true1991-05-012024-03-27173ALD1_MOUSEThe genomic organization and DNA sequence of the mouse vas deferens androgen regulated protein gene.Pailhoux E.A.Veyssiere G.M.Fabre S.Tournaire C.Jean C.G.doi:10.1016/0960-0760(92)90445-o1992J. Steroid Biochem. Mol. Biol.42561-568NUCLEOTIDE SEQUENCE [GENOMIC DNA]TISSUE SPECIFICITYVas deferensAndrogen-dependent protein from mouse vas deferens. cDNA cloning and protein homology with the aldo-keto reductase superfamily.Pailhoux E.A.Martinez A.Veyssiere G.M.Jean C.G.doi:10.1016/s0021-9258(17)45463-91990J. Biol. Chem.26519932-19936NUCLEOTIDE SEQUENCE [MRNA]CD-1Prostaglandin F2alpha synthase activities of aldo-keto reductase 1B1, 1B3 and 1B7.Kabututu Z.Manin M.Pointud J.C.Maruyama T.Nagata N.Lambert S.Lefrancois-Martinez A.M.Martinez A.Urade Y.doi:10.1093/jb/mvn1522009J. Biochem.145161-168CATALYTIC ACTIVITYBIOPHYSICOCHEMICAL PROPERTIESFUNCTIONA tissue-specific atlas of mouse protein phosphorylation and expression.Huttlin E.L.Jedrychowski M.P.Elias J.E.Goswami T.Rad R.Beausoleil S.A.Villen J.Haas W.Sowa M.E.Gygi S.P.doi:10.1016/j.cell.2010.12.0012010Cell1431174-1189IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]KidneymouseAkr1b7EukaryotaEstrogen biosynthesis1 hit in 80 CRISPR screensmouseProteinExpressed in adrenal gland and 84 other cell types or tissuesbaseline and differentialAKR_AKR1B1-19NADP-dependent oxidoreductase domainAKRAldo/ket_reductase_CSNADP_OxRdtase_domNADP_OxRdtase_dom_sfALDO-KETO REDUCTASE FAMILY 1 MEMBER B10ALDO/KETO REDUCTASEAldo_ket_redAKRALDKETRDTASENAD(P)-linked oxidoreductaseALDOKETO_REDUCTASE_1ALDOKETO_REDUCTASE_2ALDOKETO_REDUCTASE_3MMAldo-keto reductase family 1 member B71.1.1.21Aldehyde reductaseARAldose reductase-related protein 1MVDPVas deferens androgen-dependent proteinAkr1b7AvdpReduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. Reduces prostaglandins (PubMed:19010934). May play a role in the metabolism of xenobiotic aromatic aldehydes (By similarity).3.8 uM for prostaglandin H2Monomer.Expressed exclusively in the epithelial cells of the deferent duct.Castration resulted in a marked decrease in the level of the mRNA coding for the protein, whereas administration of testosterone to castrated males resulted in a marked increase.Belongs to the aldo/keto reductase family.Aldo-keto reductase family 1 member B7359881316Proton donor49202144111160161184210215263269273Lowers pKa of active site Tyr78D94substrate2007-01-2343598896fc94e27edb54b6e61b60f525a88fc1MATFVELSTKAKMPLVGLGTWKSSPGQVKEAVKAAIDAGYRHIDCAYVYHNENEVGEAIQEKIKENAVKREDLFIVSKLWATFFEKSLVKKAFQNTLSDLKLDYLDLYLVHWPQGFQAGNALLPKDNKGKVLLSKSTFLDAWEAMEELVDQGLVKALGISNFNHFQIERLLNKPGLKHKPVTNQIESHPYLTQEKLIQYCQSKGIAVTAYSPLGSPDRPYAKPEDPVVMEIPKIKEIAAKHKKTVAQVLIRFHVQRNVVVIPKSVTPSRIQENLQVFDFQLSEEDMAAILSFNRNWRACDLLDARTEEDYPFHEEYtruetruetruetruetruetruetruetruetruetruetrue