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P21283 (VATC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 139. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
V-type proton ATPase subunit C 1

Short name=V-ATPase subunit C 1
Alternative name(s):
Vacuolar proton pump subunit C 1
Gene names
Name:ATP6V1C1
Synonyms:ATP6C, ATP6D, VATC
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length382 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Subunit structure

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).

Tissue specificity

Ubiquitous. Ref.6

Sequence similarities

Belongs to the V-ATPase C subunit family.

Ontologies

Keywords
   Biological processHydrogen ion transport
Ion transport
Transport
   PTMAcetylation
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processATP hydrolysis coupled proton transport

Inferred from electronic annotation. Source: InterPro

cellular iron ion homeostasis

Traceable author statement. Source: Reactome

insulin receptor signaling pathway

Traceable author statement. Source: Reactome

interaction with host

Traceable author statement. Source: Reactome

phagosome maturation

Traceable author statement. Source: Reactome

proton transport

Traceable author statement Ref.1. Source: ProtInc

transferrin transport

Traceable author statement. Source: Reactome

transmembrane transport

Traceable author statement. Source: Reactome

   Cellular_componentapical part of cell

Inferred from electronic annotation. Source: Ensembl

cytoplasmic vesicle

Inferred from electronic annotation. Source: Ensembl

cytosol

Traceable author statement. Source: Reactome

extracellular vesicular exosome

Inferred from direct assay PubMed 19056867PubMed 23376485. Source: UniProt

lysosomal membrane

Inferred from direct assay PubMed 17897319. Source: UniProtKB

plasma membrane

Inferred from sequence or structural similarity. Source: UniProtKB

proton-transporting V-type ATPase, V1 domain

Inferred from electronic annotation. Source: InterPro

proton-transporting two-sector ATPase complex

Traceable author statement Ref.1. Source: ProtInc

   Molecular_functionhydrogen-exporting ATPase activity, phosphorylative mechanism

Inferred from electronic annotation. Source: Ensembl

protein binding

Inferred from physical interaction PubMed 16415858. Source: IntAct

proton-transporting ATPase activity, rotational mechanism

Traceable author statement Ref.1. Source: ProtInc

transporter activity

Non-traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ARF6P623304EBI-988663,EBI-638181

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.4
Chain2 – 382381V-type proton ATPase subunit C 1
PRO_0000209348

Amino acid modifications

Modified residue21N-acetylthreonine Ref.4 Ref.8

Sequences

Sequence LengthMass (Da)Tools
P21283 [UniParc].

Last modified January 23, 2007. Version 4.
Checksum: 5626E2AB2BD66BA7

FASTA38243,942
        10         20         30         40         50         60 
MTEFWLISAP GEKTCQQTWE KLHAATSKNN NLAVTSKFNI PDLKVGTLDV LVGLSDELAK 

        70         80         90        100        110        120 
LDAFVEGVVK KVAQYMADVL EDSKDKVQEN LLANGVDLVT YITRFQWDMA KYPIKQSLKN 

       130        140        150        160        170        180 
ISEIIAKGVT QIDNDLKSRA SAYNNLKGNL QNLERKNAGS LLTRSLAEIV KKDDFVLDSE 

       190        200        210        220        230        240 
YLVTLLVVVP KLNHNDWIKQ YETLAEMVVP RSSNVLSEDQ DSYLCNVTLF RKAVDDFRHK 

       250        260        270        280        290        300 
ARENKFIVRD FQYNEEEMKA DKEEMNRLST DKKKQFGPLV RWLKVNFSEA FIAWIHVKAL 

       310        320        330        340        350        360 
RVFVESVLRY GLPVNFQAML LQPNKKTLKK LREVLHELYK HLDSSAAAII DAPMDIPGLN 

       370        380 
LSQQEYYPYV YYKIDCNLLE FK 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and tissue distribution of subunits C, D, and E of the human vacuolar H(+)-ATPase."
van Hille B., Vanek M., Richener H., Green J.R., Bilbe G.
Biochem. Biophys. Res. Commun. 197:15-21(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Osteoclastoma.
[2]"BAALC, the human member of a novel mammalian neuroectoderm gene lineage, is implicated in hematopoiesis and acute leukemia."
Tanner S.M., Austin J.L., Leone G., Rush L.J., Plass C., Heinonen K., Mrozek K., Sill H., Knuutila S., Kolitz J.E., Archer K.J., Caligiuri M.A., Bloomfield C.D., de La Chapelle A.
Proc. Natl. Acad. Sci. U.S.A. 98:13901-13906(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Bone marrow.
[4]Kanor S., Bienvenut W.V., Quadroni M.
Submitted (DEC-2005) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 2-13; 45-60 AND 200-211, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT THR-2, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Melanoma.
[5]"Molecular cloning of cDNA encoding the C subunit of H(+)-ATPase from bovine chromaffin granules."
Nelson H., Mandiyan S., Noumi T., Moriyama Y., Miedel M.C., Nelson N.
J. Biol. Chem. 265:20390-20393(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 36-382.
Tissue: Brain.
[6]"Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis."
Smith A.N., Borthwick K.J., Karet F.E.
Gene 297:169-177(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT THR-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X69151 mRNA. Translation: CAA48903.1.
AF363578 Genomic DNA. Translation: AAL50383.1.
BC010960 mRNA. Translation: AAH10960.1.
J05682 mRNA. Translation: AAA36803.1.
CCDSCCDS6296.1.
PIRJN0907.
RefSeqNP_001686.1. NM_001695.4.
UniGeneHs.86905.

3D structure databases

ProteinModelPortalP21283.
SMRP21283. Positions 7-346.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107011. 44 interactions.
IntActP21283. 4 interactions.
STRING9606.ENSP00000379203.

Protein family/group databases

TCDB3.A.2.2.4. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

PTM databases

PhosphoSiteP21283.

Polymorphism databases

DMDM401329.

Proteomic databases

MaxQBP21283.
PaxDbP21283.
PRIDEP21283.

Protocols and materials databases

DNASU528.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000395862; ENSP00000379203; ENSG00000155097.
ENST00000518738; ENSP00000430282; ENSG00000155097.
GeneID528.
KEGGhsa:528.
UCSCuc003ykz.4. human.

Organism-specific databases

CTD528.
GeneCardsGC08P104033.
HGNCHGNC:856. ATP6V1C1.
HPAHPA023943.
HPA024243.
MIM603097. gene.
neXtProtNX_P21283.
PharmGKBPA25156.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5127.
HOGENOMHOG000207528.
HOVERGENHBG002470.
InParanoidP21283.
KOK02148.
OMAQRQYAPL.
OrthoDBEOG7QNVKX.
PhylomeDBP21283.
TreeFamTF314912.

Enzyme and pathway databases

BioCycMetaCyc:HS08030-MONOMER.
ReactomeREACT_111102. Signal Transduction.
REACT_116125. Disease.
REACT_15518. Transmembrane transport of small molecules.

Gene expression databases

ArrayExpressP21283.
BgeeP21283.
CleanExHS_ATP6V1C1.
GenevestigatorP21283.

Family and domain databases

InterProIPR004907. ATPase_V1-cplx_csu.
[Graphical view]
PANTHERPTHR10137. PTHR10137. 1 hit.
PfamPF03223. V-ATPase_C. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSATP6V1C1. human.
GeneWikiATP6V1C1.
GenomeRNAi528.
NextBio2193.
PROP21283.
SOURCESearch...

Entry information

Entry nameVATC1_HUMAN
AccessionPrimary (citable) accession number: P21283
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 139 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM