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P21283

- VATC1_HUMAN

UniProt

P21283 - VATC1_HUMAN

Protein

V-type proton ATPase subunit C 1

Gene

ATP6V1C1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 141 (01 Oct 2014)
      Sequence version 4 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

    GO - Molecular functioni

    1. hydrogen-exporting ATPase activity, phosphorylative mechanism Source: Ensembl
    2. protein binding Source: IntAct
    3. proton-transporting ATPase activity, rotational mechanism Source: ProtInc
    4. transporter activity Source: ProtInc

    GO - Biological processi

    1. ATP hydrolysis coupled proton transport Source: InterPro
    2. cellular iron ion homeostasis Source: Reactome
    3. insulin receptor signaling pathway Source: Reactome
    4. interaction with host Source: Reactome
    5. phagosome maturation Source: Reactome
    6. proton transport Source: ProtInc
    7. transferrin transport Source: Reactome
    8. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Hydrogen ion transport, Ion transport, Transport

    Enzyme and pathway databases

    BioCyciMetaCyc:HS08030-MONOMER.
    ReactomeiREACT_1109. Insulin receptor recycling.
    REACT_121256. Phagosomal maturation (early endosomal stage).
    REACT_25283. Transferrin endocytosis and recycling.

    Protein family/group databases

    TCDBi3.A.2.2.4. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    V-type proton ATPase subunit C 1
    Short name:
    V-ATPase subunit C 1
    Alternative name(s):
    Vacuolar proton pump subunit C 1
    Gene namesi
    Name:ATP6V1C1
    Synonyms:ATP6C, ATP6D, VATC
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:856. ATP6V1C1.

    Subcellular locationi

    GO - Cellular componenti

    1. apical part of cell Source: Ensembl
    2. cytoplasmic vesicle Source: Ensembl
    3. cytosol Source: Reactome
    4. extracellular vesicular exosome Source: UniProt
    5. lysosomal membrane Source: UniProtKB
    6. plasma membrane Source: UniProtKB
    7. proton-transporting two-sector ATPase complex Source: ProtInc
    8. proton-transporting V-type ATPase, V1 domain Source: InterPro

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25156.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 382381V-type proton ATPase subunit C 1PRO_0000209348Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylthreonine2 Publications

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP21283.
    PaxDbiP21283.
    PRIDEiP21283.

    PTM databases

    PhosphoSiteiP21283.

    Expressioni

    Tissue specificityi

    Ubiquitous.1 Publication

    Gene expression databases

    ArrayExpressiP21283.
    BgeeiP21283.
    CleanExiHS_ATP6V1C1.
    GenevestigatoriP21283.

    Organism-specific databases

    HPAiHPA023943.
    HPA024243.

    Interactioni

    Subunit structurei

    V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ARF6P623304EBI-988663,EBI-638181

    Protein-protein interaction databases

    BioGridi107011. 44 interactions.
    IntActiP21283. 4 interactions.
    STRINGi9606.ENSP00000379203.

    Structurei

    3D structure databases

    ProteinModelPortaliP21283.
    SMRiP21283. Positions 7-346.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the V-ATPase C subunit family.Curated

    Phylogenomic databases

    eggNOGiCOG5127.
    HOGENOMiHOG000207528.
    HOVERGENiHBG002470.
    InParanoidiP21283.
    KOiK02148.
    OMAiQRQYAPL.
    OrthoDBiEOG7QNVKX.
    PhylomeDBiP21283.
    TreeFamiTF314912.

    Family and domain databases

    InterProiIPR004907. ATPase_V1-cplx_csu.
    [Graphical view]
    PANTHERiPTHR10137. PTHR10137. 1 hit.
    PfamiPF03223. V-ATPase_C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P21283-1 [UniParc]FASTAAdd to Basket

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    MTEFWLISAP GEKTCQQTWE KLHAATSKNN NLAVTSKFNI PDLKVGTLDV    50
    LVGLSDELAK LDAFVEGVVK KVAQYMADVL EDSKDKVQEN LLANGVDLVT 100
    YITRFQWDMA KYPIKQSLKN ISEIIAKGVT QIDNDLKSRA SAYNNLKGNL 150
    QNLERKNAGS LLTRSLAEIV KKDDFVLDSE YLVTLLVVVP KLNHNDWIKQ 200
    YETLAEMVVP RSSNVLSEDQ DSYLCNVTLF RKAVDDFRHK ARENKFIVRD 250
    FQYNEEEMKA DKEEMNRLST DKKKQFGPLV RWLKVNFSEA FIAWIHVKAL 300
    RVFVESVLRY GLPVNFQAML LQPNKKTLKK LREVLHELYK HLDSSAAAII 350
    DAPMDIPGLN LSQQEYYPYV YYKIDCNLLE FK 382
    Length:382
    Mass (Da):43,942
    Last modified:January 23, 2007 - v4
    Checksum:i5626E2AB2BD66BA7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69151 mRNA. Translation: CAA48903.1.
    AF363578 Genomic DNA. Translation: AAL50383.1.
    BC010960 mRNA. Translation: AAH10960.1.
    J05682 mRNA. Translation: AAA36803.1.
    CCDSiCCDS6296.1.
    PIRiJN0907.
    RefSeqiNP_001686.1. NM_001695.4.
    UniGeneiHs.86905.

    Genome annotation databases

    EnsembliENST00000395862; ENSP00000379203; ENSG00000155097.
    ENST00000518738; ENSP00000430282; ENSG00000155097.
    GeneIDi528.
    KEGGihsa:528.
    UCSCiuc003ykz.4. human.

    Polymorphism databases

    DMDMi401329.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69151 mRNA. Translation: CAA48903.1 .
    AF363578 Genomic DNA. Translation: AAL50383.1 .
    BC010960 mRNA. Translation: AAH10960.1 .
    J05682 mRNA. Translation: AAA36803.1 .
    CCDSi CCDS6296.1.
    PIRi JN0907.
    RefSeqi NP_001686.1. NM_001695.4.
    UniGenei Hs.86905.

    3D structure databases

    ProteinModelPortali P21283.
    SMRi P21283. Positions 7-346.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107011. 44 interactions.
    IntActi P21283. 4 interactions.
    STRINGi 9606.ENSP00000379203.

    Protein family/group databases

    TCDBi 3.A.2.2.4. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

    PTM databases

    PhosphoSitei P21283.

    Polymorphism databases

    DMDMi 401329.

    Proteomic databases

    MaxQBi P21283.
    PaxDbi P21283.
    PRIDEi P21283.

    Protocols and materials databases

    DNASUi 528.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000395862 ; ENSP00000379203 ; ENSG00000155097 .
    ENST00000518738 ; ENSP00000430282 ; ENSG00000155097 .
    GeneIDi 528.
    KEGGi hsa:528.
    UCSCi uc003ykz.4. human.

    Organism-specific databases

    CTDi 528.
    GeneCardsi GC08P104033.
    HGNCi HGNC:856. ATP6V1C1.
    HPAi HPA023943.
    HPA024243.
    MIMi 603097. gene.
    neXtProti NX_P21283.
    PharmGKBi PA25156.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5127.
    HOGENOMi HOG000207528.
    HOVERGENi HBG002470.
    InParanoidi P21283.
    KOi K02148.
    OMAi QRQYAPL.
    OrthoDBi EOG7QNVKX.
    PhylomeDBi P21283.
    TreeFami TF314912.

    Enzyme and pathway databases

    BioCyci MetaCyc:HS08030-MONOMER.
    Reactomei REACT_1109. Insulin receptor recycling.
    REACT_121256. Phagosomal maturation (early endosomal stage).
    REACT_25283. Transferrin endocytosis and recycling.

    Miscellaneous databases

    ChiTaRSi ATP6V1C1. human.
    GeneWikii ATP6V1C1.
    GenomeRNAii 528.
    NextBioi 2193.
    PROi P21283.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P21283.
    Bgeei P21283.
    CleanExi HS_ATP6V1C1.
    Genevestigatori P21283.

    Family and domain databases

    InterProi IPR004907. ATPase_V1-cplx_csu.
    [Graphical view ]
    PANTHERi PTHR10137. PTHR10137. 1 hit.
    Pfami PF03223. V-ATPase_C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and tissue distribution of subunits C, D, and E of the human vacuolar H(+)-ATPase."
      van Hille B., Vanek M., Richener H., Green J.R., Bilbe G.
      Biochem. Biophys. Res. Commun. 197:15-21(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Osteoclastoma.
    2. "BAALC, the human member of a novel mammalian neuroectoderm gene lineage, is implicated in hematopoiesis and acute leukemia."
      Tanner S.M., Austin J.L., Leone G., Rush L.J., Plass C., Heinonen K., Mrozek K., Sill H., Knuutila S., Kolitz J.E., Archer K.J., Caligiuri M.A., Bloomfield C.D., de La Chapelle A.
      Proc. Natl. Acad. Sci. U.S.A. 98:13901-13906(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Bone marrow.
    4. Kanor S., Bienvenut W.V., Quadroni M.
      Submitted (DEC-2005) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-13; 45-60 AND 200-211, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT THR-2, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Melanoma.
    5. "Molecular cloning of cDNA encoding the C subunit of H(+)-ATPase from bovine chromaffin granules."
      Nelson H., Mandiyan S., Noumi T., Moriyama Y., Miedel M.C., Nelson N.
      J. Biol. Chem. 265:20390-20393(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 36-382.
      Tissue: Brain.
    6. "Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis."
      Smith A.N., Borthwick K.J., Karet F.E.
      Gene 297:169-177(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT THR-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiVATC1_HUMAN
    AccessioniPrimary (citable) accession number: P21283
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 141 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3