Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Guanine nucleotide-binding protein subunit alpha-11

Gene

Gna11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi53 – 531MagnesiumBy similarity
Metal bindingi186 – 1861MagnesiumBy similarity
Binding sitei331 – 3311GTP; via amide nitrogenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi46 – 538GTPBy similarity
Nucleotide bindingi180 – 1867GTPBy similarity
Nucleotide bindingi205 – 2095GTPBy similarity
Nucleotide bindingi274 – 2774GTPBy similarity

GO - Molecular functioni

GO - Biological processi

  • action potential Source: MGI
  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: GO_Central
  • cellular response to pH Source: MGI
  • developmental pigmentation Source: MGI
  • G-protein coupled receptor signaling pathway Source: MGI
  • heart development Source: MGI
  • metabolic process Source: GOC
  • phospholipase C-activating dopamine receptor signaling pathway Source: MGI
  • regulation of melanocyte differentiation Source: MGI
  • skeletal system development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_275222. Thrombin signalling through proteinase activated receptors (PARs).
REACT_306601. Acetylcholine regulates insulin secretion.
REACT_334088. Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion.
REACT_334244. ADP signalling through P2Y purinoceptor 1.
REACT_335533. Platelet sensitization by LDL.
REACT_336725. Thromboxane signalling through TP receptor.
REACT_347934. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein subunit alpha-11
Short name:
G alpha-11
Short name:
G-protein subunit alpha-11
Gene namesi
Name:Gna11
Synonyms:Gna-11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:95766. Gna11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Guanine nucleotide-binding protein subunit alpha-11PRO_0000203747Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi9 – 91S-palmitoyl cysteineBy similarity
Lipidationi10 – 101S-palmitoyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

MaxQBiP21278.
PaxDbiP21278.
PRIDEiP21278.

PTM databases

PhosphoSiteiP21278.

Expressioni

Gene expression databases

BgeeiP21278.
CleanExiMM_GNA11.
ExpressionAtlasiP21278. baseline and differential.
GenevisibleiP21278. MM.

Interactioni

Subunit structurei

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with RGS22. Interacts with NTSR1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi199961. 1 interaction.
DIPiDIP-603N.
MINTiMINT-1863365.
STRINGi10090.ENSMUSP00000043190.

Structurei

3D structure databases

ProteinModelPortaliP21278.
SMRiP21278. Positions 37-354.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-alpha family. G(q) subfamily.Curated

Phylogenomic databases

eggNOGiNOG322962.
HOGENOMiHOG000038729.
HOVERGENiHBG063184.
InParanoidiP21278.
KOiK04635.
OMAiKTLWDDP.
OrthoDBiEOG7ZWD1W.
PhylomeDBiP21278.
TreeFamiTF300673.

Family and domain databases

Gene3Di1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR000654. Gprotein_alpha_Q.
IPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10218. PTHR10218. 1 hit.
PfamiPF00503. G-alpha. 1 hit.
[Graphical view]
PRINTSiPR00318. GPROTEINA.
PR00442. GPROTEINAQ.
SMARTiSM00275. G_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.

Sequencei

Sequence statusi: Complete.

P21278-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLESMMACC LSDEVKESKR INAEIEKQLR RDKRDARREL KLLLLGTGES
60 70 80 90 100
GKSTFIKQMR IIHGAGYSEE DKRGFTKLVY QNIFTAMQAM VRAMETLKIL
110 120 130 140 150
YKYEQNKANA LLIREVDVEK VTTFEHQYVN AIKTLWSDPG VQECYDRRRE
160 170 180 190 200
FQLSDSAKYY LTDVDRIATV GYLPTQQDVL RVRVPTTGII EYPFDLENII
210 220 230 240 250
FRMVDVGGQR SERRKWIHCF ENVTSIMFLV ALSEYDQVLV ESDNENRMEE
260 270 280 290 300
SKALFRTIIT YPWFQNSSVI LFLNKKDLLE DKILHSHLVD YFPEFDGPQR
310 320 330 340 350
DAQAAREFIL KMFVDLNPDS DKIIYSHFTC ATDTENIRFV FAAVKDTILQ

LNLKEYNLV
Length:359
Mass (Da):42,024
Last modified:May 1, 1991 - v1
Checksum:iA33D2D6C6C62F8D5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti77 – 771K → L in AAB36839 (PubMed:8838318).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55411 mRNA. Translation: AAA63305.1.
U37413, U37411, U37412 Genomic DNA. Translation: AAB36839.1.
M57617 mRNA. Translation: AAA63301.1.
CCDSiCCDS24061.1.
PIRiB33833.
B38414. RGMS11.
RefSeqiNP_034431.1. NM_010301.3.
UniGeneiMm.260925.
Mm.471081.

Genome annotation databases

EnsembliENSMUST00000043604; ENSMUSP00000043190; ENSMUSG00000034781.
GeneIDi14672.
KEGGimmu:14672.
UCSCiuc007gil.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55411 mRNA. Translation: AAA63305.1.
U37413, U37411, U37412 Genomic DNA. Translation: AAB36839.1.
M57617 mRNA. Translation: AAA63301.1.
CCDSiCCDS24061.1.
PIRiB33833.
B38414. RGMS11.
RefSeqiNP_034431.1. NM_010301.3.
UniGeneiMm.260925.
Mm.471081.

3D structure databases

ProteinModelPortaliP21278.
SMRiP21278. Positions 37-354.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199961. 1 interaction.
DIPiDIP-603N.
MINTiMINT-1863365.
STRINGi10090.ENSMUSP00000043190.

PTM databases

PhosphoSiteiP21278.

Proteomic databases

MaxQBiP21278.
PaxDbiP21278.
PRIDEiP21278.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043604; ENSMUSP00000043190; ENSMUSG00000034781.
GeneIDi14672.
KEGGimmu:14672.
UCSCiuc007gil.1. mouse.

Organism-specific databases

CTDi2767.
MGIiMGI:95766. Gna11.

Phylogenomic databases

eggNOGiNOG322962.
HOGENOMiHOG000038729.
HOVERGENiHBG063184.
InParanoidiP21278.
KOiK04635.
OMAiKTLWDDP.
OrthoDBiEOG7ZWD1W.
PhylomeDBiP21278.
TreeFamiTF300673.

Enzyme and pathway databases

ReactomeiREACT_275222. Thrombin signalling through proteinase activated receptors (PARs).
REACT_306601. Acetylcholine regulates insulin secretion.
REACT_334088. Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion.
REACT_334244. ADP signalling through P2Y purinoceptor 1.
REACT_335533. Platelet sensitization by LDL.
REACT_336725. Thromboxane signalling through TP receptor.
REACT_347934. G alpha (q) signalling events.

Miscellaneous databases

ChiTaRSiGna11. mouse.
NextBioi286554.
PROiP21278.
SOURCEiSearch...

Gene expression databases

BgeeiP21278.
CleanExiMM_GNA11.
ExpressionAtlasiP21278. baseline and differential.
GenevisibleiP21278. MM.

Family and domain databases

Gene3Di1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR000654. Gprotein_alpha_Q.
IPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10218. PTHR10218. 1 hit.
PfamiPF00503. G-alpha. 1 hit.
[Graphical view]
PRINTSiPR00318. GPROTEINA.
PR00442. GPROTEINAQ.
SMARTiSM00275. G_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates."
    Strathmann M., Simon M.I.
    Proc. Natl. Acad. Sci. U.S.A. 87:9113-9117(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Gene structure of murine Gna11 and Gna15: tandemly duplicated Gq class G protein alpha subunit genes."
    Davignon I., Barnard M., Gavrilova O., Sweet K.K., Wilkie T.M.
    Genomics 31:359-366(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  3. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 21-27; 121-133; 159-166; 203-210; 312-338 AND 346-354, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.
  4. "Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse."
    Strathmann M., Wilkie T.M., Simon M.I.
    Proc. Natl. Acad. Sci. U.S.A. 86:7407-7409(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 211-271.

Entry informationi

Entry nameiGNA11_MOUSE
AccessioniPrimary (citable) accession number: P21278
Secondary accession number(s): Q61939
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: May 1, 1991
Last modified: June 24, 2015
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.