P21283 (VATC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
V-type proton ATPase subunit C 1
Short name=V-ATPase subunit C 1

Alternative name(s):
Vacuolar proton pump subunit C 1

Gene names

Name:	ATP6V1C1
Synonyms:	ATP6C, ATP6D, VATC

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	382 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
Subunit structure	V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).
Tissue specificity	Ubiquitous. Ref.6
Sequence similarities	Belongs to the V-ATPase C subunit family.

Ontologies

Keywords
Biological process	Hydrogen ion transport Ion transport Transport
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	ATP hydrolysis coupled proton transport Inferred from electronic annotation. Source: InterPro cellular iron ion homeostasis Traceable author statement. Source: Reactome insulin receptor signaling pathway Traceable author statement. Source: Reactome interaction with host Traceable author statement. Source: Reactome phagosome maturation Traceable author statement. Source: Reactome transferrin transport Traceable author statement. Source: Reactome
Cellular_component	apical part of cell Inferred from electronic annotation. Source: Compara cytoplasmic vesicle Inferred from electronic annotation. Source: Compara cytosol Traceable author statement. Source: Reactome plasma membrane Inferred from sequence or structural similarity. Source: UniProtKB proton-transporting V-type ATPase, V1 domain Inferred from electronic annotation. Source: InterPro proton-transporting two-sector ATPase complex Traceable author statement Ref.1. Source: ProtInc
Molecular_function	hydrogen-exporting ATPase activity, phosphorylative mechanism Inferred from electronic annotation. Source: Compara proton-transporting ATPase activity, rotational mechanism Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ARF6	P62330	4	EBI-988663,EBI-638181

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.4
	Chain	2 – 382	381	V-type proton ATPase subunit C 1		PRO_0000209348
Amino acid modifications
	Modified residue	2	1	N-acetylthreonine Ref.4

Sequences

	Sequence		Length	Mass (Da)
	P21283 [UniParc]. Last modified January 23, 2007. Version 4. Checksum: 5626E2AB2BD66BA7	FASTA	382	43,942
	10 20 30 40 50 60 MTEFWLISAP GEKTCQQTWE KLHAATSKNN NLAVTSKFNI PDLKVGTLDV LVGLSDELAK 70 80 90 100 110 120 LDAFVEGVVK KVAQYMADVL EDSKDKVQEN LLANGVDLVT YITRFQWDMA KYPIKQSLKN 130 140 150 160 170 180 ISEIIAKGVT QIDNDLKSRA SAYNNLKGNL QNLERKNAGS LLTRSLAEIV KKDDFVLDSE 190 200 210 220 230 240 YLVTLLVVVP KLNHNDWIKQ YETLAEMVVP RSSNVLSEDQ DSYLCNVTLF RKAVDDFRHK 250 260 270 280 290 300 ARENKFIVRD FQYNEEEMKA DKEEMNRLST DKKKQFGPLV RWLKVNFSEA FIAWIHVKAL 310 320 330 340 350 360 RVFVESVLRY GLPVNFQAML LQPNKKTLKK LREVLHELYK HLDSSAAAII DAPMDIPGLN 370 380 LSQQEYYPYV YYKIDCNLLE FK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and tissue distribution of subunits C, D, and E of the human vacuolar H(+)-ATPase." van Hille B., Vanek M., Richener H., Green J.R., Bilbe G. Biochem. Biophys. Res. Commun. 197:15-21(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Osteoclastoma.
[2]	"BAALC, the human member of a novel mammalian neuroectoderm gene lineage, is implicated in hematopoiesis and acute leukemia." Tanner S.M., Austin J.L., Leone G., Rush L.J., Plass C., Heinonen K., Mrozek K., Sill H., Knuutila S., Kolitz J.E., Archer K.J., Caligiuri M.A., Bloomfield C.D., de La Chapelle A. Proc. Natl. Acad. Sci. U.S.A. 98:13901-13906(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone marrow.
[4]	Kanor S., Bienvenut W.V., Quadroni M. Submitted (DEC-2005) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-13; 45-60 AND 200-211, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT THR-2, MASS SPECTROMETRY. Tissue: Melanoma.
[5]	"Molecular cloning of cDNA encoding the C subunit of H(+)-ATPase from bovine chromaffin granules." Nelson H., Mandiyan S., Noumi T., Moriyama Y., Miedel M.C., Nelson N. J. Biol. Chem. 265:20390-20393(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 36-382. Tissue: Brain.
[6]	"Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis." Smith A.N., Borthwick K.J., Karet F.E. Gene 297:169-177(2002) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X69151 mRNA. Translation: CAA48903.1. AF363578 Genomic DNA. Translation: AAL50383.1. BC010960 mRNA. Translation: AAH10960.1. J05682 mRNA. Translation: AAA36803.1.
IPI	IPI00007814.
PIR	JN0907.
RefSeq	NP_001686.1. NM_001695.4.
UniGene	Hs.86905.
3D structure databases
ProteinModelPortal	P21283.
ModBase	Search...
Protein-protein interaction databases
IntAct	P21283. 4 interactions.
STRING	9606.ENSP00000379203.
Protein family/group databases
TCDB	3.A.2.2.4. H+- or Na+-translocating F-type, V-type and A-type ATPase (F-ATPase) superfamily.
PTM databases
PhosphoSite	P21283.
Polymorphism databases
DMDM	401329.
Proteomic databases
PaxDb	P21283.
PRIDE	P21283.
Protocols and materials databases
DNASU	528.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000395862; ENSP00000379203; ENSG00000155097. ENST00000518738; ENSP00000430282; ENSG00000155097.
GeneID	528.
KEGG	hsa:528.
UCSC	uc003ykz.4. human.
Organism-specific databases
CTD	528.
GeneCards	GC08P104033.
HGNC	HGNC:856. ATP6V1C1.
HPA	HPA023943.
MIM	603097. gene.
neXtProt	NX_P21283.
PharmGKB	PA25156.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5127.
HOGENOM	HOG000207528.
HOVERGEN	HBG002470.
InParanoid	P21283.
KO	K02148.
OMA	LADMVVP.
OrthoDB	EOG46MBJQ.
PhylomeDB	P21283.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction. REACT_116125. Disease. REACT_15518. Transmembrane transport of small molecules.
Gene expression databases
ArrayExpress	P21283.
Bgee	P21283.
CleanEx	HS_ATP6V1C1.
Genevestigator	P21283.
GermOnline	ENSG00000155097. Homo sapiens.
Family and domain databases
InterPro	IPR004907. ATPase_V1-cplx_csu. [Graphical view]
PANTHER	PTHR10137. PTHR10137. 1 hit.
Pfam	PF03223. V-ATPase_C. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ATP6V1C1. human.
GenomeRNAi	528.
NextBio	2193.
SOURCE	Search...

Entry information

Entry name

VATC1_HUMAN

Accession

Primary (citable) accession number: P21283

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 126 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.