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Reviewed, UniProtKB/Swiss-Prot P21283 (VATC1_HUMAN)

Last modified January 19, 2010. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    V-type proton ATPase subunit C 1
      Short name=V-ATPase subunit C 1
Alternative name(s):
    Vacuolar proton pump subunit C 1
Gene names
Name: ATP6V1C1
Synonyms: ATP6C, ATP6D, VATC
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length382 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Subunit structure

V-ATPase is an heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).

Tissue specificity

Ubiquitous. Ref.6

Sequence similarities

Belongs to the V-ATPase C subunit family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ARF6P623304EBI-988663,EBI-638181
Arf6P623311EBI-988663,EBI-988682From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.4
Chain2 – 382381V-type proton ATPase subunit C 1
PRO_0000209348

Amino acid modifications

Modified residue21N-acetylthreonine Ref.4

Sequences

Sequence LengthMass (Da)Tools
P21283-1 [UniParc].

Last modified January 23, 2007. Version 4.
Checksum: 5626E2AB2BD66BA7

FASTA38243,942
        10         20         30         40         50         60 
MTEFWLISAP GEKTCQQTWE KLHAATSKNN NLAVTSKFNI PDLKVGTLDV LVGLSDELAK 

        70         80         90        100        110        120 
LDAFVEGVVK KVAQYMADVL EDSKDKVQEN LLANGVDLVT YITRFQWDMA KYPIKQSLKN 

       130        140        150        160        170        180 
ISEIIAKGVT QIDNDLKSRA SAYNNLKGNL QNLERKNAGS LLTRSLAEIV KKDDFVLDSE 

       190        200        210        220        230        240 
YLVTLLVVVP KLNHNDWIKQ YETLAEMVVP RSSNVLSEDQ DSYLCNVTLF RKAVDDFRHK 

       250        260        270        280        290        300 
ARENKFIVRD FQYNEEEMKA DKEEMNRLST DKKKQFGPLV RWLKVNFSEA FIAWIHVKAL 

       310        320        330        340        350        360 
RVFVESVLRY GLPVNFQAML LQPNKKTLKK LREVLHELYK HLDSSAAAII DAPMDIPGLN 

       370        380 
LSQQEYYPYV YYKIDCNLLE FK 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and tissue distribution of subunits C, D, and E of the human vacuolar H(+)-ATPase."
van Hille B., Vanek M., Richener H., Green J.R., Bilbe G.
Biochem. Biophys. Res. Commun. 197:15-21(1993) [PubMed: 8250920] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Osteoclastoma.
[2]"BAALC, the human member of a novel mammalian neuroectoderm gene lineage, is implicated in hematopoiesis and acute leukemia."
Tanner S.M., Austin J.L., Leone G., Rush L.J., Plass C., Heinonen K., Mrozek K., Sill H., Knuutila S., Kolitz J.E., Archer K.J., Caligiuri M.A., Bloomfield C.D., de La Chapelle A.
Proc. Natl. Acad. Sci. U.S.A. 98:13901-13906(2001) [PubMed: 11707601] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Bone marrow.
[4]Kanor S., Bienvenut W.V., Quadroni M.
Submitted (DEC-2005) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 2-13; 45-60 AND 200-211, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT THR-2, MASS SPECTROMETRY.
Tissue: Melanoma.
[5]"Molecular cloning of cDNA encoding the C subunit of H(+)-ATPase from bovine chromaffin granules."
Nelson H., Mandiyan S., Noumi T., Moriyama Y., Miedel M.C., Nelson N.
J. Biol. Chem. 265:20390-20393(1990) [PubMed: 2147024] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 36-382.
Tissue: Brain.
[6]"Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis."
Smith A.N., Borthwick K.J., Karet F.E.
Gene 297:169-177(2002) [PubMed: 12384298] [Abstract]
Cited for: TISSUE SPECIFICITY.
[7]Colinge J., Superti-Furga G., Bennett K.L.
Submitted (OCT-2008) to UniProtKB
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X69151 mRNA. Translation: CAA48903.1.
AF363578 Genomic DNA. Translation: AAL50383.1.
BC010960 mRNA. Translation: AAH10960.1.
J05682 mRNA. Translation: AAA36803.1.
IPIIPI00007814.
PIRJN0907.
RefSeqNP_001686.1.
UniGeneHs.86905

3D structure databases

SMRP21283. Positions 2-375.
ModBaseSearch...

Protein-protein interaction databases

IntActP21283. 2 interactions.
STRINGP21283.

Protein family/group databases

TCDB3.A.2.2.4. H+- or Na+-translocating F-type, V-type and A-type ATPase (F-ATPase) superfamily.

PTM databases

PhosphoSiteP21283.

Proteomic databases

PRIDEP21283.

Genome annotation databases

EnsemblENST00000395862; ENSP00000379203; ENSG00000155097; Homo sapiens. [Genome view]
GeneID528.
KEGGhsa:528.
UCSCuc003ykz.2. human.

Organism-specific databases

CTD528.
GeneCardsGC08P104102.
HGNCHGNC:856. ATP6V1C1.
HPACAB009525.
HPA023943.
HPA024243.
MIM603097. gene.
PharmGKBPA25156.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHBG388608.
HOVERGENP21283.
InParanoidP21283.
OMASEIIGKQ.
OrthoDBEOG986BZ2.
PhylomeDBP21283.

Enzyme and pathway databases

BRENDA3.6.3.14. 247.

Gene expression databases

ArrayExpressP21283.
BgeeP21283.
CleanExHS_ATP6V1C1.
GenevestigatorP21283.
GermOnlineENSG00000155097. Homo sapiens.

Family and domain databases

InterProIPR004907. ATPase_V1-cplx_csu.
[Graphical view]
PANTHERPTHR10137. ATPase_V1_c. 1 hit.
PfamPF03223. V-ATPase_C. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio2193.
SOURCESearch...

Entry information

Entry nameVATC1_HUMAN
AccessionPrimary (citable) accession number: P21283
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: January 23, 2007
Last modified: January 19, 2010
This is version 96 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents