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Reviewed, UniProtKB/Swiss-Prot P21300 (ALD1_MOUSE)

Last modified January 19, 2010. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Aldose reductase-related protein 1
    EC=1.1.1.21
Alternative name(s):
    Aldehyde reductase
      Short name=AR
    Aldo-keto reductase family 1 member B7
    Vas deferens androgen-dependent protein
    MVDP
Gene names
Name: Akr1b7
Synonyms: Avdp
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

The role of MVDP in sperm maturation and storage may be related to its potential capacity to produce fructose, or MVDP may play an osmoregulatory role by producing sorbitol.

Catalytic activity

Alditol + NAD(P)+ = aldose + NAD(P)H.

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm By similarity.

Induction

Castration resulted in a marked decrease in the level of the mRNA coding for the protein, whereas administration of testosterone to castrated males resulted in a marked increase.

Sequence similarities

Belongs to the aldo/keto reductase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological processcellular lipid metabolic process

Traceable author statement. Source: MGI

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentmitochondrion

Inferred from direct assay. Source: MGI

   Molecular functionaldehyde reductase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 316315Aldose reductase-related protein 1
PRO_0000124629

Regions

Nucleotide binding211 – 27363NADP By similarity

Sites

Active site491Proton donor By similarity
Binding site1111Substrate By similarity
Site781Lowers pKa of active site Tyr By similarity

Experimental info

Sequence conflict941Q → D in AAA39773. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P21300-1 [UniParc].

Last modified January 23, 2007. Version 4.
Checksum: 6BC46B6076969742

FASTA31635,988
        10         20         30         40         50         60 
MATFVELSTK AKMPLVGLGT WKSSPGQVKE AVKAAIDAGY RHIDCAYVYH NENEVGEAIQ 

        70         80         90        100        110        120 
EKIKENAVKR EDLFIVSKLW ATFFEKSLVK KAFQNTLSDL KLDYLDLYLV HWPQGFQAGN 

       130        140        150        160        170        180 
ALLPKDNKGK VLLSKSTFLD AWEAMEELVD QGLVKALGIS NFNHFQIERL LNKPGLKHKP 

       190        200        210        220        230        240 
VTNQIESHPY LTQEKLIQYC QSKGIAVTAY SPLGSPDRPY AKPEDPVVME IPKIKEIAAK 

       250        260        270        280        290        300 
HKKTVAQVLI RFHVQRNVVV IPKSVTPSRI QENLQVFDFQ LSEEDMAAIL SFNRNWRACD 

       310 
LLDARTEEDY PFHEEY 

« Hide

References

[1]"The genomic organization and DNA sequence of the mouse vas deferens androgen regulated protein gene."
Pailhoux E.A., Veyssiere G.M., Fabre S., Tournaire C., Jean C.G.
J. Steroid Biochem. Mol. Biol. 42:561-568(1992) [PubMed: 1637719] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Vas deferens.
[2]"Androgen-dependent protein from mouse vas deferens. cDNA cloning and protein homology with the aldo-keto reductase superfamily."
Pailhoux E.A., Martinez A., Veyssiere G.M., Jean C.G.
J. Biol. Chem. 265:19932-19936(1990) [PubMed: 2123194] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: CD-1.
Tissue: Vas deferens.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M81448 Genomic DNA. Translation: AAA39774.1.
J05663 mRNA. Translation: AAA39773.1.
IPIIPI00224181.
PIRA37990.
RefSeqNP_033861.2.
UniGeneMm.5378

3D structure databases

SMRP21300. Positions 1-316.
ModBaseSearch...

Protein-protein interaction databases

STRINGP21300.

2-D gel databases

REPRODUCTION-2DPAGEP21300.

Proteomic databases

PRIDEP21300.

Genome annotation databases

EnsemblENSMUST00000007449; ENSMUSP00000007449; ENSMUSG00000052131; Mus musculus. [Genome view]
GeneID11997.
KEGGmmu:11997.

Organism-specific databases

CTD11997.
MGIMGI:101918. Akr1b7.

Phylogenomic databases

eggNOGveNOG05327.
HOGENOMHBG605727.
HOVERGENP21300.
InParanoidP21300.
OMAAWKAMEG.
OrthoDBEOG96MF48.
PhylomeDBP21300.

Enzyme and pathway databases

BRENDA1.1.1.21. 244.

Gene expression databases

ArrayExpressP21300.
BgeeP21300.
CleanExMM_AKR1B7.
GenevestigatorP21300.
GermOnlineENSMUSG00000052131. Mus musculus.

Family and domain databases

InterProIPR001395. Aldo/ket_red.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase_sg.
[Graphical view]
Gene3DG3DSA:3.20.20.100. Aldo/ket_red. 1 hit.
PANTHERPTHR11732. Aldo/ket_red. 1 hit.
PfamPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PRINTSPR00069. ALDKETRDTASE.
PROSITEPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio280181.
SOURCESearch...

Entry information

Entry nameALD1_MOUSE
AccessionPrimary (citable) accession number: P21300
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: January 23, 2007
Last modified: January 19, 2010
This is version 86 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents