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P21300 (ALD1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aldose reductase-related protein 1

EC=1.1.1.21
Alternative name(s):
Aldehyde reductase
Short name=AR
Aldo-keto reductase family 1 member B7
MVDP
Vas deferens androgen-dependent protein
Gene names
Name:Akr1b7
Synonyms:Avdp
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. May play a role in the metabolism of xenobiotic aromatic aldehydes By similarity. The role of MVDP in sperm maturation and storage may be related to its potential capacity to produce fructose, or MVDP may play an osmoregulatory role by producing sorbitol.

Catalytic activity

Alditol + NAD(P)+ = aldose + NAD(P)H.

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm By similarity.

Induction

Castration resulted in a marked decrease in the level of the mRNA coding for the protein, whereas administration of testosterone to castrated males resulted in a marked increase.

Sequence similarities

Belongs to the aldo/keto reductase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular lipid metabolic process

Traceable author statement PubMed 14739254. Source: MGI

   Cellular_componentmitochondrion

Inferred from direct assay PubMed 18614015. Source: MGI

   Molecular_functionalditol:NADP+ 1-oxidoreductase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 316316Aldose reductase-related protein 1
PRO_0000124629

Regions

Nucleotide binding20 – 212NADP By similarity
Nucleotide binding160 – 1612NADP By similarity
Nucleotide binding210 – 2156NADP By similarity
Nucleotide binding263 – 2697NADP By similarity

Sites

Active site491Proton donor By similarity
Binding site441NADP By similarity
Binding site1111Substrate By similarity
Binding site1841NADP By similarity
Binding site2731NADP By similarity
Site781Lowers pKa of active site Tyr By similarity

Experimental info

Sequence conflict941Q → D in AAA39773. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P21300 [UniParc].

Last modified January 23, 2007. Version 4.
Checksum: 6BC46B6076969742

FASTA31635,988
        10         20         30         40         50         60 
MATFVELSTK AKMPLVGLGT WKSSPGQVKE AVKAAIDAGY RHIDCAYVYH NENEVGEAIQ 

        70         80         90        100        110        120 
EKIKENAVKR EDLFIVSKLW ATFFEKSLVK KAFQNTLSDL KLDYLDLYLV HWPQGFQAGN 

       130        140        150        160        170        180 
ALLPKDNKGK VLLSKSTFLD AWEAMEELVD QGLVKALGIS NFNHFQIERL LNKPGLKHKP 

       190        200        210        220        230        240 
VTNQIESHPY LTQEKLIQYC QSKGIAVTAY SPLGSPDRPY AKPEDPVVME IPKIKEIAAK 

       250        260        270        280        290        300 
HKKTVAQVLI RFHVQRNVVV IPKSVTPSRI QENLQVFDFQ LSEEDMAAIL SFNRNWRACD 

       310 
LLDARTEEDY PFHEEY 

« Hide

References

[1]"The genomic organization and DNA sequence of the mouse vas deferens androgen regulated protein gene."
Pailhoux E.A., Veyssiere G.M., Fabre S., Tournaire C., Jean C.G.
J. Steroid Biochem. Mol. Biol. 42:561-568(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Vas deferens.
[2]"Androgen-dependent protein from mouse vas deferens. cDNA cloning and protein homology with the aldo-keto reductase superfamily."
Pailhoux E.A., Martinez A., Veyssiere G.M., Jean C.G.
J. Biol. Chem. 265:19932-19936(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: CD-1.
Tissue: Vas deferens.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M81448 Genomic DNA. Translation: AAA39774.1.
J05663 mRNA. Translation: AAA39773.1.
CCDSCCDS19993.1.
PIRA37990.
RefSeqNP_033861.2. NM_009731.2.
UniGeneMm.482073.

3D structure databases

ProteinModelPortalP21300.
SMRP21300. Positions 3-316.
ModBaseSearch...
MobiDBSearch...

2D gel databases

REPRODUCTION-2DPAGEP21300.

Proteomic databases

MaxQBP21300.
PaxDbP21300.
PRIDEP21300.

Protocols and materials databases

DNASU11997.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000007449; ENSMUSP00000007449; ENSMUSG00000052131.
GeneID11997.
KEGGmmu:11997.
UCSCuc009bhd.2. mouse.

Organism-specific databases

CTD11997.
MGIMGI:101918. Akr1b7.

Phylogenomic databases

eggNOGCOG0656.
HOGENOMHOG000250272.
HOVERGENHBG000020.
InParanoidP21300.
KOK00011.
OMALADCEIK.
OrthoDBEOG70KGQF.
PhylomeDBP21300.
TreeFamTF106492.

Gene expression databases

ArrayExpressP21300.
BgeeP21300.
CleanExMM_AKR1B7.
GenevestigatorP21300.

Family and domain databases

Gene3D3.20.20.100. 1 hit.
InterProIPR001395. Aldo/ket_red.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase_subgr.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERPTHR11732. PTHR11732. 1 hit.
PfamPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PIRSFPIRSF000097. AKR. 1 hit.
PRINTSPR00069. ALDKETRDTASE.
SUPFAMSSF51430. SSF51430. 1 hit.
PROSITEPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio280181.
PROP21300.
SOURCESearch...

Entry information

Entry nameALD1_MOUSE
AccessionPrimary (citable) accession number: P21300
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 118 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot