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Protein

Cysteine and glycine-rich protein 1

Gene

CSRP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Could play a role in neuronal development.

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • zinc ion binding Source: ProtInc

GO - Biological processi

  • platelet aggregation Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine and glycine-rich protein 1
Alternative name(s):
Cysteine-rich protein 1
Short name:
CRP
Short name:
CRP1
Epididymis luminal protein 141
Short name:
HEL-141
Gene namesi
Name:CSRP1
Synonyms:CSRP, CYRP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:2469. CSRP1.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • focal adhesion Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26967.

Polymorphism and mutation databases

BioMutaiCSRP1.
DMDMi118161.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 193193Cysteine and glycine-rich protein 1PRO_0000075715Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei81 – 811PhosphoserineBy similarity
Modified residuei84 – 841N6-acetyllysineBy similarity
Modified residuei112 – 1121N6-acetyllysineCombined sources
Modified residuei131 – 1311N6-acetyllysineCombined sources
Modified residuei137 – 1371N6-acetyllysineBy similarity
Modified residuei161 – 1611N6-acetyllysineBy similarity
Modified residuei192 – 1921PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP21291.
PaxDbiP21291.
PeptideAtlasiP21291.
PRIDEiP21291.
TopDownProteomicsiP21291.

2D gel databases

OGPiP21291.

PTM databases

iPTMnetiP21291.
PhosphoSiteiP21291.
SwissPalmiP21291.

Expressioni

Gene expression databases

BgeeiENSG00000159176.
CleanExiHS_CSRP1.
ExpressionAtlasiP21291. baseline and differential.
GenevisibleiP21291. HS.

Organism-specific databases

HPAiHPA045617.

Interactioni

Subunit structurei

Interacts with ASCC1; ASCC2 AND TRIP4.1 Publication

Protein-protein interaction databases

BioGridi107847. 21 interactions.
IntActiP21291. 5 interactions.
STRINGi9606.ENSP00000345079.

Structurei

3D structure databases

ProteinModelPortaliP21291.
SMRiP21291. Positions 1-193.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 6152LIM zinc-binding 1PROSITE-ProRule annotationAdd
BLAST
Domaini119 – 17052LIM zinc-binding 2PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi64 – 696Nuclear localization signalSequence analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi63 – 7816Gly-richAdd
BLAST
Compositional biasi176 – 18712Gly-richAdd
BLAST

Sequence similaritiesi

Contains 2 LIM zinc-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiENOG410ITI1. Eukaryota.
ENOG4111F3Y. LUCA.
GeneTreeiENSGT00550000074548.
HOGENOMiHOG000111233.
HOVERGENiHBG051143.
InParanoidiP21291.
KOiK09377.
OMAiRCPRCTQ.
OrthoDBiEOG091G11RX.
PhylomeDBiP21291.
TreeFamiTF313758.

Family and domain databases

Gene3Di2.10.110.10. 2 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00132. LIM. 2 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P21291-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNWGGGKKC GVCQKTVYFA EEVQCEGNSF HKSCFLCMVC KKNLDSTTVA
60 70 80 90 100
VHGEEIYCKS CYGKKYGPKG YGYGQGAGTL STDKGESLGI KHEEAPGHRP
110 120 130 140 150
TTNPNASKFA QKIGGSERCP RCSQAVYAAE KVIGAGKSWH KACFRCAKCG
160 170 180 190
KGLESTTLAD KDGEIYCKGC YAKNFGPKGF GFGQGAGALV HSE
Length:193
Mass (Da):20,567
Last modified:January 23, 2007 - v3
Checksum:iAC6970255D68D69A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti91 – 911K → R in BAF82822 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti108 – 1081K → I.
Corresponds to variant rs3738283 [ dbSNP | Ensembl ].
VAR_050144

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33146 mRNA. Translation: AAA35720.1.
M76378, M76376, M76377 Genomic DNA. Translation: AAA58431.1.
EU668320 mRNA. Translation: ACF94473.1.
AK290133 mRNA. Translation: BAF82822.1.
AK293053 mRNA. Translation: BAF85742.1.
BT019520 mRNA. Translation: AAV38327.1.
CH471067 Genomic DNA. Translation: EAW91371.1.
BC032493 mRNA. Translation: AAH32493.1.
CCDSiCCDS1413.1.
PIRiS12658.
RefSeqiNP_001180499.1. NM_001193570.1.
NP_001180500.1. NM_001193571.1.
NP_001180501.1. NM_001193572.1.
NP_004069.1. NM_004078.2.
UniGeneiHs.108080.

Genome annotation databases

EnsembliENST00000340006; ENSP00000345079; ENSG00000159176.
ENST00000367306; ENSP00000356275; ENSG00000159176.
ENST00000532460; ENSP00000434147; ENSG00000159176.
ENST00000533432; ENSP00000436792; ENSG00000159176.
GeneIDi1465.
KEGGihsa:1465.
UCSCiuc001gws.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33146 mRNA. Translation: AAA35720.1.
M76378, M76376, M76377 Genomic DNA. Translation: AAA58431.1.
EU668320 mRNA. Translation: ACF94473.1.
AK290133 mRNA. Translation: BAF82822.1.
AK293053 mRNA. Translation: BAF85742.1.
BT019520 mRNA. Translation: AAV38327.1.
CH471067 Genomic DNA. Translation: EAW91371.1.
BC032493 mRNA. Translation: AAH32493.1.
CCDSiCCDS1413.1.
PIRiS12658.
RefSeqiNP_001180499.1. NM_001193570.1.
NP_001180500.1. NM_001193571.1.
NP_001180501.1. NM_001193572.1.
NP_004069.1. NM_004078.2.
UniGeneiHs.108080.

3D structure databases

ProteinModelPortaliP21291.
SMRiP21291. Positions 1-193.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107847. 21 interactions.
IntActiP21291. 5 interactions.
STRINGi9606.ENSP00000345079.

PTM databases

iPTMnetiP21291.
PhosphoSiteiP21291.
SwissPalmiP21291.

Polymorphism and mutation databases

BioMutaiCSRP1.
DMDMi118161.

2D gel databases

OGPiP21291.

Proteomic databases

EPDiP21291.
PaxDbiP21291.
PeptideAtlasiP21291.
PRIDEiP21291.
TopDownProteomicsiP21291.

Protocols and materials databases

DNASUi1465.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340006; ENSP00000345079; ENSG00000159176.
ENST00000367306; ENSP00000356275; ENSG00000159176.
ENST00000532460; ENSP00000434147; ENSG00000159176.
ENST00000533432; ENSP00000436792; ENSG00000159176.
GeneIDi1465.
KEGGihsa:1465.
UCSCiuc001gws.4. human.

Organism-specific databases

CTDi1465.
GeneCardsiCSRP1.
HGNCiHGNC:2469. CSRP1.
HPAiHPA045617.
MIMi123876. gene.
neXtProtiNX_P21291.
PharmGKBiPA26967.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITI1. Eukaryota.
ENOG4111F3Y. LUCA.
GeneTreeiENSGT00550000074548.
HOGENOMiHOG000111233.
HOVERGENiHBG051143.
InParanoidiP21291.
KOiK09377.
OMAiRCPRCTQ.
OrthoDBiEOG091G11RX.
PhylomeDBiP21291.
TreeFamiTF313758.

Miscellaneous databases

ChiTaRSiCSRP1. human.
GeneWikiiCSRP1.
GenomeRNAii1465.
PROiP21291.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000159176.
CleanExiHS_CSRP1.
ExpressionAtlasiP21291. baseline and differential.
GenevisibleiP21291. HS.

Family and domain databases

Gene3Di2.10.110.10. 2 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00132. LIM. 2 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSRP1_HUMAN
AccessioniPrimary (citable) accession number: P21291
Secondary accession number(s): A8K268, Q5U0J2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 152 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.