Reviewed, UniProtKB/Swiss-Prot P21301 (NDUS2_TRYBB)

Names and origin

Protein names

Recommended name:
    NADH-ubiquinone oxidoreductase 49 kDa subunit homolog
    EC=1.6.5.3
Alternative name(s):
    NADH dehydrogenase subunit 7 homolog

Gene names

Name:	NAD7
Synonyms:	MURF 3

Encoded on

Mitochondrion

Organism

Trypanosoma brucei brucei

Taxonomic identifier

5702 [NCBI]

Taxonomic lineage

Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Trypanosoma

Protein attributes

Sequence length	386 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity. Component of the iron-sulfur (IP) fragment of the enzyme. Component of the iron-sulfur (IP) fragment of the enzyme.
Catalytic activity	NADH + ubiquinone = NAD+ + ubiquinol.
Subcellular location	Mitochondrion.
Sequence similarities	Belongs to the complex I 49 kDa subunit family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Mitochondrion
Ligand	NAD Ubiquinone
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAD or NADH binding Inferred from electronic annotation. Source: InterPro NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro quinone binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 386	386	NADH-ubiquinone oxidoreductase 49 kDa subunit homolog		PRO_0000118594

Sequences

	Sequence		Length	Mass (Da)
	P21301-1 [UniParc]. Last modified November 1, 1995. Version 2. Checksum: 448F5D52DC572071	FASTA	386	45,098
	10 20 30 40 50 60 MLFLVVFLHL YRFTFGPQHP AAHGVLCCLL YFCGEFIVYI DCIIGYLHRG TEKLCEYKSV 70 80 90 100 110 120 EQCLPYFDRL DYVSVCCNEH LLSLCFEYML RCCLSLRCAF MRLLIVEFTR SFNGLLCISC 130 140 150 160 170 180 MVLDLGCLSP LLWSFEERDK LMTFFDLCCG CRMHLAFMVL LGILDDFVFG FVDFLLLLII 190 200 210 220 230 240 SCLFVMDCYD LLFVGNRLFY LRLRGLSFFD LYDLVFNSLS GVLSRSLGMV WDCRLFSCYE 250 260 270 280 290 300 LYFMFCYDYC FCFIGDAFDR LFLRLFDMRM SLLICKQCFF VGFFVFGFVC LFDYLYCDIT 310 320 330 340 350 360 IETIIMLFYS LWCCCLPGIS FACVEHPKGE YCLLLCFCVG LCSRLRLRCA DFLHICLLDV 370 380 CLRGFLLHDL VAVLGNIDVV FGSVDR

References

[1]	"The MURF3 gene of T. brucei contains multiple domains of extensive editing and is homologous to a subunit of NADH dehydrogenase." Koslowsky D.J., Bhat G., Jayarama Perrollaz A.L., Feagin J.E., Stuart K. Cell 62:901-911(1990) [PubMed: 2393904] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	M55645 mRNA. No translation available.
PIR	A35693.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.6.5.3. 74165.
Family and domain databases
InterPro	IPR001135. NADH_Q_OxRdtase_suD. IPR014029. NADH_UbQ_OxRdtase_su-49kDa_CS. [Graphical view]
Pfam	PF00346. Complex1_49kDa. 1 hit. [Graphical view]
PROSITE	PS00535. COMPLEX1_49K. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NDUS2_TRYBB

Accession

Primary (citable) accession number: P21301

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
Last sequence update:	November 1, 1995
Last modified:	June 16, 2009
This is version 55 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)