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P21278 (GNA11_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 136. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanine nucleotide-binding protein subunit alpha-11

Short name=G alpha-11
Short name=G-protein subunit alpha-11
Gene names
Name:Gna11
Synonyms:Gna-11
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C.

Subunit structure

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with RGS22 By similarity.

Subcellular location

Cell membrane; Lipid-anchor By similarity. Cytoplasm By similarity.

Sequence similarities

Belongs to the G-alpha family. G(q) subfamily.

Ontologies

Keywords
   Cellular componentCell membrane
Cytoplasm
Membrane
   LigandGTP-binding
Magnesium
Metal-binding
Nucleotide-binding
   Molecular functionTransducer
   PTMLipoprotein
Palmitate
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Inferred from mutant phenotype PubMed 9687499. Source: MGI

action potential

Inferred from direct assay PubMed 10818132. Source: MGI

adenylate cyclase-modulating G-protein coupled receptor signaling pathway

Inferred from Biological aspect of Ancestor. Source: RefGenome

cellular response to pH

Inferred from mutant phenotype PubMed 22733973. Source: MGI

developmental pigmentation

Inferred from mutant phenotype PubMed 15322542. Source: MGI

heart development

Inferred from mutant phenotype PubMed 9687499. Source: MGI

phospholipase C-activating dopamine receptor signaling pathway

Inferred from genetic interaction PubMed 17194762. Source: MGI

regulation of melanocyte differentiation

Inferred from mutant phenotype PubMed 15322542. Source: MGI

skeletal system development

Inferred from mutant phenotype PubMed 9687499. Source: MGI

   Cellular_componentextrinsic component of cytoplasmic side of plasma membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

heterotrimeric G-protein complex

Inferred from sequence alignment Ref.4. Source: MGI

lysosomal membrane

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionG-protein beta/gamma-subunit complex binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

G-protein coupled receptor binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

GTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

GTPase activity

Inferred from sequence alignment Ref.4. Source: MGI

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

signal transducer activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 359359Guanine nucleotide-binding protein subunit alpha-11
PRO_0000203747

Regions

Nucleotide binding46 – 538GTP By similarity
Nucleotide binding180 – 1867GTP By similarity
Nucleotide binding205 – 2095GTP By similarity
Nucleotide binding274 – 2774GTP By similarity

Sites

Metal binding531Magnesium By similarity
Metal binding1861Magnesium By similarity
Binding site3311GTP; via amide nitrogen By similarity

Amino acid modifications

Lipidation91S-palmitoyl cysteine By similarity
Lipidation101S-palmitoyl cysteine By similarity

Experimental info

Sequence conflict771K → L in AAB36839. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P21278 [UniParc].

Last modified May 1, 1991. Version 1.
Checksum: A33D2D6C6C62F8D5

FASTA35942,024
        10         20         30         40         50         60 
MTLESMMACC LSDEVKESKR INAEIEKQLR RDKRDARREL KLLLLGTGES GKSTFIKQMR 

        70         80         90        100        110        120 
IIHGAGYSEE DKRGFTKLVY QNIFTAMQAM VRAMETLKIL YKYEQNKANA LLIREVDVEK 

       130        140        150        160        170        180 
VTTFEHQYVN AIKTLWSDPG VQECYDRRRE FQLSDSAKYY LTDVDRIATV GYLPTQQDVL 

       190        200        210        220        230        240 
RVRVPTTGII EYPFDLENII FRMVDVGGQR SERRKWIHCF ENVTSIMFLV ALSEYDQVLV 

       250        260        270        280        290        300 
ESDNENRMEE SKALFRTIIT YPWFQNSSVI LFLNKKDLLE DKILHSHLVD YFPEFDGPQR 

       310        320        330        340        350 
DAQAAREFIL KMFVDLNPDS DKIIYSHFTC ATDTENIRFV FAAVKDTILQ LNLKEYNLV 

« Hide

References

[1]"G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates."
Strathmann M., Simon M.I.
Proc. Natl. Acad. Sci. U.S.A. 87:9113-9117(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Gene structure of murine Gna11 and Gna15: tandemly duplicated Gq class G protein alpha subunit genes."
Davignon I., Barnard M., Gavrilova O., Sweet K.K., Wilkie T.M.
Genomics 31:359-366(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/Sv.
[3]Lubec G., Kang S.U.
Submitted (APR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 21-27; 121-133; 159-166; 203-210; 312-338 AND 346-354, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: C57BL/6.
Tissue: Brain.
[4]"Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse."
Strathmann M., Wilkie T.M., Simon M.I.
Proc. Natl. Acad. Sci. U.S.A. 86:7407-7409(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 211-271.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M55411 mRNA. Translation: AAA63305.1.
U37413, U37411, U37412 Genomic DNA. Translation: AAB36839.1.
M57617 mRNA. Translation: AAA63301.1.
CCDSCCDS24061.1.
PIRB33833.
RGMS11. B38414.
RefSeqNP_034431.1. NM_010301.3.
UniGeneMm.260925.
Mm.471081.

3D structure databases

ProteinModelPortalP21278.
SMRP21278. Positions 37-354.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid199961. 1 interaction.
DIPDIP-603N.
MINTMINT-1863365.

PTM databases

PhosphoSiteP21278.

Proteomic databases

MaxQBP21278.
PaxDbP21278.
PRIDEP21278.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000043604; ENSMUSP00000043190; ENSMUSG00000034781.
GeneID14672.
KEGGmmu:14672.
UCSCuc007gil.1. mouse.

Organism-specific databases

CTD2767.
MGIMGI:95766. Gna11.

Phylogenomic databases

eggNOGNOG322962.
HOGENOMHOG000038729.
HOVERGENHBG063184.
InParanoidP21278.
KOK04635.
OMAKTLWDDP.
OrthoDBEOG7ZWD1W.
PhylomeDBP21278.
TreeFamTF300673.

Gene expression databases

ArrayExpressP21278.
BgeeP21278.
CleanExMM_GNA11.
GenevestigatorP21278.

Family and domain databases

Gene3D1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProIPR000654. Gprotein_alpha_Q.
IPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR10218. PTHR10218. 1 hit.
PfamPF00503. G-alpha. 1 hit.
[Graphical view]
PRINTSPR00318. GPROTEINA.
PR00442. GPROTEINAQ.
SMARTSM00275. G_alpha. 1 hit.
[Graphical view]
SUPFAMSSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.
ProtoNetSearch...

Other

NextBio286554.
PROP21278.
SOURCESearch...

Entry information

Entry nameGNA11_MOUSE
AccessionPrimary (citable) accession number: P21278
Secondary accession number(s): Q61939
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: July 9, 2014
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot