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P21300

- ALD1_MOUSE

UniProt

P21300 - ALD1_MOUSE

Protein

Aldose reductase-related protein 1

Gene

Akr1b7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 4 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. May play a role in the metabolism of xenobiotic aromatic aldehydes By similarity. The role of MVDP in sperm maturation and storage may be related to its potential capacity to produce fructose, or MVDP may play an osmoregulatory role by producing sorbitol.By similarity

    Catalytic activityi

    Alditol + NAD(P)+ = aldose + NAD(P)H.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei44 – 441NADPBy similarity
    Active sitei49 – 491Proton donorBy similarity
    Sitei78 – 781Lowers pKa of active site TyrBy similarity
    Binding sitei111 – 1111SubstrateBy similarity
    Binding sitei184 – 1841NADPBy similarity
    Binding sitei273 – 2731NADPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi20 – 212NADPBy similarity
    Nucleotide bindingi160 – 1612NADPBy similarity
    Nucleotide bindingi210 – 2156NADPBy similarity
    Nucleotide bindingi263 – 2697NADPBy similarity

    GO - Molecular functioni

    1. alditol:NADP+ 1-oxidoreductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular lipid metabolic process Source: MGI

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    ReactomeiREACT_198569. Retinoid metabolism and transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aldose reductase-related protein 1 (EC:1.1.1.21)
    Alternative name(s):
    Aldehyde reductase
    Short name:
    AR
    Aldo-keto reductase family 1 member B7
    MVDP
    Vas deferens androgen-dependent protein
    Gene namesi
    Name:Akr1b7
    Synonyms:Avdp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:101918. Akr1b7.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 316316Aldose reductase-related protein 1PRO_0000124629Add
    BLAST

    Proteomic databases

    MaxQBiP21300.
    PaxDbiP21300.
    PRIDEiP21300.

    2D gel databases

    REPRODUCTION-2DPAGEP21300.

    Expressioni

    Inductioni

    Castration resulted in a marked decrease in the level of the mRNA coding for the protein, whereas administration of testosterone to castrated males resulted in a marked increase.

    Gene expression databases

    ArrayExpressiP21300.
    BgeeiP21300.
    CleanExiMM_AKR1B7.
    GenevestigatoriP21300.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP21300.
    SMRiP21300. Positions 3-316.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldo/keto reductase family.Curated

    Phylogenomic databases

    eggNOGiCOG0656.
    HOGENOMiHOG000250272.
    HOVERGENiHBG000020.
    InParanoidiP21300.
    KOiK00011.
    OMAiLADCEIK.
    OrthoDBiEOG70KGQF.
    PhylomeDBiP21300.
    TreeFamiTF106492.

    Family and domain databases

    Gene3Di3.20.20.100. 1 hit.
    InterProiIPR001395. Aldo/ket_red.
    IPR018170. Aldo/ket_reductase_CS.
    IPR020471. Aldo/keto_reductase_subgr.
    IPR023210. NADP_OxRdtase_dom.
    [Graphical view]
    PANTHERiPTHR11732. PTHR11732. 1 hit.
    PfamiPF00248. Aldo_ket_red. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000097. AKR. 1 hit.
    PRINTSiPR00069. ALDKETRDTASE.
    SUPFAMiSSF51430. SSF51430. 1 hit.
    PROSITEiPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
    PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
    PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P21300-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATFVELSTK AKMPLVGLGT WKSSPGQVKE AVKAAIDAGY RHIDCAYVYH    50
    NENEVGEAIQ EKIKENAVKR EDLFIVSKLW ATFFEKSLVK KAFQNTLSDL 100
    KLDYLDLYLV HWPQGFQAGN ALLPKDNKGK VLLSKSTFLD AWEAMEELVD 150
    QGLVKALGIS NFNHFQIERL LNKPGLKHKP VTNQIESHPY LTQEKLIQYC 200
    QSKGIAVTAY SPLGSPDRPY AKPEDPVVME IPKIKEIAAK HKKTVAQVLI 250
    RFHVQRNVVV IPKSVTPSRI QENLQVFDFQ LSEEDMAAIL SFNRNWRACD 300
    LLDARTEEDY PFHEEY 316
    Length:316
    Mass (Da):35,988
    Last modified:January 23, 2007 - v4
    Checksum:i6BC46B6076969742
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti94 – 941Q → D in AAA39773. (PubMed:2123194)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M81448 Genomic DNA. Translation: AAA39774.1.
    J05663 mRNA. Translation: AAA39773.1.
    CCDSiCCDS19993.1.
    PIRiA37990.
    RefSeqiNP_033861.2. NM_009731.2.
    UniGeneiMm.482073.

    Genome annotation databases

    EnsembliENSMUST00000007449; ENSMUSP00000007449; ENSMUSG00000052131.
    GeneIDi11997.
    KEGGimmu:11997.
    UCSCiuc009bhd.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M81448 Genomic DNA. Translation: AAA39774.1 .
    J05663 mRNA. Translation: AAA39773.1 .
    CCDSi CCDS19993.1.
    PIRi A37990.
    RefSeqi NP_033861.2. NM_009731.2.
    UniGenei Mm.482073.

    3D structure databases

    ProteinModelPortali P21300.
    SMRi P21300. Positions 3-316.
    ModBasei Search...
    MobiDBi Search...

    2D gel databases

    REPRODUCTION-2DPAGE P21300.

    Proteomic databases

    MaxQBi P21300.
    PaxDbi P21300.
    PRIDEi P21300.

    Protocols and materials databases

    DNASUi 11997.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000007449 ; ENSMUSP00000007449 ; ENSMUSG00000052131 .
    GeneIDi 11997.
    KEGGi mmu:11997.
    UCSCi uc009bhd.2. mouse.

    Organism-specific databases

    CTDi 11997.
    MGIi MGI:101918. Akr1b7.

    Phylogenomic databases

    eggNOGi COG0656.
    HOGENOMi HOG000250272.
    HOVERGENi HBG000020.
    InParanoidi P21300.
    KOi K00011.
    OMAi LADCEIK.
    OrthoDBi EOG70KGQF.
    PhylomeDBi P21300.
    TreeFami TF106492.

    Enzyme and pathway databases

    Reactomei REACT_198569. Retinoid metabolism and transport.

    Miscellaneous databases

    NextBioi 280181.
    PROi P21300.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P21300.
    Bgeei P21300.
    CleanExi MM_AKR1B7.
    Genevestigatori P21300.

    Family and domain databases

    Gene3Di 3.20.20.100. 1 hit.
    InterProi IPR001395. Aldo/ket_red.
    IPR018170. Aldo/ket_reductase_CS.
    IPR020471. Aldo/keto_reductase_subgr.
    IPR023210. NADP_OxRdtase_dom.
    [Graphical view ]
    PANTHERi PTHR11732. PTHR11732. 1 hit.
    Pfami PF00248. Aldo_ket_red. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000097. AKR. 1 hit.
    PRINTSi PR00069. ALDKETRDTASE.
    SUPFAMi SSF51430. SSF51430. 1 hit.
    PROSITEi PS00798. ALDOKETO_REDUCTASE_1. 1 hit.
    PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
    PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genomic organization and DNA sequence of the mouse vas deferens androgen regulated protein gene."
      Pailhoux E.A., Veyssiere G.M., Fabre S., Tournaire C., Jean C.G.
      J. Steroid Biochem. Mol. Biol. 42:561-568(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Vas deferens.
    2. "Androgen-dependent protein from mouse vas deferens. cDNA cloning and protein homology with the aldo-keto reductase superfamily."
      Pailhoux E.A., Martinez A., Veyssiere G.M., Jean C.G.
      J. Biol. Chem. 265:19932-19936(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: CD-1.
      Tissue: Vas deferens.

    Entry informationi

    Entry nameiALD1_MOUSE
    AccessioniPrimary (citable) accession number: P21300
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 120 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3