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P21278

- GNA11_MOUSE

UniProt

P21278 - GNA11_MOUSE

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Protein

Guanine nucleotide-binding protein subunit alpha-11

Gene

Gna11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi53 – 531MagnesiumBy similarity
Metal bindingi186 – 1861MagnesiumBy similarity
Binding sitei331 – 3311GTP; via amide nitrogenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi46 – 538GTPBy similarity
Nucleotide bindingi180 – 1867GTPBy similarity
Nucleotide bindingi205 – 2095GTPBy similarity
Nucleotide bindingi274 – 2774GTPBy similarity

GO - Molecular functioni

  1. G-protein beta/gamma-subunit complex binding Source: RefGenome
  2. GTPase activity Source: MGI
  3. GTP binding Source: UniProtKB-KW
  4. metal ion binding Source: UniProtKB-KW
  5. signal transducer activity Source: RefGenome
  6. type 2A serotonin receptor binding Source: RefGenome

GO - Biological processi

  1. action potential Source: MGI
  2. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: RefGenome
  3. cellular response to pH Source: MGI
  4. developmental pigmentation Source: MGI
  5. G-protein coupled receptor signaling pathway Source: MGI
  6. heart development Source: MGI
  7. phospholipase C-activating dopamine receptor signaling pathway Source: MGI
  8. regulation of melanocyte differentiation Source: MGI
  9. skeletal system development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.
REACT_220322. Thrombin signalling through proteinase activated receptors (PARs).
REACT_233922. Thromboxane signalling through TP receptor.
REACT_247495. Acetylcholine regulates insulin secretion.
REACT_250548. Platelet sensitization by LDL.
REACT_258788. Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion.
REACT_259068. ADP signalling through P2Y purinoceptor 1.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein subunit alpha-11
Short name:
G alpha-11
Short name:
G-protein subunit alpha-11
Gene namesi
Name:Gna11
Synonyms:Gna-11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:95766. Gna11.

Subcellular locationi

Cell membrane By similarity; Lipid-anchor By similarity. Cytoplasm By similarity

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. heterotrimeric G-protein complex Source: MGI
  3. lysosomal membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Guanine nucleotide-binding protein subunit alpha-11PRO_0000203747Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi9 – 91S-palmitoyl cysteineBy similarity
Lipidationi10 – 101S-palmitoyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

MaxQBiP21278.
PaxDbiP21278.
PRIDEiP21278.

PTM databases

PhosphoSiteiP21278.

Expressioni

Gene expression databases

BgeeiP21278.
CleanExiMM_GNA11.
ExpressionAtlasiP21278. baseline and differential.
GenevestigatoriP21278.

Interactioni

Subunit structurei

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with RGS22. Interacts with NTSR1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi199961. 1 interaction.
DIPiDIP-603N.
MINTiMINT-1863365.

Structurei

3D structure databases

ProteinModelPortaliP21278.
SMRiP21278. Positions 37-354.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-alpha family. G(q) subfamily.Curated

Phylogenomic databases

eggNOGiNOG322962.
HOGENOMiHOG000038729.
HOVERGENiHBG063184.
InParanoidiP21278.
KOiK04635.
OMAiKTLWDDP.
OrthoDBiEOG7ZWD1W.
PhylomeDBiP21278.
TreeFamiTF300673.

Family and domain databases

Gene3Di1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR000654. Gprotein_alpha_Q.
IPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10218. PTHR10218. 1 hit.
PfamiPF00503. G-alpha. 1 hit.
[Graphical view]
PRINTSiPR00318. GPROTEINA.
PR00442. GPROTEINAQ.
SMARTiSM00275. G_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.

Sequencei

Sequence statusi: Complete.

P21278-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTLESMMACC LSDEVKESKR INAEIEKQLR RDKRDARREL KLLLLGTGES
60 70 80 90 100
GKSTFIKQMR IIHGAGYSEE DKRGFTKLVY QNIFTAMQAM VRAMETLKIL
110 120 130 140 150
YKYEQNKANA LLIREVDVEK VTTFEHQYVN AIKTLWSDPG VQECYDRRRE
160 170 180 190 200
FQLSDSAKYY LTDVDRIATV GYLPTQQDVL RVRVPTTGII EYPFDLENII
210 220 230 240 250
FRMVDVGGQR SERRKWIHCF ENVTSIMFLV ALSEYDQVLV ESDNENRMEE
260 270 280 290 300
SKALFRTIIT YPWFQNSSVI LFLNKKDLLE DKILHSHLVD YFPEFDGPQR
310 320 330 340 350
DAQAAREFIL KMFVDLNPDS DKIIYSHFTC ATDTENIRFV FAAVKDTILQ

LNLKEYNLV
Length:359
Mass (Da):42,024
Last modified:May 1, 1991 - v1
Checksum:iA33D2D6C6C62F8D5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti77 – 771K → L in AAB36839. (PubMed:8838318)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55411 mRNA. Translation: AAA63305.1.
U37413, U37411, U37412 Genomic DNA. Translation: AAB36839.1.
M57617 mRNA. Translation: AAA63301.1.
CCDSiCCDS24061.1.
PIRiB33833.
B38414. RGMS11.
RefSeqiNP_034431.1. NM_010301.3.
UniGeneiMm.260925.
Mm.471081.

Genome annotation databases

EnsembliENSMUST00000043604; ENSMUSP00000043190; ENSMUSG00000034781.
GeneIDi14672.
KEGGimmu:14672.
UCSCiuc007gil.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55411 mRNA. Translation: AAA63305.1 .
U37413 , U37411 , U37412 Genomic DNA. Translation: AAB36839.1 .
M57617 mRNA. Translation: AAA63301.1 .
CCDSi CCDS24061.1.
PIRi B33833.
B38414. RGMS11.
RefSeqi NP_034431.1. NM_010301.3.
UniGenei Mm.260925.
Mm.471081.

3D structure databases

ProteinModelPortali P21278.
SMRi P21278. Positions 37-354.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199961. 1 interaction.
DIPi DIP-603N.
MINTi MINT-1863365.

PTM databases

PhosphoSitei P21278.

Proteomic databases

MaxQBi P21278.
PaxDbi P21278.
PRIDEi P21278.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000043604 ; ENSMUSP00000043190 ; ENSMUSG00000034781 .
GeneIDi 14672.
KEGGi mmu:14672.
UCSCi uc007gil.1. mouse.

Organism-specific databases

CTDi 2767.
MGIi MGI:95766. Gna11.

Phylogenomic databases

eggNOGi NOG322962.
HOGENOMi HOG000038729.
HOVERGENi HBG063184.
InParanoidi P21278.
KOi K04635.
OMAi KTLWDDP.
OrthoDBi EOG7ZWD1W.
PhylomeDBi P21278.
TreeFami TF300673.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.
REACT_220322. Thrombin signalling through proteinase activated receptors (PARs).
REACT_233922. Thromboxane signalling through TP receptor.
REACT_247495. Acetylcholine regulates insulin secretion.
REACT_250548. Platelet sensitization by LDL.
REACT_258788. Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion.
REACT_259068. ADP signalling through P2Y purinoceptor 1.

Miscellaneous databases

ChiTaRSi Gna11. mouse.
NextBioi 286554.
PROi P21278.
SOURCEi Search...

Gene expression databases

Bgeei P21278.
CleanExi MM_GNA11.
ExpressionAtlasi P21278. baseline and differential.
Genevestigatori P21278.

Family and domain databases

Gene3Di 1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProi IPR000654. Gprotein_alpha_Q.
IPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR10218. PTHR10218. 1 hit.
Pfami PF00503. G-alpha. 1 hit.
[Graphical view ]
PRINTSi PR00318. GPROTEINA.
PR00442. GPROTEINAQ.
SMARTi SM00275. G_alpha. 1 hit.
[Graphical view ]
SUPFAMi SSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates."
    Strathmann M., Simon M.I.
    Proc. Natl. Acad. Sci. U.S.A. 87:9113-9117(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Gene structure of murine Gna11 and Gna15: tandemly duplicated Gq class G protein alpha subunit genes."
    Davignon I., Barnard M., Gavrilova O., Sweet K.K., Wilkie T.M.
    Genomics 31:359-366(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  3. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 21-27; 121-133; 159-166; 203-210; 312-338 AND 346-354, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.
  4. "Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse."
    Strathmann M., Wilkie T.M., Simon M.I.
    Proc. Natl. Acad. Sci. U.S.A. 86:7407-7409(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 211-271.

Entry informationi

Entry nameiGNA11_MOUSE
AccessioniPrimary (citable) accession number: P21278
Secondary accession number(s): Q61939
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: November 26, 2014
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3