P21293 (KITH_SHV21) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidine kinase
EC=2.7.1.21

Gene names

Name:	21
Synonyms:	TK

Organism

Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) [Reference proteome]

Taxonomic identifier

10383 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Gammaherpesvirinae › Rhadinovirus › Saimiriine herpesvirus 2

Virus host

Saimiri sciureus (Common squirrel monkey) [TaxID: 9521]

Protein attributes

Sequence length	527 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + thymidine = ADP + thymidine 5'-phosphate.
Sequence similarities	Belongs to the herpesviruses thymidine kinase family.

Ontologies

Keywords
Biological process	DNA synthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW TMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW thymidine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 527	527	Thymidine kinase		PRO_0000175077
Regions
	Nucleotide binding	216 – 223	8	ATP By similarity
Sites
	Active site	243	1	Proton acceptor Potential
	Binding site	260	1	Substrate By similarity
	Binding site	281	1	Substrate By similarity
	Binding site	325	1	Substrate By similarity
	Binding site	368	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P21293 [UniParc]. Last modified May 1, 1991. Version 1. Checksum: 4E8E3A3A178FAD7D	FASTA	527	59,807
	10 20 30 40 50 60 MTGRGQPPKK NDTYDYPRKQ PPKNGSYDNY DYPTSTKTRS TNKQRKDSNY PPRETIFEPD 70 80 90 100 110 120 LAADPIYSVP RPPSRVPHKL VKVNYKSNLV PITASNSVSE LLSLHDETQV TECVEAPLIA 130 140 150 160 170 180 KSPDITVYEK MFSVRPKHTL TKLEGKQKMF TRKKKGSFVK IGSNMLEFGE SLKSKLHNDS 190 200 210 220 230 240 KKSPDEPDGL VHVPVHLLYP PKHQDPVPAF FIFLEGSIGV GKTTLLKSMN GILGGKNVLA 250 260 270 280 290 300 FHEPIAYWTD VFSNSLEEVY KLTLPAKVGR TSNSAKLLAC QLKFASPLLA LKTATDRLSS 310 320 330 340 350 360 PKNSLLSSDM WVMFDRHPLS ATVVFPYMHF QNGFLSFSHL IQLWSSFKAS RGDNIILLNL 370 380 390 400 410 420 NSQENLKRVK KRNRKEEKSV SIEHIRLLNN CYHAVYCAWL LVQNFTPEEI VEVCFNAKHI 430 440 450 460 470 480 TDLSSSKPSF LAKHVSTEDM LKSSIFNTWI EMTKAHRDSC TLMECLLTFC KELEKVQLIH 490 500 510 520 VNVSPFTDDI PGLWASIYTS IRRNSAIKPN RVNWLALEDL ARTFNSQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A comparative analysis of the sequence of the thymidine kinase gene of a gammaherpesvirus, herpesvirus saimiri." Honess R.W., Craxton M.A., Williams L., Gompels U.A. J. Gen. Virol. 70:3003-3013(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Primary structure of the herpesvirus saimiri genome." Albrecht J.-C., Nicholas J., Biller D., Cameron K.R., Biesinger B., Newman C., Wittmann S., Craxton M.A., Coleman H., Fleckenstein B., Honess R.W. J. Virol. 66:5047-5058(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X64346 Genomic DNA. Translation: CAA45643.1. D00543 Genomic DNA. Translation: BAA00432.1.
RefSeq	NP_040223.1. NC_001350.1.
3D structure databases
ProteinModelPortal	P21293.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1488261.
Phylogenomic databases
ProtClustDB	PHA3132.
Family and domain databases
InterPro	IPR001889. Herpes_TK. IPR013672. Herpes_TK_C. [Graphical view]
Pfam	PF00693. Herpes_TK. 1 hit. PF08465. Herpes_TK_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KITH_SHV21

Accession

Primary (citable) accession number: P21293

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
Last sequence update:	May 1, 1991
Last modified:	April 3, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program