Reviewed, UniProtKB/Swiss-Prot P21300 (ALD1_MOUSE)

Names and origin

Protein names

Recommended name:
    Aldose reductase-related protein 1
    EC=1.1.1.21
Alternative name(s):
    Aldehyde reductase
      Short name=AR
    Aldo-keto reductase family 1 member B7
    Vas deferens androgen-dependent protein
    MVDP

Gene names

Name:	Akr1b7
Synonyms:	Avdp

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	316 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	The role of MVDP in sperm maturation and storage may be related to its potential capacity to produce fructose, or MVDP may play an osmoregulatory role by producing sorbitol.
Catalytic activity	Alditol + NAD(P)+ = aldose + NAD(P)H.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Induction	Castration resulted in a marked decrease in the level of the mRNA coding for the protein, whereas administration of testosterone to castrated males resulted in a marked increase.
Sequence similarities	Belongs to the aldo/keto reductase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	cellular lipid metabolic process Traceable author statement. Source: MGI oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from direct assay. Source: MGI
Molecular function	aldehyde reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 316	315	Aldose reductase-related protein 1		PRO_0000124629
Regions
	Nucleotide binding	211 – 273	63	NADP By similarity
Sites
	Active site	49	1	Proton donor By similarity
	Binding site	111	1	Substrate By similarity
	Site	78	1	Lowers pKa of active site Tyr By similarity
Experimental info
	Sequence conflict	94	1	Q → D in AAA39773. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P21300-1 [UniParc]. Last modified January 23, 2007. Version 4. Checksum: 6BC46B6076969742	FASTA	316	35,988
	10 20 30 40 50 60 MATFVELSTK AKMPLVGLGT WKSSPGQVKE AVKAAIDAGY RHIDCAYVYH NENEVGEAIQ 70 80 90 100 110 120 EKIKENAVKR EDLFIVSKLW ATFFEKSLVK KAFQNTLSDL KLDYLDLYLV HWPQGFQAGN 130 140 150 160 170 180 ALLPKDNKGK VLLSKSTFLD AWEAMEELVD QGLVKALGIS NFNHFQIERL LNKPGLKHKP 190 200 210 220 230 240 VTNQIESHPY LTQEKLIQYC QSKGIAVTAY SPLGSPDRPY AKPEDPVVME IPKIKEIAAK 250 260 270 280 290 300 HKKTVAQVLI RFHVQRNVVV IPKSVTPSRI QENLQVFDFQ LSEEDMAAIL SFNRNWRACD 310 LLDARTEEDY PFHEEY

References

[1]	"The genomic organization and DNA sequence of the mouse vas deferens androgen regulated protein gene." Pailhoux E.A., Veyssiere G.M., Fabre S., Tournaire C., Jean C.G. J. Steroid Biochem. Mol. Biol. 42:561-568(1992) [PubMed: 1637719] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Vas deferens.
[2]	"Androgen-dependent protein from mouse vas deferens. cDNA cloning and protein homology with the aldo-keto reductase superfamily." Pailhoux E.A., Martinez A., Veyssiere G.M., Jean C.G. J. Biol. Chem. 265:19932-19936(1990) [PubMed: 2123194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: CD-1. Tissue: Vas deferens.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M81448 Genomic DNA. Translation: AAA39774.1. J05663 mRNA. Translation: AAA39773.1.
IPI	IPI00224181.
PIR	A37990.
RefSeq	NP_033861.2.
UniGene	Mm.5378
3D structure databases
SMR	P21300. Positions 1-316.
ModBase	Search...
Protein-protein interaction databases
STRING	P21300.
2-D gel databases
REPRODUCTION-2DPAGE	P21300.
Proteomic databases
PRIDE	P21300.
Genome annotation databases
Ensembl	ENSMUST00000007449; ENSMUSP00000007449; ENSMUSG00000052131; Mus musculus. [Genome view]
GeneID	11997.
KEGG	mmu:11997.
Organism-specific databases
CTD	11997.
MGI	MGI:101918. Akr1b7.
Phylogenomic databases
eggNOG	veNOG05327.
HOGENOM	HBG605727.
HOVERGEN	P21300.
InParanoid	P21300.
OMA	AWKAMEG.
OrthoDB	EOG96MF48.
PhylomeDB	P21300.
Enzyme and pathway databases
BRENDA	1.1.1.21. 244.
Gene expression databases
ArrayExpress	P21300.
Bgee	P21300.
CleanEx	MM_AKR1B7.
Genevestigator	P21300.
GermOnline	ENSMUSG00000052131. Mus musculus.
Family and domain databases
InterPro	IPR001395. Aldo/ket_red. IPR018170. Aldo/ket_reductase_CS. IPR020471. Aldo/keto_reductase_sg. [Graphical view]
Gene3D	G3DSA:3.20.20.100. Aldo/ket_red. 1 hit.
PANTHER	PTHR11732. Aldo/ket_red. 1 hit.
Pfam	PF00248. Aldo_ket_red. 1 hit. [Graphical view]
PRINTS	PR00069. ALDKETRDTASE.
PROSITE	PS00798. ALDOKETO_REDUCTASE_1. 1 hit. PS00062. ALDOKETO_REDUCTASE_2. 1 hit. PS00063. ALDOKETO_REDUCTASE_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	280181.
SOURCE	Search...

Entry information

Entry name

ALD1_MOUSE

Accession

Primary (citable) accession number: P21300

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
Last sequence update:	January 23, 2007
Last modified:	January 19, 2010
This is version 86 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)