P21278 (GNA11_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Guanine nucleotide-binding protein subunit alpha-11
Short name=G alpha-11
Short name=G-protein subunit alpha-11

Gene names

Name:	Gna11
Synonyms:	Gna-11

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C.
Subunit structure	G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
Subcellular location	Cell membrane; Lipid-anchor By similarity.
Sequence similarities	Belongs to the G-alpha family. G(q) subfamily.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Ligand	GTP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Transducer
PTM	Lipoprotein Palmitate
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	adenylate cyclase-modulating G-protein coupled receptor signaling pathway Inferred from Biological aspect of Ancestor. Source: RefGenome developmental pigmentation Inferred from mutant phenotype PubMed 15322542. Source: MGI heart development Inferred from mutant phenotype PubMed 9687499. Source: MGI phospholipase C-activating dopamine receptor signaling pathway Inferred from genetic interaction PubMed 17194762. Source: MGI regulation of action potential Inferred from direct assay PubMed 10818132. Source: MGI regulation of melanocyte differentiation Inferred from mutant phenotype PubMed 15322542. Source: MGI skeletal system development Inferred from mutant phenotype PubMed 9687499. Source: MGI
Cellular_component	heterotrimeric G-protein complex Inferred from sequence alignment Ref.4. Source: MGI
Molecular_function	G-protein beta/gamma-subunit complex binding Inferred from Biological aspect of Ancestor. Source: RefGenome G-protein coupled receptor binding Inferred from Biological aspect of Ancestor. Source: RefGenome GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from sequence alignment Ref.4. Source: MGI metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW signal transducer activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 359	359	Guanine nucleotide-binding protein subunit alpha-11		PRO_0000203747
Regions
	Nucleotide binding	46 – 53	8	GTP By similarity
	Nucleotide binding	180 – 186	7	GTP By similarity
	Nucleotide binding	205 – 209	5	GTP By similarity
	Nucleotide binding	274 – 277	4	GTP By similarity
Sites
	Metal binding	53	1	Magnesium By similarity
	Metal binding	186	1	Magnesium By similarity
	Binding site	331	1	GTP; via amide nitrogen By similarity
Amino acid modifications
	Lipidation	9	1	S-palmitoyl cysteine By similarity
	Lipidation	10	1	S-palmitoyl cysteine By similarity
Experimental info
	Sequence conflict	77	1	K → L in AAB36839. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P21278 [UniParc]. Last modified May 1, 1991. Version 1. Checksum: A33D2D6C6C62F8D5	FASTA	359	42,024
	10 20 30 40 50 60 MTLESMMACC LSDEVKESKR INAEIEKQLR RDKRDARREL KLLLLGTGES GKSTFIKQMR 70 80 90 100 110 120 IIHGAGYSEE DKRGFTKLVY QNIFTAMQAM VRAMETLKIL YKYEQNKANA LLIREVDVEK 130 140 150 160 170 180 VTTFEHQYVN AIKTLWSDPG VQECYDRRRE FQLSDSAKYY LTDVDRIATV GYLPTQQDVL 190 200 210 220 230 240 RVRVPTTGII EYPFDLENII FRMVDVGGQR SERRKWIHCF ENVTSIMFLV ALSEYDQVLV 250 260 270 280 290 300 ESDNENRMEE SKALFRTIIT YPWFQNSSVI LFLNKKDLLE DKILHSHLVD YFPEFDGPQR 310 320 330 340 350 DAQAAREFIL KMFVDLNPDS DKIIYSHFTC ATDTENIRFV FAAVKDTILQ LNLKEYNLV

References

[1]	"G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates." Strathmann M., Simon M.I. Proc. Natl. Acad. Sci. U.S.A. 87:9113-9117(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Gene structure of murine Gna11 and Gna15: tandemly duplicated Gq class G protein alpha subunit genes." Davignon I., Barnard M., Gavrilova O., Sweet K.K., Wilkie T.M. Genomics 31:359-366(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/Sv.
[3]	Lubec G., Kang S.U. Submitted (APR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 21-27; 121-133; 159-166; 203-210; 312-338 AND 346-354, MASS SPECTROMETRY. Strain: C57BL/6. Tissue: Brain.
[4]	"Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse." Strathmann M., Wilkie T.M., Simon M.I. Proc. Natl. Acad. Sci. U.S.A. 86:7407-7409(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 211-271.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M55411 mRNA. Translation: AAA63305.1. U37413, U37411, U37412 Genomic DNA. Translation: AAB36839.1. M57617 mRNA. Translation: AAA63301.1.
IPI	IPI00121387.
PIR	B33833. RGMS11. B38414.
RefSeq	NP_034431.1. NM_010301.3.
UniGene	Mm.260925. Mm.471081.
3D structure databases
ProteinModelPortal	P21278.
SMR	P21278. Positions 37-354.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-603N.
PTM databases
PhosphoSite	P21278.
Proteomic databases
PaxDb	P21278.
PRIDE	P21278.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000043604; ENSMUSP00000043190; ENSMUSG00000034781.
GeneID	14672.
KEGG	mmu:14672.
Organism-specific databases
CTD	2767.
MGI	MGI:95766. Gna11.
Phylogenomic databases
eggNOG	NOG322962.
HOGENOM	HOG000038729.
HOVERGEN	HBG063184.
InParanoid	P21278.
KO	K04635.
OMA	KTLWSDP.
OrthoDB	EOG4S4PGD.
Gene expression databases
ArrayExpress	P21278.
Bgee	P21278.
CleanEx	MM_GNA11.
Genevestigator	P21278.
GermOnline	ENSMUSG00000034781. Mus musculus.
Family and domain databases
Gene3D	1.10.400.10. 1 hit.
InterPro	IPR000654. Gprotein_alpha_Q. IPR001019. Gprotein_alpha_su. IPR011025. GproteinA_insert. [Graphical view]
PANTHER	PTHR10218. PTHR10218. 1 hit.
Pfam	PF00503. G-alpha. 1 hit. [Graphical view]
PRINTS	PR00318. GPROTEINA. PR00442. GPROTEINAQ.
SMART	SM00275. G_alpha. 1 hit. [Graphical view]
SUPFAM	SSF47895. Transducn_insert. 1 hit.
ProtoNet	Search...
Other
NextBio	286554.
SOURCE	Search...

Entry information

Entry name

GNA11_MOUSE

Accession

Primary (citable) accession number: P21278
Secondary accession number(s): Q61939

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1991
Last sequence update:	May 1, 1991
Last modified:	May 1, 2013
This is version 126 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program