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P21278

- GNA11_MOUSE

UniProt

P21278 - GNA11_MOUSE

Protein

Guanine nucleotide-binding protein subunit alpha-11

Gene

Gna11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 1 (01 May 1991)
      Previous versions | rss
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    Functioni

    Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi53 – 531MagnesiumBy similarity
    Metal bindingi186 – 1861MagnesiumBy similarity
    Binding sitei331 – 3311GTP; via amide nitrogenBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi46 – 538GTPBy similarity
    Nucleotide bindingi180 – 1867GTPBy similarity
    Nucleotide bindingi205 – 2095GTPBy similarity
    Nucleotide bindingi274 – 2774GTPBy similarity

    GO - Molecular functioni

    1. G-protein beta/gamma-subunit complex binding Source: RefGenome
    2. GTPase activity Source: MGI
    3. GTP binding Source: UniProtKB-KW
    4. metal ion binding Source: UniProtKB-KW
    5. signal transducer activity Source: RefGenome
    6. type 2A serotonin receptor binding Source: RefGenome

    GO - Biological processi

    1. action potential Source: MGI
    2. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: RefGenome
    3. cellular response to pH Source: MGI
    4. developmental pigmentation Source: MGI
    5. G-protein coupled receptor signaling pathway Source: MGI
    6. heart development Source: MGI
    7. phospholipase C-activating dopamine receptor signaling pathway Source: MGI
    8. regulation of melanocyte differentiation Source: MGI
    9. skeletal system development Source: MGI

    Keywords - Molecular functioni

    Transducer

    Keywords - Ligandi

    GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.
    REACT_220322. Thrombin signalling through proteinase activated receptors (PARs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanine nucleotide-binding protein subunit alpha-11
    Short name:
    G alpha-11
    Short name:
    G-protein subunit alpha-11
    Gene namesi
    Name:Gna11
    Synonyms:Gna-11
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:95766. Gna11.

    Subcellular locationi

    Cell membrane By similarity; Lipid-anchor By similarity. Cytoplasm By similarity

    GO - Cellular componenti

    1. heterotrimeric G-protein complex Source: MGI
    2. lysosomal membrane Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 359359Guanine nucleotide-binding protein subunit alpha-11PRO_0000203747Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi9 – 91S-palmitoyl cysteineBy similarity
    Lipidationi10 – 101S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Palmitate

    Proteomic databases

    MaxQBiP21278.
    PaxDbiP21278.
    PRIDEiP21278.

    PTM databases

    PhosphoSiteiP21278.

    Expressioni

    Gene expression databases

    ArrayExpressiP21278.
    BgeeiP21278.
    CleanExiMM_GNA11.
    GenevestigatoriP21278.

    Interactioni

    Subunit structurei

    G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with RGS22. Interacts with NTSR1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi199961. 1 interaction.
    DIPiDIP-603N.
    MINTiMINT-1863365.

    Structurei

    3D structure databases

    ProteinModelPortaliP21278.
    SMRiP21278. Positions 37-354.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-alpha family. G(q) subfamily.Curated

    Phylogenomic databases

    eggNOGiNOG322962.
    HOGENOMiHOG000038729.
    HOVERGENiHBG063184.
    InParanoidiP21278.
    KOiK04635.
    OMAiKTLWDDP.
    OrthoDBiEOG7ZWD1W.
    PhylomeDBiP21278.
    TreeFamiTF300673.

    Family and domain databases

    Gene3Di1.10.400.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProiIPR000654. Gprotein_alpha_Q.
    IPR001019. Gprotein_alpha_su.
    IPR011025. GproteinA_insert.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR10218. PTHR10218. 1 hit.
    PfamiPF00503. G-alpha. 1 hit.
    [Graphical view]
    PRINTSiPR00318. GPROTEINA.
    PR00442. GPROTEINAQ.
    SMARTiSM00275. G_alpha. 1 hit.
    [Graphical view]
    SUPFAMiSSF47895. SSF47895. 1 hit.
    SSF52540. SSF52540. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    P21278-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTLESMMACC LSDEVKESKR INAEIEKQLR RDKRDARREL KLLLLGTGES    50
    GKSTFIKQMR IIHGAGYSEE DKRGFTKLVY QNIFTAMQAM VRAMETLKIL 100
    YKYEQNKANA LLIREVDVEK VTTFEHQYVN AIKTLWSDPG VQECYDRRRE 150
    FQLSDSAKYY LTDVDRIATV GYLPTQQDVL RVRVPTTGII EYPFDLENII 200
    FRMVDVGGQR SERRKWIHCF ENVTSIMFLV ALSEYDQVLV ESDNENRMEE 250
    SKALFRTIIT YPWFQNSSVI LFLNKKDLLE DKILHSHLVD YFPEFDGPQR 300
    DAQAAREFIL KMFVDLNPDS DKIIYSHFTC ATDTENIRFV FAAVKDTILQ 350
    LNLKEYNLV 359
    Length:359
    Mass (Da):42,024
    Last modified:May 1, 1991 - v1
    Checksum:iA33D2D6C6C62F8D5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti77 – 771K → L in AAB36839. (PubMed:8838318)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M55411 mRNA. Translation: AAA63305.1.
    U37413, U37411, U37412 Genomic DNA. Translation: AAB36839.1.
    M57617 mRNA. Translation: AAA63301.1.
    CCDSiCCDS24061.1.
    PIRiB33833.
    B38414. RGMS11.
    RefSeqiNP_034431.1. NM_010301.3.
    UniGeneiMm.260925.
    Mm.471081.

    Genome annotation databases

    EnsembliENSMUST00000043604; ENSMUSP00000043190; ENSMUSG00000034781.
    GeneIDi14672.
    KEGGimmu:14672.
    UCSCiuc007gil.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M55411 mRNA. Translation: AAA63305.1 .
    U37413 , U37411 , U37412 Genomic DNA. Translation: AAB36839.1 .
    M57617 mRNA. Translation: AAA63301.1 .
    CCDSi CCDS24061.1.
    PIRi B33833.
    B38414. RGMS11.
    RefSeqi NP_034431.1. NM_010301.3.
    UniGenei Mm.260925.
    Mm.471081.

    3D structure databases

    ProteinModelPortali P21278.
    SMRi P21278. Positions 37-354.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199961. 1 interaction.
    DIPi DIP-603N.
    MINTi MINT-1863365.

    PTM databases

    PhosphoSitei P21278.

    Proteomic databases

    MaxQBi P21278.
    PaxDbi P21278.
    PRIDEi P21278.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000043604 ; ENSMUSP00000043190 ; ENSMUSG00000034781 .
    GeneIDi 14672.
    KEGGi mmu:14672.
    UCSCi uc007gil.1. mouse.

    Organism-specific databases

    CTDi 2767.
    MGIi MGI:95766. Gna11.

    Phylogenomic databases

    eggNOGi NOG322962.
    HOGENOMi HOG000038729.
    HOVERGENi HBG063184.
    InParanoidi P21278.
    KOi K04635.
    OMAi KTLWDDP.
    OrthoDBi EOG7ZWD1W.
    PhylomeDBi P21278.
    TreeFami TF300673.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.
    REACT_220322. Thrombin signalling through proteinase activated receptors (PARs).

    Miscellaneous databases

    NextBioi 286554.
    PROi P21278.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P21278.
    Bgeei P21278.
    CleanExi MM_GNA11.
    Genevestigatori P21278.

    Family and domain databases

    Gene3Di 1.10.400.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProi IPR000654. Gprotein_alpha_Q.
    IPR001019. Gprotein_alpha_su.
    IPR011025. GproteinA_insert.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR10218. PTHR10218. 1 hit.
    Pfami PF00503. G-alpha. 1 hit.
    [Graphical view ]
    PRINTSi PR00318. GPROTEINA.
    PR00442. GPROTEINAQ.
    SMARTi SM00275. G_alpha. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47895. SSF47895. 1 hit.
    SSF52540. SSF52540. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates."
      Strathmann M., Simon M.I.
      Proc. Natl. Acad. Sci. U.S.A. 87:9113-9117(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Gene structure of murine Gna11 and Gna15: tandemly duplicated Gq class G protein alpha subunit genes."
      Davignon I., Barnard M., Gavrilova O., Sweet K.K., Wilkie T.M.
      Genomics 31:359-366(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    3. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 21-27; 121-133; 159-166; 203-210; 312-338 AND 346-354, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.
    4. "Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse."
      Strathmann M., Wilkie T.M., Simon M.I.
      Proc. Natl. Acad. Sci. U.S.A. 86:7407-7409(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 211-271.

    Entry informationi

    Entry nameiGNA11_MOUSE
    AccessioniPrimary (citable) accession number: P21278
    Secondary accession number(s): Q61939
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1991
    Last sequence update: May 1, 1991
    Last modified: October 1, 2014
    This is version 138 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3