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P21293

- KITH_SHV21

UniProt

P21293 - KITH_SHV21

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Protein

Thymidine kinase

Gene
21, TK
Organism
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei243 – 2431Proton acceptor Reviewed prediction
Binding sitei260 – 2601Substrate By similarity
Binding sitei281 – 2811Substrate By similarity
Binding sitei325 – 3251Substrate By similarity
Binding sitei368 – 3681ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi216 – 2238ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphotransferase activity, alcohol group as acceptor Source: InterPro
  3. thymidine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
  2. TMP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:21
Synonyms:TK
OrganismiSaimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri)
Taxonomic identifieri10383 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostiSaimiri sciureus (Common squirrel monkey) [TaxID: 9521]
ProteomesiUP000000587: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 527527Thymidine kinasePRO_0000175077Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP21293.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR002624. DNK.
IPR001889. Herpes_TK.
IPR013672. Herpes_TK_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10513. PTHR10513. 1 hit.
PfamiPF00693. Herpes_TK. 1 hit.
PF08465. Herpes_TK_C. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

P21293-1 [UniParc]FASTAAdd to Basket

« Hide

MTGRGQPPKK NDTYDYPRKQ PPKNGSYDNY DYPTSTKTRS TNKQRKDSNY    50
PPRETIFEPD LAADPIYSVP RPPSRVPHKL VKVNYKSNLV PITASNSVSE 100
LLSLHDETQV TECVEAPLIA KSPDITVYEK MFSVRPKHTL TKLEGKQKMF 150
TRKKKGSFVK IGSNMLEFGE SLKSKLHNDS KKSPDEPDGL VHVPVHLLYP 200
PKHQDPVPAF FIFLEGSIGV GKTTLLKSMN GILGGKNVLA FHEPIAYWTD 250
VFSNSLEEVY KLTLPAKVGR TSNSAKLLAC QLKFASPLLA LKTATDRLSS 300
PKNSLLSSDM WVMFDRHPLS ATVVFPYMHF QNGFLSFSHL IQLWSSFKAS 350
RGDNIILLNL NSQENLKRVK KRNRKEEKSV SIEHIRLLNN CYHAVYCAWL 400
LVQNFTPEEI VEVCFNAKHI TDLSSSKPSF LAKHVSTEDM LKSSIFNTWI 450
EMTKAHRDSC TLMECLLTFC KELEKVQLIH VNVSPFTDDI PGLWASIYTS 500
IRRNSAIKPN RVNWLALEDL ARTFNSQ 527
Length:527
Mass (Da):59,807
Last modified:May 1, 1991 - v1
Checksum:i4E8E3A3A178FAD7D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X64346 Genomic DNA. Translation: CAA45643.1.
D00543 Genomic DNA. Translation: BAA00432.1.
RefSeqiNP_040223.1. NC_001350.1.

Genome annotation databases

GeneIDi1488261.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X64346 Genomic DNA. Translation: CAA45643.1 .
D00543 Genomic DNA. Translation: BAA00432.1 .
RefSeqi NP_040223.1. NC_001350.1.

3D structure databases

ProteinModelPortali P21293.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1488261.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR002624. DNK.
IPR001889. Herpes_TK.
IPR013672. Herpes_TK_C.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR10513. PTHR10513. 1 hit.
Pfami PF00693. Herpes_TK. 1 hit.
PF08465. Herpes_TK_C. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A comparative analysis of the sequence of the thymidine kinase gene of a gammaherpesvirus, herpesvirus saimiri."
    Honess R.W., Craxton M.A., Williams L., Gompels U.A.
    J. Gen. Virol. 70:3003-3013(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Primary structure of the herpesvirus saimiri genome."
    Albrecht J.-C., Nicholas J., Biller D., Cameron K.R., Biesinger B., Newman C., Wittmann S., Craxton M.A., Coleman H., Fleckenstein B., Honess R.W.
    J. Virol. 66:5047-5058(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiKITH_SHV21
AccessioniPrimary (citable) accession number: P21293
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: September 3, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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