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Protein

V-type proton ATPase subunit C 1

Gene

ATP6V1C1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-1222556 ROS, RNS production in phagocytes
R-BTA-77387 Insulin receptor recycling
R-BTA-917977 Transferrin endocytosis and recycling
R-BTA-983712 Ion channel transport

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit C 1
Short name:
V-ATPase subunit C 1
Alternative name(s):
Vacuolar proton pump subunit C 1
Gene namesi
Name:ATP6V1C1
Synonyms:ATP6C, VATC
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 14

Organism-specific databases

VGNCiVGNC:26319 ATP6V1C1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002093472 – 382V-type proton ATPase subunit C 1Add BLAST381

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP21282
PRIDEiP21282

Expressioni

Gene expression databases

BgeeiENSBTAG00000013513

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).

Protein-protein interaction databases

CORUMiP21282
STRINGi9913.ENSBTAP00000017968

Structurei

3D structure databases

ProteinModelPortaliP21282
SMRiP21282
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase C subunit family.Curated

Phylogenomic databases

eggNOGiKOG2909 Eukaryota
COG5127 LUCA
GeneTreeiENSGT00390000004263
HOGENOMiHOG000207528
HOVERGENiHBG002470
InParanoidiP21282
KOiK02148
OMAiCRENKFI
OrthoDBiEOG091G03CP
TreeFamiTF314912

Family and domain databases

CDDicd14785 V-ATPase_C, 1 hit
InterProiView protein in InterPro
IPR004907 ATPase_V1-cplx_csu
IPR036132 Vac_ATP_synth_c_sf
PANTHERiPTHR10137 PTHR10137, 1 hit
PfamiView protein in Pfam
PF03223 V-ATPase_C, 1 hit
SUPFAMiSSF118203 SSF118203, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P21282-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEFWLISAP GEKTCQQTWE KLHAATTKNN NLAVSSKFNI PDLKVGTLDV
60 70 80 90 100
LVGLSDELAK LDAFVEGVVK KVAQYMADVL EDSKDKVQEN LLANGVDLVT
110 120 130 140 150
YITRFQWDMA KYPIKQSLKN ISEIIAKGVT QIDNDLKSRA SAYNNLKGNL
160 170 180 190 200
QNLERKNAGS LLTRSLAEIV KKDDFVLDSE YLVTLLVVVP KLNHNDWIKQ
210 220 230 240 250
YETLAEMVVP RSSNVLSEDQ DSYLCNVTLF RKAVDDFRHK ARENKFIVRD
260 270 280 290 300
FQYNEEEMKA DKEEMNRLST DKKKQFGPLV RWLKVNFSEA FIAWIHVKAL
310 320 330 340 350
RVFVESVLRY GLPVNFQAML LQPNKKTMKK LREVLYELYK HLDSSAAAII
360 370 380
DAPMDIPGLN LSQQEYYPYV YYKIDCNLLE FK
Length:382
Mass (Da):43,986
Last modified:January 23, 2007 - v3
Checksum:i122FECB9F8A8AC9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05681 mRNA Translation: AAA30803.1
BC119957 mRNA Translation: AAI19958.1
PIRiA23671
RefSeqiNP_788849.1, NM_176676.1
UniGeneiBt.52307

Genome annotation databases

EnsembliENSBTAT00000017968; ENSBTAP00000017968; ENSBTAG00000013513
GeneIDi338089
KEGGibta:338089

Similar proteinsi

Entry informationi

Entry nameiVATC1_BOVIN
AccessioniPrimary (citable) accession number: P21282
Secondary accession number(s): Q0VCX0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 121 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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