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Protein

V-type proton ATPase subunit C 1

Gene

ATP6V1C1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

GO - Molecular functioni

  • proton-exporting ATPase activity, phosphorylative mechanism Source: GO_Central
  • proton-transporting ATPase activity, rotational mechanism Source: ProtInc
  • transporter activity Source: ProtInc

GO - Biological processi

  • ATP hydrolysis coupled proton transport Source: InterPro
  • insulin receptor signaling pathway Source: Reactome
  • ion transmembrane transport Source: Reactome
  • proton transmembrane transport Source: ProtInc
  • regulation of macroautophagy Source: ParkinsonsUK-UCL
  • transferrin transport Source: Reactome

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciMetaCyc:HS08030-MONOMER
ReactomeiR-HSA-1222556 ROS, RNS production in phagocytes
R-HSA-77387 Insulin receptor recycling
R-HSA-917977 Transferrin endocytosis and recycling
R-HSA-983712 Ion channel transport

Protein family/group databases

TCDBi3.A.2.2.4 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit C 1
Short name:
V-ATPase subunit C 1
Alternative name(s):
Vacuolar proton pump subunit C 1
Gene namesi
Name:ATP6V1C1
Synonyms:ATP6C, ATP6D, VATC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000155097.11
HGNCiHGNC:856 ATP6V1C1
MIMi603097 gene
neXtProtiNX_P21283

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi528
OpenTargetsiENSG00000155097
PharmGKBiPA25156

Chemistry databases

DrugBankiDB01694 D-tartaric acid

Polymorphism and mutation databases

BioMutaiATP6V1C1
DMDMi401329

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00002093482 – 382V-type proton ATPase subunit C 1Add BLAST381

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineCombined sources1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP21283
MaxQBiP21283
PaxDbiP21283
PeptideAtlasiP21283
PRIDEiP21283

PTM databases

iPTMnetiP21283
PhosphoSitePlusiP21283
SwissPalmiP21283

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000155097
CleanExiHS_ATP6V1C1
ExpressionAtlasiP21283 baseline and differential
GenevisibleiP21283 HS

Organism-specific databases

HPAiHPA023943
HPA057297

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).

Binary interactionsi

WithEntry#Exp.IntActNotes
ARF6P623304EBI-988663,EBI-638181

Protein-protein interaction databases

BioGridi107011, 62 interactors
IntActiP21283, 7 interactors
STRINGi9606.ENSP00000379203

Structurei

3D structure databases

ProteinModelPortaliP21283
SMRiP21283
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase C subunit family.Curated

Phylogenomic databases

eggNOGiKOG2909 Eukaryota
COG5127 LUCA
GeneTreeiENSGT00390000004263
HOGENOMiHOG000207528
HOVERGENiHBG002470
InParanoidiP21283
KOiK02148
OMAiCRENKFI
OrthoDBiEOG091G03CP
PhylomeDBiP21283
TreeFamiTF314912

Family and domain databases

CDDicd14785 V-ATPase_C, 1 hit
InterProiView protein in InterPro
IPR004907 ATPase_V1-cplx_csu
IPR036132 Vac_ATP_synth_c_sf
PANTHERiPTHR10137 PTHR10137, 1 hit
PfamiView protein in Pfam
PF03223 V-ATPase_C, 1 hit
SUPFAMiSSF118203 SSF118203, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21283-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEFWLISAP GEKTCQQTWE KLHAATSKNN NLAVTSKFNI PDLKVGTLDV
60 70 80 90 100
LVGLSDELAK LDAFVEGVVK KVAQYMADVL EDSKDKVQEN LLANGVDLVT
110 120 130 140 150
YITRFQWDMA KYPIKQSLKN ISEIIAKGVT QIDNDLKSRA SAYNNLKGNL
160 170 180 190 200
QNLERKNAGS LLTRSLAEIV KKDDFVLDSE YLVTLLVVVP KLNHNDWIKQ
210 220 230 240 250
YETLAEMVVP RSSNVLSEDQ DSYLCNVTLF RKAVDDFRHK ARENKFIVRD
260 270 280 290 300
FQYNEEEMKA DKEEMNRLST DKKKQFGPLV RWLKVNFSEA FIAWIHVKAL
310 320 330 340 350
RVFVESVLRY GLPVNFQAML LQPNKKTLKK LREVLHELYK HLDSSAAAII
360 370 380
DAPMDIPGLN LSQQEYYPYV YYKIDCNLLE FK
Length:382
Mass (Da):43,942
Last modified:January 23, 2007 - v4
Checksum:i5626E2AB2BD66BA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69151 mRNA Translation: CAA48903.1
AF363578 Genomic DNA Translation: AAL50383.1
BC010960 mRNA Translation: AAH10960.1
J05682 mRNA Translation: AAA36803.1
CCDSiCCDS6296.1
PIRiJN0907
RefSeqiNP_001686.1, NM_001695.4
UniGeneiHs.86905

Genome annotation databases

EnsembliENST00000395862; ENSP00000379203; ENSG00000155097
ENST00000518738; ENSP00000430282; ENSG00000155097
GeneIDi528
KEGGihsa:528
UCSCiuc003ykz.5 human

Similar proteinsi

Entry informationi

Entry nameiVATC1_HUMAN
AccessioniPrimary (citable) accession number: P21283
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 174 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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