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Protein

Thymidine kinase

Gene

TK

Organism
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of the gamma-phospho group of ATP to thymidine to generate dTMP in the salvage pathway of pyrimidine synthesis. The dTMP serves as a substrate for DNA polymerase during viral DNA replication. Allows the virus to be reactivated and to grow in non-proliferative cells lacking a high concentration of phosphorylated nucleic acid precursors.UniRule annotation

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei243Proton acceptorUniRule annotation1
Binding sitei260SubstrateUniRule annotation1
Binding sitei281SubstrateUniRule annotation1
Binding sitei368ATPUniRule annotation1
Binding sitei374SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi216 – 223ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processDNA synthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:TKUniRule annotation
Ordered Locus Names:21
OrganismiSaimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri)
Taxonomic identifieri10383 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostiSaimiri sciureus (Common squirrel monkey) [TaxID: 9521]
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001750771 – 527Thymidine kinaseAdd BLAST527

Proteomic databases

PRIDEiP21293

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP21293
SMRiP21293
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae thymidine kinase family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG0900004C

Family and domain databases

HAMAPiMF_04029 HSV_KITH, 1 hit
InterProiView protein in InterPro
IPR001889 Herpes_TK
IPR013672 Herpes_TK_C
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00693 Herpes_TK, 1 hit
PF08465 Herpes_TK_C, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

P21293-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGRGQPPKK NDTYDYPRKQ PPKNGSYDNY DYPTSTKTRS TNKQRKDSNY
60 70 80 90 100
PPRETIFEPD LAADPIYSVP RPPSRVPHKL VKVNYKSNLV PITASNSVSE
110 120 130 140 150
LLSLHDETQV TECVEAPLIA KSPDITVYEK MFSVRPKHTL TKLEGKQKMF
160 170 180 190 200
TRKKKGSFVK IGSNMLEFGE SLKSKLHNDS KKSPDEPDGL VHVPVHLLYP
210 220 230 240 250
PKHQDPVPAF FIFLEGSIGV GKTTLLKSMN GILGGKNVLA FHEPIAYWTD
260 270 280 290 300
VFSNSLEEVY KLTLPAKVGR TSNSAKLLAC QLKFASPLLA LKTATDRLSS
310 320 330 340 350
PKNSLLSSDM WVMFDRHPLS ATVVFPYMHF QNGFLSFSHL IQLWSSFKAS
360 370 380 390 400
RGDNIILLNL NSQENLKRVK KRNRKEEKSV SIEHIRLLNN CYHAVYCAWL
410 420 430 440 450
LVQNFTPEEI VEVCFNAKHI TDLSSSKPSF LAKHVSTEDM LKSSIFNTWI
460 470 480 490 500
EMTKAHRDSC TLMECLLTFC KELEKVQLIH VNVSPFTDDI PGLWASIYTS
510 520
IRRNSAIKPN RVNWLALEDL ARTFNSQ
Length:527
Mass (Da):59,807
Last modified:May 1, 1991 - v1
Checksum:i4E8E3A3A178FAD7D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64346 Genomic DNA Translation: CAA45643.1
D00543 Genomic DNA Translation: BAA00432.1
RefSeqiNP_040223.1, NC_001350.1

Genome annotation databases

GeneIDi1488261
KEGGivg:1488261

Similar proteinsi

Entry informationi

Entry nameiKITH_SHV21
AccessioniPrimary (citable) accession number: P21293
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: May 23, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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