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P21293 (KITH_SHV21) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine kinase

EC=2.7.1.21
Gene names
Name:21
Synonyms:TK
OrganismSaimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) [Reference proteome]
Taxonomic identifier10383 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostSaimiri sciureus (Common squirrel monkey) [TaxID: 9521]

Protein attributes

Sequence length527 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sequence similarities

Belongs to the herpesviridae thymidine kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 527527Thymidine kinase
PRO_0000175077

Regions

Nucleotide binding216 – 2238ATP By similarity

Sites

Active site2431Proton acceptor Potential
Binding site2601Substrate By similarity
Binding site2811Substrate By similarity
Binding site3251Substrate By similarity
Binding site3681ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P21293 [UniParc].

Last modified May 1, 1991. Version 1.
Checksum: 4E8E3A3A178FAD7D

FASTA52759,807
        10         20         30         40         50         60 
MTGRGQPPKK NDTYDYPRKQ PPKNGSYDNY DYPTSTKTRS TNKQRKDSNY PPRETIFEPD 

        70         80         90        100        110        120 
LAADPIYSVP RPPSRVPHKL VKVNYKSNLV PITASNSVSE LLSLHDETQV TECVEAPLIA 

       130        140        150        160        170        180 
KSPDITVYEK MFSVRPKHTL TKLEGKQKMF TRKKKGSFVK IGSNMLEFGE SLKSKLHNDS 

       190        200        210        220        230        240 
KKSPDEPDGL VHVPVHLLYP PKHQDPVPAF FIFLEGSIGV GKTTLLKSMN GILGGKNVLA 

       250        260        270        280        290        300 
FHEPIAYWTD VFSNSLEEVY KLTLPAKVGR TSNSAKLLAC QLKFASPLLA LKTATDRLSS 

       310        320        330        340        350        360 
PKNSLLSSDM WVMFDRHPLS ATVVFPYMHF QNGFLSFSHL IQLWSSFKAS RGDNIILLNL 

       370        380        390        400        410        420 
NSQENLKRVK KRNRKEEKSV SIEHIRLLNN CYHAVYCAWL LVQNFTPEEI VEVCFNAKHI 

       430        440        450        460        470        480 
TDLSSSKPSF LAKHVSTEDM LKSSIFNTWI EMTKAHRDSC TLMECLLTFC KELEKVQLIH 

       490        500        510        520 
VNVSPFTDDI PGLWASIYTS IRRNSAIKPN RVNWLALEDL ARTFNSQ 

« Hide

References

« Hide 'large scale' references
[1]"A comparative analysis of the sequence of the thymidine kinase gene of a gammaherpesvirus, herpesvirus saimiri."
Honess R.W., Craxton M.A., Williams L., Gompels U.A.
J. Gen. Virol. 70:3003-3013(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Primary structure of the herpesvirus saimiri genome."
Albrecht J.-C., Nicholas J., Biller D., Cameron K.R., Biesinger B., Newman C., Wittmann S., Craxton M.A., Coleman H., Fleckenstein B., Honess R.W.
J. Virol. 66:5047-5058(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X64346 Genomic DNA. Translation: CAA45643.1.
D00543 Genomic DNA. Translation: BAA00432.1.
RefSeqNP_040223.1. NC_001350.1.

3D structure databases

ProteinModelPortalP21293.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1488261.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR002624. Deoxynucleoside_kinase.
IPR001889. Herpes_TK.
IPR013672. Herpes_TK_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR10513. PTHR10513. 1 hit.
PfamPF00693. Herpes_TK. 1 hit.
PF08465. Herpes_TK_C. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKITH_SHV21
AccessionPrimary (citable) accession number: P21293
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: June 11, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families