD AKATLEEAEG
60 70 80 90 100
ESGVEDDAAT GSSNKLKDQL DIDDDLKEYN LEEYDDEEIA DNEGGKDVSM
110 120 130 140 150
FPGLSNDSDV KFHEGEKGED PYISLPNQED SQEEKQELQV YPSDNLVLAA
160 170 180 190 200
RTEDDVSYLD IYVYDDGAGF HSSDIPVEEG DEADPDVARG LVRDPALYVH
210 220 230 240 250
HDLMLPAFPL CVEWLDYKVG SNSEEAANYA AIGTFDPQIE IWNLDCVDKA
260 270 280 290 300
FPDMILGEPL DNSMVSLKSK KKKKKSKTGH ITTHHTDAVL SMAHNKYFRS
310 320 330 340 350
VLASTSADHT VKLWDLNSGN AARSLASIHS NKNVSSSEWH MLNGSILLTG
360 370 380 390 400
GYDSRVALTD VRISDESQMS KYWSAMAGEE IETVTFASEN IILCGTDSGN
410 420 430 440 450
VYSFDIRNNE NRKPVWTLKA HDAGISTLCS NKFIPGMMST GAMGEKTVKL
460 470 480 490 500
WKFPLDDATN TKGPSMVLSR DFDVGNVLTS SFAPDIEVAG TMVIGGVNKV
510 520 530 540 550
LKLWDVFTNR SVRKSFKSEL ENVQARAKEE AQKIGKSSRI ARKYTSNDNP
560 570
DTVITIDDQG EDEEEREGGD EHDDMA
Length:576
Mass (Da):63,803
Last modified:May 1, 1991 - v1
Checksum:iFC0189B289494AB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37578 Genomic DNA Translation: AAA34926.1
U14913 Genomic DNA Translation: AAB67432.1
BK006945 Genomic DNA Translation: DAA09515.1
PIRiS29367
RefSeqiNP_013297.1, NM_001182083.1

Genome annotation databases

EnsemblFungiiYLR196W; YLR196W; YLR196W
GeneIDi850893
KEGGisce:YLR196W

Similar proteinsi

Entry informationi

Entry nameiPWP1_YEAST
AccessioniPrimary (citable) accession number: P21304
Secondary accession number(s): D6VYJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: April 25, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health